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See detailAntihypertensive therapy and blood pressure control in renal transplant recipients.
Saint-Remy, Annie ULg; Ait Oile, Fatima; Weekers, Laurent ULg et al

in American Journal of Hypertension : Journal of the American Society of Hypertension (2004), 17(5), 122-123

Renal transplant recipients are at high risk of cardiovascular diseases which represent,with infections, their major cause of excessive deaths. Immunosuppressive treatments are partly responsible leading ... [more ▼]

Renal transplant recipients are at high risk of cardiovascular diseases which represent,with infections, their major cause of excessive deaths. Immunosuppressive treatments are partly responsible leading to hypertension (HT), diabetes and hyperlipidemia. Aim: This study analyses the blood pressure (BP) control in renal transplant recipients with functioning graft according to their current antihypertensive and immunosuppressive therapies. Data were collected for 211 patients (M:58%; F:42%) transplanted on average since 7.7 years (2-360 months). Mean age was 50 years (16–72), 84% had hypercholesterolemia (>1.9 g/l), 18% were diabetics and 24% were smokers. Seventy-eight % were under antihypertensive treatment. Results: HT (mean OBP of 3 visits: >140 and/or >90 mmHg or treated) was observed in half of the untreated patients and uncontrolled in 80% of the treated ones. Ninety % of the treated hypertensive diabetic patients didn't reach target BP <130/80 mmHg. HT was significantly more frequent in patients whose glomerular filtration(GFR) was lower than the median value of GFR (55 ml/min/1.73 m2) of the population. Among treated patients, 48% had 1 drug, 29% had 2 drugs and 23% had 3 drugs or more. Beta-Blockers were the most prescribed even in association, while diuretics were less used since, even in 3 drugs therapy, only 60% received such class. Calcium inhibitors were not prescribed readily in first line but accounted for 47% in 2 drugs combinations. These observations were not related to the GFR level. Only 26% received an ACE inhibitor, their prescription decreases roughly in patients with impaired GFR. AII-RB concerned only 10% of therapies. Body weight, creatinine, graft survival and recipient's age were significantly related to SBP and DBP. In patients treated with cyclosporin, a highly significant relation (p=0.02) was found between BP and blood level of CsA, this was not observed in patients treated with tacrolimus . Conclusion: HT was highly prevalent in renal transplant recipients( 88% of patients) even when treated. This study leads to reconsider habits of prescrition in view to improve the BP control by increasing the use of diuretics and to improve cardioprotection by using more often ACE inhibitors (when not contra-indicated) in that high cardiovascular risk population. As mentioned in literature, the effect of tacrolimus on BP appears lesser than the cyclosporine one. [less ▲]

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See detailAntiinflammatory activity of Centaurea cyanus flowers
Bodart, Patricia; Damas, Jacques ULg; Goldsztajn, V. et al

in Journal de Pharmacie de Belgique (1994, February), 59(1), 73

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See detailAntiinflammatory activity of centaurea cyanus flowers
Bodart, Patricia; Goldsztajn, V.; Tits, Monique ULg et al

Poster (1994, March)

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See detailAntiinflammatory and chonroprotective activity of prodelphinidins isolated from Ribes nigrum leaves
Tits, Monique ULg; de Leval Xavier; Dierckxsens, Yvan et al

Poster (2000, July)

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See detailAntiinflammatory Prodelphinidins from Black Currant (Ribes nigrum) Leaves
Tits, Monique ULg; Angenot, Luc ULg; Damas, Jacques ULg et al

in Planta Medica (1991), 57(Supplement issue 2), 134

In a study to select anti-inflammatory medicinal plants, we have observed that extracts of Ribes nigrum significantly inhibited at a dose of 50mg/kg i.p. the carrageenan rat paw edema. We have now proved ... [more ▼]

In a study to select anti-inflammatory medicinal plants, we have observed that extracts of Ribes nigrum significantly inhibited at a dose of 50mg/kg i.p. the carrageenan rat paw edema. We have now proved that the most active fractions contained proanthocyanidins . In the present study, we report on the isolation of three bioactive compounds: two prodelphinidins dimers and a new trimeric one. [less ▲]

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See detailAntilisterial Activity on Poultry Meat of Amylolysin, a Bacteriocin from Bacillus amyloliquefaciens GA1
Halimi, Badre Eddine ULg; Dortu, Carine; Arguelles Arias, Anthony ULg et al

in Probiotics and Antimicrobial Proteins (2010)

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See detailAntilisterial Bacteriocin-Producing Strain Of Lactobacillus Curvatus Cwbi-B28 As A Preservative Culture In Bacon Meat And Influence Of Fat And Nitrites On Bacteriocins Production And Activity
Ghalfi, H.; Kouakou, P.; Duroy, M. et al

in Food Science and Technology International (2006), 12(4),

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See detailLes antilopes
Vermeulen, Cédric ULg

in Delvingt, W.; Vermeulen, Cédric (Eds.) Nazinga (2007)

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See detailAntimalarial Activity of Cryptolepine and some otrher Anhydronium Bases
Wright, C. W.; Phillipson, J. D.; Awe, S. O. et al

in Phytotherapy Research (1996), 10

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar ... [more ▼]

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitemia was suppressed by 80% at 50 mg/kg/day. [less ▲]

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See detailAntimalarial compounds isolated from plants used in traditional medicine.
Bero, Joanne; Frederich, Michel ULg; Quetin-Leclercq, Joelle

in Journal of Pharmacy & Pharmacology (2009), 61(11), 1401-33

OBJECTIVES: This review covers the compounds with antiplasmodial activity isolated from plants published from 2005 to the end of 2008, organized according to their phytochemical classes. Details are given ... [more ▼]

OBJECTIVES: This review covers the compounds with antiplasmodial activity isolated from plants published from 2005 to the end of 2008, organized according to their phytochemical classes. Details are given for substances with IC50 values < or = 11 microm. KEY FINDINGS: Malaria is a major parasitic disease in many tropical and subtropical regions and is responsible for more than 1 million deaths each year in Africa. The rapid spread of resistance encourages the search for new active compounds. Nature and particularly plants used in traditional medicine are a potential source of new antimalarial drugs as they contain molecules with a great variety of structures and pharmacological activities. SUMMARY: A large number of antimalarial compounds with a wide variety of structures have been isolated from plants and can play a role in the development of new antimalarial drugs. Ethnopharmacological approaches appear to be a promising way to find plant metabolites that could be used as templates for designing new derivatives with improved properties. [less ▲]

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See detailAntimicrobial activities of commercial essential oils and their components against food-borne pathogens and food spoilage bacteria.
Mith, Hasika; Dure, Remi; Delcenserie, Véronique ULg et al

in Food science & nutrition (2014), 2(4), 403-16

This study was undertaken to determine the in vitro antimicrobial activities of 15 commercial essential oils and their main components in order to pre-select candidates for potential application in highly ... [more ▼]

This study was undertaken to determine the in vitro antimicrobial activities of 15 commercial essential oils and their main components in order to pre-select candidates for potential application in highly perishable food preservation. The antibacterial effects against food-borne pathogenic bacteria (Listeria monocytogenes, Salmonella Typhimurium, and enterohemorrhagic Escherichia coli O157:H7) and food spoilage bacteria (Brochothrix thermosphacta and Pseudomonas fluorescens) were tested using paper disk diffusion method, followed by determination of minimum inhibitory (MIC) and bactericidal (MBC) concentrations. Most of the tested essential oils exhibited antimicrobial activity against all tested bacteria, except galangal oil. The essential oils of cinnamon, oregano, and thyme showed strong antimicrobial activities with MIC >/= 0.125 muL/mL and MBC >/= 0.25 muL/mL. Among tested bacteria, P. fluorescens was the most resistant to selected essential oils with MICs and MBCs of 1 muL/mL. The results suggest that the activity of the essential oils of cinnamon, oregano, thyme, and clove can be attributed to the existence mostly of cinnamaldehyde, carvacrol, thymol, and eugenol, which appear to possess similar activities against all the tested bacteria. These materials could be served as an important natural alternative to prevent bacterial growth in food products. [less ▲]

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See detailAntimicrobial activity against gram negative bacilli from Yaounde Central Hospital, Cameroon
Gangoue Pieboji, Joseph ULg; Koulla-Shiro, S.; Ngassam, P. et al

in African Health Sciences (2006), 6(4), 232-5

BACKGROUND: Antimicrobial resistance among bacteria pathogens is a world-wide issue. The antimicrobial susceptibility patterns of common pathogenic bacteria are essential to guide empirical and pathogen ... [more ▼]

BACKGROUND: Antimicrobial resistance among bacteria pathogens is a world-wide issue. The antimicrobial susceptibility patterns of common pathogenic bacteria are essential to guide empirical and pathogen-specific therapy; unfortunately, these data are scarse in Cameroon. OBJECTIVE: To determine the antimicrobial susceptibility patterns of Gram-negative bacilli isolated in Yaounde Central Hospital Laboratory of Bacteriology. METHODS: Gram-negative bacilli isolates (n = 505), obtained from a wide range of clinical specimens (urine, pus and blood) in Yaounde Central Hospital Laboratory of Bacteriology between March 1995 and April 1998, were evaluated for resistance to antibiotics (amoxicillin, amoxicillin/clavulanate, piperacillin, cefazolin, cefoxitin, cefotaxime, ceftazidime, aztreonam, imipenem, gentamicin, tobramicin, ofloxacin and trimethoprim/sulfamethoxazole) by the Kirby-Bauer disk diffusion method. RESULTS: High rates of resistance were found in most of the bacteria studied. Resistance to all isolates was mostly observed for amoxicillin (87%), piperacillin (74%) and trimethoprim/sulfamethoxazole (73%). Susceptibilities to third generation cephalosporins (cefotaxime, ceftazidime) and monobactame (aztreonam) were = 91% for Escherichia coli, = 71% for Klebsiella spp., = 98% for Proteus mirabilis, = 50% for Enterobacter spp. and Citrobacter spp. Pseudomonas aeruginosa was less susceptible to cefotaxime (2%) and aztreonam (33%), and highly susceptible to ceftazidime (72%) whereas Acinetobacter baumannii was highly resistant to aztreonam (100%), to cefotaxime (96%) and cetazidime (62%). Imipenem (98%) was the most active antibiotic followed by the ofloxacine (88%). Susceptibility of all isolates to gentamicin was 67%. CONCLUSION: These results indicate that surveillance to antimicrobial resistance in Cameroon is necessary to monitor microbial trends, antimicrobial resistance pattern, and provide information for choosing empirical or direct therapy to physicians. [less ▲]

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See detailAntimicrobial activity of 5,6-dihydrobenzo-[a]-carbazoles.
Pappa, H.; Segall, A.; Pizzorno, M. T. et al

in Farmaco (Societa chimica italiana : 1989) (1994), 49(5), 333-6

A new series of 5,6-dihydrobenzo[a]carbazoles was synthesized, some showing good antibacterial activity. The presence of a dialkylamino ethyl chain on the 2-, 3- or 4-O-substituent seems to be critical ... [more ▼]

A new series of 5,6-dihydrobenzo[a]carbazoles was synthesized, some showing good antibacterial activity. The presence of a dialkylamino ethyl chain on the 2-, 3- or 4-O-substituent seems to be critical for such activity. [less ▲]

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See detailAntimicrobial Activity of Bacillus amyloliquefaciens ANT1 Toward Pathogenic Bacteria and Mold: Effects on Biofilm Formation
Arguelles Arias, Anthony ULg; Nastro, Rosa Anna; Ongena, Marc ULg et al

in Probiotics and Antimicrobial Proteins (2013)

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See detailAntimicrobial Activity of Bacillus amyloliquefaciens ANT1 Toward Pathogenic Bacteria and Mold: Effects on Biofilm Formation
Nastro, R. A.; Arguelles-Arias, A.; Ongena, Marc ULg et al

in Probiotics and Antimicrobial Proteins (2013), 5

The intensive use and misuse of antibiotics over the last decades have generated a strong selective pressure for the emergence of multi-resistant strains and nosocomial infections. Biofilm has been ... [more ▼]

The intensive use and misuse of antibiotics over the last decades have generated a strong selective pressure for the emergence of multi-resistant strains and nosocomial infections. Biofilm has been demonstrated as a key parameter in spreading infections, especially in hospitals and healthcare units. Therefore, the development of novel anti-biofilm drugs is actually of the upmost importance. Here, the antimicrobial and antibiofilm activities toward pathogenic microorganisms of a set of non-ribosomal synthesized peptides and polyketides isolated from Bacillus amyloliquefaciens ANT1 culture supernatant are presented. © 2013 Springer Science+Business Media New York. [less ▲]

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See detailAntimicrobial activity of polyestyrene particles coated by photo-crooslinked block copolymers containing a biocidal polymethacrylate block
Lenoir, Sandrine ULg; Pagnoulle, Christophe; Detrembleur, Christophe ULg et al

in e-Polymers (2005), 74

A commercially available poly(ethylene-co-butylene) copolymer, end-capped by a short polyisoprene block and a hydroxyl group (PI-b-PEB-OH), has been derivatized into a macroinitiator for atom transfer ... [more ▼]

A commercially available poly(ethylene-co-butylene) copolymer, end-capped by a short polyisoprene block and a hydroxyl group (PI-b-PEB-OH), has been derivatized into a macroinitiator for atom transfer radical polymerization (ATRP) by esterification of the hydroxyl end-group by an activated bromide-containing acyl bromide. Two types of triblock copolymers, Pl-b-PEB-b-poly(dimethylaminoethyl methacrylate) (PDMAEMA) and Pl-b-PEB-b-poly[2-(tert-butylamino)ethyl methacrylate] (PTBAEMA), have been synthesized and used to coat polystyrene particles. These coatings have been permanently immobilized by UV cross-linking of the isoprene units. They exhibit a biocidal activity against Gram-negative bacteria either intrinsically in case of the PTBAEMA block or upon quaternization of the PDMAEMA block by octyl bromide. The antimicrobial activity is directly related to the concentration of coated PS particles in the medium. [less ▲]

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See detailAntimicrobial and molecular analysis of Salmonella serovar Livingstone strains isolated from humans in Tunisia and Belgium
Guedda, Intissar; Taminiau, Bernard ULg; Ferjani, Asma et al

in Journal of Infection in Developing Countries [=JIDC] (2014), 8

Introduction: Salmonella Livingstone is one of the most common serotypes responsible for nosocomial outbreaks in Tunisia. In this study, 42 isolates of Salmonella Livingstone were analyzed. Most of these ... [more ▼]

Introduction: Salmonella Livingstone is one of the most common serotypes responsible for nosocomial outbreaks in Tunisia. In this study, 42 isolates of Salmonella Livingstone were analyzed. Most of these were isolated from humans (31 strains from Tunisia and 9 strains from Belgium) and 2 isolates came from food products (beef and pork). Methodology: All strains were characterized by antibiogram, multilocus sequence typing (MLST), and virulotyping. This last technique was carried out by simple PCR of five chromosomal genes (agfA, hin/H2, iroB, phoP/Q, and slyA) and two plasmid genes (spvA and spvC). Results: All Tunisian strains were resistant to amoxicillin, amoxicillin-clavulanic acid, ticarcillin, cefalotin, gentamicin, and kanamycin. They were also resistant to third-generation cephalosporin antibiotics (cefotaxim and ceftazidim). Belgian isolates were susceptible to all antibiotics tested. Further to MLST analyses, Tunisian strains belonged to the same sequence type, ST543. For Belgian isolates, eight strains had a ST543 profile, two strains had a ST638 profile, and one strain had a ST457 profile. Analyses of the virulence gene contents showed that strains isolated in different years and from different origins had the same virulence profile. These carried all five chromosomal genes and lacked plasmid-located virulence genes spvA and spvC. Conclusions: A combination of different typing methods showed that the majority of Belgian strains and all Tunisian strains were closely related; they belonged to the same sequence type (ST543) and had the same virulence profile, but different antibiotic resistance profiles depended on the country of origin. [less ▲]

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See detailAntimicrobial potential of probiotic or potentially probiotic lactic acid bacteria, the first results of the international European research project PROPATH of the PROEUHEALTH cluster
De Vuyst, L.; Lefteris, M.; Lazlo, A. et al

in Microbial Ecology in Health & Disease (2004), 16

The EU-funded PROPATH project addresses the important health issue of prevention of gastrointestinal disorders through probiotics and prebiotics. Seven European laboratories are co-operating in this ... [more ▼]

The EU-funded PROPATH project addresses the important health issue of prevention of gastrointestinal disorders through probiotics and prebiotics. Seven European laboratories are co-operating in this project, which aims to isolate and characterize the relevant antimicrobial agents to combat Gram-negative bacteria including Helicobacter pylori and Salmonella enterica serovar Typhimurium. In this paper, the first results on the screening for probiotic or potentially probiotic lactobacilli that exhibit antimicrobial activity towards these Gram-negative pathogenic bacteria are presented. Spot-on-lawn assays, well-diffusion assays and time-kill studies were performed among the lactic acid bacteria strains that were either collected from fermented foods and faeces (breast-fed babies, infants and animals) or isolated from commercial products to investigate whether any of the collected strains were inhibiting growth of or were killing certain indicator bacteria. Strains inhibiting the gastrointestinal pathogens mentioned above were found. Evidence has been obtained that compounds different from organic acids are produced. [less ▲]

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See detailAntimicrobial properties of Pseudomonas strains producing the antibiotic mupirocin
Matthijs, S.; Vander Wauven, C.; Cornu, B. et al

in Research in Microbiology (2014), 165

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