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See detailThe antiangiogenic factor, 16-kDa human prolactin, induces endothelial cell cycle arrest by acting at both the G(0)-G(1) and the G(2)-M phases
Tabruyn, Sébastien ULg; Nguyen, Ngoc-Quynh-Nhu ULg; Cornet, Anne ULg et al

in Molecular Endocrinology (2005), 19(7), 1932-1942

The 16-kDa N-terminal fragment of human prolactin (16K hPRL) is a potent antiangiogenic factor that has been shown to prevent tumor growth in a xenograph mouse model. In this paper we first demonstrate ... [more ▼]

The 16-kDa N-terminal fragment of human prolactin (16K hPRL) is a potent antiangiogenic factor that has been shown to prevent tumor growth in a xenograph mouse model. In this paper we first demonstrate that 16K hPRL inhibits serum-induced DNA synthesis in adult bovine aortic endothelial cells. This inhibition is associated with cell cycle arrest at both the G(0)-G(1) and the G(2)-M phase. Western blot analysis revealed that 16K hPRL strongly decreases levels of cyclin D1 and cyclin B1, but not cyclin E. The effect on cyclin D1 is at least partially transcriptional, because treatment with 16K hPRL both reduces the cyclin D1 mRNA level and down-regulates cyclin D1 promoter activity. This regulation may be due to inhibition of the MAPK pathway, but it is independent of the glycogen synthase kinase-3 beta pathway. Lastly, 16K hPRL induces the expression of negative cell cycle regulators, the cyclin-dependent kinase inhibitors p21(cip1) and p27(kip1). In summary, 16K hPRL inhibits serum-induced proliferation of endothelial cells through combined effects on positive and negative regulators of cell cycle progression. [less ▲]

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See detailAntiangiogenic liposomal gene therapy with 16K human prolactin efficiently reduces tumor growth.
Kinet, Virginie ULg; Nguyen, Ngoc-Quynh-Nhu ULg; Sabatel, Céline ULg et al

in Cancer Letters (2009), 284(2), 222-228

Human 16K PRL (16K hPRL) is a potent inhibitor of angiogenesis both in vitro and in vivo. It has been shown to prevent tumor growth in three xenograft mouse models. Here we have used a gene transfer ... [more ▼]

Human 16K PRL (16K hPRL) is a potent inhibitor of angiogenesis both in vitro and in vivo. It has been shown to prevent tumor growth in three xenograft mouse models. Here we have used a gene transfer method based on cationic liposomes to produce 16K hPRL and demonstrate that 16K hPRL inhibits tumor growth in a subcutaneous B16F10 mouse melanoma model. Computer-assisted image analysis shows that 16K hPRL treatment results in the reduction of tumor vessel length and width, leading to a 57% reduction in average vessel size. We thus show, for the first time, that administration of the 16K hPRL gene complexed to cationic liposomes is effective to maintain antiangiogenic activities of 16K hPRL level. [less ▲]

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See detailAntiangiogenic peptides
Martial, Joseph ULg; Struman, Ingrid ULg; Nguyen, Ngoc-Quynh-Nhu ULg et al

Patent (2007)

The present invention refers to antiangiogenic peptides, especially to tilted peptides having antiangiogenic properties and peptides from the prolactin/growth hormone familiy having antiangiogenic ... [more ▼]

The present invention refers to antiangiogenic peptides, especially to tilted peptides having antiangiogenic properties and peptides from the prolactin/growth hormone familiy having antiangiogenic properties. [less ▲]

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See detailAntiangiogenic peptides
Martial, Joseph ULg; Struman, Ingrid ULg; Nguyen, Ngoc-Quynh-Nhu ULg et al

Patent (2008)

The present invention refers to a pharmaceutical composition comprising an isolated antiangiogenic peptide or a recombinant protein comprising the antiangiogenic peptide, wherein the peptide is between 11 ... [more ▼]

The present invention refers to a pharmaceutical composition comprising an isolated antiangiogenic peptide or a recombinant protein comprising the antiangiogenic peptide, wherein the peptide is between 11 and 40 amino acids in length and having antiangiogenic activity, the peptide comprising the amino acid sequence: X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14, wherein X1 is any amino acid residue comptabile with forming a helix; X2 is an amino acid redisue of : Leu, Ile, Val; X3 is an amino acid residue of: Arg, Lys, His, Ser, Thr; X4 is an amino acid residue of: Ile, Leu, Val; X5 is any amino acid residue compatible with forming a helix; X6 is an amino acid residue of: Leu, Ile, Val; X7 is an amino acid residue of: Leu, Ile, Val, Ser, Thr; X8 is any amino acid residue compatible with forming a helix; X9 is any amino acid residue compatible with forming a helix; X10 is an amino acid residue of: Gln, Glu, Asp, Arg, His, Lys, Asn; X11 is an amino acid residue of: Ser, Thr; X12 is an amino acid residue of: Trp, Tyr, Phe; X13 is an animo acid residue of Leu, Ile, Val, Asn, Gln; X14 is an amino acid residue of: Glu, Gln, Asp, Asn. [less ▲]

Detailed reference viewed: 60 (16 ULg)
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See detailAntiapoptotic effect of GM-CSF activated STAT5 signaling pathway in chronic mastitis-affected cows : possible involvement in persistent accumulation of neutrophils in milk
Boutet, Philippe ULg; Bureau, Fabrice ULg; Gillet, Laurent ULg et al

in Congress COST Action 844: “Apoptosis and programmed cell death : molecular mechanisms and applications in Biotechnology and Agriculture” (2004)

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See detailAntibacterial activity of 5-acylaminothiazole derivatives, synthetic drugs related to β-lactam antibiotics
Pirotte, Bernard ULg; Delarge, Jacques; Coyette, Jacques ULg et al

in Journal of Antibiotics (The) (1991), 44

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See detailAntibacterial activity of poly(vinyl alcohol)-b-poly(acrylonitrile) based micelles loaded with silver nanoparticles
Bryaskova, Rayna; Pencheva, Daniela; Kyulavska, Mariya et al

in Journal of Colloid & Interface Science (2010), 344(2), 424-448

A new amphiphilic poly(vinyl alcohol)-b-poly(acrylonitrile) (PVOH-b-PAN) copolymer obtained by selective hydrolysis of well-defined poly(vinyl acetate)-b-poly(acrylonitrile) copolymer synthesized by ... [more ▼]

A new amphiphilic poly(vinyl alcohol)-b-poly(acrylonitrile) (PVOH-b-PAN) copolymer obtained by selective hydrolysis of well-defined poly(vinyl acetate)-b-poly(acrylonitrile) copolymer synthesized by cobalt mediated radical polymerization was used for the preparation of PVOH-b-PAN based micelles with embedded silver nanoparticles. The successful formation of silver loaded micelles has been confirmed by UV–vis, DLS and TEM analysis and their antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa) and spore solution of Bacillus subtilis (B. subtilis) has been studied. PVOH-b-PAN based micelles with embedded silver nanoparticles showed a strong bactericidal effect against E. coli, S. aureus and P. aeruginosa and the minimum bactericidal concentration for each system (MBC) has been determined. [less ▲]

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See detailAntibacterial polyelectrolyte micelles for coating stainless steel
Falentin, Céline ULg; Faure, Emilie ULg; Svaldo Lanero, Tiziana ULg et al

in Langmuir (2012), 28(18), 7233-7241

In this study, we report on the original synthesis and characterization of novel antimicrobial coatings for stainless steel by alternating the deposition of aqueous solutions of positively charged ... [more ▼]

In this study, we report on the original synthesis and characterization of novel antimicrobial coatings for stainless steel by alternating the deposition of aqueous solutions of positively charged polyelectrolytes micelles doped with silver based nanoparticles with a polyanion. The micelles are formed by electrostatic interaction between two oppositely charged polymers, a polycation bearing 3,4-dihydroxyphenylalanine units (DOPA, a major component of natural adhesives) and a polyanion (poly(styrene sulfonate), PSS) without using any block copolymer. DOPA units are exploited for their well-known ability to anchor to stainless steel and to form and stabilize biocidal silver nanoparticles (Ag0). The chlorine counter-anion of the polycation forms and stabilizes biocidal silver chloride nanoparticles (AgCl). We demonstrate that two layers of micelles (alternated by PSS) doped by silver particles are enough to impart to the surface a strong antibacterial activity against Gram-negative E. coli. Moreover, micelles that are reservoirs of biocidal Ag+ can be easily reactivated after depletion. This novel water-based approach is convenient, simple and attractive for industrial applications. [less ▲]

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See detailL'antibiorésistance chez l'animal et ses conséquences
Mainil, Jacques ULg

Scientific conference (1999, May)

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See detailL'antibiothérapie en néonatalogie: mise-au-point
Langhendries, JP; Kalenga, Masendu ULg; Battisti, Oreste ULg et al

in Journal du Pédiatre Belge (2000), 2

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See detailAntibiothérapie topique et infections cutanées
Henry, Frédérique ULg; Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (1996), 51(2), 160-162

Les infections cutanées bactériennes, qui restent souvent limitées en extension, méritent un traitement local. Dans cette indication, l'antibiothérapie topique est toujours d'actualité. Le choix du ... [more ▼]

Les infections cutanées bactériennes, qui restent souvent limitées en extension, méritent un traitement local. Dans cette indication, l'antibiothérapie topique est toujours d'actualité. Le choix du médicament doit être guidé par son spectre d'activité. Les risques de développement d'une résistance bactérienne et d'une hypersensibilité allergique à l'antibiotique ou à sa base galénique doivent également être pris en considération. [less ▲]

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See detailAntibiotherapy in bovine mastitis – Drugs or Therapeutics?
Theron, Léonard ULg; Hanzen, Christian ULg

Conference given outside the academic context (2012)

The 21st century is rich in mutations regarding veterinary medicine; society has never been so far from farm animal practices in industrialized countries, and so demanding in developing nations for a ... [more ▼]

The 21st century is rich in mutations regarding veterinary medicine; society has never been so far from farm animal practices in industrialized countries, and so demanding in developing nations for a continuous milk and meat production. Meanwhile, even this great distance in northern nations between agriculture and society, our work has never been so much analyzed for its potential risk on human health and production quality. As health is now globalized, following trade and science, exchange could be the source of several pathological emergences. Focusing on animal health, our responsibility toward “larga manu” use of antibiotics has been identified and criticized. This situation is also happening in a time where, nevertheless our industrialization of agricultural production, ancillary exams are still expensive, and most of the time non valuable regarding a common cattle practice time schedule. So yes, we are mainly still experiencing empirical use of antibiotics like our pairs did, back several decades before. Yet, there exists nowadays many tools to analyze whether our practice could be considered as harmful to humanity survival and good use of priority antibiotics. We therefore have to reconsider our practice of Antibiotherapy, regarding these new challenges and find new ways for medical management of infectious diseases. [less ▲]

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See detailAntibiotherapy in pet rodents and rabbits: a preliminary analysis of practitioners’ habits
Marlier, Didier ULg

in Proceedings of the European College of Zoological Medicine Symposium (2016, April)

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See detailAntibiothérpaie chez le chien : choix raisonné et raisonnable
Mainil, Jacques ULg

Scientific conference (2015, December)

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See detailThe antibiotic ceftazidime is a singlet oxygen quencher as demonstrated by ultra-weak chemiluminescence and by inhibition of AAP consumption.
Deby, Ginette ULg; Deby, C.; Mouithys-Mickalad, Ange ULg et al

in Biochimica et Biophysica Acta (1998), 1379(1), 61-8

We demonstrated that the cephalosporin antibiotic ceftazidime (CAZ) deactivated singlet oxygen (1O2). We then studied the mechanisms of the CAZ effects on the ultra weak chemiluminescence (uwCL ... [more ▼]

We demonstrated that the cephalosporin antibiotic ceftazidime (CAZ) deactivated singlet oxygen (1O2). We then studied the mechanisms of the CAZ effects on the ultra weak chemiluminescence (uwCL) associated with the energy decay of 1O2 generated by the Mallet reaction (H2O2 + HOCl --> HCl + H2O + 1O2), and on the anthracene-9,10-dipropionic acid (AAP) consumption by 1O2 generated by irradiation of Rose Bengal (RB). The uwCL generated by the Mallet reaction was amplified (6.2 times) by CAZ. The use of red and blue filters, which absorb radiation below 610 nm and between 470 and 700 nm respectively, demonstrated that CAZ increased the uwCL by a radiation emission at wavelengths shorter than the 633 and 704 nm wavelength emissions of 1O2. CAZ was excited by scavenging the energy excess of 1O2, which so returned to its fundamental state, while CAZ deactivated with light emission between 430-480 nm. CAZ also inhibited in a dose-dependent manner the consumption of AAP by 1O2 generated by the irradiation of RB. The protection of AAP by 5 x 10(-3) M CAZ was equivalent to that of 10(-3) M histidine and 3 X 10(-6) M sodium azide. This process of 1O2 deactivation will be useful in diseases characterized by an excessive PMN activation with a release of activated oxygen species. [less ▲]

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See detailAntibiotic compounds from Bacillus: why are they so amazing
Fickers, Patrick ULg

in American Journal of Biochemistry & Biotechnology (2012), (8), 38-43

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See detailAntibiotic compounds from Bacillus: why are they so amazing?
Fickers, Patrick ULg

Conference (2014, April)

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See detailAntibiotic consumption and bacterial resistance
ZAOUI, Kuider; MELIN, Pierrette ULg; CHRISTIAENS, Geneviève ULg et al

Conference (2010, June 25)

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See detailAntibiotic prescribing in dental practice in Belgium.
Mainjot, Amélie ULg; D'Hoore, W.; Van Heusden, Alain ULg et al

in International Endodontic Journal (2009), 42(12), 1112-7

AIM: To assess the types and frequency of antibiotic prescriptions by Belgian dentists, the indications for antibiotic prescription, and dentists' knowledge about recommended practice in antibiotic use ... [more ▼]

AIM: To assess the types and frequency of antibiotic prescriptions by Belgian dentists, the indications for antibiotic prescription, and dentists' knowledge about recommended practice in antibiotic use. METHODOLOGY: In this cross-sectional survey, dental practitioners were asked to record information about all antibiotics prescribed to their patients during a 2-week period. The dental practitioners were also asked to complete a self-administered questionnaire regarding demographic data, prescribing practices, and knowledge about antibiotic use. A random sample of 268 Belgian dentists participated in the survey. RESULTS: During the 2-week period, 24 421 patient encounters were recorded; 1033 patients were prescribed an antibiotic (4.2%). The median number of prescriptions per dentist for the 2 weeks was 3. Broad spectrum antibiotics were most commonly prescribed: 82% of all prescriptions were for amoxycillin, amoxycillin-clavulanic acid and clindamycin. Antibiotics were often prescribed in the absence of fever (92.2%) and without any local treatment (54.2%). The most frequent diagnosis for which antibiotics were prescribed was periapical abscess (51.9%). Antibiotics were prescribed to 63.3% of patients with periapical abscess and 4.3% of patients with pulpitis. Patterns of prescriptions were confirmed by the data from the self-reported practice. CONCLUSIONS: Discrepancies between observed and recommended practice support the need for educational initiatives to promote rational use of antibiotics in dentistry in Belgium. [less ▲]

Detailed reference viewed: 48 (3 ULg)