Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailAndrogen metabolism and the activation of male sexual behavior: It's more complicated than you think!
Ball, G. F.; Balthazart, Jacques ULiege

in Hormones & Behavior (2006), 49(1), 1-3

Detailed reference viewed: 20 (0 ULiège)
Full Text
Peer Reviewed
See detailAndrogen receptor controls EGFR and ERBB2 gene expression at different levels in prostate cancer cell lines.
Pignon, Jean-Christophe ULiege; Koopmansch, Benjamin ULiege; Nolens, Grégory ULiege et al

in Cancer Research (2009), 69(7), 2941-2949

EGFR or ERBB2 contributes to prostate cancer (PCa) progression by activating the androgen receptor (AR) in hormone-poor conditions. Here, we investigated the mechanisms by which androgens regulate EGFR ... [more ▼]

EGFR or ERBB2 contributes to prostate cancer (PCa) progression by activating the androgen receptor (AR) in hormone-poor conditions. Here, we investigated the mechanisms by which androgens regulate EGFR and ERBB2 expression in PCa cells. In steroid-depleted medium (SDM), EGFR protein was less abundant in androgen-sensitive LNCaP than in androgen ablation-resistant 22Rv1 cells, whereas transcript levels were similar. Dihydrotestosterone (DHT) treatment increased both EGFR mRNA and protein levels and stimulated RNA polymerase II recruitment to the EGFR gene promoter, whereas it decreased ERBB2 transcript and protein levels in LNCaP cells. DHT altered neither EGFR or ERBB2 levels nor the abundance of prostate-specific antigen (PSA), TMEPA1, or TMPRSS2 mRNAs in 22Rv1 cells, which express the full-length and a shorter AR isoform deleted from the COOH-terminal domain (ARDeltaCTD). The contribution of both AR isoforms to the expression of these genes was assessed by small interfering RNAs targeting only the full-length or both AR isoforms. Silencing of both isoforms strongly reduced PSA, TMEPA1, and TMPRSS2 transcript levels. Inhibition of both AR isoforms did not affect EGFR and ERBB2 transcript levels but decreased EGFR and increased ERBB2 protein levels. Proliferation of 22Rv1 cells in SDM was inhibited in the absence of AR and ARDeltaCTD. A further decrease was obtained with PKI166, an EGFR/ERBB2 kinase inhibitor. Overall, we showed that ARDeltaCTD is responsible for constitutive EGFR expression and ERBB2 repression in 22Rv1 cells and that ARDeltaCTD and tyrosine kinase receptors are necessary for sustained 22Rv1 cell growth. [less ▲]

Detailed reference viewed: 65 (24 ULiège)
Peer Reviewed
See detailAndrogen-dependent vasopressinergic neurons are involved in social recognition in rats.
Bluthe, R. M.; Schoenen, Jean ULiege; Dantzer, R.

in Brain Research (1990), 519(1-2), 150-7

Socal recognition of juvenile conspecifics by adult male rats has been shown to be modulated by vasopressin. Because part of the extrahypothalamic vasopressinergic innervation of the brain is androgen ... [more ▼]

Socal recognition of juvenile conspecifics by adult male rats has been shown to be modulated by vasopressin. Because part of the extrahypothalamic vasopressinergic innervation of the brain is androgen-dependent, the present experiments were undertaken to assess possible interactions between androgens and vasopressin in social recognition. Castrated male rats displayed a temporary disruption of social recognition when they were tested 1 week after surgery. There was no impairment, however, when they were tested every other day following surgery. The peripheral injection of a vasopressor antagonist of vasopressin, dPTyr(Me)AVP (30 micrograms/kg) impaired social recognition in normal male rats but was ineffective in castrated ones. This was not due to an effect of castration on the basic pharmacological properties of dPTyr(Me)AVP since the antagonist peptide was still able to block the facilitating effects of vasopressin on social recognition in castrated male rats. Implantation of a testosterone-filled capsule in castrated male rats restored sensitivity of social recognition to the action of the vasopressin antagonist. These results suggest that androgen-dependent vasopressinergic neurons are physiologically involved in the modulation of social recognition in male rats. [less ▲]

Detailed reference viewed: 24 (0 ULiège)
Full Text
Peer Reviewed
See detailAndrogen-driven prostate epithelial cell proliferation and differentiation in vivo involve the regulation of p27.
Waltregny, David ULiege; Leav, Irwin; Signoretti, Sabina et al

in Molecular Endocrinology (2001), 15(5), 765-82

Androgens control both growth and differentiation of the normal prostate gland. However, the mechanisms by which androgens act upon the cell cycle machinery to regulate these two fundamental processes are ... [more ▼]

Androgens control both growth and differentiation of the normal prostate gland. However, the mechanisms by which androgens act upon the cell cycle machinery to regulate these two fundamental processes are largely unknown. The cyclin-dependent kinase (cdk) inhibitor p27 is a negative cell cycle regulator involved in differentiation-associated growth arrest. Here, we investigate the role and regulation of p27 in the testosterone proprionate (TP)-stimulated regeneration of the ventral prostate (VP) of castrated rats. Continuous TP administration to castrated rats triggered epithelial cell proliferation, which peaked at 72 h, and then declined despite further treatment. Castration-induced atrophy of the VP was associated with a significant increase in p27 expression as compared with the VP of intact animals. Twelve hours after the initiation of androgen treatment, total p27 levels as well as its fraction bound to cdk2, its main target, significantly dropped in the VP of castrated rats. Thereafter, concomitantly to the induction of epithelial cell proliferation, the glandular morphology of VP was progressively restored at 48-96 h of TP treatment. During this period of the regenerative process, whereas both proliferating basal and secretory epithelial cells did not express p27, the protein was selectively up-regulated in the nonproliferating secretory epithelial compartment. This up-regulation of p27 expression was coincident with an increase in its association with, and presumably inhibition of, cdk2. At each time point of TP treatment, p27 abundance in the VP was inversely correlated with the level of its proteasome-dependent degradation activity measured in vitro in VP lysates, whereas only slight changes in the amount of p27 transcripts were detected. In addition, the antiandrogen flutamide blocked maximal TP-induced p27 degradation completely. Finally, the expression of skp2, the ubiquitin ligase that targets p27 for degradation, was seen to increase with androgen administration, preceding maximal proliferation and concomitantly to augmented p27 degradation activity. Taken together, our data indicate that androgens mediate both proliferation and differentiation signals in normal prostate epithelial cells in vivo, through regulation of p27. [less ▲]

Detailed reference viewed: 25 (4 ULiège)
Full Text
See detailAndrogenic alopecia and stress-induced premature senescence by cumulative ultraviolet light exposure.
Franchimont, Claudine ULiege; Uhoda, I.; Saint Léger, Didier et al

in Exogenous Dermatology : Physical, Chemical, Biological (2002), 1

Background : Ultraviolet light radiations (UVR) may be responsible for hair cycle synchronization and telogen effluvium in the animal and humans. The effect if any of cumulative UVR on chronic hair ... [more ▼]

Background : Ultraviolet light radiations (UVR) may be responsible for hair cycle synchronization and telogen effluvium in the animal and humans. The effect if any of cumulative UVR on chronic hair shedding and androgenic alopecia (AGA) is largely unknown. Objective : To compare the severity of AGA with the extent in solar elastosis. Method : The present study combining immunohistochemistry and computerized image analysis was undertaken in 140 men with AGA and 50 non-alopecic men. Solar elastosis was identified using the antibody to lyzozyme, and collagen was revealed by sirius red staining. The number and diameter of hair shafts were also assessed. Results : The scalp dermis was significantly thicker in AGA than in unaffected subjects. The difference was mainly due to a more severe elastosis in baldness. The earliest signs of solar elastosis preceded hair thinning. When elastosis was thicker than 0.2 mm, a negative exponential correlation was found between hair diameter and severity in solar elastosis. Conclusion : Chronic UVR exposure of the scalp may affect the hair cycle and be one exogenous factors influencing negatively the progression of AGA. The induction of stress-induced premature senescence (SIPS) through reactive oxygen species and microinflammation might be operative at the level of the follicular stem cells. [less ▲]

Detailed reference viewed: 175 (0 ULiège)
Full Text
Peer Reviewed
See detailAndrogenic potential and anther in vitro culture of Lagenaria siceraria (Molina) Standl and edible-seed cucurbit
Kouakou, Kouakou L.; Doubi, Tra Serge; Koffi, Kouame Kevin et al

in International Journal of Biological and Chemical Sciences (2015), 9(4), 1779-1789

Detailed reference viewed: 13 (1 ULiège)
Full Text
Peer Reviewed
See detailAndrogens and estrogens synergistically regulate the expression of doublecortin and enhance neuronal recruitment in the song system of adult female canaries.
Yamamura, Takashi; Barker, Jennifer ULiege; Balthazart, Jacques ULiege et al

in Journal of Neuroscience (2011)

Vocal control nuclei in songbirds display seasonal changes in volume that are regulated by testosterone (T) and its androgenic (5α-dihydrotestosterone; DHT) or estrogenic metabolites (17β-estradiol; E2 ... [more ▼]

Vocal control nuclei in songbirds display seasonal changes in volume that are regulated by testosterone (T) and its androgenic (5α-dihydrotestosterone; DHT) or estrogenic metabolites (17β-estradiol; E2). In male canaries, T regulates expression of the microtubule-associated protein doublecortin (DCX), a marker of neurogenesis. We examined the effect of T and its two metabolites alone or in combination on DCX expression in adult female canaries. Treatment with T or with DHT+E2 increased HVC volume and neuron numbers as well as the total numbers of fusiform (migrating) and round (differentiating) DCX neurons in the nucleus but generally not in adjacent areas. DHT or E2 alone did not increase these measures but increased the density of fusiform DCX cells per section. Similar results were observed in Area X although some effects did not reach significance presumably because plasticity in X is mediated transynaptically and follows HVC changes with some delay. There was no effect of any treatment on the total number of neurons in Area X and no change in DCX cell densities was detected in other parts of the nidopallium nor in LMAN. DHT and E2 by themselves thus increase density of DCX cells migrating through HVC but are not sufficient in isolation to induce the recruitment of these newborn neurons in the nucleus. These effects are generally not observed in the rest of the nidopallium implying that steroids only act on the attraction and recruitment of new neurons in HVC without having any major effects on their production at the ventricle wall. [less ▲]

Detailed reference viewed: 32 (0 ULiège)
Peer Reviewed
See detailAndrogens regulation of the ERBB1 and ERBB2 oncogene expression in human prostate cancer cells
Pignon, Jean-Christophe; Delacroix, Laurence; Nolens, Grégory et al

Poster (2006)

Detailed reference viewed: 24 (0 ULiège)
Peer Reviewed
See detailAndrogens regulation of the ERBB1 and ERBB2 oncogene expression in human prostate cancer cells
Pignon, Jean-Christophe ULiege; Delacroix, Laurence; Waltregny, David ULiege et al

in Acta Clinica Belgica (2006), 61(2, MAR-APR), 95-95

Detailed reference viewed: 52 (15 ULiège)
Full Text
Peer Reviewed
See detailAndropause and psychopathology: minor symptoms rather than pathological ones.
Delhez, Marie; Hansenne, Michel ULiege; Legros, Jean-Jacques ULiege

in Psychoneuroendocrinology (2003), 28(7), 863-74

This study examined the psychological symptomatology of men diagnosed with andropause and the association between calculated free testosterone (T) and depressed mood, anxiety and quality of life. Subjects ... [more ▼]

This study examined the psychological symptomatology of men diagnosed with andropause and the association between calculated free testosterone (T) and depressed mood, anxiety and quality of life. Subjects were 153 men, aged 50-70 years, who participated in a screening of andropause. Total testosterone, FSH, LH and SHBG levels were measured. Depressed mood was assessed with the Carroll Rating Scale, anxiety with the "anxiety-insomnia" dimension of the General Health Questionnaire, and quality of life with the World Health Organisation Quality of Life questionnaire. The results showed that levels of free T decreased with age, whereas FSH and LH increased. Carroll Rating Scale scores were higher among hypogonadal subjects, but the mean score was low and not pathological. A negative correlation was observed between severity of depression as assessed by the Carroll Rating Scale and free T levels. However, subjects with a significant score on this scale did not exhibit different free T levels compared to subjects with a non-significant depressive score. Anxiety and quality of life did not differ between hypogonadal and eugonadal subjects. The present study therefore suggests that andropause is not characterised by specific psychological symptoms, but may be associated with "depressive symptoms" that are not considered as pathological. [less ▲]

Detailed reference viewed: 71 (3 ULiège)
Full Text
See detailAndy Warhol had spirituele kant (over Warhol-tentoonstelling in Mons)
Mus, Francis ULiege

Article for general public (2013)

Detailed reference viewed: 8 (0 ULiège)
Full Text
Peer Reviewed
See detailL’anéantissement des donations : questions de droit international privé
Wautelet, Patrick ULiege; Fongaro, Eric

in Revue de planification patrimoniale belge et internationale (2015), 2(1), 39-64

Avec le développement d'une véritable pratique transfrontière de la planification successorale, les questions de droit international privé entourant les donations ont beaucoup retenu l'attention ces ... [more ▼]

Avec le développement d'une véritable pratique transfrontière de la planification successorale, les questions de droit international privé entourant les donations ont beaucoup retenu l'attention ces dernières années. Cet intérêt renouvelé pour un sujet classique a permis d'élucider le statut pour le moins complexe de la donation qui présente une dimension internationale. On a toutefois peu évoqué les difficultés que peuvent susciter la fragilité des donations : institution de droit civil aux contours pour le moins polymorphes, la donation est entourée de nombreuses limitations et obstacles qui ont pour objectif de conjurer les risques que peut faire naître, tant pour le donateur, sa famille que pour ses créanciers, cet acte particulier d'appauvrissement sans contrepartie. Le régime contemporain des donations est fondé sur une série de règles et mécanismes qui permettent de remettre en question la libéralité. Tantôt c'est la capacité d'une des parties (à donner ou à recevoir) qui fait l'objet de dispositions dérogatoires au droit commun, tantôt c'est le consentement du donateur qui suscite l'application d'une règle spéciale, tantôt encore des exigences particulières sont posées à propos des formes que doit revêtir une donation. Ces règles complexes, qui nourrissent un contentieux fourni, sont autant d'obstacles qui peuvent être posés au plein accomplissement des donations. Elles conduisent parfois à la révocation de la donation, qui peut produire ses effets ex nunc ou dans certains cas de façon rétroactive. Dans d'autres situations, la donation est annulée et dès lors considérée comme n'ayant jamais existé. Une donation peut également faire l'objet d'une déclaration ou encore être frappée de caducité ou de déchéance. Ces questions sont abordées dans la présente contribution sous l'angle du droit international privé belge et français, en mettant l'accent tant sur les différences que sur les simillitudes entre ces droits. [less ▲]

Detailed reference viewed: 98 (6 ULiège)
See detailL'anéantissement des donations entre vifs
Moreau, Pierre ULiege

in Moreau, Pierre (Ed.) Libéralités et successions (2012)

Detailed reference viewed: 36 (7 ULiège)
Full Text
See detailAneignung Herrenloser Sachen
Gerkens, Jean-François ULiege

Scientific conference (2014, June 19)

Detailed reference viewed: 16 (2 ULiège)
Full Text
Peer Reviewed
See detailAnemia in children with cancer is associated with decreased erythropoietic activity and not with inadequate erythropoietin production.
Corazza, Francis; Beguin, Yves ULiege; Bergmann, Pierre et al

in Blood (1998), 92(5), 1793-8

A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect ... [more ▼]

A defect in erythropoietin (EPO) production has been advocated as being the main cause of anemia presented at time of diagnosis or during treatment by adults with solid tumors. On the basis of this defect, anemic cancer patients, both adults and children, have been treated with recombinant human EPO (rHuEPO). To further elucidate the pathophysiology of anemia in children with cancer, we measured serum soluble transferrin receptor (sTfR), a quantitative marker of erythropoiesis, and serum EPO at time of diagnosis and during chemotherapy in children suffering from solid tumor or leukemia. We determined serum EPO in 111 children (55 leukemia, 56 solid tumors) at time of diagnosis. In the last 44 patients (23 leukemia and 21 solid tumors), sTfR levels were also measured. Serum EPO together with sTfR levels were also determined in 60 children receiving chemotherapy (29 leukemia, 31 solid tumors). These results were compared with those obtained from appropriate control groups. In all patients, we found a highly significant correlation between the logarithm of EPO (log[EPO]) and the hemoglobin (Hb) level. In all subsets of patients, sTfR levels were inappropriately low for the degree of anemia. Neither leukemic nor solid tumor groups showed a significant inverse relationship between log(sTfR) and the Hb level as would be expected in anemic patients with appropriate marrow response. Thus, in children with cancer, anemia is associated with a decreased total bone marrow erythropoietic activity which, in contrast to what has been reported in anemic cancer adults, is not related to defective EPO production. [less ▲]

Detailed reference viewed: 57 (1 ULiège)
Full Text
See detailAnémie aigue du cœur de chien sans fibrillation. Fibrillation en l’absence de toute action vasomotrice
Fredericq, Léon ULiege

in Archives Internationales de Physiologie (1905), II

Detailed reference viewed: 8 (0 ULiège)
Full Text
Peer Reviewed
See detailL'anemie chronique dans les maladies inflammatoires de l'intestin: revue de litterature
Vijverman, A.; Belaiche, Jacques ULiege; Louis, Edouard ULiege

in Revue Médicale de Liège (2005), 60(11), 888-92

Chronic anemia has been considered as an overlooked complication of inflammatory bowel disease (IBD). However it deserves full attention since even mild to moderate anemia has significant impact on ... [more ▼]

Chronic anemia has been considered as an overlooked complication of inflammatory bowel disease (IBD). However it deserves full attention since even mild to moderate anemia has significant impact on quality of life. During the past decade relevant progress has been made in the understanding and treatment of this pathology. In our review, we focus on frequency, mechanisms, diagnosis and treatment of anemia in IBD. [less ▲]

Detailed reference viewed: 90 (0 ULiège)
Full Text
Peer Reviewed
See detailAnemie et insuffisance cardiaque
Nellessen, Eric ULiege; Pierard, Luc ULiege

in Revue Médicale de Liège (2006), 61(3), 154-8

The prevalence of heart failure is increasing. Anemia is often present, particularly in severe cases. The Fick equation illustrates the relationship between anemia and heart failure. The concepts of ... [more ▼]

The prevalence of heart failure is increasing. Anemia is often present, particularly in severe cases. The Fick equation illustrates the relationship between anemia and heart failure. The concepts of cardiorenal syndrome and erythropoietin resistance are parts of the physiopathology. Anemia is associated with a bad prognosis in heart failure. Nevertheless, it is too early to know precisely whether anemia represents a simple marker of severity or if specific treatment, especially with erythropoietin, is useful in terms of morbidity and mortality. Current guidelines recommend the correction of secondary causes when anemia is present in a heart failure patient. [less ▲]

Detailed reference viewed: 46 (1 ULiège)
Full Text
Peer Reviewed
See detailAnémie et risque cardio-vasculaire chez l'insuffisant rénal chronique. Nouvelles données sur la cible en hémoglobine à atteindre
Krzesinski, Jean-Marie ULiege; Dubois, Bernard ULiege

in Revue Médicale de Liège (2007), 62(5-6), 366-370

Anemia is frequent when chronic kidney disease develops. Its correction by the use of erythropoietin improves the quality of life, and exercise tolerance, and decreases the cardiovascular risk. However ... [more ▼]

Anemia is frequent when chronic kidney disease develops. Its correction by the use of erythropoietin improves the quality of life, and exercise tolerance, and decreases the cardiovascular risk. However, this later risk is not further decreased or even is increased when the hemoglobin target is set above 13 g/dl as compared to the recommended hemoglobin level between 11 and 12 g/dl.This last target therefore gives the best cost-beneficial effect ratio in the chronic kidney disease population. This target must be the new one. [less ▲]

Detailed reference viewed: 243 (7 ULiège)
Full Text
See detailAnémie et risque cardiovasculaire chez l'insuffisant rénal
Krzesinski, Jean-Marie ULiege

in Brochure "Roche" Ericabell (2005)

Le patient souffrant d'insuffisance rénale terminale est exposé à une mortalité de 5 à 30 fois supérieure à celle de la population générale à âge identique. Au moins 50% de cette surmortalité sont dus à ... [more ▼]

Le patient souffrant d'insuffisance rénale terminale est exposé à une mortalité de 5 à 30 fois supérieure à celle de la population générale à âge identique. Au moins 50% de cette surmortalité sont dus à des complications cardiovasculaires. Des signes de coronaropathie et d'insuffisance cardiaque sont déjà présents chez 40% de patients au début des traitements par dialyse. Ce risque cardiovasculaire apparaît très tôt dans le processus de dégradation de la fonction rénale et aumente au fur et à mesure de la progression de l'insuffisance rénale. Un patient souffrant de maladie rénale a plus de probabilité de décéder d'un problème cardiovasculaire que d'évoluer vers l'insuffisance rénale terminale. Plusieurs études épidémiologiques menées aux Etats-Unis, que ce soit l'étude NHANES III (National Health And Nutrition Examination Survey) ou encore l'étude ARIC (Atherosclerosis Risk in Communities), démontrent toutes que ce risque cardiovasculaire s'élève particulièrement dès que la filtration glomérulaire s'abaisse en dessous de 60 ml/min/1,73 m². Ceci vient d'être confirmé sur un suivi de près de 3 ans chez plus d'un million de sujets, tant pour le risque de décès, d'accidents cardiovasculaires que d'hospitalisations. Par ailleurs, le devenir de patients ayant présenté un infarctus du myocarde est plus sombre en présence d'une insuffisance rénale. Chaque diminution de 10 ml/min de la filtration glomérulaire, à partir de 80 ml/min, augmente le risque de complication de 10% chez des sujets ayant souffert d'un infarctus. [less ▲]

Detailed reference viewed: 77 (5 ULiège)