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See detailLife in the cold: psychrophilic enzymes
Collins, T.; Claverie, P.; D'Amico, Salvino ULg et al

in Recent Res. Devl. Proteins vol. 1 (2002)

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See detailThe life of stars and their planets
Catala, C.; Aerts, C.; Aigrain, S. et al

in Favata, F.; Sanz-Forcada, J.; Giménez, A. (Eds.) et al 39TH ESLAB Symposium on Trends in Space Science and Cosmic Vision 2020 (2005, December 01)

We lack a reliable scenario for the formation and evolution of stars and their planetary systems, involving key factors such as magnetic fields and turbulence. We present the case for a mission concept ... [more ▼]

We lack a reliable scenario for the formation and evolution of stars and their planetary systems, involving key factors such as magnetic fields and turbulence. We present the case for a mission concept that will clarify these problems and give us a global view of the evolution of combined star and planetary systems. This will be achieved by simultaneously addressing the search for planetary transits in front of a large number of stars, including many nearby stars, the study of their internal structure and evolution via asteroseismology, and that of their magnetic activity, via UV monitoring. [less ▲]

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See detailLife Sciences in the Euregio Meuse-Rhine
Jérôme, Robert ULg; Klee, D; Koole, L et al

Conference (2000, November 09)

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See detailA life-attenuated BLV deletant as a candidate vaccine to inhibit viral transmission in bovine herds
Rodriguez, Sabrina ULg; Gutiérrez, G.; Florins, A. et al

Scientific conference (2011, June 06)

A life-attenuated BLV deletant as a candidate vaccine to inhibit viral transmission in bovine herds Sabrina M. Rodríguez1*†, Gerónimo Gutiérrez2*, Arnaud Florins3, Lucas Vagnoni2, Irene Alvarez2, Nicolas ... [more ▼]

A life-attenuated BLV deletant as a candidate vaccine to inhibit viral transmission in bovine herds Sabrina M. Rodríguez1*†, Gerónimo Gutiérrez2*, Arnaud Florins3, Lucas Vagnoni2, Irene Alvarez2, Nicolas Gillet1, Karina Trono2‡, Luc Willems1,3‡ *‡S.M. Rodríguez / G. Gutiérrez and K.Trono / L. Willems contributed equally to this work. 1 Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège (ULg), Liège (4100), Belgium. 2 Instituto de Virología, CICVyA, Instituto Nacional de Tecnología Agropecuaria, (1712), Castelar, Argentina. 3 Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Liège (ULg), Gembloux (5030), Belgium †E-mail: sabrina.rodriguez@ulg.ac.be Bovine Leukemia Virus (BLV) is a major sanitary concern in many countries where the virus is widely disseminated among dairy herds with obvious economic impact. Different control strategies have been implemented worldwide to control BLV infection or eradicate the disease with diverse success. Eradication by culling is not economically sustainable in highly infected regions such as Argentina, US or Japan. Segregation of BLV-infected cattle is expensive due to duplication of facilities. Finally, several candidate vaccines based on recombinant viral proteins were unsuccessful to protect from challenge. Therefore, here we propose a novel strategy aimed to decrease seroprevalence based on the employ of a life-attenuated BLV provirus as a candidate vaccine. The rationale behind this strategy is the deletion of genes required to induce pathogenesis leaving those involved in infectivity, resulting in an attenuated deletant with impaired transmissibility. Preliminary experiments showed that the deletant provirus is infectious and elicits an efficient immune response in sheep (n=3) and in the natural host, bovines (n=9). Lack of spread to sentinels further supports the safety of the vaccine. Based on these promissory results, an ongoing validation program is being performed to evaluate the capacity of the candidate vaccine to protect from wild-type BLV infection in herd conditions (n=105). Infection will be routinely monitored and proviral loads will be determined. The efficiency of the immune response will be evaluated by titration of specific antibodies, cytotoxic lysis efficiency and cytokine profile. Viral expression ex vivo and provirus clonality will be also evaluated. This data will be instrumental for understanding the basic mechanisms undergoing during BLV infection and for elaborating a novel vaccine. We do believe this practical and cost-effective vaccination strategy is the sole economically viable in countries with high prevalence. [less ▲]

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See detailA life-attenuated BLV deletant as a candidate vaccine to inhibit viral transmission in bovine herds
Gutiérrez, G.; Rodriguez, Sabrina ULg; Florins, A. et al

in AIDS Research and Human Retroviruses (2011, June 05), 8(1), 12

A life-attenuated BLV deletant as a candidate vaccine to inhibit viral transmission in bovine herds Gerónimo Gutiérrez2*, Sabrina M. Rodríguez1*†, Arnaud Florins3, Lucas Vagnoni2, Irene Alvarez2, Nicolas ... [more ▼]

A life-attenuated BLV deletant as a candidate vaccine to inhibit viral transmission in bovine herds Gerónimo Gutiérrez2*, Sabrina M. Rodríguez1*†, Arnaud Florins3, Lucas Vagnoni2, Irene Alvarez2, Nicolas Gillet3, Karina Trono2‡, Luc Willems1,3‡ *‡S.M. Rodríguez / G. Gutiérrez and K.Trono / L. Willems contributed equally to this work. 1 Molecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège (ULg), Liège (4100), Belgium. 2 Instituto de Virología, CICVyA, Instituto Nacional de Tecnología Agropecuaria, (1712), Castelar, Argentina. 3 Molecular and Cellular Biology, Gembloux Agro-Bio Tech, University of Liège (ULg), Gembloux (5030), Belgium †E-mail: sabrina.rodriguez@ulg.ac.be There are different strategies to reduce BLV prevalence. Eradication by culling of infected animals is not economically sustainable in highly infected regions such as Argentina, US or Japan. Partition and confinement on BLV-infected cows is expensive due to duplication of facilities. Finally, several candidate vaccines based on recombinant viral proteins were unsuccessful to protect from challenge. Facing these failures, we propose a novel strategy based on the use of a live-attenuated BLV provirus. The rationale behind this strategy relies on the deletion of genes required to induce pathogenesis leaving those involved in infectivity, resulting in an attenuated mutant with impaired transmissibility. In a first set of experiments, we show that the mutant is infectious and elicits an efficient immune response in sheep (n=3) and in cows (n=9). Lack of spread to uninfected sentinels further supports the safety of the vaccine. Based on these promising results, a validation program in herd (n=105) is ongoing to evaluate the capacity of the candidate vaccine to protect from wild-type BLV infection. The following experiments are carried out: quantification of the proviral loads, assessment of immune response efficiency (antibody titers, CTL response and cytokine profiling), measure of viral expression in vivo (qRT-PCR) and ex vivo (expression of Tax and p24gag) and determination of provirus clonality during infection. This data will be instrumental for understanding the basic mechanisms undergoing during BLV infection and for elaborating of a novel vaccine. [less ▲]

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See detailA life-cycle assessment of injectable drug primary packaging : comparing the traditional process in glass vials with the new Closed Vial technology (polymer vials)
Belboom, Sandra ULg; Renzoni, Roberto ULg; Verjans, Benoît et al

in Programme book : SETAC EUrope 16th LCA Case Studies Symposium : From simplified LCA to advanced LCA (2010, February)

This study based on the life cycle assessment methodology compares environmental impacts of two packaging alternatives used for injectable drugs: the traditional method based on glass vials and the new ... [more ▼]

This study based on the life cycle assessment methodology compares environmental impacts of two packaging alternatives used for injectable drugs: the traditional method based on glass vials and the new method developed by Aseptic Technologies based on polymer vials. [less ▲]

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See detailA life-cycle assessment of injectable drug primary packaging : comparing the traditional process in glass vials with the new Closed Vial technology (polymer vials)
Belboom, Sandra ULg; Renzoni, Roberto ULg; Verjans, Benoît et al

Poster (2010, February 01)

This study based on the life cycle assessment methodology compares environmental impacts of two packaging alternatives used for injectable drugs: the traditional method based on glass vials and the new ... [more ▼]

This study based on the life cycle assessment methodology compares environmental impacts of two packaging alternatives used for injectable drugs: the traditional method based on glass vials and the new method developed by Aseptic Technologies based on polymer vials. [less ▲]

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See detailLife-cycle assessment of residential buildings in three different European locations, basic tool
Rossi, Barbara ULg; Marique, Anne-Françoise ULg; Glaumann, Mauritz et al

in Building & Environment (2012), 51

The paper deals with the development of a tool used for the life cycle assessment of residential buildings located in three different European towns: Brussels (Belgium), Coimbra (Portugal) and Luleå ... [more ▼]

The paper deals with the development of a tool used for the life cycle assessment of residential buildings located in three different European towns: Brussels (Belgium), Coimbra (Portugal) and Luleå (Sweden). The basic tool focuses on the structure and the materials of the buildings and permits the evaluation of the Embodied energy, Embodied carbon and yearly energy consumption. For that purpose, a different set of original data is taken into account for each location, in which the monthly temperatures, energy mix, heating and cooling systems are defined. The energy consumption, being for heating space or water, for cooling or for lighting is transformed into CO2 emissions to deduce the Operational carbon as well. The influence of the energy mix can therefore be assessed in the basic tool. As a matter of fact, the heating and cooling systems habitually used in the three countries are also of great importance. The District Heating system, is, for instance, incorporated in the basic tool. The presence of solar water heater or photovoltaic panels is also strongly influencing the operational carbon. After a short literature review on building LCA and the description of the basic tool, the software Pleiades+Comfie combined with Equer is used to achieve the complete LCA for one building using two different load bearing frames. The results of the calculations for Brussels climate are verified against these software results. The dependence of the results to parameters such as climate, energy mix and habits is then discussed in the companion paper. [less ▲]

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See detailLife-cycle assessment of residential buildings in three different European locations, case study
Rossi, Barbara ULg; Marique, Anne-Françoise ULg; Reiter, Sigrid ULg

in Building & Environment (2012), 51

The paper presents the comparative results of the life-cycle assessment (LCA) of one residential building with two constructive systems in Brussels and one steel frame house located in three different ... [more ▼]

The paper presents the comparative results of the life-cycle assessment (LCA) of one residential building with two constructive systems in Brussels and one steel frame house located in three different European towns: Brussels (Belgium), Coimbra (Portugal) and Luleå (Sweden). In a recent study, a modular building was studied in Coimbra and Luleå. It was shown that in terms of CO2 emissions, the Use Stage was the most harmful stage during the building life-cycle for Coimbra climate. Contrarily, in Luleå, it was the Product Stage, despite energy consumption being higher than Coimbra, due to the way electricity and heat are generated. In the present study, two structural systems are first compared for the Belgian house: steel frame and traditional masonry. A different life-cycle scenario is taken into account for the steel frame house for the three different locations, in which the monthly temperatures, energy mix, heating and cooling systems are defined. The LCA is carried out using the basic tool described in the companion paper. It is worth recalling that the results obtained with the basic tool were verified against Pleiades+Comfie and Equer software, enabling to carry out a complete LCA, for Brussels. Our results confirm that for all the three climates, the Use Stage (Operational energy) is the most harmful period during the building life-cycle and that the energy mix of the country strongly influences the equivalent CO2 emissions related to the Use Stage (Operational carbon) and may entirely reverse the conclusions about the life-cycle carbon footprint of the building. [less ▲]

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See detailLife-cycle carbon footprint of a residential steel framed building in different climates
Rossi, Barbara ULg; Marique, Anne-Françoise ULg; Reiter, Sigrid ULg

in World Sustainable Building Conference: SB11, Helsinki 18-21 October 2011 (2011, October 19)

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See detailLife-cycle impacts assessment of steel, composite, concrete and wooden columns
Rossi, Barbara ULg; Lukic, Ivan; Iqbal, Naveed et al

in Final International Conference of COST Action C25 - Sustainability of Constructions : Towards a better built environment: Innsbruck 3-5 February 2011 (2011, February)

This paper presents a comparative study showing the environmental profile of structural members used in the construction domain. The functional unit is a column that is realistic in terms of dimensions ... [more ▼]

This paper presents a comparative study showing the environmental profile of structural members used in the construction domain. The functional unit is a column that is realistic in terms of dimensions and load bearing capacity, made of steel or high strength steel sections, steel and concrete (composite), reinforced concrete, solid wood and glue-laminated wood. The design of the columns is made following the Eurocodes. Several environmental impacts are assessed, such as the global warming potential and energy consumption while also focusing on the acidification potential. The results are presented in the forms of bar charts for each considered column. For steel and concrete, depending on the source of information, the inven-tory can vary substantially e.g. the CO and CH4 emissions. Several sources of information are provided and used to perform a brief sensitivity analysis. The influence of the recycling of steel taking into account the IISI methodology will also be discussed. [less ▲]

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See detailLife-cycle impacts assessment of steel, composite, concrete and wooden columns
Rossi, Barbara ULg

Conference (2011, February)

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See detailLife-cycle modelling of bequests and its implications for annuity valuation
Jousten, Alain ULg

in Journal of Public Economics (2001), 79

In this paper we introduce a linear bequest motive into a standard life-cycle model, both allowing for credit and annuity market imperfections. First, we characterize the consumption and wealth processes ... [more ▼]

In this paper we introduce a linear bequest motive into a standard life-cycle model, both allowing for credit and annuity market imperfections. First, we characterize the consumption and wealth processes.We find that consumption is non-increasing in the linear bequest parameter for the simplest certainty case, but that the same is not true for life-span uncertainty. Second, we study the issue of annuity valuation. For a sufficiently strong bequest motive, the true value of an annuity is equal to the actuarial value. This invalidates a previous claim that, for imperfect annuity markets, it is close to the simple financial value. [less ▲]

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See detailThe Life-Cycle Proteins Roda of Escherichia Coli and Spove of Bacillus Subtilis Have Very Similar Primary Structures
Joris, Bernard ULg; Dive, Georges ULg; Henriques, A. et al

in Molecular Microbiology (1990), 4(3), 513-517

Comparison of the predicted amino acid sequence of the cell-cycle RodA protein with the National Research Foundation protein sequence database shows that the 370-amino-acid RodA, a protein that is ... [more ▼]

Comparison of the predicted amino acid sequence of the cell-cycle RodA protein with the National Research Foundation protein sequence database shows that the 370-amino-acid RodA, a protein that is essential for wall elongation in Escherichia coli and maintenance of the rod shape of the cell, is highly analogous, in terms of primary structure, with the Bacillus subtilis SpoVE protein involved in stage V of sporulation. [less ▲]

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See detailLifestyle Behaviours and Plasma Vitamin C and β-Carotene Levels from ELAN Population (Liège, Belgium)
PINCEMAIL, Joël ULg; Vanbelle, Sophie ULg; Degrune, Fabien et al

in Journal of Nutrition and Metabolism (2011), 2011

Several factors, including fruit and vegetables intakes, have been shown to significantly influence the plasma concentrations of the two antioxidants vitamin C and β-carotene. Deficiency levels of 6 mg/L ... [more ▼]

Several factors, including fruit and vegetables intakes, have been shown to significantly influence the plasma concentrations of the two antioxidants vitamin C and β-carotene. Deficiency levels of 6 mg/L (34.2 μM) for vitamin C and of 0.22 mg/L (0.4 μM) for β-carotene have been suggested below which cardiovascular risk might be increased. The present study performed on 897 presumably healthy subjects aged 40–60 years aimed to examine how modifiable lifestyle factors may be related to vitamin C and/or β-carotene deficiency. Gender, smoking, lack of regular physical activity and of daily fruit consumption (≥2/day), and social status (in particular, unemployment) were found to be significant risk factors for vitamin C deficiency. For β-carotene deficiency, the same factors were identified except social status; moreover, overweight and OC use in women were also found to have a deleterious effect. For non exposed subjects, the probability of developing vitamin C deficiency was 4% in men and 2.4% in women. This probability increased to 66.3% for men and to 44.3% for women (and even to 50.4% under OC use), when all risk factors were present. For β-carotene deficiency, the corresponding probabilities were equal to 29.7% in men and 13.7% in women (no risk factor present), and to 86.1% for men and 69.9% (91.6% for OC use) for women (all factors present), respectively [less ▲]

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See detailLifestyle factors and serum androgens among 636 middle aged men from seven countries in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Suzuki, Reiko; Allen, Naomi E.; Appleby, Paul N. et al

in Cancer causes & control : CCC (2009), 20(6), 811-21

OBJECTIVE: To evaluate the association between lifestyle and dietary factors and serum concentrations of androgens in middle-aged healthy men. METHODS: We conducted a cross-sectional analysis of the ... [more ▼]

OBJECTIVE: To evaluate the association between lifestyle and dietary factors and serum concentrations of androgens in middle-aged healthy men. METHODS: We conducted a cross-sectional analysis of the association of lifestyle factors with circulating concentrations of androstenedione (A-dione), 3-alpha-androstanediol glucuronide (A-diol-g), testosterone (T), SHBG (sex hormone-binding globulin), and free testosterone (FT) among 636 men in the European Prospective Investigation into Cancer and Nutrition. RESULTS: Compared with the youngest age group (40-49 years), the oldest (70-79 years) had a higher mean concentration of SHBG (by 44%) and lower mean concentrations of A-diol-g (by 29%) FT (19%). Men in the highest BMI group (> or =29.83 kg/m(2)) had a higher mean A-diol-g concentration (by 38%) and lower mean concentration of T (by 20%) SHBG (29%) compared with the lowest (<24.16 kg/m(2)). Current smokers had higher mean concentrations of T (by 13%), SHBG (14%), and A-dione (15%) compared with never smokers. Physical activity and dietary factors were not associated with androgen concentrations, although men in the highest fifth of alcohol intake had higher mean concentrations of A-dione (by 9%), FT (11%) compared with the lowest. CONCLUSION: Our results suggest that age, body weight, smoking, and alcohol intake are associated with circulating androgen concentrations in men. [less ▲]

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See detailLifetime absolute risk of hip and other osteoporotic fracture in Belgian women.
Hiligsmann, Mickaël ULg; Bruyère, Olivier ULg; Ethgen, Olivier ULg et al

in BONE (2008), 43(6), 991-4

OBJECTIVES: To estimate the lifetime absolute risks of hip and other osteoporotic fracture in Belgian women aged 60 years and to examine the effect of changes in baseline population fracture risk and ... [more ▼]

OBJECTIVES: To estimate the lifetime absolute risks of hip and other osteoporotic fracture in Belgian women aged 60 years and to examine the effect of changes in baseline population fracture risk and changes in life expectancy. MATERIALS AND METHODS: Estimates were performed using a Markov microsimulation model and were based on the incidence of first fracture as well as life expectancy. Baseline scenario included projected mortality rates and increasing fracture incidence by 1% per year. Alternative scenarios were performed on age, life expectancy and trends in fracture incidence. Lifetime fracture risk for osteoporotic population (T-score <or= -2.5) was also estimated. RESULTS: In the baseline scenario, lifetime absolute risks of hip fracture and of any major osteoporotic fracture (hip, clinical vertebral or wrist) were respectively 24.8% and 44.3%. Alternative scenarios showed that when assuming no change of age-specific fracture rates over time, these lifetime risks were 18.3% and 35.2%, while these values were 20.0% and 38.3% assuming no future mortality reductions. For osteoporotic women, these values were respectively 34.5% and 51.5%. CONCLUSION: We conclude that absolute lifetime fracture risks are substantial and that trends in fracture incidence and changes in life expectancy have a marked impact on absolute lifetime fracture risks. [less ▲]

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See detailLifetime and Landé factor measurements of 5p7p levels of Sn I by time-resolved laser spectroscopy
Zhang, Y.; Xu, J.; Zhang, W. et al

in Physical Review. A (2008), 78

Lifetimes for nine levels and Landé gJ factors for eight levels of the 5p7p configuration of neutral tin have been measured by the time-resolved fluorescence method and by the Zeeman quantum beat ... [more ▼]

Lifetimes for nine levels and Landé gJ factors for eight levels of the 5p7p configuration of neutral tin have been measured by the time-resolved fluorescence method and by the Zeeman quantum beat technique, respectively. A two-step laser excitation technique has been used for the measurements. The results obtained are compared with relativistic Hartree-Fock lifetime and gJ values taking core-polarization effects into account. [less ▲]

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