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See detailHuman/bovine chimeric MxA-like GTPases reveal a contribution of N-terminal domains to the magnitude of anti-influenza A activity
Garigliany, Mutien-Marie ULg; Cornet, Anne ULg; Desmecht, Daniel ULg

in Journal of Interferon & Cytokine Research (2012), 32(7), 326-331

Type I interferons (IFN-) provide powerful and universal innate intracellular defence mechanisms against viruses. Among the antiviral effectors induced by IFN-, Mx proteins of some species appear as ... [more ▼]

Type I interferons (IFN-) provide powerful and universal innate intracellular defence mechanisms against viruses. Among the antiviral effectors induced by IFN-, Mx proteins of some species appear as key components of defence against influenza A viruses. The body of work published to date suggests that to exert anti-influenza activity, an Mx protein must possess a GTP-binding site, structural bases allowing multimerisation, and a specific C-terminal GTPase effector domain (GED). The human MxA and bovine Mx1 proteins both meet these minimal requirements, but the bovine protein is more active against influenza viruses. Here we measured the anti-influenza activity exerted by two human/bovine chimeric Mx proteins. We show that substituting the bovine GED for the human one in human MxA does not affect the magnitude of anti-influenza activity. Strikingly, however, substituting the human GED for the bovine one in bovine Mx1 yields a chimeric protein with much higher anti-influenza activity than the human protein. We conclude, in contradiction to the hypothesis currently in vogue in the literature, that the GED is not the sole determinant controlling the magnitude of the anti-influenza activity exercised by an Mx protein that can bind GTP and multimerise. Our results suggest that one or several motifs that remain to be discovered, located N-terminally with respect to the GED, may interact with a viral component or a cellular factor so as to alter the viral cycle. Identifying, in the N-terminal portion of bovine Mx1, the motif(s) responsible for its higher anti-influenza activity could contribute to the development of new anti-influenza molecules. [less ▲]

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See detailHumanisation de la marque et web 2.0
Brandt, Céline ULg

Article for general public (2012)

La personnification est l’action de représenter sous les traits d’une personne une chose abstraite ou inanimée. Au sein des réseaux sociaux, les consommateurs souhaitent s’adresser directement au porte ... [more ▼]

La personnification est l’action de représenter sous les traits d’une personne une chose abstraite ou inanimée. Au sein des réseaux sociaux, les consommateurs souhaitent s’adresser directement au porte-parole de la marque, en général le dirigeant de la société. Les conséquences de ce type de communication personnelle sur le comportement du consommateur sont l’amélioration de la confiance, la satisfaction et l’engagement du consommateur. [less ▲]

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See detailL'humanisation de la mort
Lamy, Maurice ULg

in Annales de l'Anesthésiologie Française (1980), 21(3), 313-314

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See detailHumanisme de conviction ou humanisme instrumental ? Une comparaison des directeurs de prison belges et français
Dubois, Christophe ULg; Mouhanna, Christian

Conference (2014, May 20)

Bien que peu étudiés, les directeurs de prison se situent au centre de l’institution pénitentiaire et font office de véritables interfaces entre les politiques étatiques et les pratiques locales. L’étude ... [more ▼]

Bien que peu étudiés, les directeurs de prison se situent au centre de l’institution pénitentiaire et font office de véritables interfaces entre les politiques étatiques et les pratiques locales. L’étude empiriquement ancrée des pratiques de ce groupe professionnel révèle divers modes de prise en compte de la question humaniste par les acteurs d’un « système pénitentiaire » souvent considéré comme dominé par « l’impératif sécuritaire ». Quant à l’analyse de leurs discours, elle permet de rendre compte du positionnement particulier de nombreux directeurs de prison vis-à-vis de leur administration (collectivement, via les syndicats et associations de directeurs, ou individuellement, via les médias et autres publications) et vis-à-vis de l’institution judiciaire (juges d’instruction, tribunaux de l’application des peines, Conseil d’Etat). Notre contribution repose sur deux enquêtes réalisées au cours des trois dernières années auprès de directeurs belges (n = 32) et français (n = 20). Les degrés de hiérarchisation et de judiciarisation des contextes de travail des directeurs varient au sein des ces deux pays et déterminent, en partie, les modalités d’interaction quotidienne des directeurs en détention (avec les détenus, les services psychosociaux, les surveillants, etc.) et autour de la détention (avec l’administration centrale, le TAP, la justice, les associations diverses, etc.). Il s’agira de saisir et de rendre visible la dimension humaniste du travail des directeurs, tant au niveau de leurs pratiques (cultures professionnelle et organisationnelle) que de leurs discours professionnels (logiques de justification). En effet, ce qu’ils qualifient, par exemple, d’ « empathie », d’ « intensité des relations », de « recherche du sens de leur travail » et de « sens de la peine », semblent orienter leur travail dans des marges qu’il conviendra de préciser. [less ▲]

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See detailL'humanisme face au terrorisme
Seron, Vincent ULg

in Cahiers de défense sociale (2000)

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See detailHumanisme pratique et antihumanisme théorique
Delruelle, Edouard ULg

Article for general public (2012)

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See detailHumanisme, classicisme et tradition dans la vie et l’œuvre d’Arsène Soreil
Delhalle, Nancy ULg

in La Vie Wallonne (1989), 405-406

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See detailL'humanisme, inutile et incertain? Une critique des droits de l'homme
Delruelle, Edouard ULg

Book published by Labor (1999)

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See detailHumanitarian aid and health services in Eastern Kivu, Zaïre: collaboration or competition
Goyens, Philippe; Porignon, Denis ULg; Mugisho Soron'Gane, Etienne et al

in Journal of Refugee Studies (1996), 9(3), 268-280

The population of eastern Kivu, like that of Rwanda, has been surviving in critical conditions for many years. The Rwandan refugees of 1994 fled into an area with its own serious problems. The Zairean ... [more ▼]

The population of eastern Kivu, like that of Rwanda, has been surviving in critical conditions for many years. The Rwandan refugees of 1994 fled into an area with its own serious problems. The Zairean health services in the health districts of Rutshuru, Kirotshe and Masisi, in spite of the political and socioeconomic disintegration of the country, were still functioning, and the local hospitals and health centres, although overwhelmed, contributed to a large extent to the disaster response. Prominent among the major problems facing the local health services were their limited adaptability, the inadequate coordination and collaboration offered to them by the humanitarian aid agencies, and the discrimination between the direct and secondary victims of the emergency. The public health consequences of the Rwandan refugee crisis for the Zairean population constitute an integral part of the disaster. [less ▲]

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See detailLes humanités chrétiennes
Kurth, Godefroid ULg

Speech/Talk (1901)

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See detailLes humanités de demain
Kurth, Godefroid ULg

in Bulletin de la Classe des Lettres et des Sciences Morales et Politiques (1902)

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See detailHumanities 2.0. Document, interpretation and intersubjectivity in the digital age
Bénel, Aurélien; Lejeune, Christophe ULg

in International Journal of Web-Based Communities (2009), 5(4), 562-576

With their focus on documents, interpretation and intersubjectivity, Web 2.0 technologies have surprising analogies with philosophical hermeneutics, the theory of texts interpretation. Philosophical ... [more ▼]

With their focus on documents, interpretation and intersubjectivity, Web 2.0 technologies have surprising analogies with philosophical hermeneutics, the theory of texts interpretation. Philosophical hermeneutics was generalised from biblical hermeneutics by Dilthey in the 19th century, and chosen as an alternative to positivism as a foundation for the epistemology and methodology of the humanities and social sciences. This article explores how Web 2.0 technologies might better meet the needs of social and human sciences than traditional information technologies that are historically bound with logical positivism. Illustrations are provided from archaeology and sociology, two social and human sciences which were early adopters of punched cards and computers. [less ▲]

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See detailHumanized mice as a useful model to study HIV-1 induced immune activation, its mechanisms and potential therapeutic approaches
Singh, Maneesh; Singh, Pratibha; VAIRA, Dolorès ULg et al

in Retrovirology (2011, October 03), 8

Recent understanding of HIV-1 pathogenesis mechanism has changed our views about possible mechanisms of CD4T-cell depletion during infection. Apart from HIV-1-mediated killing a more comprehensive ... [more ▼]

Recent understanding of HIV-1 pathogenesis mechanism has changed our views about possible mechanisms of CD4T-cell depletion during infection. Apart from HIV-1-mediated killing a more comprehensive explanation has appeared that includes T cell exhaustion and chronic immune activation as a central feature in HIV-1 pathogenesis. While highly active antiretroviral therapy (HAART) markedly reduces viral load, T cell activation levels and soluble markers of inflammation remain abnormally high. Markers of chronic activation, such as CD38, PD-1 or HLA-DR on T cells, appear to be better predictors for clinical progression during HIV infection than HIV RNA levels and CD4Tcell counts alone. Therefore, a better understanding of HIV-índuced immune activation and the design of new immunomodulatory approches in combination with HAART are needed. We have generated an efficient model of human stem cells (HSCs) engraftment in NOD/LtsZ-scidlL-2Rnull (NSG) mice that supports chronic HIV infection with high plasma viral loads. HIV-1 infection in these humanized mice is characterized by widespread immune activation with increased expression of PD-1, HLA-DR, CD38, CD69, CD25 and other immune activation markers. These humanized mice provide an effective in vivo system for the assessing novel approaches for their potential in suppressing chronic immune activation during HIV-1 infection, in absence of interference of antiretroviral therapy. In this study, we evaluated in vivo the benefits of two novel approaches aimed at reducing HIV-induced immune activation. Minocycline is an antibiotic of the tetracycline family with anti-inflammatory and immunomodulatory properties affecting CD4 T cells activation by a mechanism involving the inhibition of the NF-AT1 transcription factor activity. We hypothesized that this antibiotic could suppress the HIV-1-induced chronic immune activation and thus, limit the HIV pathogenesis when combined to HAART. Therefore, we treated HIV-1 (JRCSF) infected-humanized NSG mice with minocycline (100mg/kg/day) for 60 days. We next evaluated the expression, by flow cytometry, of several T cells activation markers together with CD4+T cells counts. Our data suggest that minocycline is effective in suppressing HIV-1 induced immune activation in peripheral blood and lymphoid organs (spleen, lymph nodes and bone marrow). Levels of cellular immune activation markers such as PD-1, HLA-DR, CD38, CD69, CD25, CD28 and CTLA-4 were significantly lower in minocycline treated group. These immunological benefits of minocycline were correlated with higher CD4+T cell counts in the treated group. The immune activation which is associated with retroviral infection is also associated with increased levels of intracytoplasmic cyclic AMP which could act as a positive feedback loop in the infection since several reports have suggested that cAMP and downstream signaling pathways play an important role in the permissivity of susceptible cells to HIV infection and replication. We have used a peptide which prevents the binding of the catalytic subunit of PKA type I to its anchoring protein and therefore blocks most effects of cyclic AMP within lymphocytes and monocytes (RIAD peptide). Mice were treated with 3.5 mg/kg of RIAD peptide weekly. Treatment of humanized mice with RIAD peptide limited viral replication after high dose of HIV intraperitoneal challenge and reduced the intracytoplasmic levels of cyclic AMP. Further experiments are needed to better appreciate the therapeutic potential of these novel therapies in the suppression of HIV-induced chronic immune activation. [less ▲]

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See detailHumanizing the Clinical Gaze: Movies and the Empathic Understanding of Psychosis
Raballo, A.; Laroi, Frank ULg; Bell, V.

in Family Medicine (2009), 41(6), 387-388

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See detailHument et diplomatie : le sacré comme source de normes morales et éthique
Leroy, Patrick ULg

in klaousen, patrick (Ed.) Renseignement et éthique - le moindre mal nécessaire (2014)

Associer les termes Renseignement et Éthique au sein d'un même propos semble être un oxymore tant le renseignement a une réputation sulfureuse. Pourtant, et il faut le marteler avec insistance : dans un ... [more ▼]

Associer les termes Renseignement et Éthique au sein d'un même propos semble être un oxymore tant le renseignement a une réputation sulfureuse. Pourtant, et il faut le marteler avec insistance : dans un État démocratique les services de renseignement, parce qu'ils tiennent la ligne de front face à des menaces invisibles mais bien réelles, sont au service de l'État de droit, des citoyens et de la démocratie. Toutefois, par delà l'encadrement juridique auquel il est soumis, et à l'instar de la plupart des activités humaines, force est de constater que le renseignement ne manque pas d'interpeller par les dilemmes éthiques qu'il soulève. Le Groupe Européen de Recherches en Éthique et Renseignement (GERER) constitué de praticiens du renseignement et d'universitaires francophones ne cherche pas pour autant à surfer sur le regain d'intérêt pour l'espionnage suscité récemment par l'affaire Snowden, mais s'attache plutôt à combler le retard pris par les pays de culture francophone dans un domaine dont les contours commencent à se figer sur la base d'approches intellectuelles et opérationnelles purement anglosaxonnes. Soucieux de développer une réflexion de fond autour d'un problème crucial pour l'avenir de la démocratie, le présent ouvrage, parce qu'il met en perspective des sujets trop souvent déformés par un traitement médiatique accrocheur, s'adresse tant aux professionnels du renseignement qu'à un public plus large. Au travers d'études de cas, il permet de s'initier aux dilemmes éthiques qui se posent à ces agents de l'État qui exercent un métier hors du commun. (4ème de couv) [less ▲]

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See detailHumidity 3D field comparisons between GNSS tomography, IASI satellite observations and ALARO model
Brenot, Hugues; Champollion, Cedric; Deckmyn, Alex et al

in Geophysical Research Abstracts (2012, April), 14

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See detailHumn Bocavirus, a newly discovered Parvovirus of the respiratory tract
RICOUR, Céline ULg; GOUBAU, P

in Acta Clinica Belgica (2008), 64(5), 329-332

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See detailHumnétriai… Un rite mis en images chez Philostrate
Pironti, Gabriella; Pirenne-Delforge, Vinciane ULg

in Calame, Claude; Ellinger, Pierre (Eds.) Du récit au rituel par la forme esthétique : pragmatique cultuelle des formes discursives et des images en Grèce ancienne (in press)

Detailed reference viewed: 29 (1 ULg)