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See detailImportance of the reconciliation method to handle experimental data: application to a reversible heat pump / organic Rankine cycle unit integrated in a positive energy building
Dumont, Olivier ULg; Quoilin, Sylvain ULg; Lemort, Vincent ULg

Conference (2015, June)

Experimental data is often the result of long and costly experimentations. Many times, measurements are used directly without (or with few) analysis and treatment. This paper therefore presents a detailed ... [more ▼]

Experimental data is often the result of long and costly experimentations. Many times, measurements are used directly without (or with few) analysis and treatment. This paper therefore presents a detailed methodology to use steady-state measurements efficiently in the analysis of a thermodynamic cycle. The reconciliation method allows to correct each measurement as little as possible, taking its accuracy into account, in order to satisfy all constraints and to evaluate the most probable physical state. The reconciliation method should be used for multiple reasons. First, this method allows to close energy and mass balances exactly, which is needed for predictive models. Also, it allows determining some unknowns that are not or that cannot be measured precisely. Furthermore, it fully exploits the collected measurements with redundancy and it allows to know which sensor should be checked or replaced if necessary. An application of this method is presented in the case of a reversible HP/ORC unit. This unit is a modified heat pump which is able to work as an organic Rankine cycle by reversing its cycle. Combined with a passive house comprising a solar roof and a ground heat exchanger, it allows to get a plus energy house. In this study case, the oil mass fraction is not measured despite of its strong influence on the results. The reconciliation method allows to evaluate it. The efficiency of this method is proven by comparing the error on the outputs of steady-state models of compressor and exchangers. An example is given with the prediction of the pinch-point of an evaporator. In this case, the normalized root mean square deviation (NRMSD) is decreased from 14.3 % to 4.1 % when using the reconciliation method. This paper proves the efficiency of the method and also that the method should be considered more often when dealing with experimentation. [less ▲]

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See detailThe importance of the tumor microenvironment in the therapeutic management of cancer
Pottier, Charles ULg; Wheatherspoon, Alodie; RONCARATI, Patrick ULg et al

in Expert Review of Anticancer Therapy (2015), 15

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See detailImportance of the Two Tryptophan Residues in the Streptomyces R61 Exocellular Dd-Peptidase
Bourguignon-Bellefroid, Catherine; Wilkin, Jean-Marc; Joris, Bernard ULg et al

in Biochemical Journal (1992), 282(Pt 2), 361-367

Modification of the Streptomyces R61 DD-peptidase by N-bromosuccinimide resulted in a rapid loss of enzyme activity. In consequence, the role of the enzyme's two tryptophan residues was investigated by ... [more ▼]

Modification of the Streptomyces R61 DD-peptidase by N-bromosuccinimide resulted in a rapid loss of enzyme activity. In consequence, the role of the enzyme's two tryptophan residues was investigated by site-directed mutagenesis. Trp271 was replaced by Leu. The modification yielded a stable enzyme whose structural and catalytic properties were similar to those of the wild-type protein. Thus the Trp271 residue, though almost invariant among the beta-lactamases of classes A and C and the low-Mr penicillin-binding proteins, did not appear to be essential for enzyme activity. Mutations of the Trp233 into Leu and Ser strongly decreased the enzymic activity, the affinity for beta-lactams and the protein stability. Surprisingly, the benzylpenicilloyl-(W233L)enzyme deacylated at least 300-fold more quickly than the corresponding acyl-enzyme formed with the wild-type protein and gave rise to benzylpenicilloate instead of phenylacetylglycine. This mutant DD-peptidase thus behaved as a weak beta-lactamase. [less ▲]

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See detailImportance of Tumor Pathology
Beckers, Albert ULg

Scientific conference (2001, June)

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See detailImportance of Tumor Regression Assessment in Predicting the Outcome in Patients with Locally Advanced Rectal Carcinoma Who Are Treated with Preoperative Radiotherapy
Bouzourene, Hanifa; Bosman, Fred; Seelentag, Walter et al

in Cancer (2002), 94(4), 1121-1130

BACKGROUND: Locally advanced rectal carcinoma has a poor prognosis. However, <br />since the introduction of preoperative radiotherapy, the outcome of patients with <br />rectal carcinoma has been ... [more ▼]

BACKGROUND: Locally advanced rectal carcinoma has a poor prognosis. However, <br />since the introduction of preoperative radiotherapy, the outcome of patients with <br />rectal carcinoma has been reported to have improved. Nevertheless, to the authors’ <br />knowledge few data are available regarding the histopathologic response to <br />radiotherapy as assessed on surgical specimens as a potential predictive factor for <br />outcome. <br />METHODS: To estimate the effect of radiotherapy on rectal carcinoma, the authors <br />retrospectively reviewed the surgical specimens of 102 patients with T3-4, N0 or <br /> N1 rectal carcinoma and 1 patient with T2 but N1 rectal carcinoma. All patients <br />were treated preoperatively with a hyperfractionated accelerated radiotherapy <br />schedule in a prospective protocol (Trial 93-01). Using a standardized approach, <br />tumor regression was graded using a system that varies from Grade 1 (tumor <br />regression Grade [TRG] 1) when complete tumor regression is observed to Grade 5 <br />(TRG5) when no tumor regression is observed. <br />RESULTS: Radiotherapy resulted in tumor downstaging in 43% of the patients. <br />There were 2 pT1 tumors (2%), 21 pT2 tumors (20%), 66 pT3 tumors (64%), and 14 <br />pT4 tumors (14%) after treatment. Regional lymph nodes were involved in 55 <br />patients (53%). None of the patients demonstrated a complete tumor regression <br />after radiotherapy, but in 79% of the specimens a partial tumor regression was <br />observed (TRG1: 0%; TRG2: 20%; TRG3: 39%; TRG4: 20%; and TRG5: 21%). The <br />median actuarial overall survival (OS) and disease-free survival (DFS) were 52 <br />months. Actuarial local recurrence rates at 2 years and 5 years were 6.4% and 7.6%, <br />respectively. Univariate analysis showed the actuarial DFS to be significantly lower <br />in patients with lymph node metastases (P 0.0004) and advanced pT stages <br />(pT3-4) (P 0.03). A favorable outcome for OS, DFS, and local control was <br />observed in patients with TRG2-4 (i.e., responders) compared with patients with <br />TRG5 (i.e., nonresponders), but also in patients with low residual tumor cell <br />density (TRG2, 3, and 4). On multivariate analysis, TRG remained an independent <br />prognostic indicator for local tumor control. <br />CONCLUSIONS. Tumor regression as well as residual tumor cell density were found <br />to be predictive factors of survival in rectal carcinoma patients after preoperative <br />radiotherapy. Even after preoperative radiotherapy, the pathologic stage of the <br />surgical specimen remained a prognostic factor. The use of a standardized approach <br />for pathologic evaluation must be implemented to allow comparison between <br />the results of various treatment approaches. [less ▲]

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See detailImportance of wavenumber dependence of Biot numbers in one-sided models of evaporative Marangoni instability: horizontal layer and spherical droplet
Machrafi, Hatim ULg; Rednikov, Alexey; Colinet, Pierre et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2015)

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See detailImportance of Weight Loss and Sodium Restriction in the Treatment of Mild and Moderate Essential Hypertension
Krzesinski, Jean-Marie ULg; Janssens, Marion; Vanderspeeten, Francine et al

in Acta Clinica Belgica (1993), 48(4), 234-245

The effectiveness of non pharmacological treatment of chronic arterial hypertension has been evaluated in 116 treated or not primary hypertensive out-patients. Those receiving diuretics were however ... [more ▼]

The effectiveness of non pharmacological treatment of chronic arterial hypertension has been evaluated in 116 treated or not primary hypertensive out-patients. Those receiving diuretics were however excluded. This population was requested to follow for 3 months a modification of their usual diet characterized by salt restriction combined with energy intake restriction when the patients were above their ideal body weight. Only 62 patients (53%) completed the study. However, this approach was effective by decreasing blood pressure and total cholesterol. The weight loss appears the most effective way to decrease blood pressure in untreated patients, but needs 3 months to be significant. In drug-treated patients, the sodium restriction significantly influences the blood pressure level, already after 1 month. However, salt sensitivity has been noted, especially in the most severe forms of the hypertensive disease. The combination of both modifications (weight loss and sodium restriction) does not appear to be more effective than each separate dietary measure. [less ▲]

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See detailImportance quantitative de la chitine dans les biocenoses benthiques et les sédiments marins
Jeuniaux, Charles ULg; Boutique, R.; Voss-Foucart, M.F.

Conference (1979)

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See detailL’importance stratégique de la Basse-Meuse en août 1914
Bechet, Christophe ULg

Conference given outside the academic context (2014)

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See detailL'importance stratégique de la Belgique avant la Première Guerre mondiale
Bechet, Christophe ULg

Scientific conference (2013, November 12)

Présentation des principaux résultats de notre thèse à un groupe d'étudiants de master en Histoire

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See detailL’importance stratégique des chemins de fer belges avant la Première Guerre mondiale. Un enjeu international
Bechet, Christophe ULg

in Société archéologique de Namur (Ed.) Actes du LVème Congrès de la Fédération des Cercles d’Archéologie et d’Histoire de Belgique – Namur 2008 (2011)

Schlieffen réfléchit à la possibilité d’un passage par la Belgique depuis fin 1896 et la première trace écrite d’une stratégie de débordement de l’aile gauche française par le nord se trouve dans un ... [more ▼]

Schlieffen réfléchit à la possibilité d’un passage par la Belgique depuis fin 1896 et la première trace écrite d’une stratégie de débordement de l’aile gauche française par le nord se trouve dans un Denkschrift rédigé par lui le 2 août 1897. Toutefois, à ce moment, il n’est pas encore question pour Schlieffen de concrétiser ses réflexions dans le plan allemand officiel car il lui faut vaincre deux obstacles majeurs. Primo, la nécessité de créer un nombre de corps d’armée suffisant pour que la réalisation du mouvement tournant par la Belgique se fasse sans trop dégarnir les fronts d’Alsace-Lorraine et de Russie. Secundo, Schlieffen ne peut aligner de nombreuses divisions face à la Belgique que grâce à un réseau ferroviaire suffisamment développé dans l’Eiffel allemand. Le développement des lignes de chemin de fer dans la zone frontalière belgo-allemande offre de nouvelles perspectives stratégiques en cas de guerre future. [less ▲]

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See detailL’importance stratégique du territoire belge jugée par les attachés militaires anglais en poste à Bruxelles (1891-1914)
Bechet, Christophe ULg

Scientific conference (2012, March 06)

La série de rapports militaires encore présents dans la correspondance de la légation britannique à Bruxelles est incomplète et moins riche que les nombreux rapports conservés aux archives de l’Armée de ... [more ▼]

La série de rapports militaires encore présents dans la correspondance de la légation britannique à Bruxelles est incomplète et moins riche que les nombreux rapports conservés aux archives de l’Armée de Terre à Vincennes ; il n’empêche, le nombre de documents existants demeure important et susceptible de livrer des informations de première main sur les relations militaires belgo-britanniques avant la Première Guerre mondiale. Notre intervention consistera à faire un état des lieux des documents conservés, de leur localisation et de ce qu’ils peuvent nous apprendre sur la perception britannique du territoire belge. A l’aide des recherches que nous avons réalisées dans le cadre de notre thèse sur les plans français et allemands dans leurs rapports avec la Belgique, nous élargirons nos réflexions sur les relations belgo-britanniques dans une perspective militaire européenne. [less ▲]

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See detailImportances des profils phénotypiques dans la prise en charge des enfants présentant des retards mentaux
Comblain, Annick ULg

Conference (2001, September 28)

Les difficultés d'acquisition et de développement du langage oral des personnes retardées mentales, et plus particulièrement, de celles atteintes d'un retard mental d'origine génétique, sont, à l'heure ... [more ▼]

Les difficultés d'acquisition et de développement du langage oral des personnes retardées mentales, et plus particulièrement, de celles atteintes d'un retard mental d'origine génétique, sont, à l'heure actuelle, reconnues mais malheureusement encore mal connues. Il existe en effet une grand variabilité inter- et intra-syndromes qu'il est aujourd'hui important d'étudier et ce dans une perspective d'intervention adaptée et efficace. Les recherches menés depuis quelques années dans le domaine de la spécificité syndromique suggèrent que les développements et les fonctionnements cognitif, langagier, mnésique, perceptuel et attentionnel diffèrent considérablement d'un syndrome à l'autre. Jusqu'au début des années 1990, on envisageait le développement des personnes présentant un retard mental (plus particulièrement modéré) en référence à un modèle dit "prototypique" : le syndrome de Down ou trisomie 21. [less ▲]

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See detailImportancia de la elección de distintos oligonucleótidos para el diagnostico de BLV por PCR en productos de origen bovino
Trono, K.; Gutiérrez, G.; Rodriguez, Sabrina ULg et al

Poster (2006, December 05)

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See detailImportant differences between multiple offenders ans non-multiple offenders
Gavray, Claire ULg

Conference (2012, September 13)

importance to distinguish between young people who have a 'single- light' experience' of crime and those who do repeat illegal behaviours over time. The profile of those young people is quite different ... [more ▼]

importance to distinguish between young people who have a 'single- light' experience' of crime and those who do repeat illegal behaviours over time. The profile of those young people is quite different and the necessary prevention is specific in both cases [less ▲]

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See detailImportant differences in management policies for children with end-stage renal disease in the Netherlands and Belgium--report from the RICH-Q study.
Tromp, Wilma F.; Schoenmaker, Nikki J.; van der Lee, Johanna H. et al

in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2012), 27(5), 1984-92

BACKGROUND: The low prevalence of childhood end-stage renal disease and the small centre sizes have been a barrier for clinical studies and the development of evidence-based guidelines for chronic renal ... [more ▼]

BACKGROUND: The low prevalence of childhood end-stage renal disease and the small centre sizes have been a barrier for clinical studies and the development of evidence-based guidelines for chronic renal replacement therapy (cRRT) in children. Few data exist on the quality of care for these patients and the applicability of existing guidelines. The aim of this study is to quantify variation in treatment policies and actually delivered care in nine centres that deliver cRRT for children. METHODS: We surveyed treatment policies in all nine centres in the Netherlands and Belgium and compared them with the actually provided therapies and with recommendations from available guidelines. Data on treatment policies were gathered by questionnaires; actually provided care and outcomes were registered prospectively from 2007 to 2010. RESULTS: Data on policies and actual patient care were obtained from all nine centres. We found relevant differences between centres in treatment policies on various topics, e.g. estimated glomerular filtration rate threshold as an indication for initiation of cRRT, preferred initial mode of cRRT, peritoneal dialysis catheter care, haemodialysis frequency and vascular access. Discrepancies were seen between stated treatment policies and actual performed therapies. For the majority of policies, no evidence-based guidelines are available. CONCLUSIONS: Health care disparities exist due to large and unwanted variation in treatment policies between hospitals providing cRRT for children. Delivered care does not live up to stated policies, for which clear and internationally accepted guidelines are lacking. [less ▲]

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See detailImportant role of the mid-tropospheric atmospheric circulation in the recent surface melt increase over the Greenland ice sheet
Fettweis, Xavier ULg; Hanna, Edward; Lang, Charlotte ULg et al

in Cryosphere (The) (2013), 7

Since 2007, there has been a series of surface melt records over the Greenland ice sheet (GrIS), continuing the trend towards increased melt observed since the end of the 1990's. The last two decades are ... [more ▼]

Since 2007, there has been a series of surface melt records over the Greenland ice sheet (GrIS), continuing the trend towards increased melt observed since the end of the 1990's. The last two decades are characterized by an increase of negative phases of the North Atlantic Oscillation (NAO) favouring warmer and drier summers than normal over GrIS. In this context, we use a circulation type classification based on daily 500 hPa geopotential height to evaluate the role of atmospheric dynamics in this surface melt acceleration for the last two decades. Due to the lack of direct observations, the interannual melt variability is gauged here by the summer (June–July–August) mean temperature from reanalyses at 700 hPa over Greenland; analogous atmospheric circulations in the past show that ~70% of the 1993–2012 warming at 700 hPa over Greenland has been driven by changes in the atmospheric flow frequencies. Indeed, the occurrence of anticyclones centred over the GrIS at the surface and at 500 hPa has doubled since the end of 1990's, which induces more frequent southerly warm air advection along the western Greenland coast and over the neighbouring Canadian Arctic Archipelago (CAA). These changes in the NAO modes explain also why no significant warming has been observed these last summers over Svalbard, where northerly atmospheric flows are twice as frequent as before. Therefore, the recent warmer summers over GrIS and CAA cannot be considered as a long-term climate warming but are more a consequence of NAO variability affecting atmospheric heat transport. Although no global model from the CMIP5 database projects subsequent significant changes in NAO through this century, we cannot exclude the possibility that the observed NAO changes are due to global warming. [less ▲]

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See detailImportant roles of SoHo proteins in vascular development: Sorbs1 and Sorbs2 have related but distinct functions in endothelial cells angiogenic properties
Bleuart, Anouck ULg

Doctoral thesis (2014)

Vascular system in all vertebrate organisms has in charge essential functions such as to bring nutrients, oxygen and signalling molecules to distant organs. Vascular network is established through ... [more ▼]

Vascular system in all vertebrate organisms has in charge essential functions such as to bring nutrients, oxygen and signalling molecules to distant organs. Vascular network is established through sequential and distinct processes. During embryogenesis, angioblasts give rise to differentiated endothelial cells, which form primary vessels through vasculogenesis. Expansion of this primary network is then achieved through a multistep process known as angiogenesis. During angiogenesis, remodelling of endothelial cell shape relies on cytoskeleton dynamics. In this study, our goal was to investigate the potential role of the SoHo family of adaptor proteins in angiogenesis. The SoHo family comprises three members, Sorbs1, Sorbs2 and Sorbs3. Although accumulative evidence links this protein family to the regulation of cell adhesion and actin cytoskeletal organisation, their expression and potential functions in endothelial cells remain unknown. Using zebrafish loss of function experiments combined with confocal imaging, we show that loss of Sorbs1 affects caudal vein-derived vessel formation, whereas Sorbs2 depletion impairs ISV development essentially derived from the dorsal aorta. We then demonstrated that both members impact on EC behaviour via regulation of RhoGTPases activity, leading to the vascular defects observed in vivo. Using a series of in vitro functional assays, we found that Sorbs1 and Sorbs2 have opposite effects on adhesives properties of HUVECs related to their ability to regulate different RhoGTPases. Sorbs1 depleted ECs adhere excessively to the ECM due to decrease in Rac1 activity. In contrast, loss of Sorbs2 impaired RhoA activation during adhesion and decreases cell adhesiveness to the matrix. Interestingly, these opposite effects on cell adhesion lead to similar outcome on EC migratory abilities, a decrease in cell migration. Here, for the first time, we establish a role for Sorbs1 and Sorbs2 in angiogenesis and demonstrate that these SoHo members are essential for EC adhesiveness and subsequent migratory abilities. [less ▲]

Detailed reference viewed: 77 (9 ULg)