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See detailApplication of Lempel-Ziv complexity to alignment-free sequence comparison of protein families
Bacha, Sofiène; Baurain, Denis ULg

Poster (2005, April)

Detailed reference viewed: 35 (3 ULg)
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See detailAn application of luminescence dating to building archaeology: The study of ceramic building materials in early medieval churches in south-eastern England and north-western France
Blain, Sophie ULg

in Arqueologia de la Arquitectura (2010), 7

The research reported in this thesis concerns the re-evaluation of an archaeological assumption surrounding the origin of Ceramic Building Materials (CBM) used from the 9th to the 11th century in ... [more ▼]

The research reported in this thesis concerns the re-evaluation of an archaeological assumption surrounding the origin of Ceramic Building Materials (CBM) used from the 9th to the 11th century in religious buildings of north-western France and south-eastern England. Are the bricks used in the masonry structures Roman spolia or a novo productions? Amongst the dating methods that can contribute to building archaeology, it is the technique of stimulated luminescence applied to CBM that is the focus of this study. Results from thermoluminescence (TL) and optically stimulated luminescence (OSL) dating performed on 52 CBM samples from 11 churches showed that the practice of reusing Roman brick was commonplace in small parish churches, but also that brick-making was not a totally unknown skill of the early medieval craftsmen as it has long been supposed. Most importantly, by identifying that the building material is contemporary to the church, a defined chronology emerges resulting in a new and extremely useful reference point in the history of early medieval architecture. [less ▲]

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See detailApplication of magnetic susceptibility on different carbonate platform type
Da Silva, Anne-Christine ULg; Boulvain, Frédéric ULg; Mabille, Cédric ULg

in Abstract book 17th ISC - Fukuoka, Japan - 2006 (2006)

Detailed reference viewed: 8 (3 ULg)
See detailapplication of magnetic susceptibility on different carbonate platform types.
Da Silva, Anne-Christine ULg

Scientific conference (2008, November 27)

Detailed reference viewed: 4 (2 ULg)
See detailApplication of magnetic susceptibility on different carbonate platforms
Da Silva, Anne-Christine ULg

Scientific conference (2010, December 13)

Detailed reference viewed: 7 (1 ULg)
See detailApplication of magnetic susceptibility on different carbonate systems
Da Silva, Anne-Christine ULg

Scientific conference (2010, February 02)

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See detailApplication of magnetic susceptibility on Palaeozoic sedimentary rocks
Spassov, Simo; Da Silva, Anne-Christine ULg; Whalen, Michael et al

in Abstract book of the IAGA 11th Scientific assembly (2009)

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See detailApplication of magnetic susceptibility to the Maastrichtian-Eocene phosphatic deposits of Séjla section in Gafsa-Métlaoui basin (Southern Tunisia)
Akermi, Souha; Abdallah, H.; Da Silva, Anne-Christine ULg et al

in Geologica Belgica (2010, December), 13(4),

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See detailApplication of mechanoregulatory models to simulate peri-implant tissue formation in an in vivo bone chamber
Geris, Liesbet ULg; Vandamme, Katleen; Naert, Ignace et al

in Journal of Biomechanics (2008), 41(1), 145-154

Several mechanoregulatory tissue differentiation models have been proposed over the last decade. Corroboration of these models by comparison with experimental data is necessary to determine their ... [more ▼]

Several mechanoregulatory tissue differentiation models have been proposed over the last decade. Corroboration of these models by comparison with experimental data is necessary to determine their predictive power. So far, models have been applied with various success rates to different experimental set-ups investigating mainly secondary fracture heating. In this study, the mechanoregulatory models are applied to simulate the implant osseointegration process in a repeated sampling in vivo bone chamber, placed in a rabbit tibia. This bone chamber provides a mechanically isolated environment to study tissue differentiation around titanium implants loaded in a controlled manner. For the purpose of this study, bone formation around loaded cylindrical and screw-shaped implants was investigated. Histologically, no differences were found between the two implant geometries for the global amount of bone formation in the entire chamber. However, a significantly larger amount of bone-to-implant contact was observed for the screw-shaped implant compared to the cylindrical implant. In the simulations, a larger amount of bone was also predicted to be in contact with the screw-shaped implant. However, other experimental observations could not be predicted. The simulation results showed a distribution of cartilage, fibrous tissue and (im)mature bone, depending on the mechanoregulatory model that was applied. In reality, no cartilage was observed. Adaptations to the differentiation models did not lead to a better correlation between experimentally observed and numerically predicted tissue distribution patterns. The hypothesis that the existing mechanoregulatory models were able to predict the patterns of tissue formation in the in vivo bone chamber could not be fully sustained. (c) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailApplication of Metabolomic Approaches to the Age-related Macular Degeneration (AMD)
De Tullio, Pascal ULg

Conference (2009, January 30)

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See detailApplication of Microtremor Measurements for Geological Mapping and Comparison with Other Geophysical Methods
Teerlynck, H.; Jongmans, D.; Nguyen, Frédéric ULg et al

in Proceedings of the 7th Meeting on ‘Environmental and Engineering Geophysics (2001)

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See detailApplication of Miller's theorem to the stability analysis of numerical schemes; some useful tools for rapid inspection of discretisations in ocean modelling
Beckers, Jean-Marie ULg

in Ocean Modelling (1999), 1

An old theorem about the roots of a polynomial is resurfaced and examined, focusing on the practical question of determining stability criteria for numerical schemes. Is is demonstrated that the theorem ... [more ▼]

An old theorem about the roots of a polynomial is resurfaced and examined, focusing on the practical question of determining stability criteria for numerical schemes. Is is demonstrated that the theorem can be useful both for analytical studies of the stability limits, as well as numerical searches for stability regions. It is particularly important that when deciding whether the scheme is stable or not, it is not necessary to search for the roots of the polynomial. Indeed, such a decision may be reached through a finite and small number of arithmetic operations and verifications of inequalities. In addition to the analysis of the theorem, some practical conditions for polynomial of different orders are presented, as well as some useful tips on how simply necessary or sufficient stability conditions can be obtained. [less ▲]

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See detailApplication of mixed polygenic model to control for cryptic/genuine relatedness and population stratification.
Gusareva, Elena ULg; Mahachie John, Jestinah ULg; Isaacs, Aaron et al

Poster (2012, March 12)

In genome-wide association studies (GWAs), population stratification may cause inflated type I errors and overly-optimistic test results, when not properly corrected for. During the past decade, several ... [more ▼]

In genome-wide association studies (GWAs), population stratification may cause inflated type I errors and overly-optimistic test results, when not properly corrected for. During the past decade, several methods have been proposed for association testing in the presence of population stratification. Among these, principal components-based approaches are the most popular. Principal component analysis (PCA) allows data transformation to a new coordinate system such that the projection of the data along the first new coordinate (called the PC1) has the largest variance; the second PC has the second largest variance, and so on. In practice, two components are usually enough to adjust or to control for population stratification. They can easily be included in parametric association models as covariates. Despite the success of this strategy, there are still some caveats which need further attention. Among these are that principal component-based methods generally do not account for cryptic relatedness (kinship) between supposedly unrelated individuals, are not straightforwardly adapted to accommodate family-based designs or mixtures of families and unrelated individuals, and do not always take proper account of the trait under investigation. In this work, we present an easy-to-use alternative that addresses the aforementioned issues. For quantitative traits, we propose to first use the mixed polygenic model (possibly taking into account important non-genetic confounders as covariates), second to derive “polygenic” residuals from this model – hereby removing genomic kinship relationships, and third to consider these residuals as new traits in a classical genome-wide QTL analysis for “unrelated individuals”. The polygenic component of the aforementioned mixed polygenic model describes the contribution from multiple independently segregating genes, all having a small additive effect on the trait under investigation. Via an extensive simulation study, with various settings of population stratification and admixture, we show that this approach not only removes most of the “relatedness” between individuals (cryptic relatedness or known relatedness), but also removes most of the remaining substructures caused by population stratification or admixture. As a proof of concept, we demonstrate the efficiency of this robust method to control for population stratification on real-life genome-scale data from the SNP Health Association Resource (SHARe) Asthma Resource project (SHARP) (dbGaP accession number phs000166.v2.p1). We also provide leads to extend this method to dichotomous traits. [less ▲]

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See detailApplication of molecular imaging in combination with quantitative proteomic approaches to determine the molecular players of adaptation to anti-angiogenic therapy in breast cancer.
Cimino, Jonathan ULg; Sounni, Nor Eddine ULg; Calligaris, David ULg et al

Poster (2012, May 04)

The recognition of the “angiogenic switch” as a rate-limiting secondary step in tumorigenesis led to extensive pre-clinical researches on angiogenesis and finally the approval of VEGF-neutralizing ... [more ▼]

The recognition of the “angiogenic switch” as a rate-limiting secondary step in tumorigenesis led to extensive pre-clinical researches on angiogenesis and finally the approval of VEGF-neutralizing antibodies (bevacizumab) and VEGF receptor tyrosine kinase inhibitors (RTKs:Sunitinib). The Sunitinib has been used clinically in patients with breast cancer refractory to other therapeutic agents. Unfortunately, like the cytotoxic therapies, these drugs do not produce lasting effects and resistance to treatment appeared clinically. Questions have emerged about the failure of anti-angiogenic therapy in clinic and the limitations of predictive preclinical models, and also about the molecular assessment of all stages of tumor adaptation and metastatic disease. To this end, we applied a quantitative proteomics and imaging mass spectrometry tools to visualize and study the profiles of proteins and small molecules associated with tumor treated or not with Sunitinib using a novel preclinical model of breast carcinoma cells. [less ▲]

Detailed reference viewed: 70 (13 ULg)