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See detailLes apports en macro- et oligo-éléments 4. Le sélénium
Cabaraux, Jean-François ULg

in Knoden, D.; Lambert, R.; Nihoul, P. (Eds.) et al Fertilisation raisonnée des prairies (2007)

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See detailApports et limites de la diplomatie préventive dans la gestion des conflits ethniques
Martiniello, Marco ULg

Scientific conference (1995, November 06)

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See detailApports et limites de trois approches courantes des associations
Defourny, Jacques ULg

in Coopératives et Développement (1994), 26(1), 81-101

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See detailApports et perspectives des dérivés de l'hémoglobine
Remy, Bernadette ULg; Deby, Ginette ULg; Lamy, Maurice ULg

in Schweizerische Medizinische Wochenschrift (1997), 127(25), 1088-96

Anoxia-reoxygenation leads to severe metabolic alterations, which result in a generalized inflammatory reaction and multiple organ dysfunction. Direct blood transfusion limits these alterations, but is ... [more ▼]

Anoxia-reoxygenation leads to severe metabolic alterations, which result in a generalized inflammatory reaction and multiple organ dysfunction. Direct blood transfusion limits these alterations, but is accompanied by risk of transmission of infections or viral diseases. To avoid these risks, "blood substitutes" have been designed. The modified hemoglobins are not true blood substitutes because they do not possess the complex functions of erythrocytes. They are only oxygen carriers, with a short intravascular life, adapted for temporary use. They are stable, devoid of toxicity and antigenicity, and are able to carry and deliver O2 without regulation of this oxygen transport and without chemical reaction with O2. They possess rheologic properties and an oncotic pressure like those of blood. The use of natural hemoglobin solutions, obtained after lysis of erythrocytes, remains "at risk" because these solutions easily form methemoglobin, increase the oncotic pressure, present renal toxicity, and possess a too high affinity for O2. For these reasons, 5 types of modified hemoglobin solutions have been designed, prepared from human or bovine hemoglobin or by genetic engineering. These hemoglobins are highly purified to eliminate trace amounts of stroma, lipids and endotoxins, which are responsible for acute toxicity. They are modified by internal cross-linking between the monomers, or by binding to macromolecules. Afterwards, they can be polymerized or encapsulated in liposomes. The purpose of these modifications is to modulate the affinity for O2 (by decreasing the binding of O2 and increasing its delivery to tissue), to reduce the dissociation into monomers and to guard against oxidation into methemoglobin. Encapsulation in liposomes allows co-encapsulation of effector molecules and protective substances. Genetic engineering allows the production of recombinant hemoglobin with selective modifications. The modified hemoglobin solutions are essentially used in hemorrhagic shock and perioperative hemodilution. Experimental work in animals has afforded good results: restoration of normal O2 pressure and no toxicity. These assays allow frequent observation of an unexpected rapid hypertensive effect, transient, reversible, and that could be controlled by antihypertensive drugs. The mechanisms of this hypertensive effect remain controverted (stimulation of endothelin production, inhibition of nitric oxide effects, etc.). In humans, studies with healthy volunteers have been completed, while phase II clinical studies are under way in hypovolemic shock, in major abdominal, orthopedic and cardiac surgery, in stroke and in intensive care patients after surgery. The detailed results are awaited, but the modified hemoglobin solutions already appear to be without toxicity and present the same hypertensive effect as observed in animals. However, until now only low doses have been used, and the catabolism of these solutions remains largely unknown. [less ▲]

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See detailApports et potentialités de l’utilisation de la carte mentale en science politique
Breux, Sandra; Reuchamps, Min ULg; Loiseau, Hugo

in Transeo Review (2010), (2-3),

L’objectif de notre propos est de mettre en évidence les potentiels de l’utilisation de la carte mentale en science politique. Souvent utilisée en psychologie et en géographie, les politologues ont ... [more ▼]

L’objectif de notre propos est de mettre en évidence les potentiels de l’utilisation de la carte mentale en science politique. Souvent utilisée en psychologie et en géographie, les politologues ont toutefois rarement recours à cet outil de collecte de l’information dans leurs recherches. En revenant sur les avantages et les limites de l’usage de cet outil en sciences sociales, et en nous basant sur deux études originales, nous montrerons dans quelle mesure la carte mentale peut permettre d’aborder des questions propres à la science politique sous un angle nouveau. [less ▲]

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See detailApports et problèmes de la recherche pédagogique au niveau de l'enseignement secondaire inférieur
de Landsheere, Gilbert ULg

in Institut supérieur de pédagogie (Ed.) Les premières années de l’enseignement secondaire : colloque international des 9-10 mars 1968 (1968)

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See detailApports qualitatifs d'une structure de support aux enseignants à une méthodologie basée sur l'étude de cas en EAD
Poumay, Marianne ULg; Leclercq, Dieudonné ULg; Demily, Fabian et al

in Ianni, G. (Ed.) Identités multiples et pratiques interculturelles (2000)

Depuis 1997, l'Université de Liège (ULg - Belgique) pratique l'enseignement à distance dans plusieurs cours de la Faculté de Psychologie et des Sciences de l'Education. Une étude interne réalisée par le ... [more ▼]

Depuis 1997, l'Université de Liège (ULg - Belgique) pratique l'enseignement à distance dans plusieurs cours de la Faculté de Psychologie et des Sciences de l'Education. Une étude interne réalisée par le LabSET (Laboratoire de Soutien à l'Enseignement Télématique) a mené à l'adoption d'une plate-forme intégrée d'enseignement distribué (WebCT) en vue d'un déploiement plus coordonné du Campus Virtuel de l'Université. Aujourd'hui, 800 personnes (étudiants de candidatures, de licences et de troisièmes cycles universitaires mais aussi clients d'entreprises externes) bénéficient, sur Internet, de ce que nous appelons des activités de "qualité". En mai 2001, 1600 personnes seront concernées.Après avoir cadré les grandes questions méthodologiques qui ont présidé à nos choix, le présent article illustre notre conception de la qualité d'activités d'enseignement à dsitance, présente la structure mise en place à l'ULg pour soutenir et développer un campus virtuel. [less ▲]

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See detailApports qualitatifs de l'étude de cas en enseignement/apprentissage à distance
Poumay, Marianne ULg; Leclercq, Dieudonné ULg; Demily, F.

in Le point sur la recherche en éducation en Communauté française : actes du 1er congrès des chercheurs en éducation, Bruxelles, 24-25 mai 2000 (2001)

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See detailApports récents de la génétique dans les maladies inflammatoires intestinales
Louis, Edouard ULg; Belaiche, Jacques ULg; Franchimont, D. et al

in Acta Clinica Belgica (1993), 48(6), 383-91

It is clear since many years that the liability to develop inflammatory bowel disease is influenced by genetic factors. Recent progresses in the field of genetic markers and genetic models bring the ... [more ▼]

It is clear since many years that the liability to develop inflammatory bowel disease is influenced by genetic factors. Recent progresses in the field of genetic markers and genetic models bring the concept of genetic heterogeneity. This new concept leads us to try to classify different forms of inflammatory bowel disease and could have in the future an impact on the prevention, the follow up and the treatment of these diseases. [less ▲]

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See detailL'apposition en latin classique : quels critères pour quelle description ?
Longrée, Dominique ULg

Scientific conference (1988)

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See detailAn Appraisal of 18-Fluorodeoxyglucose Positron Emission Tomography for Melanoma Staging
Paquet, Philippe ULg; Henry, Frédérique ULg; Belhocine, Tarik et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2000), 200(2), 167-9

BACKGROUND: Positron emission tomography (PET scan) using fluorodeoxyglucose (FDG) is increasingly recognized as a reliable diagnostic method to detect metastases of malignant melanoma (MM). OBJECTIVE: To ... [more ▼]

BACKGROUND: Positron emission tomography (PET scan) using fluorodeoxyglucose (FDG) is increasingly recognized as a reliable diagnostic method to detect metastases of malignant melanoma (MM). OBJECTIVE: To compare the diagnostic performance of 18-FDG PET scan to that of conventional imaging. METHODS: A total of 28 assessments were conducted in 24 patients at risk of metastatic MM. Results: The diagnostic accuracy was over 80% and similar for PET scan and conventional imaging. CONCLUSION: Both the specificity and sensitivity of PET scan are high although not perfect. Confrontation of data with anatomical location and clinicopathological findings remains mandatory. [less ▲]

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See detailAppraisal of the validity of histamine-induced wheal and flare to predict the clinical efficacy of antihistamines.
Monroe, E. W.; Daly, Adrian ULg; Shalhoub, R. F.

in Journal of Allergy and Clinical Immunology (The) (1997), 99(2), 798-806

Antihistaminic drugs have been used successfully for many years in the treatment of allergic diseases. Second-generation antihistamines have fewer sedating side effects than first-generation agents, and ... [more ▼]

Antihistaminic drugs have been used successfully for many years in the treatment of allergic diseases. Second-generation antihistamines have fewer sedating side effects than first-generation agents, and the number of newer drugs available for clinical use is growing. Various methods have been used to assess antihistaminic activity, the most popular of which is the epicutaneous histamine-induced wheal and flare. This test relies on the ability of epicutaneously injected histamine to bring about the wheal and flare, a neurovascular response that involves reflex vasodilation (flare) and local swelling caused by plasma extravasation (wheal). Antihistamines have been compared on the basis of their ability to block the histamine-induced wheal and flare in the skin. Results of these trials have been applied to predict the global antiallergic efficacy of various antihistamines. The review has examined the reliability of suppression of the histamine wheal and flare reaction in the skin to predict an antihistamine's clinical efficacy in two common allergic diseases seasonal allergic rhinitis and chronic idiopathic urticaria. Although histamine is one mediator in the allergic response in the skin and nasal mucosa, many other agents are important modulators of the allergic response. In addition, the major structural and functional differences that exist between the nasal mucosa and the skin affect the type of local response. These manifest themselves as differences between the responses to antigen and histamine challenge in the skin and the nose. The allergic responses in these tissues are not simply the consequence of one chemical but are the result of a cascade of interactions among various cells and mediators. The clinical manifestations of these complex interactions obviously cannot be fully replicated by injection of one chemical mediator, histamine, into the outer layer of the skin. Studies with antihistamines have shown that certain drugs, such as cetirizine, are more suppressive than others (loratadine, terfenadine) in controlling the histamine-induced wheal and flare reaction in the skin. When the clinical efficacy of these medications is compared in clinical trials in seasonal allergic rhinitis and chronic idiopathic urticaria, all are equally efficacious in controlling symptoms. Although the histamine-induced wheal and flare reaction can serve as a useful clinical pharmacologic test to assess dose-response relations for an antihistamine, its lack of correlation with clinical responses among antihistamines indicates that this model should not be used to predict or compare clinical efficacies of antihistamines in seasonal allergic rhinitis and chronic idiopathic urticaria. [less ▲]

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See detailAppraisal of work environment changes and stress : validation of a new scale
De Zanet, Fabrice ULg; Vandenberghe, Christian

Conference (2001, October)

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See detailAppréciation de la qualité de l'air dans les locaux de maternité d'une porcherie
Nicks, Baudouin ULg; Dechamps, P.; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1989), 133(8), 691-701

Detailed reference viewed: 8 (0 ULg)