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See detailAnalytical model for the evaluation of torsional connection restraints of steel beams in bending
Amara, Salah; Zaidi, Ali; Lamara, Mohamed et al

Scientific conference (2012, May 08)

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See detailAnalytical model of micromachining of brittle materials with sharp particles
Moktadir, Zakaria; Wensink, Henk; Kraft, Michael ULg

in Microelectronics Journal (2005), 36(3-6),

We present an analytical model for the powder blasting of brittle materials with sharp particles. We developed a continuum equation, which describes the surface evolution during the powder blasting, into ... [more ▼]

We present an analytical model for the powder blasting of brittle materials with sharp particles. We developed a continuum equation, which describes the surface evolution during the powder blasting, into which we introduced surface energetics as the major relaxation mechanism. The experimental and the calculated erosion rates match extremely well. Also, the developed model explains why the sidewalls of a powder blasted channel are not straight, e.g. have a blast lag, for which we also found a good agreement between experiments and theory. [less ▲]

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See detailAnalytical model to characterize bolted beam-to-column joints with four bolts per row
Demonceau, Jean-François ULg; Weynand, Klaus; Jaspart, Jean-Pierre ULg et al

Report (2010)

Eurocode 3 Part 1-8 provides detailed application rules for the design of bolted end-plate connections. Although these rules apply to connections with any number of vertical bolt rows, most of them are ... [more ▼]

Eurocode 3 Part 1-8 provides detailed application rules for the design of bolted end-plate connections. Although these rules apply to connections with any number of vertical bolt rows, most of them are limited to configurations with two bolts only in each horizontal row, i.e. one bolt on each side of the beam or column web. However, it is sometimes more economic to place four bolts in one row, for instance when wide flange H-sections are used. This configuration is commonly met in different countries in Europe and, in particular, in Germany where this configuration is even standardized. The theoretical model on which the Eurocode 3 application rules are founded is general and can be potentially applied to connections with four bolts per horizontal row. However, specific design rules need to be developed. Within the present document, easy-to-apply analytical design rules aimed at predicting the mechanical properties of connections with four bolts per row in full agreement with the Eurocode 3 approach are detailed. The latter are validated through comparisons to experimental tests performed at the University of Dortmund. The present document is organised as follows: • First, the component method, on which the proposed analytical model is founded, is briefly described (§ 2); • Then, the T-stub model used to characterise the joint component in bending is detailed (§ 3) and adapted to connection with four bolts per row (§ 4). • Finally, the proposed adaptations of the analytical model are validated in § 5 and compare to previous analytical methods in § 6. [less ▲]

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See detailAnalytical Orbit Propagator Based on Vectorial Orbital Elements
Condurache, Daniel; Martinusi, Vladimir ULg

Conference (2013, August 20)

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See detailAnalytical performance and diagnostic efficiency of quantitative ultrasonography of the phalanxes
Reginster, Jean-Yves ULg; Dethor, M; Pirenne, H et al

in Journal of Bone and Mineral Research (1997), 12(S1), 384

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See detailAnalytical performance of a biomarker: what the clinician should know
CAVALIER, Etienne ULg

Conference (2015, September 17)

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See detailANALYTICAL PERFORMANCE OF THE C-TERMINAL FGF-23 (IMMUTOPICS)
Cavalier, Etienne ULg; Rozet, Eric ULg; Carlisi, Ignazia ULg et al

in Clinical Chemistry & Laboratory Medicine (2009, June), 47(M-A032),

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See detailAn analytical pipeline for MALDI in-source decay mass spectrometry imaging
Zimmerman, Tyler ULg; Debois, Delphine ULg; Mazzucchelli, Gabriel ULg et al

in Analytical Chemistry (2011), 83(15), 6090-6097

In-source decay (ISD) fragmentation as combined with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry allows protein sequencing directly from mass spectra. Acquisition of MALDI-ISD ... [more ▼]

In-source decay (ISD) fragmentation as combined with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry allows protein sequencing directly from mass spectra. Acquisition of MALDI-ISD mass spectra from tissue samples is achieved using an appropriate MALDI matrix, such as 1,5-diaminonaphthalene (DAN). Recent efforts have focused on combining MALDI-ISD with mass spectrometry imaging (MSI) to provide simultaneous sequencing and localization of proteins over a thin tissue surface. Successfully coupling these approaches requires the development of new data analysis tools, but first, investigating the properties of MALDI-ISD as applied to mixtures of protein standards reveals a high sensitivity to the relative protein ionization efficiency. This finding translates to the protein mixtures found in tissues and is used to inform the development of an analytical pipeline for data analysis in MALDI-ISD MS imaging, including software to identify the most pertinent spectra, to sequence protein mixtures, and to generate ion images for comparison with tissue morphology. The ability to simultaneously identify and localize proteins is demonstrated by using the analytical pipeline on three tissue sections from porcine eye lens, resulting in localizations for crystallins and cytochrome c. The variety of protein identifications provided by MALDI-ISD-MSI between tissue sections creates a discovery tool, and the analytical pipeline makes this process more efficient. [less ▲]

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See detailANALYTICAL PREDICTION OF THE BEARING RESISTANCE OF BOLTED CONNECTIONS FOR TUBULAR RACKING STRUCTURES
Armenante, Vittorio; D'Antimo, Marina ULg; Demonceau, Jean-François ULg et al

in THE INTERNATIONAL COLLOQUIUM ON STABILITY AND DUCTILITY OF STEEL STRUCTURES, Timisoara 30 May-01 June 2016 (2016, May)

The aim of this paper is to provide a formulation able to predict the resistance of simple shear connections realized by fastening a plate to a hollow square section by means of long bolts. The research ... [more ▼]

The aim of this paper is to provide a formulation able to predict the resistance of simple shear connections realized by fastening a plate to a hollow square section by means of long bolts. The research is motivated by the fact that the rules currently provided by EC3 for defining the bearing resistance of steel connections are limited to the case of stacks of plates, where every plate composing the connection is always restrained out of plane by the adjoining plate or by the bolt head or nut. This is a condition not verified in case of connections realized with long bolts fastening hollow sections. The work is organized in two sections. First, the results of an experimental campaign are presented and successively, the results of a parametric analysis carried out by means of a Finite Element model calibrated on the experimental data are reported. Afterwards, an analytical approach able to include the local buckling effects arising in these kinds of connections is presented, proposing a coefficient for the reduction of the resistance, to be included in the EC3 formulation. [less ▲]

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See detailAnalytical procedure to derive P-I diagram of a beam under explosion
Hamra, Lotfi ULg; Demonceau, Jean-François ULg; Denoël, Vincent ULg

in Proceeding of the IABSE Workshop - Safety, Robustness and Condition Assessments of Structures (2015, February)

The aim of this paper is to study a beam extracted from a frame and subjected to blast loading. The demand of ductility depends on six dimensionless parameters: two related to the blast loading, two ... [more ▼]

The aim of this paper is to study a beam extracted from a frame and subjected to blast loading. The demand of ductility depends on six dimensionless parameters: two related to the blast loading, two referring to the bending behaviour of the beam and two corresponding to the dynamic behaviour of the rest of the structure. We develop a full analytical procedure that provides the ductility demand as a function of these six dimensionless parameters. [less ▲]

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See detailAnalytical Procedure Validation and the Quality by Design Paradigm
Rozet, Eric ULg; Lebrun, Pierre; Michiels, Jean-François et al

in Journal of Biopharmaceutical Statistics (2015)

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a Quality by Design (QbD) approach, there have been many discussions on the opportunity for ... [more ▼]

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a Quality by Design (QbD) approach, there have been many discussions on the opportunity for analytical procedure developments to follow a similar approach. While development and optimization of analytical procedure following QbD principles have been largely discussed and described, the place of analytical procedure validation in this framework has not been clarified. This article aims at showing that analytical procedure validation is fully integrated into the QbD paradigm and is an essential step in developing analytical procedure that are effectively fit for purpose. Adequate statistical methodologies have also their role to play: such as design of experiments, statistical modelling and probabilistic statements. The outcome of analytical procedure validation is also an analytical procedure Design Space and from it, control strategy can be set. [less ▲]

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See detailAnalytical Procedure Validation and the Quality by Design Paradigm
Rozet, Eric ULg; Lebrun, Pierre ULg; Michiels, Jean-François et al

in Journal of Biopharmaceutical Statistics (2015), 25

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a quality by design (QbD) approach, there have been many discussions on the opportunity for ... [more ▼]

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a quality by design (QbD) approach, there have been many discussions on the opportunity for analytical procedure developments to follow a similar approach. While development and optimization of analytical procedure following QbD principles have been largely discussed and described, the place of analytical procedure validation in this framework has not been clarified. This article aims at showing that analytical procedure validation is fully integrated into the QbD paradigm and is an essential step in developing analytical procedures that are effectively fit for purpose. Adequate statistical methodologies have also their role to play: such as design of experiments, statistical modelling, and probabilistic statements. The outcome of analytical procedure validation is also an analytical procedure design space, and from it, control strategy can be set. [less ▲]

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See detailAnalytical Properties of the Mean Field in Many Fermion Systems
Cugnon, Joseph ULg; Gossiaux, Pol-Bernard; Harouna, Oumaru

in Zeitschrift für Physik. A, Atomic Nuclei (1989), 333

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See detailAnalytical quantification of the inflammatory cell infiltrate and CD95R expression during treatment of drug-induced toxic epidermal necrolysis.
Paquet, Philippe ULg; Jacob, Eric; Damas, Pierre ULg et al

in Archives of Dermatological Research (2005), 297(6), 266-73

The treatment of drug-induced toxic epidermal necrolysis (TEN) remains unsatisfactory. Intravenous immunoglobulins (IVIg) and intravenous cyclosporin A (CsA) have shown some efficacy in short series of ... [more ▼]

The treatment of drug-induced toxic epidermal necrolysis (TEN) remains unsatisfactory. Intravenous immunoglobulins (IVIg) and intravenous cyclosporin A (CsA) have shown some efficacy in short series of patients. We assessed the effects of IVIg and CsA on TEN lesional and apparently uninvolved skin using standard histology and immunohistochemistry. Cutaneous biopsies were taken from necrotic and clinically uninvolved TEN skin at admission (D1) before any treatment, and after a 5-day treatment (D5). Two IVIg-treated patients (0.75 g/kg/day), two CsA-treated patients (5 mg/kg/day) and two control patients only receiving supportive care were compared. Biopsies were examined by standard histology and immunohistochemistry using antibodies directed to CD68 antigen (macrophages), CD45R0 antigen (activated T lymphocytes), Factor XIIIa (dermal dendrocytes) and the CD95 receptor (apoptosis marker). The different cell densities were evaluated by computerized image analysis. The clinical outcomes with the different treatments were also recorded. There was no obvious difference in the duration of hospitalization in intensive care unit between the three groups but one patient passed away in each of the IVIg- and CsA-groups. At D5, no differences were found between the three groups in the histological and clinical rate of re-epithelialization, and in the evolution of T lymphocyte, macrophage and dendrocyte densities in the epidermis and dermis. However, the expression of the CD95 receptor was similarly and strongly abated at D5 in the epidermis of IVIg- and CsA-treated patients, while it was conversely increased in the two patients under supportive care only. Such a difference was found both in necrotic and uninvolved sites. IVIg and CsA treatments thus appeared to exert no obvious effect on the inflammatory infiltrate, but both abated the expression of the CD95 receptor in the skin of TEN patients. This effect did not seem sufficient to fully reverse the clinical evolution of the disease. It is inferred that IVIg and CsA do not completely abate the TEN process. [less ▲]

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