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See detail(596) Scheila
Jehin, Emmanuel ULg; Manfroid, Jean ULg; Hutsemekers, Damien ULg et al

in Central Bureau Electronic Telegrams (CBETs) (2011), 2632

E. Jehin, J. Manfroid, D. Hutsemekers, M. Gillon, and P. Magain, Fonds National de la Recherche Scientifique, Liege University, report on broad- and narrow-band imaging of the (596) Scheila outburst (CBET ... [more ▼]

E. Jehin, J. Manfroid, D. Hutsemekers, M. Gillon, and P. Magain, Fonds National de la Recherche Scientifique, Liege University, report on broad- and narrow-band imaging of the (596) Scheila outburst (CBET 2583) with the TRAPPIST 0.60-m telescope at La Silla, and on optical spectroscopy with the European Southern Observatory's Very Large Telescope (VLT) at Paranal. R-band imaging from 2010 Dec. 12.3 to 21.3 UT revealed two arc-like coma features expanding at a regular pace. The first such feature was 1' long on 2010 Dec. 12, oriented to the northeast and bending to p.a. 280 deg (the anti-solar direction). The second feature was shorter, 30" on Dec. 12, oriented to the south and bending to p.a. 230 deg. Both features were getting larger and fainter with time (4' and 2' long, respectively, on Dec. 21.3). A narrow 45"-long tail, opposite the sun (p.a. 280 deg), was also observed in good seeing. R-band images taken on 2011 Jan. 4.3 and 5.3 after the full moon allowed Jehin et al. to again observe these features, seen as 7' and 4' long, respectively -- and much fainter. This discards any sustained activity of the minor planet. Narrow-band images obtained on 2010 Dec. 12.3 with cometary filters do not show any contribution from gases. A 20-min optical spectrum was obtained with FORS2 at the VLT on Dec. 13.3; it does not show any extended cometary gaseous emissions, but only a spatially extended continuum due to dust-scattered sunlight. Short B, V, R, and I exposures performed nearly every two nights from 2010 Dec. 12.3 to 2011 Jan. 5.3 give a magnitude for the nuclear condensation of V = 14.2 +/- 0.1 over the whole period, in agreement with the "APmag" value reported in the Jet Propulsion Laboratory ephemeris. No flux variation of the nuclear condensation was observed. Those preliminary results are in favor of a collisional scenario to explain the outburst of (596) Scheila, rather than a cometary driven activity. This case might be similar to the outburst of comet P/2010 A2, which may have resulted from an impact of a minor planet (Snodgrass 2010, Nature 467, 814). [less ▲]

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See detail6 - Functional analysis of the lithics
Rots, Veerle ULg

in Vermeersch, Pierre M. (Ed.) The Ahrensburgian at Zonhoven-Molenheide (Belgium) (2013)

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See detailThe 6 kb c-erbB2 promoter contains positive and negative regulatory elements functional in human mammary cell lines.
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Dijkmans, Huguette et al

Conference (1994, September)

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See detail6,7-Disubstituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: new potent ATP-sensitive potassium channel openers
De Tullio, Pascal ULg; Boverie, S.; Becker, B. et al

Poster (2002, September)

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See detailLe 6-(acetoxymethyl)-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-chlorophényle agissant en tant qu’inhibiteur potentiel de l’invasion tumorale
Kempen, I.; Papapostolu, D.; Pochet, L. et al

Poster (2000, May)

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See detailA 6-hour nocturnal interruption of a continuous subcutaneous insulin infusion: 1. Metabolic and hormonal consequences and scheme for a prompt return to adequate control.
Krzentowski, G.; Scheen, André ULg; Castillo, M. et al

in Diabetologia (1983), 24(5), 314-8

Interruption of a continuous subcutaneous insulin infusion, most often due to technical problems occurring during the night, is a not uncommon event whose metabolic consequences have received relatively ... [more ▼]

Interruption of a continuous subcutaneous insulin infusion, most often due to technical problems occurring during the night, is a not uncommon event whose metabolic consequences have received relatively little attention until now. We have therefore investigated the changes in blood glucose, plasma non-esterified fatty acids, 3-hydroxybutyrate, glucagon and free insulin in eight C-peptide negative Type 1 diabetic patients whose pumps were deliberately stopped between 23.00 h and 05.00 h. A control test with the pump functioning normally was carried out in each patient and the studies were randomized. Considering the values at 23.00 h as reference, interruption of the insulin infusion resulted in (1) a rapid decrease in plasma free insulin significant after 1 h and reaching a nadir of 6 +/- 2 mU/l after 6 h; (2) a rise in blood glucose which was significant at hour 3 and reached 17.4 +/- 1.9 mmol/l at hour 6; (3) a moderate increase in plasma nonesterified fatty acids which remained in the range of 700-800 mumol/l; (4) an early and linear rise in plasma 3-hydroxybutyrate, significant after 1 h and averaging 1290 +/- 140 mumol/l after 6 h; (5) a late increase (hour 5) in plasma glucagon. The second aim of our study was to provide for the patient a precise scheme of insulin supplements administered via the pump and based on blood glucose monitoring (Dextrostix - Glucometer) and semi-quantitative evaluation of ketonuria (Acetest). Resetting the pump at its basal rate at 05.00 h and giving insulin supplements (2-8 U) at 06.45 h (with the usual breakfast dose) and again at 10.00 h have proved efficacious in restoring satisfactory metabolic control by noon the day after starting the experiment. These results form practical recommendations to patients undergoing this type of accident. [less ▲]

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See detailThe 6-Kilobase C-Erbb2 Promoter Contains Positive and Negative Regulatory Elements Functional in Human Mammary Cell Lines
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Dijkmans, Huguette et al

in Cancer Research (1994), 54(15), 4193-9

A 6-kilobase fragment extending at the 5'-end of the c-erbB2 protooncogene was isolated from a normal human lymphocyte genomic DNA library. The full-length fragment and five subfragments with identical 3 ... [more ▼]

A 6-kilobase fragment extending at the 5'-end of the c-erbB2 protooncogene was isolated from a normal human lymphocyte genomic DNA library. The full-length fragment and five subfragments with identical 3'-ends were obtained by progressive unidirectional deletion from the 5'-end and were cloned in front of the luciferase reporter gene. The hybrid genes were analyzed for transcriptional activity in human mammary cell lines synthesizing low (HBL-100 and T-47D), moderate (MDA-MB-453), or high (BT-474) amounts of the c-erbB2 mRNA and were also analyzed in HeLa cells. Gene-specific expression was observed, indicating the presence of multiple cis-acting sequences in the c-erbB2 promoter. A major negative element is located in the -2- to -4-kilobase region. It is flanked on both sides by positive elements that display enhanced transcriptional activity in the BT-474 tumor cells only. While predominant in the low-expressing cells, the effect of the repressor appears to be overcome by the distal transactivator in the high-expressing BT-474 cells, resulting in a 15 to 50 times increase in luciferase activity relative to the HBL-100 and T-47D cells, respectively. Cell-specific expression relies on the trans-acting factors present in the different cell lines. The formation of cell-specific protein-DNA complexes was demonstrated by gel retardation assay. [less ▲]

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See detail6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid as a core structure for selective inhibitors of human leucocyte elastase
Doucet, C.; Pochet, L.; Thierry, N. et al

in Journal of Medicinal Chemistry (1999), 42

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See detail6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of the Treatment of Cancer Cell Invasion and Metastasis
Kempen, I.; Hemmer, Marc ULg; Counerotte, Stéphane ULg et al

in European Journal of Medicinal Chemistry (2008), 43(12), 2735-50

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure ... [more ▼]

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure-activity relationships were deduced from biological results and will be used in further design of new active compounds. In particular, the acetoxymethyl substituent found at the 6-position of previously described active compounds can be replaced by an acetamidomethyl substituent without loss of potency; while the presence of an aryl ester function at the 3-position was preferred to a thioester or an amide function to induce marked biological activity. This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anti-cancer agents. [less ▲]

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See detail6-Substituted benzopyran derivatives as potent KATP channel openers: synthesis and biological in vitro evaluation
Florence, X.; De Tullio, Pascal ULg; Lebrun, P. et al

Poster (2008, May)

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See detail6-Years Experience of NBS for Hemoglobin Disorders using TMS
BOEMER, François ULg

Conference (2014, October)

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See detail6. Lutte contre les maladies - 2.3. Réduire la pression des maladies: impact pratique des "leviers agronomiques"
Seutin, Benoit ULg; Vancutsem, Françoise ULg; Jacquemin, Guillaume et al

in Livre Blanc: Céréales - Gembloux (2011, February 23)

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See detail6. Lutte intégrée contre les maladies
Bataille, Charlotte; Duvivier, Maxime; Eylenbosch, Damien ULg et al

in Watillon, Bernard; Bodson, Bernard (Eds.) Livre Blanc Céréales (2015, February 25)

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See detail6. Lutte intégrée contre les maladies
Duvivier, Maxime; Bataille, Charlotte; Mahieu, Olivier et al

in Bodson, Bernard; Destain, Jean-Pierre (Eds.) Livre blanc céréales (2014, February 26)

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See detail6. Lutte intégrée contre les maladies
Duvivier, Maxime; Mahieu, Olivier; Heens, B. et al

in Bodson, Bernard; Destain, Jean-Pierre (Eds.) Livre Blanc - Céréales (2013, February 27)

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See detail60 h of anhepatic state without neurologic deficit
Detry, Olivier ULg; De Roover, Arnaud ULg; Delwaide, Jean ULg et al

in Transplant International (2006), 19(9), 769-769

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See detailA 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock
Kumar Kadri, Naveen; Sahana, Goutam; Charlier, Carole ULg et al

in PLoS Genetics (2014), 10(1), 1004049

In dairy cattle, the widespread use of artificial insemination has resulted in increased selection intensity, which has led to spectacular increase in productivity. However, cow fertility has ... [more ▼]

In dairy cattle, the widespread use of artificial insemination has resulted in increased selection intensity, which has led to spectacular increase in productivity. However, cow fertility has concomitantly severely declined. It is generally assumed that this reduction is primarily due to the negative energy balance of high-producing cows at the peak of lactation. We herein describe the fine-mapping of a major fertility QTL in Nordic Red cattle, and identify a 660-kb deletion encompassing four genes as the causative variant. We show that the deletion is a recessive embryonically lethal mutation. This probably results from the loss of RNASEH2B, which is known to cause embryonic death in mice. Despite its dramatic effect on fertility, 13%, 23% and 32% of the animals carry the deletion in Danish, Swedish and Finnish Red Cattle, respectively. To explain this, we searched for favorable effects on other traits and found that the deletion has strong positive effects on milk yield. This study demonstrates that embryonic lethal mutations account for a non-negligible fraction of the decline in fertility of domestic cattle, and that associated positive effects on milk yield may account for part of the negative genetic correlation. Our study adds to the evidence that structural variants contribute to animal phenotypic variation, and that balancing selection might be more common in livestock species than previously appreciated. [less ▲]

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See detailThe "666" collaboration on OGLE transits. I. Accurate radius of the planets OGLE-TR-10b and OGLE-TR-56b with VLT deconvolution photometry
Pont, F.; Moutou, C.; Gillon, Michaël ULg et al

in Astronomy and Astrophysics (2007), 465

Transiting planets are essential to study the structure and evolution of extra-solar planets. For that purpose, it is important to measure precisely the radius of these planets. Here we report new high ... [more ▼]

Transiting planets are essential to study the structure and evolution of extra-solar planets. For that purpose, it is important to measure precisely the radius of these planets. Here we report new high-accuracy photometry of the transits of OGLE-TR-10 and OGLE-TR-56 with VLT/FORS1. One transit of each object was covered in Bessel V and R filters, and treated with the deconvolution-based photometry algorithm DECPHOT, to ensure accurate millimagnitude light curves. Together with earlier spectroscopic measurements, the data imply a radius of 1.22{[SUP]+0.12[/SUP][SUB]-0.07[/SUB]} R[SUB]J[/SUB] for OGLE-TR-10b and 1.30 ± 0.05 R[SUB]J[/SUB] for OGLE-TR-56b. A re-analysis of the original OGLE photometry resolves an earlier discrepancy about the radius of OGLE-TR-10. The transit of OGLE-TR-56 is almost grazing, so that small systematics in the photometry can cause large changes in the derived radius. Our study confirms both planets as inflated hot Jupiters, with large radii comparable to that of HD 209458b and at least two other recently discovered transiting gas giants. Based on data collected with the FORS1 imager at the VLT-Kueyen telescope (Paranal Observatory, ESO, Chile) in the programme 177.C-0666E. [less ▲]

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