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See detailLeukemia Viruses
Burny, A.; Bex, F.; Dequiedt, Franck ULg et al

in Encyclopedia of Immunology, Academic Press (1998)

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See detailLeukemic cell xenograft in zebrafish embryo for investigating drug efficacy.
Pruvot, Benoist ULg; Jacquel, Arnaud; Droin, Nathalie et al

in Haematologica (2011), 96(4), 612-6

Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored ... [more ▼]

Zebrafish were proposed as an alternative to mammalian models to assess the efficacy and toxicity of antileukemic drugs. Due to the limited number of transgenic zebrafish leukemia models, we explored human leukemic cell xenograft in zebrafish embryos. Human leukemic cell lines and blast cells sorted from patients with acute myelogenous leukemia were injected 48 hours post-fertilization and remained in the circulation of zebrafish embryos for several days without affecting their development. Imatinib and oxaphorines did not demonstrate any toxicity on normal zebrafish embryos and decreased the leukemic burden in animals xenografted with sensitive leukemic cell lines. Two other molecules, all-trans retinoic acid and the translation inhibitor 4EGI-1, demonstrated teratogenic effects at concentrations shown to be efficient in vitro, which precluded investigation of their antileukemic activity in such models. Altogether, xenografted leukemic cells in zebrafish embryos are a pharmacologically relevant model for screening non-teratogenic drugs. [less ▲]

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See detailLeukemic target susceptibility to natural killer cytotoxicity: relationship with BCR-ABL expression.
Baron, Frédéric ULg; Turhan, Ali G; Giron-Michel, Julien et al

in Blood (2002), 99(6), 2107-13

Chronic myeloid leukemia is a clonal myeloproliferative expansion of transformed primitive hematopoietic progenitor cells characterized by high-level expression of BCR-ABL chimeric gene, which induces ... [more ▼]

Chronic myeloid leukemia is a clonal myeloproliferative expansion of transformed primitive hematopoietic progenitor cells characterized by high-level expression of BCR-ABL chimeric gene, which induces growth factor independence. However, the influence of BCR-ABL expression on cell-mediated cytotoxicity is poorly understood. In the present study, we asked whether BCR-ABL expression interferes with leukemic target sensitivity to natural killer (NK) cell cytolysis. Our approach was based on the use of 2 BCR-ABL transfectants of the pluripotent hematopoietic cell line UT-7 expressing low (UT-7/E8, UT-7/G6) and high (UT-7/9) levels of BCR-ABL. As effector cells, we used CD56(bright), CD16-, CD2- NK cells differentiated in vitro from CD34 cord blood progenitors. We demonstrated that BCR-ABL transfectants UT-7/9 were lysed by NK cells with a higher efficiency than parental and low UT-7/E8.1 and UT-7/G6 transfectants. This enhanced susceptibility to lysis correlated with an increase in expression of intercellular adhesion molecule 1 (ICAM-1) by target cells. Treatment of UT-7/9 cells by STI571 (a specific inhibitor of the abl kinase) resulted in a decrease in NK susceptibility to lysis and ICAM-1 down-regulation in target cells. Furthermore, the constitutive activation of nuclear factor-kappaB (NF-kappaB) detected in BCR-ABL transfectant UT-7/9, was significantly attenuated when cells were treated by STI571. Interestingly, inhibition of NF-kappaB activation by BAY11-67082 (a specific NF-kappaB inhibitor) resulted in down-regulation of ICAM-1 expression and a subsequent decrease in NK-induced killing of UT-7/9 transfectants. Our results show that oncogenic transformation by BCR-ABL may increase susceptibility of leukemic progenitors to NK cell cytotoxicity by a mechanism involving overexpression of ICAM-1 as a consequence of NF-kappaB activation. [less ▲]

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See detailLeukemogenesis by bovine leukemia virus (BLV)
Burny, A.; Cleuter, Y.; Dandoy, C. et al

in Viruses and human cancer, Liss Press, New York (1987)

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See detailLeukemogenesis by bovine leukemia virus (BLV) and human T-cell lymphotropic viruses : facts and hypotheses
Burny, A.; Cleuter, Y.; Kettmann, Richard ULg et al

in Cancer letters (suppl.) (1986)

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See detailLeukemogenesis by transactivating retroviruses : bovine leukemia virus as a model system
Burny, A.; Cleuter, Y.; Dandoy, C. et al

in Concepts and theories in carcinogenesis (1987)

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See detailLeukemogenesis by transactivating retroviruses: bovine leukemia virus as a model system
Burny, A.; Kettmann, Richard ULg; Mammerickx, M. et al

in Springer-Verlag Press (Berlin, Heidelberg) (1988)

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See detailLeukotriene B4 Contributes to Exhaled Breath Condensate and Sputum Neutrophil Chemotaxis in COPD.
Corhay, Jean-Louis ULg; Henket, Monique ULg; Nguyen Dang, Delphine ULg et al

in CHEST (2009), 136(4), 1047-1054

Background Neutrophils have been implicated in the pathogenesis of COPD. Several chemoattractants for neutrophils have been measured in exhaled breath condensate (EBC) and induced-sputum (IS) from ... [more ▼]

Background Neutrophils have been implicated in the pathogenesis of COPD. Several chemoattractants for neutrophils have been measured in exhaled breath condensate (EBC) and induced-sputum (IS) from patients with COPD. Objectives The aims of this study were to compare EBC and IS supernatant neutrophil chemotactic activity from ex-smoking COPD and healthy ex-smokers, and to assess the contribution of LTB(4) to this activity. Methods 34 COPD were compared to 24 controls. EBC and IS chemotactic activity for neutrophils were assessed by using Boyden microchambers. Chemotactic index (CI) was used to evaluate cell migration. LTB(4) was measured by a specific enzyme immunoassay. Contribution of LTB4 to EBC and sputum neutrophil chemotaxis was assessed by an LTB(4) receptor antagonist (U-75302: Cayman Chemical Company, Ann Arbor, MI, USA). Results EBC and IS from both COPD and healthy subjects displayed significant neutrophil chemotactic activity but this activity was raised in COPD compared to healthy subjects. Chemotactic activity contained in sputum, however, failed to correlate with that in EBC. In COPD there was a significant correlation between EBC neutrophil chemotactic activity and sputum neutrophil counts. LTB(4) levels were raised in EBC, but not in sputum, from COPD as compared to healthy subjects. LTB(4) receptor antagonist (2.5 10(-4) M) reduced by 44.6% and by 44.4% chemotactic activity contained in EBC and sputum respectively. Conclusions EBC and IS from COPD patients have a raised neutrophil chemotactic activity to which LTB4 contributes. [less ▲]

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See detailLeur première pièce. L'émergence des auteurs dramatiques dans le théâtre belge francophone
Delhalle, Nancy ULg

Scientific conference (2011, April 27)

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See detailLeurres de la qualité dans l'enseignement supérieur ? Variations internationales sur un thème ambigu
Fallon, Catherine ULg; Leclercq, Bruno ULg

Book published by Academia (2013)

Comme d’autres services publics, l’enseignement supérieur s’est, en quelques années seulement, doté, partout dans le monde, de dispositifs d’évaluation « Qualité ». Ces nouvelles approches mobilisent le ... [more ▼]

Comme d’autres services publics, l’enseignement supérieur s’est, en quelques années seulement, doté, partout dans le monde, de dispositifs d’évaluation « Qualité ». Ces nouvelles approches mobilisent le plus souvent des principes inspirés du New Public Management qui s'enracinent dans une critique néo-libérale de l’Etat providence. D’un endroit à l’autre, ce sont toutefois des méthodes, des critères et surtout des usages très différents de l’évaluation des formations qui se rangent sous cette appellation. Les textes rassemblés dans ce volume font état de cette diversité des pratiques internationales ainsi que de l’irréductible multiplicité des projets que cherche à servir simultanément la démarche « Qualité » dans l’enseignement supérieur. En soulignant les ambiguïtés d’un dispositif tout à la fois discursif et technique, ils cherchent à en déjouer les éventuels « leurres ». [less ▲]

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See detailLeuven English Old to New (LEON): Some ideas on a new corpus for longitudinal diachronic studies.
Petré, Peter ULg

Conference (2009, July 09)

Despite the explosion of diachronic corpora of English in the last few decades, still not a single corpus exists that covers the entire documented history of English. Although its compilation is generally ... [more ▼]

Despite the explosion of diachronic corpora of English in the last few decades, still not a single corpus exists that covers the entire documented history of English. Although its compilation is generally perceived as most attractive (Rissanen 2000: 13), corpus compilers do not seem to believe in its creation in the near future. This is regrettable, as many linguists dealing with longitudinal developments such as grammaticalization need to cover very long time spans, and are forced to combine several, not necessarily compatible, corpora (e.g. Hilpert 2008, van Linden 2009). Clearly, their results are less reliable than they might be if a single corpus existed (for example, Gries and Hilpert’s data (2008) show a major shift in the collocational profile of shall about 1710; however, this is precisely where one corpus they use ends and a second – rather different one – begins). So I tentatively started compiling a corpus myself, provisionally called LEON (Leuven English Old to New). The basic architecture of LEON comprises a 400,000 word corpus for each HC-period, and after 1710 for the periods 1710-1780, 1780-1850, 1850-1920, 1920-1990 and post-1990. Data available from 1250-1350, a less well represented period, serve as a template on which other subperiods are to be based to acquire best comparability of genre and region. To make up for the lack of some genres (letters, diaries) and social stratification, for each period after 1350 an additional, selfsufficient 600,000 words corpus is envisaged. While LEON is primarily conceived as a ‘meta-corpus’, mining existing corpora, some additions are envisaged too (e.g. the unedited Statutes Rwl. B.520, dated a1325). LEON does not aim at full comparability (which would be presumptuous), but wants to optimize the usefulness of concepts like ‘equal size of subperiods’ or ‘diachronic text prototype’ (HC). LEON might be, as compared to the present ‘big evil’, a ‘lesser evil’. References Gries, Stefan Th. and Martin Hilpert. The identification of stages in diachronic data: variability-based neighbour clustering. Corpora Vol. 3 (1): 59–81. Hilpert, Martin. 2008. Germanic future constructions A usage-based approach to language change. Amsterdam & Philadelphia: John Benjamins. Los, Bettelou. 2005. The rise of the to-infinitive. Oxford: Oxford University Press. Rissanen, Matti & Merja Kytö. 1993. General introduction. In Rissanen, Matti, Merja Kytö & Minna Palander-Collin, eds. 1993. Early English in the computer age: Explorations through the Helsinki Corpus. Berlin: Mouton de Gruyter. 1-17. Rissanen, Matti. 2000. The world of English historical corpora: From Cædmon to computer age. Journal of English Linguistics 28: 7-20. van Linden, An. 2009. Dynamic, deontic and evaluative adjectives and their clausal complement patterns: A synchronic-diachronic account. PhD dissertation, University of Leuven. [less ▲]

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See detailLevallois et Gravettien
Otte, Marcel ULg; Noiret, Pierre ULg

in Praehistoria (in press)

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein ... [more ▼]

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein du Gravettien touchent autant les processus de symbolisation dans l’art et les sépultures. Elles affectent différents substrats eurasiatiques, plutôt septentrionaux, comme mis en réserve dès les Néandertaliens. [less ▲]

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See detailLève-toi et entreprends !...
Choffray, Jean-Marie ULg

E-print/Working paper (2011)

Quelques pistes de réflexion pour faire face, avec solidarité, créativité, intelligence, et détermination, aux défis humains et économiques que pose la reconversion industrielle d'ArcelorMittal.

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See detailLevel lifetimes in 3p and 3d configurations of Fe XII
Biémont, Emile ULg; Palmeri, P.; Quinet, Pascal ULg et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (2002), 20(1), 37-44

Transitions between the five fine-structure levels in the 3s(2)3p(3) ground configuration of Fe XII (P-like) are of interest in astrophysics and terrestrial plasma diagnostics. The decay rates give rise ... [more ▼]

Transitions between the five fine-structure levels in the 3s(2)3p(3) ground configuration of Fe XII (P-like) are of interest in astrophysics and terrestrial plasma diagnostics. The decay rates give rise to level lifetimes in the millisecond range, which have been measured recently at a heavy-ion storage ring. While most of the 3s(2)3p(2)3d levels are short-lived, two of these levels have no El decay channels and may also have millisecond lifetimes. We present HFR and MCDF calculations of the El, M1, E2 and M2 transition rates between the 3s(2)3p(3), 3s3p(4) and 3s(2)3p(2)3d levels and compare the lifetime results to most recent experimental data as well as to other predictions. [less ▲]

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See detailLevel of agency in sub-clinical checking
Belayachi, Sanaa ULg; Van der Linden, Martial ULg

in Consciousness & Cognition (2009), 18(1), 293-299

This study examined cognitive representations of routine action, through the assessment of level of agency, in individuals with sub-clinical checking. The level of agency stems from Action Identification ... [more ▼]

This study examined cognitive representations of routine action, through the assessment of level of agency, in individuals with sub-clinical checking. The level of agency stems from Action Identification Theory [Vallacher, R. R., Wegner, D. M. (1989). Levels of personal agency: Individual variation in action identification. Journal of Personality and Social Psychology 57, 660-671], which states that how actions are usually identified (based on instrumental aspects or purpose) reflects the predominant accessibility of internal representation (movements executed vs. goal pursued). Furthermore, this framework proposed that altered action regulation is related to low-level of agency (i.e., action identification at an instrumental level). In the current study, the main result indicated that checking symptoms were related to a low-level of agency, that is, individuals with sub-clinical checking identified habitual actions on the basis of instrumental aspects. This seems to indicate that checkers may act with a lack of goal representations. The results are discussed in terms of the role of low-level of agency in checking phenomena and related cognitive dysfunction. [less ▲]

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See detailLevel of S100B protein expression in the amnion at various gestational ages in the third trimester of normal pregnancies.
Tskitishvili, Ekaterine ULg; Komoto, Yoshiko; Kinugasa, Yukiko et al

in Acta Obstetricia et Gynecologica Scandinavica (2007), 86(8), 915-20

BACKGROUND: S100B protein is a unique calcium-binding protein. Its biological role within the cell populations is not completely defined. Some pathological conditions that develop during pregnancy could ... [more ▼]

BACKGROUND: S100B protein is a unique calcium-binding protein. Its biological role within the cell populations is not completely defined. Some pathological conditions that develop during pregnancy could affect S100B concentrations in the amniotic fluid, cord blood, and maternal serum. The aim of our study was to assess the correlation between S100B protein expression in the amnion, amniotic fluid and gestational age in the third trimester of uncomplicated pregnancies. METHODS: Amnion, amniotic fluid, maternal peripheral and umbilical cord blood samples were collected from healthy women who delivered at 31-36 weeks (n=17), 37-40 weeks (n=22), and 41-42 weeks (n=21). The expression of S100B in the amnion was assessed by immunohistochemistry and real-time (RT)-PCR, and its concentrations in amniotic fluid, maternal and cord blood sera were determined by ELISA. RESULTS: The S100B protein expression in the amnion and its concentrations in amniotic fluid, maternal and cord blood sera of patients in the third trimester were not significantly different at various gestational ages. CONCLUSIONS: The S100B protein expression in the amnion and the S100B protein concentrations in amniotic fluid, maternal and cord blood do not vary significantly in the third trimester of uncomplicated pregnancies. [less ▲]

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