NEW CHALLENGES FOR 21ST CENTURY COMPETITION AUTHORITIES

E-print/Working paper (2012)

This paper discusses challenges for competition authorities in the 21st century. Those challenges were identified on the basis of a statistical review of the articles published since January 2011 in five ... [more ▼]

This paper discusses challenges for competition authorities in the 21st century. Those challenges were identified on the basis of a statistical review of the articles published since January 2011 in five major antitrust law journals. The assumption underlying this literature review is that the topics that statistically attract the most the attention from contemporary antitrust scholars are those that will likely constitute the main challenges for 21st century competition authorities. [less ▲]

New chemical and pharmacological developments in the field of positive allosteric modulators of AMPA receptors structurally related to cyclothiazide and diazoxide

Poster (2000, March 04)

A New Cis Element Is Involved in the Her2 Gene Overexpression in Human Breast Cancer Cells

in Cancer Research (1999), 59(11), 2527-31

The HER2 proto-oncogene product is overexpressed in 30% of breast cancers, and this correlates with poor prognosis. Increased levels of HER2 mRNA in breast cancer cell lines result from increased gene ... [more ▼]

The HER2 proto-oncogene product is overexpressed in 30% of breast cancers, and this correlates with poor prognosis. Increased levels of HER2 mRNA in breast cancer cell lines result from increased gene transcription. We report the identification of a new 17-bp-long cis sequence located between positions -506 and -489 from the transcription start site. This sequence is recognized by a trans-activating factor that we tentatively named HER2 transcription factor (HTF). This factor, involved in the increased transcription of the HER2 gene in the BT-474 mammary tumor cells, has a molecular weight of about Mr 50,000. HTF can also bind, but with a lower affinity, to a related cis sequence present in the epidermal growth factor receptor promoter. Interestingly, the HTF binding activity is high in nuclear extracts from several mammary tumor cells overexpressing the HER2 gene. [less ▲]

New Colliding-Wind Massive Binaries

in Massive Stars in Interactive Binaries (2007)

We report on the recent discovery of two new massive binary systems: WR20a and CygOB2#8A. For both systems, we briefly present the orbital solutions and we discuss the strong phase-locked line profile ... [more ▼]

We report on the recent discovery of two new massive binary systems: WR20a and CygOB2#8A. For both systems, we briefly present the orbital solutions and we discuss the strong phase-locked line profile variability of the Halpha and HeII lambda 4686 lines for WR20a, and the HeII &; 4686 line in the case of CygOB2#8A. In both cases, we show that the profile variability reveals the signature of a wind interaction. The prospects for future high-energy observations are also discussed. [less ▲]

New combinations in the Amblystegiaceae

in Journal of Bryology (2009), 31

A new concept for bisphosphonate therapy: a rationale for the development of monthly oral dosing of ibandronate

in Osteoporosis International (2006), 17(2), 159-166

Oral daily and weekly bisphosphonates represent the current mainstay of treatment for postmenopausal osteoporosis (PMO). However, the inconvenience of frequent dosing is known to negatively affect ... [more ▼]

Oral daily and weekly bisphosphonates represent the current mainstay of treatment for postmenopausal osteoporosis (PMO). However, the inconvenience of frequent dosing is known to negatively affect adherence to therapy in the long term. This has prompted the development of convenient oral bisphosphonate regimens that feature simple, less frequent dosing schedules. Such regimens require high potency agents, which can be given at low effective doses and that also have good tolerability. Ibandronate is a potent, nitrogen-containing bisphosphonate with proven efficacy when given intermittently to estrogen-depleted beagle dogs, rats and cynomolgus monkeys. Clinically, a pivotal prospective study has established that oral ibandronate has significant vertebral fracture efficacy in PMO, whether given daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months; extended between-dose interval > 2 months). Both oral regimens were well tolerated, which is noteworthy as patients with a history of gastrointestinal (GI) disturbance were not specifically excluded. As a result of these findings, a large, multinational, randomized, double-blind study (Monthly Oral iBandronate In LadiEs: MOBILE) is currently exploring the non-inferiority of once-monthly oral ibandronate (100 or 150 mg) to the oral daily ibandronate (2.5 mg) regimen with proven anti-fracture efficacy, in terms of lumbar spine bone mineral density (BMD) change. As with the trials investigating the weekly administration of other bisphosphonates, vertebral fracture efficacy will be inferred if the study demonstrates the non-inferiority of once-monthly ibandronate to the proven oral daily regimen in terms of spinal BMD change. The availability of this once-monthly ibandronate regimen is expected to offer benefits in terms of convenience (by having to follow dosing recommendations once a month vs. once daily or weekly) and potentially tolerability (by reducing the potential for upper GI irritation that can result from frequent, repeated exposure). Greater convenience and tolerability may enhance the therapy adherence and, hence, improve long-term therapeutic outcomes in PMO. [less ▲]

New concepts for the design of joints

in Proceedings of the 10th DASt-Forschungs-kolloquium Stahlbau (1997)

New constraints on the delivery of cometary water and nitrogen to Earth from the 15N/14N isotopic ratio

in Icarus: International Journal of Solar System Studies (2009), 204

New independent constraints on the amount of water delivered to Earth by comets are derived using the [SUP]15[/SUP]N/[SUP]14[/SUP]N isotopic ratio, measured to be roughly twice as high in cometary CN and ... [more ▼]

New independent constraints on the amount of water delivered to Earth by comets are derived using the [SUP]15[/SUP]N/[SUP]14[/SUP]N isotopic ratio, measured to be roughly twice as high in cometary CN and HCN as in the present Earth. Under reasonable assumptions, we find that no more than a few percent of Earthâ s water can be attributed to comets, in agreement with the constraints derived from D/H. Our results also suggest that a significant part of Earthâ s atmospheric nitrogen might come from comets. Since the [SUP]15[/SUP]N/[SUP]14[/SUP]N isotopic ratio is not different in Oort-cloud and Kuiper-belt comets, our estimates apply to the contribution of both types of objects. [less ▲]

New constraints on the slip rate of the North Anatolian Fault, Turkey

in Terra nova (European Union of Geosciences abstracts) (1997, March), 9

New contributions to heavy-quarkonium production

in Physics Letters B (2006), 633(2-3), 301-308

We reconsider quarkonium production in a field-theoretical setting and we show that the lowest-order mechanism for heavy-quarkonium production receives in general contributions from two different cuts ... [more ▼]

We reconsider quarkonium production in a field-theoretical setting and we show that the lowest-order mechanism for heavy-quarkonium production receives in general contributions from two different cuts. The first one corresponds to the usual colour-singlet mechanism. The second one has not been considered so far. We treat it in a gauge-invariant manner, and introduce new 4-point vertices, suggestive of the colour-octet mechanism. These new objects enable us to go beyond the static approximation. We show that the contribution of the new cut can be as large as the usual colour-singlet mechanism at high P-T for J/psi. In the psi' case, theoretical uncertainties are shown to be large and agreement with data is possible. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]