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See detailGenetic evaluation of calving ease for Walloon Holstein dairy cattle
Vanderick, Sylvie ULg; Troch, Thibault ULg; Gillon, Alain et al

Conference (2013, August 25)

Calving complications have an incidence on the economic profitability of dairy herds. In the Walloon Region of Belgium, calving ease data recording is being done on voluntary basis since 2000. This allows ... [more ▼]

Calving complications have an incidence on the economic profitability of dairy herds. In the Walloon Region of Belgium, calving ease data recording is being done on voluntary basis since 2000. This allows now the implementation of a genetic evaluation of Holstein dairy cattle addressing the need of dairy breeders to select bulls in order to reduce frequency of calving problems. Calving ease scores were analyzed using univariate animal linear models, which were fitted with the genetic correlation between direct and maternal additive genetic effects either estimated or constrained to zero. Variance components and related genetic parameters were estimated from a dataset including 33,155 calving records. Included in the models were fixed season effects, fixed herd effects and fixed sex of calf*age of dam classes*group of calvings interaction effects, random herd*year of calving effects, random maternal permanent environment effects, and random animal direct and maternal additive genetic effects. For both models, direct and maternal heritabilities for calving ease were about 8% and about 2%, respectively. Genetic correlation between direct and maternal additive effects was found to be non-significantly different from zero. So, an animal linear model with genetic correlation between direct and maternal effects constrained to zero was adopted for the routine genetic evaluation of calving ease for Walloon Holstein dairy cattle. This model was validated by Interbull in January 2013 and, since April 2013, the Walloon Region of Belgium has officially participated to the international MACE evaluation for calving traits. [less ▲]

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See detailGenetic evaluation of calving ease for Walloon Holstein dairy cattle.
Vanderick, Sylvie ULg; Troch, Thibault ULg; Gillon, Alain et al

in Interbull Bulletin (2013), 47

Calving complications have an incidence on the economic profitability of dairy herds. In the Walloon Region of Belgium, calving ease data recording is being done on voluntary basis since 2000. This allows ... [more ▼]

Calving complications have an incidence on the economic profitability of dairy herds. In the Walloon Region of Belgium, calving ease data recording is being done on voluntary basis since 2000. This allows now the implementation of a genetic evaluation of Holstein dairy cattle addressing the need of dairy breeders to select bulls in order to reduce frequency of calving problems. Calving ease scores were analyzed using univariate animal linear models, which were fitted with the genetic correlation between direct and maternal additive genetic effects either estimated or constrained to zero. Variance components and related genetic parameters were estimated from a dataset including 33,155 calving records. Included in the models were fixed season effects, fixed herd effects and fixed sex of calf*age of dam classes*group of calvings interaction effects, random herd*year of calving effects, random maternal permanent environment effects, and random animal direct and maternal additive genetic effects. For both models, direct and maternal heritabilities for calving ease were about 8% and about 2%, respectively. Genetic correlation between direct and maternal additive effects was found to be non-significantly different from zero. So, an animal linear model with genetic correlation between direct and maternal effects constrained to zero was adopted for the routine genetic evaluation of calving ease for Walloon Holstein dairy cattle. This model was validated by Interbull in January 2013 and, since April 2013, the Walloon Region of Belgium has officially participated to the international MACE evaluation for calving traits. [less ▲]

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See detailGenetic evaluation of cow survival using a lactation random regression model
Gengler, Nicolas ULg; Vanderick, Sylvie ULg; Mayeres, Patrick et al

in INTERBULL Bulletin (2005), 33

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See detailGenetic evaluation of female fertility for Walloon dairy and dual purpose cows using a parity random regression model: first results
Mayeres, Patrick; Vanderick, Sylvie ULg; Croquet, Coraline et al

in INTERBULL Bulletin (2006), 34

Detailed reference viewed: 31 (6 ULg)
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See detailGenetic evaluation of type traits in Northern part of Belgium
Detilleux, Johann ULg; Volckaert, D.; Leroy, Pascal ULg

(1996)

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See detailGenetic evaluation using multi-trait and random regression models in Simmental beef cattle
REIS MOTA, Rodrigo ULg; Marques, L. F. A.; Lopes, P. S. et al

in Genetics & Molecular Research [=GMR] (2013), 12(3), 2465-2480

The Brazilian Association of Simmental and Simbrasil Cattle Farmers provided 29,510 records from 10,659 Simmental beef cattle; these were used to estimate (co)variance components and genetic parameters ... [more ▼]

The Brazilian Association of Simmental and Simbrasil Cattle Farmers provided 29,510 records from 10,659 Simmental beef cattle; these were used to estimate (co)variance components and genetic parameters for weights in the growth trajectory, based on multi-trait (MTM) and random regression models (RRM). The (co)variance components and genetic parameters were estimated by restricted maximum likelihood. In the MTM analysis, the likelihood ratio test was used to determine the significance of random effects included in the model and to define the most appropriate model. All random effects were significant and included in the final model. In the RRM analysis, different adjustments of polynomial orders were compared for 5 different criteria to choose the best fit model. An RRM of third order for the direct additive genetic, direct permanent environmental, maternal additive genetic, and maternal permanent environment effects was sufficient to model variance structures in the growth trajectory of the animals. The (co)variance components were generally similar in MTM and RRM. Direct heritabilities of MTM were slightly lower than RRM and varied from 0.04 to 0.42 and 0.16 to 0.45, respectively. Additive direct correlations were mostly positive and of high magnitude, being highest at closest ages. Considering the results and that pre-adjustment of the weights to standard ages is not required, RRM is recommended for genetic evaluation of Simmental beef cattle in Brazil. ©FUNPEC-RP. [less ▲]

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See detailGenetic evidence for a TatC dimer at the core of the Escherichia coli twin arginine (Tat) protein translocase
Maldonado-Larrosa, Barbara Maria ULg

in Journal of Molecular Microbiology & Biotechnology (2011)

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See detailGenetic evidence from Indian red jungle fowl corroborates multiple domestication of modern day chicken.
Kanginakudru, Sriramana; Metta, Muralidhar ULg; Jakati, R. D. et al

in BMC Evolutionary Biology (2008), 8

BACKGROUND: Domestication of chicken is believed to have occurred in Southeast Asia, especially in Indus valley. However, non-inclusion of Indian red jungle fowl (RJF), Gallus gallus murghi in previous ... [more ▼]

BACKGROUND: Domestication of chicken is believed to have occurred in Southeast Asia, especially in Indus valley. However, non-inclusion of Indian red jungle fowl (RJF), Gallus gallus murghi in previous studies has left a big gap in understanding the relationship of this major group of birds. In the present study, we addressed this issue by analyzing 76 Indian birds that included 56 G. g. murghi (RJF), 16 G. g. domesticus (domestic chicken) and 4 G. sonneratii (Grey JF) using both microsatellite markers and mitochondrial D-loop sequences. We also compared the D-loop sequences of Indian birds with those of 779 birds obtained from GenBank. RESULTS: Microsatellite marker analyses of Indian birds indicated an average FST of 0.126 within G. g. murghi, and 0.154 within G. g. domesticus while it was more than 0.2 between the two groups. The microsatellite-based phylogenetic trees showed a clear separation of G. g. domesticus from G. g. murghi, and G. sonneratii. Mitochondrial DNA based mismatch distribution analyses showed a lower Harpending's raggedness index in both G. g. murghi (0.001515) and in Indian G. g. domesticus (0.0149) birds indicating population expansion. When meta analysis of global populations of 855 birds was carried out using median joining haplotype network, 43 Indian birds of G. g. domesticus (19 haplotypes) were distributed throughout the network sharing haplotypes with the RJFs of different origins. CONCLUSION: Our results suggest that the domestication of chicken has occurred independently in different locations of Asia including India. We found evidence for domestication of Indian birds from G. g. spadiceus and G. g. gallus as well as from G. g. murghi, corroborating multiple domestication of Indian and other domestic chicken. In contrast to the commonly held view that RJF and domestic birds hybridize in nature, the present study shows that G. g. murghi is relatively pure. Further, the study also suggested that the chicken populations have undergone population expansion, especially in the Indus valley. [less ▲]

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See detailGenetic factors affecting susceptibility to udder pathogens
Detilleux, Johann ULg

in Veterinary Microbiology (2009), 134(1-2), 157-164

Many studies have identified genetic factors underlying resistance or susceptibility to mastitis in dairy cows and heifers. Some authors focused on polygenic variation while others searched for genes and ... [more ▼]

Many studies have identified genetic factors underlying resistance or susceptibility to mastitis in dairy cows and heifers. Some authors focused on polygenic variation while others searched for genes and/or quantitative trait loci with major effects on mastitis. Classical traits related to mastitis include somatic cell counts, electrical conductivity and clinical cases of the disease. With the development of automatic milking devices and '-omics' technologies, new traits are considered, such as acute phase proteins, immunological assays, and milk flow patterns, and new biological pathways are discovered, for example the role of mammary epithelium and the nervous system. The usefulness of these traits for the identification of resistant cows is discussed in relation to the biological mechanisms underlying the development of the disease. In addition, the utility of these traits for genetic improvement is reviewed. Finally, the problem of durability in resistance is addressed, including co-evolution and the cost of resistance. [less ▲]

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See detailGenetic factors affecting susceptibility to udder pathogens
Detilleux, Johann ULg

in Veterinary Immunology and Immunopathology (2002), 88(3-4), 103-110

Bovine mastitis remains the most costly disease in dairy cattle. Breeding for resistance to udder pathogens has been proposed as a complementary tool to therapeutic and prophylactic measures not totally ... [more ▼]

Bovine mastitis remains the most costly disease in dairy cattle. Breeding for resistance to udder pathogens has been proposed as a complementary tool to therapeutic and prophylactic measures not totally effective against the disease. This paper reviews factors affecting cows’ susceptibility to pathogens at the animal, cellular/hormonal and DNA levels. Such factors will be useful in achieving genetic improvement for resistance only if they have desirable properties at the genetic and immunological levels. Because such properties are not always of significant magnitude, further research is necessary to identify characteristics of resistance in cows, considering the constant and complex interactions that occur between hosts and pathogens. [less ▲]

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See detailGenetic Factors in the Development of Pituitary Adenomas.
Vandeva, S.; Tichomirowa, M. A.; Zacharieva, S. et al

in Endocrine Development (2010), 17

Pituitary adenomas are one of the most frequent intracranial tumors. Usually, they are benign but are of great clinical significance because of tumor compression syndrome and hormone overproduction. The ... [more ▼]

Pituitary adenomas are one of the most frequent intracranial tumors. Usually, they are benign but are of great clinical significance because of tumor compression syndrome and hormone overproduction. The interest in this pathology is increasing, particularly after some recent reports on their prevalence that proved to be 3-5 times more than previously estimated. Pituitary tumors arise in a sporadic setting and rarely as part of hereditary genetic syndromes. Such rare hereditary conditions like MEN1, Carney complex and McCune-Albright syndrome give significant insight into pituitary tumorigenesis. Newer genes associated pituitary tumor development include CDKN1B (MEN4) and AIP, the latter of which is involved in the pathophysiology of 15% of FIPA kindreds. The number of genes involved in pituitary tumorigenesis is progressively increasing and the possible mechanisms of action include signal transduction pathways, cell cycle regulators, growth factors, chromosome instability and others. Nevertheless, in the majority of sporadic adenomas, the primary genetic defect remains unknown. Furthermore, there is not a well established relationship between the genotype and its influence on the protein expression, ligand-receptor interaction, tumor growth or hormone hyperproduction. Further studies should evaluate the clinical significance of genetic alterations and their implications for existing and new therapeutic options. [less ▲]

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See detailGenetic heritage of the Eastern Belgium Red and White breed, an endangered local breed
Colinet, Frédéric ULg; Bouffioux, Aude; Mayeres, Patrick et al

Poster (2015, August)

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See detailGenetic heritage of the Eastern Belgium Red and White breed, an endangered local breed
Colinet, Frédéric ULg; Bouffioux, Aude; Mayeres, Patrick et al

in Book of Abstracts of the 66th Annual Meeting of the European Federation of Animal Science (2015, August)

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See detailGenetic Heterogeneicity and Clinical Variability in Musculo contractural Ehlers-Danlos syndrome caused by Impaired Dermatan Sulfate Biosynthesis
Syx, Delfien; Van Damme, Tim; Symoens, Sofie et al

in Human Mutation (2015), 36(5), 535-547

Bi-allelic variants in CHTS-14, encoding dermatan 4-O sulfotransferase-1(D4ST-1), cause musculocontractural Ehlers-Danlos syndrome (MC-EDS), a recessive disorder characterized by connective tissue ... [more ▼]

Bi-allelic variants in CHTS-14, encoding dermatan 4-O sulfotransferase-1(D4ST-1), cause musculocontractural Ehlers-Danlos syndrome (MC-EDS), a recessive disorder characterized by connective tissue fragility, craniofacial abnormalities, congenital contractures and developmental abnormalities. Recently, the identification of bi-allelic variants in DSE, encoding dermatan-sulfate epimerase-1(DS-epi1), in a child with MC-EDS features, suggested locus heterogeneity of this condition. DS-epi1 and D4ST1 are crucial for biosynthesis of dermatan sulfate (DS) moieties in the hybrid chondoitin sulfate (CS)/DS glycosaminoglycans (GAGs). Here, we report four novel families with severe MC-EDS caused by unique homozygous CHST14 variants and a second family with a homozygous DSE missense variant, presenting a somewhat milder MC-EDS phenotype. The glycanation of a dermal DS protoglycan decorin is impaired in fibroblasts from D4ST1, as well as DS-epi1-deficient patients. However, D4ST1-deficiency, decorin GAG is completely replaced by CS, whereas in DS-epi1-deficency, still some DS moieties are present. The multisystemic abnormalities observed in our patients support a tight spatiotemporal control of the balance between CS and DS, which is crucial for multiple processes including cell differentiation, organ development, cell migration, coagulation and connective tissue integrity. [less ▲]

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See detailGenetic heterogeneity of bovine noroviruses in Italy
Di Martino, Barbara; Di Profio, Federica; Di Felice, Elisabetta et al

in Archives of Virology (2014), 159

By screening 104 faecal samples from asymptomatic calves in Italy, bovine norovirus RNA was detected with a prevalence rate of 10.5 % (11/104). A continuous sequence spanning the RdRp region and the 50 ... [more ▼]

By screening 104 faecal samples from asymptomatic calves in Italy, bovine norovirus RNA was detected with a prevalence rate of 10.5 % (11/104). A continuous sequence spanning the RdRp region and the 50 end of the capsid gene was generated for 7 of the 11 strains. Upon phylogenetic analysis, five strains were grouped with GIII.2 Newbury2-like viruses, and one strain was grouped with GIII.1 Jena-like noroviruses. Interestingly, one strain (80TE/IT) was genetically related to the GIII.1/Jena/80/De in the RdRp but resembled the GIII.2/Newbury2/76/UK in the capsid gene, suggesting a recombination event occurring in the ORF1/ORF2 junction region. [less ▲]

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See detailGenetic identification of distinct loci controlling mammary tumor multiplicity, latency and aggressiveness in the rat
Quan, X.; Laes, Jean-François; Stieber, D. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (2006), 17(4), 310-321

The rat is considered an excellent model for studying human breast cancer. Therefore, understanding the genetic basis of susceptibility to mammary cancer in this species is of great interest. Previous ... [more ▼]

The rat is considered an excellent model for studying human breast cancer. Therefore, understanding the genetic basis of susceptibility to mammary cancer in this species is of great interest. Previous studies based on crosses involving the susceptible strain WF (crossed with the resistant strains COP or WKY) and focusing on tumor multiplicity as the susceptibility phenotype led to the identification of several loci that control chemically induced mammary cancer. The present study was aimed to determine whether other loci can be identified by analyzing crosses derived from another susceptible strain on the one hand, and by including phenotypes other than tumor multiplicity on the other hand. A backcross was generated between the susceptible SPRD-Cu3 strain and the resistant WKY strain. Female progeny were genotyped with microsatellite markers covering all rat autosomes, treated with a single dose of DMBA, and phenotyped with respect to tumor latency, tumor multiplicity, and tumor aggressiveness. Seven loci controlling mammary tumor development were detected. Different loci control tumor multiplicity, latency, and aggressiveness. While some of these loci colocalize with loci identified in crosses involving the susceptible strain WF, new loci have been uncovered, indicating that the use of distinct susceptible and resistant strain pairs will help in establishing a comprehensive inventory of mammary cancer susceptibility loci [less ▲]

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