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See detailInterleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells.
Franchimont, Nathalie; Lambert, Cécile ULg; Huynen, Pascale ULg et al

in Arthritis and Rheumatism (2005), 52(1), 84-93

OBJECTIVE: Interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) activation of gp130 represents an alternative pathway for osteoclast development in inflammatory conditions. The goal of the present ... [more ▼]

OBJECTIVE: Interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) activation of gp130 represents an alternative pathway for osteoclast development in inflammatory conditions. The goal of the present study was to investigate changes in sIL-6R levels in response to the inflammatory cytokines IL-1beta and tumor necrosis factor alpha (TNFalpha) and to determine the role of TNFalpha-converting enzyme (TACE) in this process. METHODS: Levels of sIL-6R in the culture media of MG63 and SAOS-2 osteoblast-like cell lines after exposure to various agents were determined by immunoassay. TACE protein levels were measured by Western immunoblotting. Cells were transfected with small interfering RNA (siRNA) or with an expression plasmid for IL-6R and TACE to determine the potential involvement of TACE in IL-6R shedding. RESULTS: IL-1beta and TNFalpha increased the levels of sIL-6R in the culture media of MG63 osteoblast-like cells. This effect was not influenced by cycloheximide or 5,6-dichlorobenzimidazole riboside but was markedly inhibited by the calcium chelator EGTA and by the TACE and matrix metalloproteinase inhibitor hydroxamate (Ru36156). IL-1beta and TNFalpha had no influence on the alternatively spliced form of IL-6R RNA. Levels of sIL-6R were reduced when MG63 cells were transiently transfected with TACE siRNA. Transfection of SAOS-2 cells with expression plasmids for IL-6R and TACE produced a dose-dependent increase in sIL-6R levels. CONCLUSION: IL-1beta- and TNFalpha-mediated induction of IL-6R shedding in osteoblast-like cells is at least partly dependent on TACE activation. [less ▲]

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See detailInterleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
Eddahri, Fouad; Denanglaire, Sebastien; Bureau, Fabrice ULg et al

in Blood (2009), 113(11), 2426-2433

The conditions leading to the activation/differentiation of T-helper (Th) cells dedicated for B-cell antibody production are still poorly characterized. We now demonstrate that interleukin-6 (IL-6 ... [more ▼]

The conditions leading to the activation/differentiation of T-helper (Th) cells dedicated for B-cell antibody production are still poorly characterized. We now demonstrate that interleukin-6 (IL-6) promotes the differentiation of naive T lymphocytes into helper cells able to promote B-cell activation and antibody secretion. IL-6-driven acquisition of B-cell help capacity requires expression of the signal transducer and activator of transcription 3 (STAT3), but not STAT4 or STAT6 transcription factors, suggesting that the ability to provide help to B cells is not restricted to a well-defined Th1 or Th2 effector population. T cell-specific STAT3-deficient mice displayed reduced humoral responses in vivo that could not be related to an altered expansion of CXCR5-expressing helper T cells. IL-6 was shown to promote IL-21 secretion, a cytokine that was similarly found to promote the differentiation of naive T cells into potent B-cell helper cells. Collectively, these data indicate that the ability to provide B-cell help is regulated by IL-6/IL-21 through STAT3 activation, independently of Th1, Th2, Th17, or follicular helper T cell (T(FH)) differentiation [less ▲]

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See detailInterleukin-6: An osteotropic factor influencing bone formation?
Franchimont, N.; Wertz, Sylvie ULg; Malaise, Michel ULg

in BONE (2005), 37(5), 601-606

Interleukin (IL)-6 has long been considered as an osteoresorptive factor. However, recent data indicate that IL-6 could influence bone formation in conditions of increased bone turnover. In this paper ... [more ▼]

Interleukin (IL)-6 has long been considered as an osteoresorptive factor. However, recent data indicate that IL-6 could influence bone formation in conditions of increased bone turnover. In this paper, the effects of IL-6 and its soluble receptor on osteoblast proliferation, differentiation and apoptosis are readdressed. A brief summary of IL-6 signaling after binding to its receptor is provided and hypotheses concerning IL-6 and the central control of bone formation are also highlighted. (c) 2005 Elsevier Inc. All rights reserved. [less ▲]

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See detailInterleukine 1 et métabolisme osseux
Reginster, Jean-Yves ULg; Zheng, SX

in Revue du Praticien (La) (1996), 46

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See detailInterleukine-1 β regulation of transforming growth factor-β1 expression in articular chondrocytes : influence of aceclofenac
Andriamanalijaona, R; Ayache, N; Mathy-Hartert, M et al

in Osteoarthritis and Cartilage (2001), 9SB

Detailed reference viewed: 5 (1 ULg)
See detailInterlocking Biological and Political Uncertainties in Public Decision Making : A Case Study at Mellery (Belgium)
Fallon, Catherine ULg; Laurent, Christian

Conference (1998, October 13)

A central question in health hazard associated with environmental pollution is the evaluation of level of exposure to a mixture of carcinogens and the estimation of the global health impact on the ... [more ▼]

A central question in health hazard associated with environmental pollution is the evaluation of level of exposure to a mixture of carcinogens and the estimation of the global health impact on the residents. The point is important to found a public health decision for site intervention or residents relocalisation. Belgium had to face such a problem at Mellery, a village which became internationally famous some years ago, when local residents denonced a local pollution originating from an industrial waste depository facility situated only 500 m from the centre of their village, in a former sand quarry. A central piece of the actions of the authorities was the original campaign organised to measure directly the level of exposure to carcinogens of a large group of voluntary local residents, children included, by measuring biomarkers of exposure in blood lymphocytes : for its high sensitivity, the frequency of sister chromatid exchanges (SCES) had been chosen. This biomonitoring method, quite commonly used to monitor occupational environment, had never before been applied to evaluate the potential health impact of the environment on a general population. Such data, although sophisticate and integrative, are only indicators of exposure and cannot be used, so far, as individual quantitative predictors of the possible evolution of the health of the individual persons. First designed as an epidemiological study, the campaign at Mellery revealed so high exposure levels that the experts did not keep with the original experimental line and decided to release individual information to the concerned persons, without much preparation nor risk communication policy. Several groups (experts, local doctors, local and regional authorities, public agencies and residents associations) were active integrating the information in their respective discourses, giving them specific interpretative and competing meanings. Any scenario for intervention had to be embedded in some meaningful and legitimating discourse : a quite difficult task for the authorities. The evolution of the expertise system used for public decision-making were marked by several such uncertainties (geological, biological, medical) but also by the difficult integration of health related aspects within environment interventions in the regulatory structures in Belgium : health responsibilities are scattered between federal and "communautaire" bodies, while most of the environmental actions are funded at the regional level. In this first heavy case, the young regional institutions reacted in a disorganized manner: they choose to not put at risk their frail power equilibrium and to not reconsider the attribution of the responsibilities. The authors propose to analyse how peculiar interlocking of the biological and political uncertainties were at the core of the general failure in public risk management around this landfill site: Mellery, after 10 years and a huge budget for site treatment, is still a nightmare for environmental authorities in Southern Belgium. [less ▲]

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See detailIntermédiaire du marché du travail : un métier en tensions
Orianne, Jean-François ULg

Conference (2011, November 21)

Detailed reference viewed: 33 (10 ULg)
See detailLes intermédiaires du marché du travail en Région wallonne : une conception clinique de l’employabilité
Orianne, Jean-François ULg

Conference given outside the academic context (2009)

Detailed reference viewed: 24 (5 ULg)
See detailLes intermédiaires du marché du travail en Wallonie : une profession consultante ?
Orianne, Jean-François ULg

Scientific conference (2009, January 26)

Detailed reference viewed: 39 (13 ULg)
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See detailIntermédiaires et dynamique des réseaux fluides. Du mode d'existence de la norme ISO 14001 en Région wallonne
Semal, Nathalie ULg

Doctoral thesis (2011)

How does a standard "make a living"? How does a written list of requirements acquire some reality? How can a particular agreement take effect in numerous worldwide distant sites?

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See detailIntermédialité visuelle
Badir, Sémir ULg; Roelens, Nathalie

in Visible (2008), 2007/3

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See detailIntermediaries, transport costs and interlinked transaction
Tharakan, Joseph ULg

Conference (2011, November)

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See detailIntermediaries, transport costs and interlinked transaction
Tharakan, Joseph ULg

Conference (2014, March 28)

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See detailIntermediaries, transport costs and interlinked transaction
Tharakan, Joseph ULg

Conference (2014, April 29)

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See detailIntermediaries, transport costs and interlinked transactions
Lefevre, Mélanie ULg

Scientific conference (2011, March)

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See detailIntermediaries, transport costs and interlinked transactions
Tharakan, Joseph ULg

Conference (2014, January 28)

Detailed reference viewed: 10 (1 ULg)
See detailIntermediaries, transport costs and interlinked transactions
Tharakan, Joseph ULg

Conference (2013, July)

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See detailIntermediaries, transport costs and interlinked transactions
Lefevre, Mélanie ULg

Conference (2011, December)

Detailed reference viewed: 7 (0 ULg)