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See detailApollinaire et la rime (deuxième partie)
Purnelle, Gérald ULg

in Apollinaire (2013), 13

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See detailApollinaire et la rime (première partie)
Purnelle, Gérald ULg

in Apollinaire (2012), 12

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See detailApollinaire poète en prose
Delbreil, Daniel; Purnelle, Gérald ULg

Book published by Calliopées (2014)

Au début du 20e siècle, la poésie éprouve la tentation de la prose : nombre de poètes, lassés par des formes qu'ils jugent épuisées ou obsolètes, cherchent des voies nouvelles hors des vers et se font ... [more ▼]

Au début du 20e siècle, la poésie éprouve la tentation de la prose : nombre de poètes, lassés par des formes qu'ils jugent épuisées ou obsolètes, cherchent des voies nouvelles hors des vers et se font prosateurs. Apollinaire est de ceux-là. Les études réunies ici s'attachent à montrer de quelle façon il nous invite à admettre que la poésie trouve aussi bien sa place entre vers et prose que dans des formes scripturales et graphiques nouvelles, d'une hybridité déroutante (ni pleinement prose, ni pleinement vers, ou mi-prose, mi-vers) ou encore s'inscrit, comme le calligramme, dans la dimension spatiale. Apollinaire, poète en prose et inventeur de formes, apparaît ainsi comme étant toujours en quête d'un langage et d'un lyrisme neufs jusqu'à perdre le vers : "Perdre Mais perdre vraiment Pour laisser place à la trouvaille". [less ▲]

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See detailApollo 13. Jos de Haes en het reële van zijn verlangen
Spinoy, Erik ULg

in De Haes, Jos (Ed.) Gedichten (2004)

This is a rereading of the poetry of the Flemish poet Jos de Haes, the author of a limited body of work which, notwithstanding, had great influence in postwar Flemish poetry.

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See detailApollo op vrijersvoeten. een onderzoek naar de thematische coherentie in de Verzamelde verhalen van Simon Vestdijk
Nachtergaele, Lutgarde ULg

Book published by Editions Peeters (1996)

study of the thematical coherence in the short stories written by Simon Vestdijk (1898-1971)

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See detailApologie et Comédie chez Platon: essai de reconstitution croisée (Nuées, Apologie de Socrate et Théétète)
Gavray, Marc-Antoine ULg

in Revue Philosophique de la France et de l'Etranger (2007), 132(2, APR-JUN), 131

In the Apology, Plato gives a philosophical answer to critics contained in Aristophanes' Clouds. However, through Socrates, The Clouds target Protagoras too. As a matter of fact, Plato composed an apology ... [more ▼]

In the Apology, Plato gives a philosophical answer to critics contained in Aristophanes' Clouds. However, through Socrates, The Clouds target Protagoras too. As a matter of fact, Plato composed an apology for him, as well in the Theaetetus, that answers the charges in the comedy against Protagoras, becoming in a certain way his << lawyer >>. But why and what for ? Analysing the concepts of geloion and comic mimesis, we show how Plato undertakes to give a philosophical reading of Protagoras' thought, which, in the same time, constitutes a critical thinking about the object of comedy. [less ▲]

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See detailApomorphine-induced conditioned sensitization and differential habituation to environmental novelty
Tirelli, Ezio ULg; Heidbreder, C.

in Progress in Neuro-Psychopharmacology & Biological Psychiatry (1998), 23

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See detailL'Apophyse du massif stratiforme de Bjerkreim-Sokndal (Rogaland, Norvège) : une intrusion composite de la suite charnockitique
Bolle, Olivier ULg

in Demaiffe, Daniel (Ed.) Petrology and Geochemistry of magmatic suites of rocks in the continental and oceanic crusts (1996)

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See detailL'apoprotéine E et ses implications
Chapelle, Jean-Paul ULg; Férir, A. M.

Conference (1996, March 21)

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See detailL’apoptose mammaire dans le sein normal et en pathologie
DESREUX, Joëlle ULg; GOFFIN, Frédéric ULg; BELIARD, Aude ULg et al

in Références en Gynécologie Obstétrique (1999), 6

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See detailApoptosis and cytolysis induced by giganteosides and hederacolchisides in HL-60 cells
Gerkens, Pascal; Dobson, Rowan ULg; tabatadze, Nino et al

in Anticancer Research (2007), 27

The viability, cytolysis and apoptosis-mediated cellular death induced by giganteosides D and E (Gig-D and Gig-E) and hederacolchisides A and A1 (Hcol-A and Hcol- A1) were analysed in HL-60 cells ... [more ▼]

The viability, cytolysis and apoptosis-mediated cellular death induced by giganteosides D and E (Gig-D and Gig-E) and hederacolchisides A and A1 (Hcol-A and Hcol- A1) were analysed in HL-60 cells. Materials and Methods: the end-point metabolic (WST1) and lactate dehydrogenase (LDH) assays were used. Cell cycle analysis and apoptosis were measured by flow cytometry, DNA laddering and caspase 3 analyses. Results: the HL-60 cell line was more sensitive to Hcol-A1 and Gig-D (IC50 3-5 ÌM) than to Gig-E and Hcol-A (IC50 8-13 ÌM; WST1 assay). This was related to LDH release. The induction of apoptosis could be detected without caspase 3 activation after 24 h of treatment. DNA fragmentation could be detected only with Gig-D. With Hcol- A1 and Gig-D, an accumulation of cells in the S-phase and an increase of cells in sub-G1 peak were observed. By the annexinV-fluorescein isothiocyanate (FITC)/7-aminoactinomycin D (AAD) assay, the majority of cells were in late apoptosis with Gig-D, and in necrosis with Hcol-A1. Conclusion: Hcol-A1 is more cytotoxic than Gig-D, followed by Gig-E and finally Hcol-A. This is related to a membrane permeabilization effect, leading to cytolysis [less ▲]

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See detailApoptosis characterizes immunological failure of HIV infected patients
Mhawej, Marie-José; Brunet-Francois, Cécile; Fonteneau, Raphaël ULg et al

in Control Engineering Practice (2009), 17(7), 798-804

This paper studies the influence of apoptosis in the dynamics of the HIV infection. A new modeling of the healthy CD4+ T-cells activation-induced apoptosis is used. The parameters of this model are ... [more ▼]

This paper studies the influence of apoptosis in the dynamics of the HIV infection. A new modeling of the healthy CD4+ T-cells activation-induced apoptosis is used. The parameters of this model are identified by using clinical data generated by monitoring patients starting Highly Active Anti-Retroviral Therapy (HAART). The sampling of blood tests is performed to satisfy the constraints of dynamical system parameter identification. The apoptosis parameter, which is inferred from clinical data, is then shown to play a key role in the early diagnosis of immunological failure. [less ▲]

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See detailApoptosis During the Development of Radiogenic Thymic Lymphomas: Effects of Treatments Inhibiting Lymphoma Development
Humblet, Chantal ULg; Denis, Ghislaine; Greimers, Roland ULg et al

in Anticancer Research (1998), 18(5A, Sep-Oct), 3469-74

INTRODUCTION: Whole body fractionated irradiation induces thymic lymphomas in C57BL/Ka mice after a latent period during which preleukemic cells progressively transform into leukemic cells within an ... [more ▼]

INTRODUCTION: Whole body fractionated irradiation induces thymic lymphomas in C57BL/Ka mice after a latent period during which preleukemic cells progressively transform into leukemic cells within an abnormal thymic microenvironment. A bone marrow graft or repeated cytokine injections prevent lymphoma development. We think that these treatments restore altered mechanisms controlling apoptosis. MATERIALS AND METHODS: Apoptosis was analyzed by flow cytometry in thymocytes from different groups of mice (control, preleukemic, prevented mice). RESULTS: The apoptotic rates did not change in freshly isolated thymocytes from different experimental groups. However, after culture, the level of apoptosis increased in preleukemic thymuses; and returned to normal value in cultured thymocytes from irradiated mice after lymphoma preventing treatments. Furthermore, thymic microenvironmental factors can control thymocyte apoptosis. CONCLUSION: We propose that after leukemogenic irradiation, there is an increase of cells with an activated suicide program, but that alterations of thymic environmental factors rescue them from apoptosis, allowing their further neoplastic transformation. [less ▲]

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See detailApoptosis in v-myc-transfected MSU-1.1 fibroblasts is induced by cell-matrix contact and differs from that of normal dermal fibroblasts.
Niland, S.; Cremer, A.; Herzhoff, K. et al

in In Vitro Cellular & Developmental Biology. Animal (2001), 37(9), 606-12

In order to characterize a fibroblast cell line representing normal human skin fibroblasts in three-dimensional cultures, we compared the fibroblast line MSU-1.1, derived from human foreskin and ... [more ▼]

In order to characterize a fibroblast cell line representing normal human skin fibroblasts in three-dimensional cultures, we compared the fibroblast line MSU-1.1, derived from human foreskin and immortalized by v-myc, to primary human dermal fibroblasts (NDF). Our results demonstrate that in contrast to NDF, all MSU-1.1 fibroblasts die within 3-4 d when cultured within three-dimensional contractile collagen matrices. Also, in contrast to NDF. MSU-1.1 cells die markedly in anchored collagen gels as well. Death is due to apoptosis and is attenuated by addition of antibodies against collagen-recognizing receptors alpha1beta1 and alpha2beta1. Apoptosis of NDF in collagen lattices was repressed by an inhibitor of caspase-1, which was ineffective on apoptosis of MSU-1.1. Further, apoptosis by MSU-1.l fibroblasts was also observed in anchored, i.e., restrained collagen lattices, an environment that supports proliferation of NDF. [less ▲]

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See detailApoptosis induction in human cancer cells by sungucine from Strychnos icaja root
Frederich, Michel ULg; Bentires-Ali, M.; Tits, Monique ULg et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (2003), 367(3), 260-265

Sungucine (SG) and isosungucine (ISG) are bisindole alkaloids characterized by a 5'-23 link between the two parts of the compounds, which are till now specific to Strychnos icaja. In this work, SG and ISG ... [more ▼]

Sungucine (SG) and isosungucine (ISG) are bisindole alkaloids characterized by a 5'-23 link between the two parts of the compounds, which are till now specific to Strychnos icaja. In this work, SG and ISG were submitted to the NCI's in vitro 60 human tumor cell line screen, where SG showed interesting selectivity (6X) against the tested leukemia cell lines. In HL60-treated cells, apoptosis was demonstrated by observation of apoptotic bodies formation, and phosphatidylserine exposition at cell surface. In HeLa-treated cells, the analysis of cellular cycle by flow cytometry showed G1 accumulation and a small sub-G1 peak that could be related to DNA fragmentation characteristic of apoptosis. The eventual role of p53 was analyzed using wild-type HCT-116 colon cancer cells. Nevertheless, p53 and Bax expression were not modified in SG-treated cells. The cleavage of PARP by caspase-3 protease proved that apoptosis was also induced in this line. These results demonstrate that SG induces apoptosis, but also necrosis, in human cancer cell lines. [less ▲]

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See detailApoptosis of HL-60 leukemia cells induced by the bisindole alkaloids sungucine and isosungucine from Strychnos icaja
Lansiaux, A.; Bailly, Christian; Houssier, Claude ULg et al

in Planta Medica (2002), 68(7), 591-595

Sungucine and isosungucine are two bisindole alkaloids isolated from the roots of the African plant Strychnos icaja Baillon. They both exhibit antiplasmodial activities but also show cytotoxic effects ... [more ▼]

Sungucine and isosungucine are two bisindole alkaloids isolated from the roots of the African plant Strychnos icaja Baillon. They both exhibit antiplasmodial activities but also show cytotoxic effects against human cancer cell lines. In order to elucidate their mechanism of action, we have investigated the interaction of the alkaloids with DNA and their capacity to inhibit nucleic acids and protein synthesis in the human HL-60 promyelocytic leukemia cell line. Cell treatment with both sungucine and isosungucine leads to the appearance of a hypo-diploid DNA content peak. Western blotting analysis reveals that the two alkaloids induce cleavage of the poly(ADP-ribose) polymerase (PARP) and promote the cleavage of a caspase-3 DEVD peptide substrate. The activation of the caspase cascade is accompanied with a fragmentation of DNA in cells, as revealed by the TUNEL assay. Altogether, the results shed light on the mechanism of action of these two plant alkaloids and identify signaling factors involved in (iso)sungucine-induced apoptosis in HL-60 cells. [less ▲]

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See detailThe apoptosis of osteoblasts and osteocytes in femoral head osteonecrosis: its specificity and its distribution
Mutijima E; De Maertelaer V; Deprez M et al

in Clinical Rheumatology (2014), 33(12), 1791-5

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See detailL’aporie de la mathématisation de la physique en contexte aristotélicien
Dubouclez, Olivier ULg

Scientific conference (2014, February)

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