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See detailThe KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat
Hansen, H. H.; Ebbesen, C.; Mathiesen, C. et al

in Journal of Pharmacology and Experimental Therapeutics (The) (2006), 318(3), 1006-1019

Homo- and heteromeric complexes of KCNQ channel subunits are the molecular correlate of the M-current, a neuron-specific voltage-dependent K+ current with a well established role in control of neural ... [more ▼]

Homo- and heteromeric complexes of KCNQ channel subunits are the molecular correlate of the M-current, a neuron-specific voltage-dependent K+ current with a well established role in control of neural excitability. We investigated the effect of KCNQ channel modulators on the activity of dopaminergic neurons in vitro and in vivo in the rat ventral mesencephalon. The firing of dopaminergic neurons recorded in mesencephalic slices was robustly inhibited in a concentration-dependent manner by the KCNQ channel opener N-(2-amino-4-(4-fluorobenzylamino)phenyl) carbamic acid ethyl ester ( retigabine). The effect of retigabine persisted in the presence of tetrodotoxin and simultaneous blockade of GABA A receptors, small-conductance calcium-activated K+ ( SK) channels, and hyperpolarization-activated (I-h) channels, and it was potently reversed by the KCNQ channel blocker 4- pyridinylmethyl-9(10H)-anthracenone (XE991), indicating a direct effect on KCNQ channels. Likewise, in vivo single unit recordings from dopaminergic neurons revealed a prominent reduction in spike activity after systemic administration of retigabine. Furthermore, retigabine inhibited dopamine synthesis and c-Fos expression in the striatum under basal conditions. Retigabine completely blocked the excitatory effect of dopamine D-2 auto-receptor antagonists. Again, the in vitro and in vivo effects of retigabine were completely reversed by preadministration of XE991. Dual immunocytochemistry revealed that KCNQ4 is the major KCNQ channel subunit expressed in all dopaminergic neurons in the mesolimbic and nigrostriatal pathways. Collectively, these observations indicate that retigabine negatively modulates dopaminergic neurotransmission, likely originating from stimulation of mesencephalic KCNQ4 channels. [less ▲]

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See detailKCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum.
Singh, Nanda A; Westenskow, Peter; Charlier, Carole ULg et al

in Brain : A Journal of Neurology (2003), 126(Pt 12), 2726-37

Benign familial neonatal convulsions (BFNC) is a rare autosomal dominant generalized epilepsy of the newborn infant. Seizures occur repeatedly in the first days of life and remit by approximately 4 months ... [more ▼]

Benign familial neonatal convulsions (BFNC) is a rare autosomal dominant generalized epilepsy of the newborn infant. Seizures occur repeatedly in the first days of life and remit by approximately 4 months of age. Previously our laboratory cloned two novel potassium channel genes, KCNQ2 and KCNQ3, and showed that they are mutated in patients with BFNC. In this report, we characterize the breakpoints of a previously reported interstitial deletion in the KCNQ2 gene and show that only KCNQ2 is deleted. We identify 11 novel mutations in KCNQ2 and one novel mutation in the KCNQ3 potassium channel genes. In one family, the phenotype extends beyond neonatal seizures and includes rolandic seizures, and a subset of families has onset of seizures in infancy. In the Xenopus oocyte expression system, we characterize five KCNQ2 and one KCNQ3 disease-causing mutations. These mutations cause a variable loss of function, and selective effects on the biophysical properties of KCNQ2/KCNQ3 heteromultimeric channels. We report here the first dominant negative mutation in KCNQ2 that has a phenotype of neonatal seizures without permanent clinical CNS impairment. [less ▲]

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See detailKCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases
Bayón, Yolanda; Trinidad, Antonio G.; de la Puerta, María L et al

in FEBS Journal (2008), 275(15), 3900-3910

Potassium channel tetramerization domain (KCTD) proteins contain a bric-a-brac, tramtrak and broad complex (BTB) domain that is most similar to the tetramerization domain (T1) of voltage-gated potassium ... [more ▼]

Potassium channel tetramerization domain (KCTD) proteins contain a bric-a-brac, tramtrak and broad complex (BTB) domain that is most similar to the tetramerization domain (T1) of voltage-gated potassium channels. Some BTB-domain-containing proteins have been shown recently to participate as substrate-specific adaptors in multimeric cullin E3 ligase reactions by recruiting proteins for ubiquitination and subsequent degradation by the proteasome. Twenty-two KCTD proteins have been found in the human genome, but their functions are largely unknown. In this study, we have characterized KCTD5, a new KCTD protein found in the cytosol of cultured cell lines. The expression of KCTD5 was upregulated post-transcriptionally in peripheral blood lymphocytes stimulated through the T-cell receptor. KCTD5 interacted specifically with cullin3, bound ubiquitinated proteins, and formed oligomers through its BTB domain. Analysis of the interaction with cullin3 showed that, in addition to the BTB domain, some amino acids in the N-terminus of KCTD5 are required for binding to cullin3. These findings suggest that KCTD5 is a substrate-specific adaptor for cullin3-based E3 ligases. [less ▲]

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See detailKDIGO – prise en charge de l’hypertension artérielle en dialyse
Krzesinski, Jean-Marie ULg

Conference (2013, March 28)

1. A lower target may be chosen in CKD patients with proteinuria but after individualized risk-benefit assessment. The price to pay is a need for a higher number of antiHTA drugs and a risk of more ... [more ▼]

1. A lower target may be chosen in CKD patients with proteinuria but after individualized risk-benefit assessment. The price to pay is a need for a higher number of antiHTA drugs and a risk of more frequent side-effects. 2. Confirmation of a high BP level is necessary through out-of-the clinic BP measurement In CKD, ABPM offers night-time BP information useful for CV and renal risk evaluation. BP variability is a new point to be considered in the future. Proteinuria but also other specific risk factors (Phosphate, anemia, inflammation,..) should be integrated in the management of hypertension in CKD [less ▲]

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See detailKeep bacteria under control: Dietary modulation of gut microflora in farm animals by use of hen egg yolk antibodies
Marcq, Christopher ULg; Thewis, André ULg; Portetelle, Daniel ULg et al

E-print/Working paper (2010)

This review article focuses on the use of IgY in therapy or prophylaxis of diseases in veterinary medicine as well as in the context of functional foods to modulate microflora in animal.

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See detailKeep the nest clean: survival advantages of corpse removal in ants
Diez, Lise; Lejeune, Philippe ULg; Detrain, Claire

in Biology Letters (2014), 10(7),

Sociality increases exposure to pathogens. Therefore, social insects have developed a wide range of behavioural defences, known as ‘social immunity’. However, the benefits of these behaviours in terms of ... [more ▼]

Sociality increases exposure to pathogens. Therefore, social insects have developed a wide range of behavioural defences, known as ‘social immunity’. However, the benefits of these behaviours in terms of colony survival have been scarcely investigated. We tested the survival advantage of prophylaxis, i.e. corpse removal, in ants. Over 50 days, we compared the survival of ants in colonies that were free to remove corpses with those that were restricted in their corpse removal. From Day 8 onwards, the survival of adult workers was significantly higher in colonies that were allowed to remove corpses normally. Overall, larvae survived better than adults, but were slightly affected by the presence of corpses in the nest. When removal was restricted, ants removed as many corpses as they could and moved the remaining corpses away from brood, typically to the nest corners. These results show the importance of nest maintenance and prophylactic behaviour in social insects. [less ▲]

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See detailKeeping track of the EEG's brain dynamics using Kalman filtering
Lehembre, Remy ULg; Noirhomme, Quentin ULg; Macq, B.

in Proceedings of the 3rd International BCI Workshop (2006)

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See detailKein Ey gleicht dem anderen. Rezension zu "Im Bergwerk der Sprache"
Viehöver, Vera ULg

in ReLü: Rezensionszeitschrift zur Literaturübersetzung (2013)

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See detailKein „Liebhaber des Vulkans“. Goethes Italienerfahrung im Spiegel zeitgenössischer Belletristik
Pontzen, Alexandra ULg

in Hirdt, Willi (Ed.) Goethe und Italien. Akten des deutsch-italienischen Colloquiums 7.-9. Oktober 1999 (1999)

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See detailKeine reine Hommage
Pontzen, Alexandra ULg

in Literaturkritik.de (2008)

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See detailKenneth Koch, New Addresses
Delville, Michel ULg

in Verse (2001)

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See detailKeping Tabs on Dioxins
Focant, Jean-François ULg

in The Analytical Scientist (2014), 15

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See detailKepler Detected Gravity-Mode Period Spacings in a Red Giant Star
Beck, P. G.; Bedding, T. R.; Mosser, B. et al

in Science (2011), 332

Stellar interiors are inaccessible through direct observations. For this reason, helioseismologists made use of the Sun’s acoustic oscillation modes to tune models of its structure. The quest to detect ... [more ▼]

Stellar interiors are inaccessible through direct observations. For this reason, helioseismologists made use of the Sun’s acoustic oscillation modes to tune models of its structure. The quest to detect modes that probe the solar core has been ongoing for decades. We report the detection of mixed modes penetrating all the way to the core of an evolved star from 320 days of observations with the Kepler satellite. The period spacings of these mixed modes are directly dependent on the density gradient between the core region and the convective envelope. [less ▲]

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See detailKepler detection of a new extreme planetary system orbiting the subdwarf-B pulsator KIC 10001893
Silvotti, R.; Charpinet, S.; Green, E.M. et al

in Astronomy and Astrophysics (in press)

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See detailKepler observations of the beaming binary KPD 1946+4340
Bloemen, S.; Marsh, T. R.; Ostensen, R. H. et al

in Monthly Notices of the Royal Astronomical Society (2011), 410

The Kepler Mission has acquired 33.5 d of continuous 1-min photometry of KPD 1946+4340, a short-period binary system that consists of a subdwarf B star (sdB) and a white dwarf. In the light curve ... [more ▼]

The Kepler Mission has acquired 33.5 d of continuous 1-min photometry of KPD 1946+4340, a short-period binary system that consists of a subdwarf B star (sdB) and a white dwarf. In the light curve, eclipses are clearly seen, with the deepest occurring when the compact white dwarf crosses the disc of the sdB (0.4 per cent) and the more shallow ones (0.1 per cent) when the sdB eclipses the white dwarf. As expected, the sdB is deformed by the gravitational field of the white dwarf, which produces an ellipsoidal modulation of the light curve. Spectacularly, a very strong Doppler beaming (also known as Doppler boosting) effect is also clearly evident at the 0.1 per cent level. This originates from the sdB's orbital velocity, which we measure to be 164.0 ± 1.9 km s-1 from supporting spectroscopy. We present light-curve models that account for all these effects, as well as gravitational lensing, which decreases the apparent radius of the white dwarf by about 6 per cent, when it eclipses the sdB. We derive system parameters and uncertainties from the light curve using Markov chain Monte Carlo simulations. Adopting a theoretical white dwarf mass-radius relation, the mass of the subdwarf is found to be 0.47 ± 0.03 Msun and the mass of the white dwarf 0.59 ± 0.02 Msun. The effective temperature of the white dwarf is 15 900 ± 300 K. With a spectroscopic effective temperature of Teff= 34 730 ± 250 K and a surface gravity of log g= 5.43 ± 0.04, the subdwarf has most likely exhausted its core helium, and is in a shell He burning stage. The detection of Doppler beaming in Kepler light curves potentially allows one to measure radial velocities without the need of spectroscopic data. For the first time, a photometrically observed Doppler beaming amplitude is compared to a spectroscopically established value. The sdB's radial velocity amplitude derived from the photometry (168 ± 4 km s-1) is in perfect agreement with the spectroscopic value. After subtracting our best model for the orbital effects, we searched the residuals for stellar oscillations but did not find any significant pulsation frequencies. [less ▲]

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See detailKepler observations of the variability in B-type stars
Balona, L. A.; Pigulski, A.; Cat, P De et al

in Monthly Notices of the Royal Astronomical Society (2011), 413

The analysis of the light curves of 48 B-type stars observed by Kepler is presented. Among these are 15 pulsating stars, all of which show low frequencies, characteristic of slowly pulsating B (SPB) stars ... [more ▼]

The analysis of the light curves of 48 B-type stars observed by Kepler is presented. Among these are 15 pulsating stars, all of which show low frequencies, characteristic of slowly pulsating B (SPB) stars. Seven of these stars also show a few weak, isolated high frequencies and they could be considered as SPB/β Cephei (β Cep) hybrids. In all cases, the frequency spectra are quite different from what is seen from ground-based observations. We suggest that this is because most of the low frequencies are modes of high degree which are predicted to be unstable in models of mid-B stars. We find that there are non-pulsating stars within the β Cep and SPB instability strips. Apart from the pulsating stars, we can identify stars with frequency groupings similar to what is seen in Be stars but which are not Be stars. The origin of the groupings is not clear, but may be related to rotation. We find periodic variations in other stars which we attribute to proximity effects in binary systems or possibly rotational modulation. We find no evidence for pulsating stars between the cool edge of the SPB and the hot edge of the δ Sct instability strips. None of the stars shows the broad features which can be attributed to stochastically excited modes as recently proposed. Among our sample of B stars are two chemically peculiar stars, one of which is a HgMn star showing rotational modulation in the light curve. [less ▲]

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See detailKepler observations: Light shed on the hybrid γ Doradus - δ Scuti pulsation phenomenon
Grigahcène, A.; Uytterhoeven, K.; Antoci, V. et al

in Astronomische Nachrichten (2010), 331

Through the observational study of stellar pulsations, the internal structure of stars can be probed and theoretical models can be tested. The main sequence γ Doradus (Dor) and δ Scuti (Sct) stars with ... [more ▼]

Through the observational study of stellar pulsations, the internal structure of stars can be probed and theoretical models can be tested. The main sequence γ Doradus (Dor) and δ Scuti (Sct) stars with masses 1.2-2.5 M[SUB]ȯ[/SUB] are particularly interesting for asteroseismic study. The γ Dor stars pulsate in high-order gravity (g) modes, with pulsational periods of order of one day. The δ Sct stars, on the other hand, show low-order g and pressure (p) modes with periods of order of 2 hours. Theory predicts the existence of `hybrid' stars, i.e. stars pulsating in both types of modes, in an overlap region between the instability strips of γ Dor and δ Sct stars in the Hertzsprung-Russell diagram. Hybrid stars are particularly interesting as the two types of modes probe different regions of the stellar interior and hence provide complementary model constraints. Before the advent of Kepler, only a few hybrid stars had been confirmed. The {{Kepler}} satellite is providing a true revolution in the study of and search for hybrid stars. Analysis of the first 50 days of {{Kepler}} data of hundreds of γ Dor and δ Sct candidates reveals extremely rich frequency spectra, with most stars showing frequencies in both the δ Sct and γ Dor frequency range. As these results show that there are practically no pure δ Sct or γ Dor pulsators, a new observational classification scheme is proposed by \cite{Grig10}. We present their results and characterize 234 stars in terms of δ Sct, γ Dor, δ Sct/γ Dor or γ Dor/δ Sct hybrids. [less ▲]

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