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See detailHypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.
Delmaghani, Sedigheh; Defourny, Jean; Aghaie, Asadollah et al

in Cell (2015), 163(4), 894-906

A deficiency in pejvakin, a protein of unknown function, causes a strikingly heterogeneous form of human deafness. Pejvakin-deficient (Pjvk(-/-)) mice also exhibit variable auditory phenotypes ... [more ▼]

A deficiency in pejvakin, a protein of unknown function, causes a strikingly heterogeneous form of human deafness. Pejvakin-deficient (Pjvk(-/-)) mice also exhibit variable auditory phenotypes. Correlation between their hearing thresholds and the number of pups per cage suggest a possible harmful effect of pup vocalizations. Direct sound or electrical stimulation show that the cochlear sensory hair cells and auditory pathway neurons of Pjvk(-/-) mice and patients are exceptionally vulnerable to sound. Subcellular analysis revealed that pejvakin is associated with peroxisomes and required for their oxidative-stress-induced proliferation. Pjvk(-/-) cochleas display features of marked oxidative stress and impaired antioxidant defenses, and peroxisomes in Pjvk(-/-) hair cells show structural abnormalities after the onset of hearing. Noise exposure rapidly upregulates Pjvk cochlear transcription in wild-type mice and triggers peroxisome proliferation in hair cells and primary auditory neurons. Our results reveal that the antioxidant activity of peroxisomes protects the auditory system against noise-induced damage. [less ▲]

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See detailHyperworld / Hypermonde
Dejasse, Erwin ULg

in Fol, Carine (Ed.) Serge Delaunay (2007)

The article deals with medias, communication and the reiventing of the language into the work of artist Serge Delaunay.

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See detailHypnoanesthesia for endocrine cervical surgery: a statement of practice.
Defechereux, Thierry ULg; Meurisse, Michel ULg; Hamoir, Etienne ULg et al

in Journal of Alternative & Complementary Medicine : Research on Paradigm, Practice, & Policy (1999), 5(6), 509-20

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and ... [more ▼]

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and June 1997, 197 thyroidectomies and 21 cervical explorations for hyperparathyroidism were performed under hypnoanesthesia (HYP) using Erikson's method. Operative data and postoperative course of this initial series were compared to a contemporary population of patients (n = 119) clinically similar except that they declined HYP or were judged unsuitable for it, and who were therefore operated on under general anesthesia (GA). RESULTS: The surgeons all reported better operating conditions for cervicotomy using HYP. Conversion from hypnosis to GA was needed in two cases (1%). All patients having HYP reported a pleasant experience and, keeping in mind that the GA group is not a randomly assigned control group, both had significantly less postoperative pain and analgesic use. Hospital stay was also significantly shorter, providing a substantial reduction in the costs of medical care. The postoperative convalescence was significantly improved after HYP and a full return to social or professional activity was significantly quicker. CONCLUSION: From this study, we conclude that HYP is an effective technique for providing relief of intraoperative and postoperative pain in endocrine cervical surgery. The technique results in high patient satisfaction and better surgical convalescence. This technique can therefore be used in most well-chosen patients and reduces the socioeconomic impact of hospitalization. [less ▲]

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See detailL'hypnose dans la prise en charge des douleurs chroniques
Zelinka, V.; Faymonville, Marie-Elisabeth ULg; Pitchot, William ULg et al

in Acta Psychiatrica Belgica (2009), 109(3), 21-28

OUR REVIEW OF THE LITERATURE SUGGESTSTHAT HYPNOSIS IS AN USEFUL OPTION lN THE MANAGEMENT OF CHRONIC PAIN.THE EXPLANATIONS FOR ITS EFFECTIVENESS RELIE MAINLY ON THE FINDINGS OF FUNCTIONAL NEUROIMAGING ... [more ▼]

OUR REVIEW OF THE LITERATURE SUGGESTSTHAT HYPNOSIS IS AN USEFUL OPTION lN THE MANAGEMENT OF CHRONIC PAIN.THE EXPLANATIONS FOR ITS EFFECTIVENESS RELIE MAINLY ON THE FINDINGS OF FUNCTIONAL NEUROIMAGING, CLINICAL STUDIES AND EMPIRICAL OBSERVATIONS. THESE DATA SHOWTHAT THROUGH THE DIVERSITY OF ITS EFFECTS, HYPNOSIS CAN MODULATE THE BIO-PSYCHO-SOCIAL DIMENSIONS OF CHRONIC PAIN. THE CHOICE OF THIS THERAPEUTIC TECHNIQUE SHOULD BE GUIDED BY THE ESTIMATE OF ITS USEFULNESS. THE EFFICACY IS ASSESSED ON AN INDIVIDUAL BASIS, TAKING INTO ACCOUNT THE BENEFITS AND LIMITATIONS OF HYPNOSIS FOR EACH PATIENT. [less ▲]

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See detailHypnose et conscience
FAYMONVILLE, Marie-Elisabeth ULg

in Douleur et Analgésie (2008), 21(1), 3-6

Hypnotic-like behavior has been reported from the dawn of history. The early origins are shrouded in mystery and magic; but Franz Anton Mesmer, an Austrian physician, conducted his therapeutic sessions ... [more ▼]

Hypnotic-like behavior has been reported from the dawn of history. The early origins are shrouded in mystery and magic; but Franz Anton Mesmer, an Austrian physician, conducted his therapeutic sessions under the name of ‘‘animal magnestism’’. He proposed a theory that the ‘‘magnetic’’ influence could be transfered by iron bars. However a committee of leading scientists of the day showed that the ‘‘magnetic’’ influence could be transfered as well by wooden rods as by iron bars and that influence upon the patient was a result of imagination. Mesmer was obviously wrong in his theory, but he was the first attempting to use modern physical science to replace some of the superstition of his day. This in turn became opposition between supporters of physiological theories and those of psychological theories. Salpetriere, with Charcot, saw a pathological state in hypnosis, an artificial hysterical neurosis. On the other hand, the Nancy school of thought, represented by Bernheim, Liebault and Liegeois, suggested that it was a normal psychological phenomenon. The fight between the two schools was very bitter. Other theories initially inspired by the Pavlov school of thought came to light; these were replaced by those inspired by experimental psychology and a third psychoanalytic theory became predominant. A description of the hypnotic state revealed the reality and non-reality of the hypnotic state. This was the outcome of functional neuro-imaging techniques that are currently revolutionising our knowledge of cerebral functioning and research in the area of cognitive neuroscience allows questions about consciousness and its neurobiological substrate to be asked. Research into hypnosis requires a distinction to be made between ‘‘the state of consciousness’’ and ‘‘conscious content’’. Various functional neuro-imaging studies are reported investigating the area of ‘‘neurophenomenology’’ in the hypnotic process. [less ▲]

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See detailHypnose et douleur : le paradoxe. Du pouvoir de l'hypnothérapeute au contrôle du patient
Nyssen, Anne-Sophie ULg

in Douleur et Analgésie (2008), 21

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See detailHypnose et perception de la douleur
Vanhaudenhuyse, Audrey ULg; Boveroux, Pierre ULg; Boly, Mélanie ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 424-8

Improvement in functional neuroimaging allows researchers to disentangle the brain mechanisms involved in the pain modulation encountered during hypnosis. It has been shown that the anterior cingulate and ... [more ▼]

Improvement in functional neuroimaging allows researchers to disentangle the brain mechanisms involved in the pain modulation encountered during hypnosis. It has been shown that the anterior cingulate and prefrontal cortices are important in the modulation of incoming sensory and noxious input. Moreover, clinical studies in certain types of surgery (eg thyroidectomy, mastectomy and plastic surgery) have demonstrated that hypnosis may avoid general anesthesia. [less ▲]

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See detailL'hypnose et son application en chirurgie.
Faymonville, Marie ULg; Defechereux, Thierry ULg; Joris, Jean ULg et al

in Revue Médicale de Liège (1998), 53(7), 414-8

Since 1992, we have used hypnosis routinely in more than 1400 patients undergoing surgery. We found that hypnosis used in patients as an adjunct to conscious sedation and local anesthesia was associated ... [more ▼]

Since 1992, we have used hypnosis routinely in more than 1400 patients undergoing surgery. We found that hypnosis used in patients as an adjunct to conscious sedation and local anesthesia was associated with improved intraoperative patient comfort, and with reduced anxiety, pain, intraoperative requirements for anxiolytic and analgesic drugs, optimal surgical conditions and a faster recovery of the patient. We reported our clinical experience and our fundamental research. [less ▲]

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See detailHypnose et Stress : "La communication hypnotique comme outil d'amélioration de la qualité des soins et du bien être au travail ?"
Nyssen, Anne-Sophie ULg

Conference (2015, August 27)

Hypnose et Stress : "La communication hypnotique comme outil d'amélioration de la qualité des soins et du bien être au travail ?" La communication fait partie intégrante de la relation de soin. Mais ... [more ▼]

Hypnose et Stress : "La communication hypnotique comme outil d'amélioration de la qualité des soins et du bien être au travail ?" La communication fait partie intégrante de la relation de soin. Mais, quelle attention portons-nous aux mots que nous utilisons au quotidien dans nos interactions ? On estime que 70 à 80% des plaintes et des poursuites en matière médicale sont liés à des problèmes de communication : manque d’attention du personnel pressé, jargon incompréhensible, manque de collaboration,... Ces difficultés de communication manifestent leurs conséquences à la fois chez les patients et chez le personnel soignant, qui ne sort pas indemne des difficultés relationnelles. Ces dernières années, il n’y a pas un mois sans qu’une nouvelle étude parle de stress et de burnout chez le personnel soignant. Dans cet exposé, nous présenterons l’évolution du concept du stress, sa relation à la perception de contrôle et nous inviterons les soignants que nous sommes à observer un regard critique sur nos échanges verbaux. Nous montrerons comment les mots que nous utilisons au quotidien peuvent être porteurs de suggestions négatives et avoir un « effet nocebo » et comment l’apprentissage de l’hypnose constitue un outil puissant permettant d’améliorer à la fois la qualité des soins et le bien être au travail. [less ▲]

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See detailHypnose in der Anästhesie
FAYMONVILLE, Marie-Elisabeth ULg

in Ebell, Hansjörg; Hansen, Ernil (Eds.) Medizin und Hypnose (2010)

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See detailHypnose, hypnosédation. Conceptions actuelles et leurs applications en chirurgie plastique
Faymonville, Marie-Elisabeth ULg; Fissette, Jean ULg; Mambourg, P. H. et al

in Revue Médicale de Liège (1994), 49(1), 13-22

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See detailL'hypnosedation, un nouveau mode d'anesthesie pour la chirurgie endocrinienne cervicale. Etude prospective randomisee.
Defechereux, Thierry ULg; Degauque, C.; Fumal, I. et al

in Annales de Chirurgie (2000), 125(6), 539-46

Retrospective studies have confirmed the feasibility and safety of thyroid and parathyroid procedures performed under hypnoanesthesia (hypnosis, local anesthesia and minimal conscious sedation) as sole ... [more ▼]

Retrospective studies have confirmed the feasibility and safety of thyroid and parathyroid procedures performed under hypnoanesthesia (hypnosis, local anesthesia and minimal conscious sedation) as sole method of anesthesia. This very effective technique seems to provide physiological, psychological and economic benefits for the patient. STUDY AIM: To assess, by means of a prospective randomized study, the advantages of hypnosedation as an alternative to general anesthesia in terms of clinical and laboratory parameters. PATIENTS AND METHODS: Twenty patients operated under hypnoanesthesia were compared to 20 patients operated under conventional anesthesia. The two groups were compared in terms of inflammatory, neuroendocrine, hemodynamic and immunologic parameters and postoperative course (pain, fatigue, muscle strength and stress). RESULTS: No clinical or demographic differences were observed between the two groups. Operative times, bleeding, weight of specimens, and surgical comfort were similar. Significant differences in terms of inflammatory response and hemodynamic parameters were observed in favor of hypnoanesthesia. Neuroendocrine and immunological parameters were similar. Patients of the hypnoanesthesia group had significantly less postoperative pain. Postoperative fatigue syndrome and convalescence were significantly improved in these patients. CONCLUSION: This study confirms that, in our hands, hypnosedation presents real advantages over general anesthesia, in patients undergoing thyroid surgery. [less ▲]

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See detailHypnosedation: a valuable alternative to traditional anaesthetic techniques.
Faymonville, Marie-Elisabeth ULg; Meurisse, Michel ULg; Fissette, Jean ULg

in Acta Chirurgica Belgica (1999), 99(4), 141-6

Hypnosis has become routine practice in our plastic and endocrine surgery services. Revivication of pleasant life experiences has served as the hypnotic substratum in a series of over 1650 patients since ... [more ▼]

Hypnosis has become routine practice in our plastic and endocrine surgery services. Revivication of pleasant life experiences has served as the hypnotic substratum in a series of over 1650 patients since 1992. In retrospective studies, followed by randomised prospective studies, we have confirmed the usefulness of hypnosedation (hypnosis in combination with conscious IV sedation) and local anaesthesia as a valuable alternative to traditional anaesthetic techniques. The credibility of hypnotic techniques and their acceptance by the scientific community will depend on independently-confirmed and reproducible criteria of assessing the hypnotic state. Based on the clinical success of this technique, we were interested in confirming this phenomenon in healthy volunteers. The revivication of pleasant life experiences thus served as the cornerstone of a basic research program developed to objectify the neurophysiological attributes of the hypnotic state. We compared hypnosis to normal alertness with similar thought content. In our experience, the activation profile obtained during the hypnotic state was completely different from simple re-memoration of the same subject matter during normal alertness. This represents an objective and independent criteria by which to assess the hypnotic state. [less ▲]

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See detailHypnosédation: une nouvelle technique anesthésique
Kirsch, Murielle ULg; Joris, Jean ULg; Faymonville, Marie ULg

in Hypnose et Thérapies brèves (2006), 2

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See detailL'hypnosédation: une technique nouvelle d'anesthésie en chirurgie endocrine cervicale
Defechereux, Thierry ULg; Meurisse, Michel ULg; Joris, Jean ULg et al

in Michaux, Didier (Ed.) Douleur et Hypnose. Deuxième partie: Le traitement des douleurs organiques et psychogènes (2004)

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See detailHypnosis and cingulate-mediated mechanisms of analgesia
FAYMONVILLE, Marie-Elisabeth ULg; Vogt, Brent; Maquet, Pierre ULg et al

in Vogt, Brent (Ed.) Cingulate Neurobiology and Disease (2009)

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See detailHypnosis as adjunct therapy in conscious sedation for plastic surgery
Faymonville, Marie ULg; Fissette, Jean ULg; Mambourg, P.-H. et al

in Regional Anesthesia (1995), 20(2), 145-151

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See detailHypnosis for pain management
MALAISE, Nicole ULg; SALAMUN, Irène ULg; PALMARICCIOTTI, Valérie ULg et al

in Fernandez de las Penas, César; Chaitow, Léon; Schoenen, Jean (Eds.) Multidisciplinary management of migraine : pharmacological, manual and other therapies (2012)

The purposes of this chapter are : - to provide a brief definition of hypnosis, hypnotic process and self-hypnosis. - to describe briefly the neurophysiological correlates of hypnosis and hypnotic ... [more ▼]

The purposes of this chapter are : - to provide a brief definition of hypnosis, hypnotic process and self-hypnosis. - to describe briefly the neurophysiological correlates of hypnosis and hypnotic analgesia. - to propose a short review of recent literature concerning the effectiveness of clinical hypnosis in chronic pain, emphasizing more specifically research on the effectiveness of hypnosis with migraine. - to address some questions about its daily clinical use. [less ▲]

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