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See detailInteraction médicamenteuse : de la théorie à l'ordonnance
Krzesinski, Jean-Marie ULg

Learning material (2006)

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See detailInteraction network of antimicrobial peptides of Arabidopsis thaliana, based on hith-throughput yeast two-hybrid screening
Damon, Coralie ULg; Dmitrieva, Joelia Borisnova; Muhovski, Yordan et al

in Plant Physiology & Biochemistry (2012)

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See detailInteraction of 6,6-bis(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-1,2,4-benzotriazin-3-yl)-2,2:6,2-terpyridine (CyMe4-BTTP) with some trivalent ions such as lanthanide(III) ions and americium(III)
Lewis, Frank; Harwood, Laurance; Hudson, Michael J. et al

in Dalton Transactions (2010), 39

The new solvent extraction reagent 6,6’’-bis(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-1,2,4-benzotriazin-3-yl)-2,2’:6’,2’’-terpyridine (CyMe4-BTTP) has been synthesized in 4 steps from 2,2’:6’,2’’ ... [more ▼]

The new solvent extraction reagent 6,6’’-bis(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-1,2,4-benzotriazin-3-yl)-2,2’:6’,2’’-terpyridine (CyMe4-BTTP) has been synthesized in 4 steps from 2,2’:6’,2’’-terpyridine. Detailed NMR and mass spectrometry studies indicate that the ligand forms 1:2 complexes with lanthanide(III) perchlorates where the aliphatic rings are conformationally constrained whereas 1:1 complexes are formed with lanthanide(III) nitrates where the rings are conformationally mobile. An optimized structure of the 1:2 solution complex with Yb(III) was obtained from the relative magnitude of the induced paramagnetic shifts. X-ray crystallographic structures of the ligand and of its 1:1 complex with Y(III) were also obtained. The NMR and mass spectra of [Pd(CyMe4-BTTP)]n2n+ are consistent with a dinuclear double helical structure (n = 2). In the absence of a phase-modifier, CyMe4-BTTP in 1-octanol showed a maximum distribution coefficient of Am(III) of 0.039 (±20%) and a maximum separation factor of Am(III) over Eu(III) of 12.0 from nitric acid. From nitric acid, the metal(III) cations are extracted as the 1:1 complex. The generally low distribution coefficients observed compared with the BTBPs arise because the 1:1 complex of CyMe4-BTTP is considerably less hydrophobic than the 1:2 complexes formed by the BTBPs. In M(BTTP)3+ complexes, there is a competition between the nitrate ions and the ligand for the complexation of the metal. [less ▲]

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See detailInteraction of a slot-tone with a pipe
Billon, Alexis ULg; Valeau, Vincent; Sakout, Anas

in Journal of the Acoustical Society of America (2002, November), 111(5), 2373-2373

The self-sustained tone generated by a low Mach number free flow impinging on a slotted plate, usually referred to slot-tone, is experimentaly studied. In this work we focus on its coupling with the pipe ... [more ▼]

The self-sustained tone generated by a low Mach number free flow impinging on a slotted plate, usually referred to slot-tone, is experimentaly studied. In this work we focus on its coupling with the pipe from which the jet flows out. The jet nozzle and the beveled slot are aligned and have the same large aspect ratio. The tones generated have a single well defined frequency (around 1 kHz), a high amplitude (typically, 105 to 115 dB) and exhibit typical characteristics of self-sustained tones. Their frequencies are about the same order of magnitude than the natural frequency of the shear layer calculated from the linear stability theory. For some Reynolds numbers and some plate distances, a standing wave pattern is observed in the pipe. The outer and inner acoustic fields show high coherence and the slot-tone locks on a pipe eigenmode, which indicates an acoustic feedback. However, especially for lower Reynolds numbers, this coherence vanishes but the self-sustained tones are still present. It suggests that the hydrodynamic feedback becomes preponderant. [less ▲]

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See detailInteraction of an odorant lactone with model phospholipid bilayers and its strong fluidizing action in yeast membrane.
Aguedo, Mario ULg; Beney, Laurent; Wache, Yves et al

in International journal of food microbiology (2002), 80(3), 211-5

Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological ... [more ▼]

Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological processes. Gamma-decalactone was previously shown to have antimicrobial properties. We determined by infrared spectroscopy measurements that this compound rapidly diffused into model phospholipid bilayers (within 2 min), modifying the general physical state of a dimyristoyl-L-alpha-phosphatidylcholine (DMPC) film. In vivo, the lactone strongly increased membrane fluidity in the model yeast Yarrowia lipolytica, as evaluated by fluorescence anisotropy measurements. This effect was more important than that of benzyl alcohol, which is known as a fluidizing agent in living cells, and may explain the toxic action of gamma-decalactone in microorganisms. [less ▲]

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See detailInteraction of androgens and estrogens in the control of sexual behavior in male Japanese quail.
Balthazart, Jacques ULg; Schumacher, M.; Malacarne, G.

in Physiology & Behavior (1985), 35(2), 157-66

A series of 4 experiments was performed to study the relative contribution of androgens and estrogens in the activation of sexual behavior in castrated male quail. The synthetic androgen methyltrienolone ... [more ▼]

A series of 4 experiments was performed to study the relative contribution of androgens and estrogens in the activation of sexual behavior in castrated male quail. The synthetic androgen methyltrienolone (R 1881) which is not metabolized in androgen target tissues activated sexual behavior in castrated birds and at the dose level of 0.5-1 mg/day/animal had the same potency as testosterone (T). However R 1881 was much more active than T in the induction of cloacal gland growth and activation of crowing, two typically androgen-dependent responses. This suggests that sexual behavior is not controlled by exactly the same mechanism as crowing or cloacal gland growth. In another experiment, estradiol (E2) alone activated sexual behavior but it is only at very high doses which had clear toxic effects that a significant behavioral activation could be observed. This questions the role of E2 as the physiological agent stimulating copulation in intact birds unless it is assumed that centrally administered E2 would be much more active compared to peripheral E2 which is exposed to a very intense peripheral catabolism. In the last two experiments, a clear synergism could be detected between 5 alpha-dihydrotestosterone (5 alpha-DHT) and E2 in the activation of sexual activity and doses of hormones could be defined which had almost no activity by themselves but significantly stimulated sexual behavior when given simultaneously. It was however impossible to define a hormonal treatment with T metabolites which restored behavior to its precastration level, a result very easily achieved with T treatments. Taken together, these data suggest that activation of sexual behavior in quail does not depend only on E2, nor 5 alpha-DHT nor even on their combined action. Considering that specific T receptors which probably do not bind 5 alpha-DHT are present in the brain, it would seem justified to reconsider the possible role played by T itself in the activation of behavior. [less ▲]

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See detailInteraction of antimicrobial lipopeptides from Bacillus subtilis with lipid membranes
Deleu, Magali ULg; Paquot, Michel ULg; Olofsson, Gerd et al

Poster (2004)

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See detailInteraction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium
Henry, X.; Amoroso, Ana Maria ULg; Coyette, Jacques ULg et al

in Antimicrobial Agents and Chemotherapy (2010), 54

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See detailInteraction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study
Dilly, Sébastien ULg; Liégeois, Jean-François ULg

in Journal of Computer-Aided Molecular Design (2011), 25(2), 163-169

The interaction of diazepine analogues like clozapine or olanzapine with D2 receptor was greatly affected by a mixture of HRP/H2O2 known to induce the formation of nitrenium ion. Unlike diazepine ... [more ▼]

The interaction of diazepine analogues like clozapine or olanzapine with D2 receptor was greatly affected by a mixture of HRP/H2O2 known to induce the formation of nitrenium ion. Unlike diazepine derivatives, the oxidative mixture had low impact on the affinity of oxa- and thiazepine derivatives such as loxapine, clothiapine or JL13 for the D2 receptor. Molecular docking simulations revealed a huge difference between the mode of interaction of clozapine nitrenium ion and the parent drug. Electronic and geometric changes of the tricyclic ring system caused by the oxidation appeared to prevent the compound finding the correct binding mode and could therefore explain the difference observed in binding affinities. [less ▲]

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See detailInteraction of Defined Benefit Pension Plans and Social Security
Possen, Uri M.; Pestieau, Pierre ULg

in Pensions : An International Journal (2008)

This paper explores the shift from defi ned benefi t to defi ned contribution pension plans when the payout rate from social security is set optimally. This paper shows that when employees are receiving ... [more ▼]

This paper explores the shift from defi ned benefi t to defi ned contribution pension plans when the payout rate from social security is set optimally. This paper shows that when employees are receiving more of their private pensions from defi ned contribution plans one should be raising the payout rate from traditional social security rather than trying to privatise part of it. [less ▲]

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See detailInteraction of fengycin with stratum corneum mimicking model membranes: a calorimetry study
Nasir, Mehmet Nail ULg; Eeman, Marc; Olofsson, Gerd et al

in European Biophysics Journal [=EBJ] (2013), 42(S1), 168

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See detailInteraction of fengycin with stratum corneum mimicking model membranes: a calorimetry study
Eeman, Marc; Oloffson, Gerd; Sparr, Emma et al

in Colloids and Surfaces B : Biointerfaces (2014), In Press

Based on its outstanding antifungal properties, it is reasonable to believe that fengycin might be efficient to topically treat localized dermatomycoses. Since most of the fungi species involved in the ... [more ▼]

Based on its outstanding antifungal properties, it is reasonable to believe that fengycin might be efficient to topically treat localized dermatomycoses. Since most of the fungi species involved in the formation of those mycotic skin diseases colonize primarily the stratum corneum (SC), studying the interaction between fengycin and SC-mimicking lipid membranes is a primary step to determine the potential of fengycin to overcome the physical barrier of the skin. In this respect, multilamellar lipid vesicles (MLVs), with a lipid composition mimicking that of the SC, were prepared and characterized by differential scanning calorimetry (DSC). The critical micelle concentration (CMC) of fengycin was also assessed under skin conditions and found to be 1.2 ± 0.1 μM. The molecular interactions of fengycin with SC-mimicking MLVs were investigated by both DSC and isothermal titration calorimetry (ITC). Results showed that the interactions were considerably affected by changes in lipid phase behaviour. At 40 °C and below, fengycin induced exothermic changes in the lipid structures suggesting that less-ordered lipid domains became more-ordered in presence of fengycin. At 60 °C, clearly endothermic interaction enthalpies were observed, which could arise from the “melting” of remaining solid domains enriched in high melting lipids that without fengycin melt at higher temperatures. [less ▲]

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See detailInteraction of global and local buckling in welded RHS compression members
Degée, Hervé ULg; Detzel, Annette; Kuhlmann, Ulrike

in Journal Of Constructional Steel Research (2008), 64(7-8), 755-765

This paper presents the results of a research project analysing some aspects of the stability failure of thin-walled compression members that are likely to exhibit combined global and local buckling. In ... [more ▼]

This paper presents the results of a research project analysing some aspects of the stability failure of thin-walled compression members that are likely to exhibit combined global and local buckling. In particular, the influence of various imperfections, namely residual stresses due to welding and local as well as global geometrical defects, on the load-carrying capacity was Subjected to detailed experimental and numerical investigations. The insights obtained into the structural behaviour led to a proposal for modification of the non-dimensional slenderness used in the global buckling verification, and to the recommendation of a shift from the Currently applied European buckling curve to a more favourable one in the case of non-stiffened members with welded box sections subjected to pure compression. (C) 2008 Elsevier Ltd. All rights reserved. [less ▲]

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See detailInteraction of global and local buckling of compression members with welded box cross section
Kuhlmann, U.; Degée, Hervé ULg; Detzel, A.

in Camotim, D. (Ed.) Proceedings of the SDSS Conference (STABILITY AND DUCTILITY OF STEEL STRUCTURES) (2006)

This paper summarises a research project that analysed aspects of stability failure of thin-walled compression members that are likely to exhibit combined global and local buckling. In particular the ... [more ▼]

This paper summarises a research project that analysed aspects of stability failure of thin-walled compression members that are likely to exhibit combined global and local buckling. In particular the influence of various imperfections on the load-carrying capacity, namely welding residual stresses and local as well as global geometrical defects was subject of detailed experimental and numerical investigations. The insight into the structural behaviour has led in the case of thin-walled box sections to a proposal for a modification of the non-dimensional slenderness value used in the buckling verification and to the recommendation of a shift of the applied European buckling curve to a more favourable one. [less ▲]

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See detailInteraction of Hexadecylbetainate Chloride with Biological Relevant Lipids
Nsimba Zakanda, Francis; Lins, Laurence ULg; Nott, Katherine ULg et al

in Langmuir (2012), 28(7), 3524-3533

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See detailInteraction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program
Barez, Pierre-Yves ULg; Willems, Luc ULg

Poster (2012, June 22)

First human retrovirus discovered, HTLV-1 infects approximately twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most important are the adult T ... [more ▼]

First human retrovirus discovered, HTLV-1 infects approximately twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most important are the adult T-cell leukemia (ATL) and a neurodegenerative disorder called HAM/TSP (Human associated myelopathy/ Tropical spastic paraparesis). We are interested in the mechanisms of transformation by the viral Tax oncoprotein. Recently, we showed that Tax interacts with the minichromosome maintenance MCM2-7 helicase and binds to origins of DNA replication (Boxus et al, 2012 Blood 119:151). Thereby, Tax modulates the spatiotemporal program of origin activation during the S phase of cell cycle. In fact, Tax accelerates S phase progression by inducing early firing of late replication origins. Concomitantly, Tax-MCM2-7 interplay also modulates viral transcription. Together, our data demonstrates that interaction between Tax and MCM2-7 is involved in replication reprogramming and viral transcription. [less ▲]

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