[131I]iodotropapride: a cerebral dopamine D2 receptor ligand.

Poster (1990, August 26)

13C NMR des alcaloïdes des Strychnos: les dérivés de l'harmane et de l'usambarensine

in Phytochemistry (1980), 19

13C NMR spectra of some tertiary and quaternary alkaloids are recorded and the signals assigned. Graphic interpretation of off-resonance spectra and substituent shielding effects together with the effect ... [more ▼]

13C NMR spectra of some tertiary and quaternary alkaloids are recorded and the signals assigned. Graphic interpretation of off-resonance spectra and substituent shielding effects together with the effect of Nb-methylation are utilized in the spectral interpretations. [less ▲]

13e Festival Images sonores : musique électronique live

Article for general public (2011)

Du 15 au 17 décembre 2011 se tiendra le 13e festival de musique électronique live et musique mixte Images Sonores. 3 soirées dans la salle du Théâtre Universitaire Royal de Liège pour découvrir des pièces ... [more ▼]

Du 15 au 17 décembre 2011 se tiendra le 13e festival de musique électronique live et musique mixte Images Sonores. 3 soirées dans la salle du Théâtre Universitaire Royal de Liège pour découvrir des pièces hors normes et rencontrer de jeunes talents. [less ▲]

13ième activité du CDS - Evaluation formative

Report (2007)

14 steps to writing clearly

in Acta Chirurgica Belgica (2009), 109

14ième activité du CDS -Prérequis

Report (2008)

The 14th International Conference on Human Retrovirology: HTLV and related retroviruses (July 1-4, 2009; Salvador, Brazil).

in Retrovirology (2009), 6

The "14th International Conference on Human Retrovirology: HTLV and Related Retroviruses" was held in Salvador, Bahia, from July 1st to July 4th 2009. The aim of this biennial meeting is to promote ... [more ▼]

The "14th International Conference on Human Retrovirology: HTLV and Related Retroviruses" was held in Salvador, Bahia, from July 1st to July 4th 2009. The aim of this biennial meeting is to promote discussion and share new findings between researchers and clinicians for the benefit of patients infected by human T-lymphotropic virus (HTLV). HTLV infects approximately 15-20 million individuals worldwide and causes a broad spectrum of diseases including neurodegeneration and leukemia. The scientific program included a breadth of HTLV research topics: epidemiology, host immune response, basic mechanisms of protein function, virology, pathogenesis, clinical aspects and treatment. Exciting new findings were presented in these different fields, and the new advances have led to novel clinical trials. Here, highlights from this conference are summarized. [less ▲]

15-deoxy-delta12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts

in Journal of Biological Chemistry (2004), 279(21), 399-403

We have previously shown that nuclear factor-kappaB inhibition by adenovirus expressing mutated IkappaB-alpha or by proteasome inhibitor increases human articular chondrocytes sensibility to apoptosis ... [more ▼]

We have previously shown that nuclear factor-kappaB inhibition by adenovirus expressing mutated IkappaB-alpha or by proteasome inhibitor increases human articular chondrocytes sensibility to apoptosis. Moreover, the nuclear factor-kappaB inhibitor BAY11-7085, a potent anti-inflammatory drug in rat adjuvant arthritis, is itself a proapoptotic agent for chondrocytes. In this work, we show that BAY 11-7085 but not the proteasome inhibitor MG-132 induced a rapid and sustained phosphorylation of extracellular signal-regulated kinases (ERK1/2) in human articular chondrocytes. The level of ERK1/2 phosphorylation correlated with BAY 11-7085 concentration and chondrocyte apoptosis. 15-Deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2) and its precursor prostaglandin (PG) D2 but not PGE2 and PGF2alpha rescued chondrocytes from BAY 11-7085-induced apoptosis. 15d-PGJ2 markedly inhibited BAY 11-7085-induced phosphorylation of ERK1/2. BAY 11-7085 also induced ERK1/2 phosphorylation and apoptosis in human synovial fibroblasts, and these reactions were down-regulated by 15d-PGJ2. Further analysis in synovial fibroblasts showed that only molecules that suppressed BAY 11-7085-induced phosphorylation of ERK1/2 (i.e. 15d-PGJ2, PGD2, and to a lesser extent, MEK1/2 inhibitor UO126, but not prostaglandins E2 and F2alpha or peroxisome proliferator-activated receptor-gamma agonist ciglitazone) were able protect cells from apoptosis. These results suggested that the antiapoptotic effect of 15d-PGJ2 on chondrocytes and synovial fibroblasts might involve inhibition of ERK1/2 phosphorylation. [less ▲]

15th Benelux Congress of Zoology abstract book

Book published by Editions de l'université de Liège (2008)

The 16 kDa N-terminal fragment of the human prolactin. Design and production of minimal peptides retaining antiangiogenic and antitumoral properties

Poster (2004)