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See detailIn vitro and in vivo modulation of neurotransmitter phenotype in adult dorsal root ganglion neurons.
Schoenen, Jean ULg; Delrée, P.; Jammaer, R. et al

Conference (1990, June 16)

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See detailIn vitro and in vivo modulation of neurotransmitter phenotype in adult DRG neuron.
Schoenen, Jean ULg; Delrée, P.; Martin, Didier ULg et al

Conference (1990)

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See detailIn vitro and in vivo modulation of neurotransmitter phenotype in adult rat DRG neurons
Schoenen, Jean ULg; Delrée, P.; Martin, Didier ULg et al

in Rapport annuel de la Fondation Médicale Reine Elisabeth (1990)

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See detailIn vitro and in vivo modulation of transmitter phenotype in adult rat DRG neurons.
Moonen, Gustave ULg; Schoenen, Jean ULg; Delrée, P. et al

Conference (1991, August 11)

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See detailIn Vitro And In Vivo Oncogenic Potential Of Bovine Leukemia Virus G4 Protein
Kerkhofs, P.; Heremans, H.; Burny, A. et al

in Journal of Virology (1998), 72(3),

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See detailIn vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea]
Hanson, Julien ULg; Rolin, Stéphanie; Reynaud, Denis et al

in Journal of Pharmacology and Experimental Therapeutics (The) (2005), 313

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See detailThe in vitro and in vivo production of a 31.5-kD keratinolytic subtilase from Microsporum canis and the clinical status in naturally infected cats.
Mignon, Bernard ULg; Nikkels, Arjen ULg; Pierard, Gérald ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1998), 196(4), 438-441

BACKGROUND: Microsporum-canis-infected cats, especially the asymptomatic infected ones, are mainly responsible for the zoonotic disease. The important variability of the clinical signs in cats is poorly ... [more ▼]

BACKGROUND: Microsporum-canis-infected cats, especially the asymptomatic infected ones, are mainly responsible for the zoonotic disease. The important variability of the clinical signs in cats is poorly understood. Recently, a 31.5-kD keratinolytic subtilase was found to be a putative virulence factor. OBJECTIVE: To investigate the possible relationship between the clinical status of dermatophytic cats and the production of the keratinase. METHODS: Seven M. canis strains isolated either from clinically affected, asymptomatic infected or mechanical carrier cats were tested for the in vitro production of the enzyme. The immunohistochemical detection of the enzyme was also assessed in skin biopsies of 4 symptomatic and 7 asymptomatic naturally infected cats. RESULTS: All the strains produced in vitro a 31.5-kD keratinolytic subtilase. The enzyme was present in all but 1 of the infected cats. CONCLUSION: The production of the keratinase is not a factor directly responsible for the clinical picture seen in M.-canis-infected cats. [less ▲]

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See detailIn Vitro and in Vivo Stimulation of the Murine Immune System by Agm-1470, a Potent Angiogenesis Inhibitor
Antoine, Nadine ULg; Daukandt, M.; Heinen, Ernst ULg et al

in American Journal of Pathology (1996), 148(2), 393-8

AGM-1470, a potent angiogenesis inhibitor, is already engaged in phase I clinical trials because of its effectiveness to restrain tumor growth and its lack of major side effects. Recently, we showed that ... [more ▼]

AGM-1470, a potent angiogenesis inhibitor, is already engaged in phase I clinical trials because of its effectiveness to restrain tumor growth and its lack of major side effects. Recently, we showed that AGM-1470 stimulates in vitro human B lymphocyte proliferation through T lymphocytes. These data prompted us to explore the in vivo effects of AGM-1470 on the immune system in a mouse model. In this study, we showed that AGM-1470, in synergy with phytohemagglutinin, stimulates the proliferation of murine lymphocytes isolated from lymph nodes. This effect was similar to the one observed with human lymphocytes. When injected subcutaneously or intraperitoneally into mice at pharmacological doses, AGM-1470 induced a significant increase of axillary and mesenteric lymph nodes, respectively. Histological and morphological analyses showed that this phenomenon is mostly due to a hyperplasia of the germinal centers. On average, the area of the germinal center of lymph nodes from AGM-1470-treated mice were three times larger than in lymph nodes from control mice. Interestingly, no effect was observed when AGM-1470 was injected subcutaneously into T-deficient nude mice. Our data demonstrate that AGM-1470 stimulates B cell proliferation in vivo as suggested by the in vitro experiments. This effect should be taken into account in the follow-up of patients treated with this molecule and calls for additional studies to determine the biological consequences of such a stimulation on the host immune system. [less ▲]

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See detailIn vitro and in vivo studies on sodium nimesulide-b-cyclodextrin inclusion complexes
Piel, Géraldine ULg; Delneuville, Isabelle; Delattre, Luc ULg

Poster (1996, April)

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See detailIn vitro antagonism of two potential biopesticides Bacillus subtilis and Pseudomonas fluorescens : biochemical aspects.
Jacques, Philippe ULg; Hbid, Ch.; Ongena, Marc ULg et al

in Proceedings "Biological control of fruit and foliar diseases" (1993, September)

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See detailIn vitro antagonistic activity evaluation of Lactic Acid Bacteria (LAB) combined with cellulase enzyme against Campylobacter jejuni growth in co-culture
Dubois Dauphin, Robin ULg; vandeplas, Sabrina; Didderen, Isabelle et al

in Journal of Microbiology and Biotechnology (2011), 21(1), 62-70

The antibacterial effects of nine Lactic Acid Bacteria (LAB) on Campylobacter jejuni were investigated using agar gel diffusion and co-culture assay. Inhibition potential was not the same between both ... [more ▼]

The antibacterial effects of nine Lactic Acid Bacteria (LAB) on Campylobacter jejuni were investigated using agar gel diffusion and co-culture assay. Inhibition potential was not the same between both techniques. Only two LAB, Lb. pentosus CWBI B78 and E. faecium THT, showed an anti-campylobacter activity in co-culture assay in using dehydrated poultry excreta mixed with ground straw (DPE/GS) as the only growth substrate source. It was observed that the complementation with Cellulase A complex (Beldem S.A.) of this medium enhanced antimicrobial effect of both bacteria. The co-culture medium acidification was correlated with the concentration in supplemented enzyme. The antibacterial effect was characterized by the production of lactic acid by the homofermentative E. faecium THT and the lactic and acetic acids production by the heterofermentative Lb. pentosus CWBI B78. The antagonistic properties from bacteria-enzyme cooperation could reduce the prevalence of Campylobacter consequently the risk of human infection. [less ▲]

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See detailIn Vitro Anticancer Potential of Tree Extracts from the Walloon Region Forest.
Frederich, Michel ULg; Marcowycz, Aline; Cieckiewicz, Ewa ULg et al

in Planta Medica (2009), 75(15), 1634-1637

Forty-eight extracts from 16 common Belgian trees from the Walloon Region forest were evaluated for IN VITRO growth inhibitory activity against the human LoVo colon cancer, PC3 prostate cancer, and U373 ... [more ▼]

Forty-eight extracts from 16 common Belgian trees from the Walloon Region forest were evaluated for IN VITRO growth inhibitory activity against the human LoVo colon cancer, PC3 prostate cancer, and U373 glioblastoma cell lines. Our study was performed with the aim of selecting plant candidates in order to later isolate new anticancer compounds from an easily affordable tree material. Extracts from ALNUS GLUTINOSA (stem bark), CARPINUS BETULUS (leaves and stem bark), CASTANEA SATIVA (stem bark), FAGUS SYLVATICA (leaves), ILEX AQUIFOLIUM (leaves), LARIX DECIDUA (leaves), QUERCUS PETRAEA (stem bark), and QUERCUS ROBUR (leaves) showed for the first time potent IN VITRO growth inhibitory activity and could become easily affordable sources of potential new anticancer agents. Root extracts from ROBINIA PSEUDOACACIA, already known for containing cytotoxic lectins, also showed interesting activity. [less ▲]

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See detailIn vitro antimicrobial activity of plants used in Cambodian traditional medicine
Chea, Aun; Jonville, Marie ULg; Bun, Sok-Siya et al

in American Journal of Chinese Medicine (The) (2007), 35(5), 867-873

The purpose of the present study was to screen 27 plant species used in the traditional medicine of Cambodia for in vitro antibacterial and antifungal activities. Thirty-three methanolic extracts were ... [more ▼]

The purpose of the present study was to screen 27 plant species used in the traditional medicine of Cambodia for in vitro antibacterial and antifungal activities. Thirty-three methanolic extracts were tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Mycobacterium smegmatis and Candida albicans. Screened by disk diffusion assay, the extracts showed antimicrobial activity especially on Gram-positive bacteria. None of the crude methanolic extracts showed activity against P. aeruginosa. Twenty-five selected extracts were evaluated using a micro-dilution test. Harrisonia perforata (roots) and Hymenodictyon excelsum (bark) exhibited a bactericidal effect against S. aureus at a concentration of 500 μg/ml. Azadirachta indica (bark), Harrisonia perforata (roots and stem) and Shorea obtusa (roots) exhibited a bactericidal effect against M. smegmatis at 250 μg/ml. [less ▲]

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See detailIn vitro antiplasmodial activity of ethnobotanically selected plants from Burkina Faso
Jansen, Olivia ULg; Angenot, Luc ULg; Tits, Monique ULg et al

in Planta Medica (2008), 74(9), 1142-1142

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See detailIn vitro antiplasmodial activity of five plants used in Benin in traditional medicine to treat malaria
Bero, J.; Frederich, Michel ULg; De Mol, Patrick ULg et al

in Planta Medica (2008), 74(9), 1002-1002

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See detailIn vitro antiplasmodial activity of plants used in Benin in traditional medicine to treat malaria
Bero, Joanne; Ganfon, Habib; Jonville, Marie ULg et al

in Journal of Ethnopharmacology (2009), 122

Aim of the study: The aim of the studywas to evaluate the in vitro antiplasmodial activity of crude extracts of 12 plant species traditionally used in Benin for the treatment of malaria in order to ... [more ▼]

Aim of the study: The aim of the studywas to evaluate the in vitro antiplasmodial activity of crude extracts of 12 plant species traditionally used in Benin for the treatment of malaria in order to validate their use. Materials and methods: For each species, dichloromethane, methanol and total aqueous extracts were tested. The antiplasmodial activity of extracts was evaluated using the measurement of the plasmodial lactate dehydrogenase activity on chloroquine-sensitive (3D7) and resistant (W2) strains of Plasmodium falciparum. The selectivity of the different extractswas evaluated using the MTT test on J774 macrophagelike murine cells and WI38 human normal fibroblasts. Results: The best growth inhibition of both strains of Plasmodium falciparum was observed with the dichloromethane extracts of Acanthospermum hispidum DC. (Asteraceae) (IC50 =7.5 g/ml on 3D7 and 4.8 g/ml on W2), Keetia leucantha (K. Krause) Bridson (syn. Plectronia leucantha Krause) (Rubiaceae) leaves and twigs (IC50 = 13.8 and 11.3 g/ml on 3D7 and IC50 = 26.5 and 15.8 g/ml on W2, respectively), Carpolobia lutea G.Don. (Polygalaceae) (IC50 = 19.4 g/ml on 3D7 and 8.1 g/ml on W2) and Strychnos spinosa Lam. (Loganiaceae) leaves (IC50 = 15.6 g/ml on 3D7 and 8.9 g/ml on W2). All these extracts had a low cytotoxicity. Conclusion: Our study gives some justifications for the traditional uses of some investigated plants. [less ▲]

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See detailIn vitro antiplasmodial activity of Tithonia diversifolia and identification of its main active constituent: tagitinin C.
Goffin, Eric ULg; Ziemons, Eric ULg; De Mol, Patrick ULg et al

in Planta Medica (2002), 68(6), 543-5

The antimalarial properties of Tithonia diversifolia, an Asteraceae traditionally used to treat malaria, were investigated in vitro against three strains of Plasmodium falciparum. The ether extract from ... [more ▼]

The antimalarial properties of Tithonia diversifolia, an Asteraceae traditionally used to treat malaria, were investigated in vitro against three strains of Plasmodium falciparum. The ether extract from aerial parts of the plant collected in Sao Tome e Principe, demonstrated good antiplasmodial activity (IC 50 on FCA strain: 0.75 microg/ml). A bioassay guided fractionation of this extract led to the isolation of the known sesquiterpene lactone tagitinin C as an active component against Plasmodium (IC 50 on FCA strain: 0.33 microg/ml), but also possessing cytotoxic properties (IC 50 on HTC-116 cells: 0.706 microg/ml). [less ▲]

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See detailIn vitro antitrypanosomal and antiplasmodial activities of crude extracts and essential oils of Ocimum gratissimum Linn from Benin and influence of vegetative stage.
Kpadonou Kpoviessi, Benedicta G. H.; Kpoviessi, Salome D. S.; Yayi Ladekan, Eleonore et al

in Journal of ethnopharmacology (2014), 155(3), 1417-23

ETHNOPHARMACOLOGICAL RELEVANCE: Different parts of Ocimum gratissimum Linn are largely used in folk medicine for the treatment of many diseases, some of which related to parasitical infections as fevers ... [more ▼]

ETHNOPHARMACOLOGICAL RELEVANCE: Different parts of Ocimum gratissimum Linn are largely used in folk medicine for the treatment of many diseases, some of which related to parasitical infections as fevers and headaches. In order to validate their use and to clarify the plant part which possesses the best antiparasitic properties, we decided to evaluate the in vitro antiplasmodial and antitrypanosomal activities of essential oils and crude extracts from leaves, stems and seeds of Ocimum gratissimum as well as their cytotoxicity. MATERIALS AND METHODS: The essential oils and ethanol crude extracts of leaves and stems of Ocimum gratissimum from Benin, were obtained in pre and full flowering stages. Seeds obtained only in full flowering stage, were also extracted. The oils were isolated by hydrodistillation and analyzed by GC/MS and GC/FID. Extracts and essential oils were tested in vitro against Trypanosoma brucei brucei and Plasmodium falciparum. Cytotoxicity was evaluated in vitro against Chinese Hamster Ovary (CHO) cells and the human non cancer fibroblast cell line (WI38) through MTT assay to evaluate the selectivity and toxicity was assessed against Artemia salina Leach. RESULTS: The essential oils and non-volatile crude extracts of Ocimum gratissimum were more active on Trypanosoma brucei brucei than on Plasmodium falciparum (3D7). This activity varies according to the vegetative stage (pre and full flowering) and the plant part (seeds, stems and leaves) extracted. The best growth inhibition of Trypanosoma brucei brucei was observed with ethanol crude extracts of leaves (IC50=1.66 +/- 0.48 mug/mL) and seeds (IC50=1.29 +/- 0.42 mug/mL) in full flowering stage with good selectivity (SI>10). The chemical composition of the essential oil from aerial parts (47 compounds), characterized by the presence as main constituents of p-cymene, thymol, gamma-terpinene, beta-myrcene and alpha-thujene, depends on the vegetative stage. The oil contained some minor compounds such as myrcene (IC50=2.24 +/- 0.27mug/mL), citronellal (IC50=2.76 +/- 1.55mug/mL), limonene (IC50=4.24 +/- 2.27mug/mL), with good antitrypanosomal activities. These oils and crude extracts were not toxic against Artemia salina Leach and had a low cytotoxicity except leaves and seeds ethanol extracts obtained in full flowering which showed toxicity against CHO and WI38 cells. CONCLUSIONS: Our study shows that ethanol crude extracts of leaves and seeds of Ocimum gratissimum in full flowering stage can be a good source of antitrypanosomal agents. This is the first report about the relation between the plant part extracted, the vegetative stage of the plant, the antitrypanosomal and antiplasmodial activities and the cytotoxicity of essential oils and non-volatile extracts of Ocimum gratissimum from Benin. [less ▲]

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See detailIn vitro approach to study the synergistic effects of tobramycin and clarithromycin against Pseudomonas aeruginosa biofilms using prokaryotic or eukaryotic culture media
Thellin, Olivier ULg; Zorzi, Willy ULg; Jolois, Olivier et al

in International Journal of Antimicrobial Agents Corresponding (in press)

Detailed reference viewed: 22 (9 ULg)