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See detailIsoform 111 of vascular endothelial growth factor (VEGF111) improves angiogenesis of ovarian tissue xenotransplantation
Labied, Soraya ULg; Delforge, Yves ULg; Blacher, Silvia ULg et al

in Journal of Assisted Reproduction & Genetics (2012), 28(11), 1009

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See detailIsoform 111 of vascular endothelial growth factor (VEGF111) improves angiogenesis of ovarian tissue xenotransplantation
Labied, Soraya ULg; Delforge, Yves ULg; Munaut, Carine ULg et al

in Transplantation (2013), 95(3), 426-433

Background: Cryopreservation of cortex ovarian tissue before anti-cancer therapy is a promising technique for fertility preservation mainly in children and young women. Ischemia in the early stage after ... [more ▼]

Background: Cryopreservation of cortex ovarian tissue before anti-cancer therapy is a promising technique for fertility preservation mainly in children and young women. Ischemia in the early stage after ovarian graft causes massive follicle loss by apoptosis. VEGF111 is a recently described VEGF isoform that does not bind to the extracellular matrix, diffuse extensively and is resistant to proteolysis. These properties confer a significantly higher angiogenic potential to VEGF111 in comparison to the other VEGF isoforms. Methods: We evaluated the morphology of cryopreserved sheep ovarian cortex, grafted in the presence or absence of VEGF111. Ovarian cortex biopsies were embedded in type I collagen with or without VEGF111 addition before transplantation to SCID mice ovaries. Transplants were retrieved 3 days or 3 weeks later. Follicular density, vasculature network, haemoglobin content and cell proliferation were analysed. Results: Addition of VEGF111 increased density of functional capillaries (p=0.01) 3 days after grafting. By double immunostaining of Ki-67 and von Willebrand Factor (vWF) we demonstrated that proliferating endothelial cells were found in 83% of the VEGF111 group when compared to 33% in the control group (p=0.001). This angio-stimulation was associated with a significant enhancement of haemoglobin content (p=0.03). Three weeks after transplantation, the number of primary follicles was significantly higher in VEGF111 grafts (p=0.02). Conclusion: VEGF111 accelerates blood vessels recruitment, functional angiogenesis and improves the viability of ovarian cortex by limiting ischemia and ovarian cortex damage. [less ▲]

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See detailIsokinetic and functional muscle performances among football players: a transversal study
Binet, J.; Lehance, Cédric ULg; Vandenbroek, G. et al

in Isokinetics & Exercise Science (2005, March), 13(1), 25-26

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See detailIsokinetic and iso-inertial assessments: Competion or complementarity?
Jidovtseff, Boris ULg; Crielaard, Jean-Michel ULg; Croisier, Jean-Louis ULg

in Isokinetics & Exercise Science (2007), 15(1), 52-53

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See detailIsokinetic assessment of complete proximal hamstring tendon rupture: Case reports
Croisier, Jean-Louis ULg; Bartsch, Valérie ULg; Burnel, M. et al

in Isokinetics & Exercise Science (2005, March), 13(1), 14-15

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See detailIsokinetic assessment of knee flexors and extensors in professional soccer players
Croisier, Jean-Louis ULg; Réveillon, Vincent; Ferret, J. M. et al

in Isokinetics & Exercise Science (2003, March), 11(1), 61-62

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See detailIsokinetic assessment of shoulder rotator cuff sutures 36 months after surgery
Binet, J.; Forthomme, Bénédicte ULg; Croisier, Jean-Louis ULg

in Isokinetics & Exercise Science (2005, March), 13(1), 79-80

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See detailIsokinetic assessment of the forearm and wrist muscles
Forthomme, Bénédicte ULg; Croisier, Jean-Louis ULg; Foidart-Dessalle, Marguerite ULg et al

in Isokinetics & Exercise Science (2002), 10(3), 121-128

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See detailIsokinetic assessment of the scapular muscles
Forthomme, Bénédicte ULg; Arimont, A.; Maquet, Didier ULg et al

in Isokinetics & Exercise Science (2007), 15

The scapula plays an important role in normal shoulder function. In sports in which demands on the shoulder are extremely high, the quality of movements depends on the interaction between scapular and ... [more ▼]

The scapula plays an important role in normal shoulder function. In sports in which demands on the shoulder are extremely high, the quality of movements depends on the interaction between scapular and glenohumeral kinematics. Comparatively to a normal status, the scapular dyskinesis is defined as observable alteration in the position of the scapula and in the patterns of scapular motion in relation to the thoracic cage [1]. Surprisingly, only sparse literature focused on the isokinetic assessment of scapulothoracic muscles. To our knowledge, only Cools et al. [2,3] have investigated such evaluation, using a closed kinetic chain system. The aim of this study was to provide new insights in the isokinetic assessment of the scapular muscle performances, among sedentary and overhead athletes populations. 10 sedentary men (23.5  2.6 years; 67.3  62 kg) and 10 overhead athletes (22.2 +/- 2.3 years; 72.9 +/- 9.7 kg) participated into the study. All subjects were free of previous shoulder pathology. The overhead population included 2 volleyball, 2 handball, 3 tennis and 3 badminton players, all with at least 9 years of intensive practice. They sustained a bilateral isokinetic assessment (Biodex 3 dynamometer) of the protractors (PRO) and retractors (RET) of the scapula (closed kinetic chain). Subjects were seated and the closed kinetic chain attachment was placed in a horizontal plane, at 30° from the frontal plane, which corresponded to the scapular plane; the elbow was placed in full extension. The range of motion was individualized from the maximal protraction to the maximal retraction positions. After a specific warm up using an elastic theraband and familiarization on the isokinetic device, the isokinetic protocol consisted in 3 repetitions at slow speed (12.2 cm/s) and 5 repetitions at high speed (36.6 cm/s). The strength performances (peak-force in N) and ratios (Protractors / Retractors; PRO/RET) are described in Tables 1 and 2. The maximum force developed by scapular muscles decreased with increase in motion velocity. Generally, there was no dominance effect, except for the RET at high speed within the sedentary population (Table 1). The PRO/RET ratios remained inferior to 1 indicating higher performances on RET muscle group (Table 2). Even if the athletes recruited in our study used their shoulder in an asymmetrical way, we did not find any significant difference between the dominant and non dominant ratios in that population; only the PRO/RET ratio of sedentaries at high speed showed a dominance effect. The PRO/RET ratios were higher into the athletes, yet the difference did not reach statistical significance. There was no significant difference between both populations, if considering the absolute strength or the bodyweight normalized peak force. The sports population appeared more homogenous with lower standard deviation values for all data. Nevertheless, in such closed kinetic chain assessment, compensations of the trunk during protraction and of the elbow during retraction must be strictly controlled. The shoulder assessment in a closed kinetic chain allowed to investigate the force developed by the protractors and the retractors of the scapula. In spite of upper limb asymmetrical use through overhead activities, a dominance effect in strength performances or agonist-antagonist ratios was not detected among athletes recruited in that study. These preliminary results could be useful for further comparison with pathological cases. REFERENCES 1. W. Kibler, The role of the scapula in athletic shoulder function, Am J Sports Med 26 (1998), 325-337. 2. A. Cools, E. Witrouw, L. Danneels, Test-retest reproducibility of concentric strength values for shoulder girdle protraction and retraction using a Biodex isokinetic dynamometer, Isokin Exerc Sci 10 (2002), 129-136. 3. A. Cools, E. Witrouw, G. Declerq, G. Vanderstraeten, D. Cambier, Evaluation of isokinetic force production and associated muscle activity in the scapular rotators during a protraction-retraction movement in overhead athletes with impingement symptoms, Br J Sports Med 38 (2004), 64-68. [less ▲]

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See detailIsokinetic assessment of the scapular muscles in serratus anterior dysfunction
Forthomme, Bénédicte ULg; Wang, François-Charles ULg; Crielaard, Jean-Michel ULg et al

in Journal of Rehabilitation Medicine Supplement (2008, June), 47

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See detailIsokinetic assessment of the shoulder rotators: A study of optimal test position
Forthomme, Bénédicte ULg; Dvir, Zeevi; Crielaard, Jean-Michel ULg et al

in Clinical Physiology & Functional Imaging (2011), 31(3), 227-232

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See detailIsokinetic eccentric exercises in treating chronic tendinitis
Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg; Foidart-Dessalle, Marguerite ULg et al

in Isokinetics & Exercise Science (2002, March), 10

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See detailAn isokinetic eccentric programme for the management of chronic lateral epicondylar tendinopathy
Croisier, Jean-Louis ULg; Foidart-Dessalle, Marguerite ULg; Tinant, France ULg et al

in British Journal of Sports Medicine (2007), 41(4), 269-275

Background: Lateral epicondylitis represents a frequent overuse injury. In spite of many conservative treatment procedures, prolonged symptoms and relapse are frequently observed. Objective: To compare ... [more ▼]

Background: Lateral epicondylitis represents a frequent overuse injury. In spite of many conservative treatment procedures, prolonged symptoms and relapse are frequently observed. Objective: To compare the outcome of patients performing an isokinetic eccentric training with that of age-, gender-, activity-matched patients receiving a non-strengthening classical rehabilitation. Methods: Ninety-two patients with unilateral chronic lateral epicondylar tendinopathy (mean duration of symptoms 8 +/- 3 months) were assigned either to a control group (n = 46) or to an eccentrically trained group (n = 46). The control group underwent a passive standardised rehabilitation programme that excluded strengthening exercises. In addition to this programme, the trained group also performed eccentric exercises based on the repetitive lengthening of the active musculo-tendinous unit. The latter exercises started with submaximal contraction intensity and slow speed movement. Modalities were progressively intensified (increase in intensity contraction and speed movement) over a long priod of treatment. Programme effectiveness was assessed through pain score evaluation, a disability questionnaire, muscle strength measurement and ultrasonographic examination. Results: Compared to the non-strengthening control group, the following observations were made in the eccentrically trained group: (1) a significantly more marked reduction of pain intensity, mainly after one month of treatment; (2) an absence of strength deficit on the involved side through bilateral comparison for the forearm supinator and wrist extensor muscles; (3) an improvement of the tendon image as demonstrated by decreasing thickness and a recovered homogenous tendon structure; and (4) a more marked improvement in disability status during occupational, spare time and sports activities. Conclusion: These results highlight the relevance of implementing isokinetic adapted eccentric training in the management of chronic lateral epicondylar tendinopathy. [less ▲]

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See detailIsokinetic evaluation of ACL reconstruction. Surgical procedure influence and rehabilitation implications
Croisier, Jean-Louis ULg; Huskin, Jean-Pierre ULg; Crielaard, Jean-Michel ULg

in Abstract book of the 9th Transactions of the European Orthopaedic Research Society (1999, June)

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See detailIsokinetic evaluation of hamstring muscle strain: interest of the eccentric mode
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Proceedings of the Third Annual Congress of the European College of Sport Science (1998, July)

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See detailIsokinetic evaluation of hip muscles in patients with coxarthrosis
Henrotin, Yves ULg; Rale, B.; Dubuc, J. E. et al

in Isokinetics & Exercise Science (2002, March), 10

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See detailIsokinetic evaluation of hip strength muscle groups in unilateral lower limb amputees
Croisier, Jean-Louis ULg; Maertens De Noordhout, Benoît ULg; Maquet, Didier ULg et al

in Isokinetics & Exercise Science (2001), 9(4), 163-169

The objectives of the study were to measure the isokinetic strength of the hip flexor-extensor and adductor-abductor muscle groups in unilateral lower limb amputees and to evaluate abnormalities in order ... [more ▼]

The objectives of the study were to measure the isokinetic strength of the hip flexor-extensor and adductor-abductor muscle groups in unilateral lower limb amputees and to evaluate abnormalities in order to improve the usual rehabilitation programs. Thirty-three patients with unilateral lower limb amputation were included in this study; they served as their own controls, the amputated side being compared to the intact side. Using an isokinetic device, the relative peak torques (N.m by body weight), bilateral asymmetries and agonist/antagonist torque ratios were calculated for the hip flexor, extensor, adductor and abductor muscle groups. A significant reduction of mean concentric relative peak torque measured on the amputated limbs was generally observed when compared to the intact contralateral limb (p < 0.05). The mean percentage of relative peak torque decrease was greater for the extensors than for the flexors (33 +/- 20% and 22 +/- 23%, respectively, at 30degrees/s angular velocity), and for the abductors than for the adductors (23 +/- 22% and 11 +/- 19%, respectively, at 30degrees/s angular velocity). Furthermore, the flexor/extensor torque ratio was significantly increased for the amputated limb (for instance, 1.25 +/- 0.33 versus 1.09 +/- 0.25 for the intact limb at 30degrees/s). The reduction of the abductor/adductor ratio of the operated limb reached the level of statistical significance at 60degrees/s only (1.25 +/- 0.46 versus 1.07 +/- 0.36 for the intact limb). In conclusion, isokinetic testing revealed a significant reduction of the hip stabilizing muscle strength as a consequence of lower limb amputation. The more marked decrease of the strength of the abductor and extensor muscle groups, resulting in imbalances of the agonist/antagonist strength ratios should be taken into account to adapt the conventional rehabilitation programs. [less ▲]

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See detailIsokinetic evaluation of hip strength muscle groups in unilateral lower limb amputees
Croisier, Jean-Louis ULg; Maertens De Noordhout, Benoît; Camus, Gérard et al

in Isokinetics & Exercise Science (2000, March), 8

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See detailIsokinetic evaluation of knee extensors and flexors in patients with unilateral symptomatic gonarthrosis
Henrotin, Yves ULg; Croisier, Jean-Louis ULg; Dumont, R et al

in Osteoarthritis and Cartilage (1999), 7(SA), 94

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