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See detailInvestigation of the Relationship between Osteoporosis and the Collagenase Gene by Means of Polymorphism of the 5'upstream Region of This Gene
Thiry-Blaise, L. M.; Taquet, A. N.; Reginster, Jean-Yves ULg et al

in Calcified Tissue International (1995), 56

Osteoporosis is a slowly progressing disease resulting from an imbalance between bone accretion and degradation. As interstitial collagenase is a key enzyme in the degradation of bone matrix, we ... [more ▼]

Osteoporosis is a slowly progressing disease resulting from an imbalance between bone accretion and degradation. As interstitial collagenase is a key enzyme in the degradation of bone matrix, we investigated a possible relationship between the collagenase gene and osteoporosis. Analysis of an amplified genomic DNA fragment from -524 to +52 by denaturing gradient gel electrophoresis and sequencing allowed us to detect three dimorphic sites upstream of base -300, one of them leading to a BanI restriction site. None of the sites could be directly associated with osteoporosis. The allele frequencies of the three dimorphic sites were estimated. The interallelic ratios were high, thus providing new useful genetic markers for linkage analysis. When comparing these ratios in osteoporotic and nonosteoporotic subjects, no significant differences could be observed. [less ▲]

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See detailInvestigation of the stellar content in the western part of the Carina nebula
Kumar, Brajesh; Sharma, Saurabh; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (2014), 567

Context. The low obscuration and proximity of the Carina nebula make it an ideal place to study the ongoing star formation process and impact of massive stars on low-mass stars in their surroundings. <BR ... [more ▼]

Context. The low obscuration and proximity of the Carina nebula make it an ideal place to study the ongoing star formation process and impact of massive stars on low-mass stars in their surroundings. <BR /> Aims: To investigate this process, we generated a new catalog of the pre-main-sequence stars in the Carina west (CrW) region and studied their nature and spatial distribution. We also determined various parameters (reddening, reddening law, age, mass), which are used further to estimate the initial mass function and K-band luminosity function for the region under study. <BR /> Methods: We obtained deep UBVRI Hα photometric data of the field situated to the west of the main Carina nebula and centered on WR 22. Medium-resolution optical spectroscopy of a subsample of X-ray selected objects along with archival data sets from Chandra, XMM-Newton and 2MASS surveys were used for the present study. Different sets of color-color and color-magnitude diagrams are used to determine reddening for the region and to identify young stellar objects (YSOs) and estimate their age and mass. <BR /> Results: Our spectroscopic results indicate that the majority of the X-ray sources are late spectral type stars. The region shows a large amount of differential reddening with minimum and maximum values of E(B - V) as 0.25 and 1.1 mag, respectively. Our analysis reveals that the total-to-selective absorption ratio R[SUB]V[/SUB] is ~3.7 ± 0.1, suggesting an abnormal grain size in the observed region. We identified 467 YSOs and studied their characteristics. The ages and masses of the 241 optically identified YSOs range from ~0.1 to 10 Myr and ~0.3 to 4.8 M[SUB]⊙[/SUB], respectively. However, the majority of them are younger than 1 Myr and have masses below 2 M[SUB]⊙[/SUB]. The high mass star WR 22 does not seem to have contributed to the formation of YSOs in the CrW region. The initial mass function slope, Γ, in this region is found to be -1.13 ± 0.20 in the mass range of 0.5 < M/M[SUB]⊙[/SUB] < 4.8. The K-band luminosity function slope (α) is also estimated as 0.31 ± 0.01. We also performed minimum spanning tree analysis of the YSOs in this region, which reveals that there are at least ten YSO cores associated with the molecular cloud, and that leads to an average core radius of 0.43 pc and a median branch length of 0.28 pc. Full Table 3 is only available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (ftp://130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/567/A109">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/567/A109</A> [less ▲]

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See detailInvestigation of the surface activity of a poly(styrene-b-dimethylsiloxane) copolymer blended within a polystyrene matrix
Petitjean, Serge; Ghitti, G.; Jérôme, Robert ULg et al

in Macromolecules (1994), 27

The surface properties of thin polystyrene films are deeply modified by the addition of various amounts of a poly(styrene-b-dimethylsiloxane) copolymer-or poly(S-b-DMS)-as confirmed by a series of ... [more ▼]

The surface properties of thin polystyrene films are deeply modified by the addition of various amounts of a poly(styrene-b-dimethylsiloxane) copolymer-or poly(S-b-DMS)-as confirmed by a series of analytical methods. In addition to the surface tension which has been estimated from wettability and contact angle measurements, surface composition has been analyzed by X-ray photoelectron spectroscopy (XPS) and secondary ion mass spectrometry (SIMS). Surface studies have been completed by the analysis of the depth distribution of siloxane from the surface by XPS and SIMS. Finally, the surface activity of poly(S-b-DMS) has been investigated in solution. Indeed, changes in the surface tension of polystyrene solutions in THF have been measured in relation to the addition of the diblock copolymer. All the experimental data agree with the complete coverage of the polystyrene films with the poly(S-b-DMS) copolymer. This situation already prevails in the solutions prepared as precursors to the thin polystyrene films. Accordingly, surface characteristics of film freshly prepared by solvent-casting are unaffected by subsequent annealing. [less ▲]

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See detailInvestigation of the susceptibility of human cell lines to bovine herpesvirus 4 infection: Demonstration that human cells can support a nonpermissive persistent infection which protects them against tumor necrosis factor alpha-induced apoptosis
Gillet, Laurent ULg; Minner, F.; Detry, Bruno et al

in Journal of Virology (2004), 78(5), 2336-2347

Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus that has a worldwide distribution in the population of cattle. Many factors make human contamination by BoHV-4 likely to occur. In this study, we ... [more ▼]

Bovine herpesvirus 4 (BoHV-4) is a gammaherpesvirus that has a worldwide distribution in the population of cattle. Many factors make human contamination by BoHV-4 likely to occur. In this study, we performed in vitro experiments to assess the risk and the consequences of human infection by BoHV-4. First, by using a recombinant BoHV-4 strain expressing enhanced green fluorescent protein under the control of the human cytomegalovirus immediate-early gene promoter, we tested 21 human cell lines for their sensitivity and their permissiveness to BoHV-4 infection. These experiments revealed that human cell lines from lymphoid and myeloid origins were resistant to infection, whereas epithelial cells, carcinoma cells, or adenocarcinoma cells isolated from various organs were sensitive but poorly permissive to BoHV-4 infection. Second, by using the HeLa cell line as a model of human cells sensitive but not permissive to BoHV-4 infection, we investigated the resistance of infected cells to apoptosis and the persistence of the infection through cellular divisions. The results obtained can be summarized as follows. (i) BoHV-4 nonpermissive infection of HeLa cells protects them against tumor necrosis factor alpha-induced apoptosis. (ii) BoHV-4 infection of HeLa cells persists in cell culture; however, the percentage of infected cells decreases with time due to erratic transmission of the viral genome through cell division. (iii) BoHV-4 infection has no effect on the rate of HeLa cell division. Altogether, these data suggest that BoHV-4 could infect humans. This study also stresses the importance of considering the insidious effects of nonpermissive infection when the biosafety of animal gammaherpesviruses for humans is being considered. [less ▲]

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See detailInvestigation of the Western Mediterranean's hydrodynamics with the GHER three-dimensional primitive equation model
Beckers, Jean-Marie ULg; Brasseur, P.; Djenidi, Salim ULg et al

in Coastal and Estuarine Studies (1994), 46

A three-dimensional, non-linear, primitive equation model with turbulent closure developed at the GeoHydrodynamics and Environment Research Laboratory (GHER), University of Liège, is designed to define ... [more ▼]

A three-dimensional, non-linear, primitive equation model with turbulent closure developed at the GeoHydrodynamics and Environment Research Laboratory (GHER), University of Liège, is designed to define marine weather-like processes ranging from mesoscale tides and storm surges, to synoptic frontal and eddy structures, to macroscale slowly-varying currents characteristic of the so-called “general circulation”. The model is applied here to the study of the hydrodynamics of the western Mediterranean as both a metagnostic (i.e. system-oriented) model and a diagnostic (i.e. process-oriented) model with both models allowed to run simultaneously and interactively. Critical processes such as deep water formation and the instabilities of the Algerian Current, are studied to provide a basic understanding of the physics needed to adequately parameterize sub-grid scale processes in the basin wide metagnostic model. This general circulation model provides boundary conditions for the finer grid diagnostic studies as well as the general overview of the basin's hydrodynamics. Further improvement is achieved by concurrent use of a variational inverse model to provide initial data fields and boundary conditions for the direct model. In turn, the metagnostic model provides hydrodynamic constraints which are imposed to the variational principle to ensure an interpolation/extrapolation of data compatible with the system's hydrodynamics. Results viz (i) a diagnostic study of the Algerian Current, (ii) a metagnostic study of the seasonal variability of the western Mediterranean Sea, are presented and compared with observations and with results of simpler (quasi-geostrophic, reduced gravity, etc.) models. Possible improved hydrodynamic forecasts of seasonal and interannual variability with the 3D primitive equation model is discussed with particular attention to the forecast's sensitivity to initial and boundary conditions. [less ▲]

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See detailInvestigation of transverse cracks initiation in continuous steel casting using a finite element approach
Castagne, S.; Habraken, Anne ULg

in Advances in Computational & Experimental Engineering (2003)

A numerical model for steel at elevated temperature which is based on a mesoscopic finite element approach is presented. The objective of the research is the analysis of damage evolution in the material ... [more ▼]

A numerical model for steel at elevated temperature which is based on a mesoscopic finite element approach is presented. The objective of the research is the analysis of damage evolution in the material using information from the macroscopic and microscopic scales. As a final application our results are used to study the industrial process of continuous casting of low carbon steel. [less ▲]

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See detailINVESTIGATION OF TWO IMPROVED TRADITIONAL MEDICINES: DEVELOPMENT AND VALIDATION OF A LC-UV METHOD FOR THE DOSAGE OF A TRACER COMPOUND
Tshisekedi Tshibangu, Pascal; Kalenda Dibungi, Pascal; Rozet, Eric ULg et al

Poster (2014, June)

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See detailAn investigation of verbal short-term memory and phonological processing in four children with Williams syndrome
Majerus, Steve ULg; Barisnikov, K.; Vuillemin, I. et al

in Neurocase : Case Studies in Neuropsychology, Neuropsychiatry & Behavioural Neurology (2003), 9(5), 390-401

Although phonological processing is generally considered to be a proficiency in Williams syndrome (WS), there are very few studies which have extensively explored phonological processing abilities in WS ... [more ▼]

Although phonological processing is generally considered to be a proficiency in Williams syndrome (WS), there are very few studies which have extensively explored phonological processing abilities in WS. In this study, we re-assessed phonological processing in WS by exploring verbal STM and phonological awareness abilities in 4 children with WS (CA: 10-12 years) and two control groups, one matched for chronological age (CA) and the other matched for verbal mental age (VA). Our results confirm and extend previous claims of preserved phonological STM in WS by showing specifically preserved STM performance for non-words, compared to both VA and CA control groups. However, we observed that this was the case only for non-words where support of phonological and lexico-semantic knowledge was minimized, with reduced phonological and lexico-semantic effects on STM performance. Furthermore, a more direct assessment of phonological processing abilities through phonological awareness tasks showed impaired performance for the 4 WS children. Our data confirm that STM for non-words represents a real strength in. WS but they do not support previous assumptions of a more general preservation of phonological processing abilities in WS. Implications for impaired and preserved cognitive processes underlying verbal STM and phonological awareness abilities in WS are discussed. [less ▲]

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See detailInvestigation olfactive de la mort
Focant, Jean-François ULg; Stefanuto, Pierre-Hugues ULg; Brasseur, Catherine ULg et al

in Acta Clinica Belgica (2013, October), 68-6

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See detailInvestigation on a scroll expander for waste heat recovery on internal combustion engines
Legros, Arnaud ULg; Guillaume, Ludovic ULg; Lemort, Vincent ULg et al

Scientific conference (2013, September 09)

In the present article, a model of scroll expander will be introduced. This model is able to evaluate the performance of a given machine with influence of the geometry. Several losses are also included by ... [more ▼]

In the present article, a model of scroll expander will be introduced. This model is able to evaluate the performance of a given machine with influence of the geometry. Several losses are also included by the model such as internal leakages, heat transfers or mechanical losses. The forces generated by the gas pressure on the involutes can also be calculated. That expander model is used in order to demonstrate its potential and provide some guidelines to the design of a new expander suitable for the application. [less ▲]

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See detailInvestigation on a ventilation heat recovery exchanger: Modeling and experimental validation in dry and partially wet conditions
Gendebien, Samuel ULg; Bertagnolio, Stéphane ULg; Lemort, Vincent ULg

in Energy & Buildings (2013), 62

The present paper focuses on the development and experimental validation of a model of air-to-air heat exchanger dedicated to domestic mechanical heat recovery ventilation. The proposed model describes ... [more ▼]

The present paper focuses on the development and experimental validation of a model of air-to-air heat exchanger dedicated to domestic mechanical heat recovery ventilation. The proposed model describes dry and partially wet regimes. The first part of the paper presents a semi-empirical model based on the physical characteristics of the heat recovery device and relying on empirical correlations available in the literature for the convective heat transfer coefficients. In the case of partially wet regime, a moving boundary model is applied in order to predict sensible and latent heat transfer rates. A model developed with friction factor coefficients estimated by correlations from the literature is also presented in order to predict the hydraulic performance in dry conditions. The second part of the paper describes the experimental investigation conducted on an off-the-shelf heat exchanger. Experimental data are used to tune correlations for the determination of the convective heat transfer coefficient and validate the proposed simulation model of the ventilation heat recovery exchanger in partially wet conditions. The model developed to determine the hydraulic performance with existing correlations for the friction factor coefficient does not require a calibration. Finally, examples of use of the developed model are presented, which includes coupling the model with a building simulation model, a study of the influence of the humidity on the evolution of the latent and sensible heat transfer rates and strategies to avoid freezing in the heat exchanger. [less ▲]

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See detailInvestigation on an air-to-air heat recovery exchanger: modeling and experimental validation in dry conditions
Gendebien, Samuel ULg; Bertagnolio, Stéphane ULg; Georges, Bernard ULg et al

in Proceedings of the RoomVent 2011 Conference (2011, June 21)

This paper deals with the development and the experimental validation of an air-to-air recovery heat exchanger model dedicated to ventilation of residential buildings. The first part of the paper presents ... [more ▼]

This paper deals with the development and the experimental validation of an air-to-air recovery heat exchanger model dedicated to ventilation of residential buildings. The first part of the paper presents a semi-empirical model based on physical characteristics of the heat exchanger. The aim of this model is to predict the behavior of the device in dry conditions. The second part of the paper describes the experimental facility designed to determine the hydraulic and thermal performance of the device and offers a comparison between simulation and experimental results. Finally, the model is calibrated in order to predict the thermal and hydraulic performance of the heat exchanger within respectively, less than 5% and less than 2% of accuracy. [less ▲]

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See detailAn investigation on climate responsive design strategies of vernacular housing in Vietnam
Nguyen, Anh Tuan ULg; Tran, Quoc Bao; Tran, Duc Quang et al

in Building & Environment (2011), 46

Energy conservation issues and environmental problems in recent years have increased interest in traditional architecture which is well known for its energy saving designs. This paper thoroughly ... [more ▼]

Energy conservation issues and environmental problems in recent years have increased interest in traditional architecture which is well known for its energy saving designs. This paper thoroughly investigates vernacular housing designs and evaluates on the aspect of building physics. A new research methodology which is adapted to the natural and social context of Vietnam was proposed and applied. The process was carried out step by step, including: climate zoning, systematic analysis, in-situ survey and building simulations. The results of this study indicate that vernacular housing in Vietnam is creatively adapted to the local natural conditions and uses various climate responsive strategies. Through this study, the most frequently used strategies and their effectiveness were derived. The authors also found that under extreme weather conditions, traditional designs might not be sufficient to maintain indoor thermal comfort. [less ▲]

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See detailInvestigation on gas pressure measurement inside small caliber weapons with piezoelectric transducers
Elkarous, Lamine ULg; Pirlot, Marc; Golinval, Jean-Claude ULg et al

in Measurement Science Conference 2012 (2011, March 20)

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See detailInvestigation on genotype by environment interaction for milk yield of Holstein cows in Luxembourg and Tunisia
Hammami, Hedi ULg; Croquet, Coraline; Soyeurt, Hélène ULg et al

in INTERBULL Bulletin (2006), 35

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See detailInvestigation on human cadaveric VOC by TD-GCxGC-TOFMS
Stefanuto, Pierre-Hugues ULg; Stadler, Sonja; Pesesse, Romain et al

Poster (2013, May)

The study of the ‘smell of death’ is a challenging task. Analytical chemists who try to understand human decomposition are facing very complex mixtures of analytes present at various levels. For the last ... [more ▼]

The study of the ‘smell of death’ is a challenging task. Analytical chemists who try to understand human decomposition are facing very complex mixtures of analytes present at various levels. For the last few decades, investigations have been conducted to better learn the process of body decomposition by mean of the measurement of the Volatile Organic Compounds (VOCs) released during decay1. However, the chemical profile of the decomposition odor is still far from being elucidated. Indeed, the complexity of the VOC mixtures makes this profiling difficult to be carried out by a classical gas chromatography mass spectrometry (GC-MS) approach. In previous studies, we developed direct-sampling based approaches for cadaveric VOC analysis from grave soils and decaying bodies by mean of thermal desorption (TD) coupled to comprehensive two-dimensional GC coupled to time-of-flight MS (GC×GC-TOFMS)2,3,4. They were based on the use of human analogs (Sus domesticus L. carcasses). For the present study, we investigated the VOC profile of early stage decomposition of human bodies. We analyzed samples collected during different trials organized during different seasons in a body farm located in Texas. Samples included environmental controls, pig carcasses, and human bodies (protected or not from scavenger insects). The data processing was performed in the light of identifying possible seasonal and species variations. Both peak capacity enhancement and spectral deconvolution helped to characterize VOC mixtures and improve comparisons of profiles. Acknowledgements: Human samples were collected during the project “Development and validation of standard operating procedures for measuring microbial populations for estimating a post-mortem interval” Grant Award No. 2010-DN-BX-K243. The authors of that grant are acknowledged for giving us the opportunity to access cadavers for sampling. 1. Vass, A.A. et al. Decompositional odor analysis database. J Forensic Sci (2004) 49, 1–10. 2. Brasseur C. et al. Comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry for the forensic study of cadaveric volatile organic compounds released in soil by buried decaying pig carcasses. J Chromatogr A (2012) 1255, 163–170. 3. Dekeirsschieter, J. et al. Enhanced characterization of the smell of death by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS). PLoS ONE (2012) 7, e39005. 4. Stadler, S. Characterization of volatile organic compounds from human analogue decomposition using thermal desorption coupled to comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry. Anal Chem (2013) 85, 998–1005. [less ▲]

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See detailInvestigation on Laser-induced Breakdown Spectroscopy of Potassium Chloride Solution
Zhang, Wenyan; Lin, Zhaoxiang; Lu, Jidong et al

in Applied Laser (2007), 27(2), 121-123

The experimental setup for laser—induced breakdown spectroscopy test was designed with pulsed Nd:YAG laser,spectrograph and ICCD and so on.Furthermore the potassium chloride solution spectra signals were ... [more ▼]

The experimental setup for laser—induced breakdown spectroscopy test was designed with pulsed Nd:YAG laser,spectrograph and ICCD and so on.Furthermore the potassium chloride solution spectra signals were detected by this setup.The spectra lines of the trace elements such as natrium (20mg/1),magnesium(1 mg/1),calcium(3 mg/1)are recorded.Experiment results show that delay time is one of the important parameters when qualitative analysis.It is easy for LIBS technology to detect multi—elements simultaneity if delay time is appropriate,and qualitative analysis has demonstrated that the feasibility of detecting trace poisonous metals in waste water using LIBS、 [less ▲]

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