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See detailFrom spherical to cyclindrical micelles formed by polystyrene-b-poly(2-vinylpyridine)-b-poly(ethylene oxide) copolymer in water
Lei, Liangcai; Gohy, Jean-François; Willet, Nicolas ULg et al

Poster (2003, May 16)

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See detailFrom Sputnik to Beanie Babies & CubeSats to OUFTI
Verly, Jacques ULg

Conference given outside the academic context (2014)

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See detailFrom standard logic to logic programming: introducing a logic based approach to artificial intelligence
Gochet, Paul; Grégoire Eric; Gribomont, Pascal ULg et al

Book published by John Wiley & Sons (1988)

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See detailFrom Statistical to Biological Interactions via Omics Integration
Bessonov, Kyrylo ULg

Doctoral thesis (2016)

The XXI century opened a new ‘Big Data’ era in which, thanks to rapid technological advancements and appearance of high throughput technologies, vast amounts of unstructured omics data (e.g ... [more ▼]

The XXI century opened a new ‘Big Data’ era in which, thanks to rapid technological advancements and appearance of high throughput technologies, vast amounts of unstructured omics data (e.g., transcriptomic, genomic, etc.) are generated every day. This thesis mainly focuses on solving the problems related diverse omics data integration and interaction identification tasks. Particular attention is given to useful knowledge extraction in the context of complex diseases including pathological mechanisms with the development of software tools and pipelines. The diseases covered included glioblastoma multiforme, asthma, and ankylosing spondylitis. Interactions detection in genomic data requires standardization of the protocols. In Chapter 3, we tested the impact of different settings in a genome-wide association interaction study (GWAIS). Some of the settings included marker selection strategy, the LD pruning, lower order effects adjustment, analytical tool. We were able to show that even small changes in each setting can have drastic impacts requiring careful assessment of proper settings and results comparisons across several analysis protocols. The greatest impact was attributed to the input dataset composition highlighting the importance of the marker selection strategy and use of prior knowledge. Expression of genes can be affected by nearby (‘cis’) or distant (‘trans’) genotypes. Thus, we developed methodology to identify complex trans/cis regulatory mechanisms between expression and genotype data in the context of asthma (CAMP data). Significant overlap between ‘trans’ and ‘cis’ gene regulatory components related to immune and signaling pathways was clearly identified matching asthma disease pathology. The semi-parametric Model-Based Multifactor Dimensionality Reduction (MB-MDR) method was applied for the first time in the context eQTL study achieving low false discovery and family-wise error rates (FDR and FWER). Identification of a meaningful data structure from omics data is a pressing topic nowadays. Gene regulatory networks (GRN) conveniently summarize large amounts of data allowing for useful knowledge generation. GRN inference is especially attractive for deciphering of complex diseases mechanisms allowing biologists to formulate a better hypothesis. We were able to generate GRNs from a single source (e.g., microarray expression data) using conditional inference forest (CIF) with more attractive features compared to classical Random-Forest (RF) including unbiased node variable selection even in the context of highly correlated variables particularly relevant in transcriptomics. The CIF methods provided attractive features and performance characteristics coupled to valuable pathological insights into type 1 diabetes. [less ▲]

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See detailFrom strokes to model: a bottom-up approach for sketching activities analysis. Workshop.
Safin, Stéphane ULg; Juchmes, Roland ULg; Elsen, Catherine ULg et al

Conference (2008)

This paper proposes a framework for sketches analysis that could be useful for sketch-based interfaces development, in the particular context of preliminary activity-centred design. We will first describe ... [more ▼]

This paper proposes a framework for sketches analysis that could be useful for sketch-based interfaces development, in the particular context of preliminary activity-centred design. We will first describe our previous works on sketch-based support tools for the preliminary design phases and the context of these researches. The next chapter declares the concrete objectives of our approach, then the methodology of sketches analysis we propose is presented with a concrete example, and finally the last section is dedicated to the expected results and specifications of a sketch-based support tool that would follow our framework. [less ▲]

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See detailFrom subspace learning to distance learning: a geometrical optimization approach
Meyer, Gilles ULg; Journée, Michel; Bonnabel, Silvère et al

in Proceedings of the 2009 IEEE Workshop on Statistical Signal Processing (SSP2009) (2009)

In this paper, we adopt a differential-geometry viewpoint to tackle the problem of learning a distance online. As this prob- lem can be cast into the estimation of a fixed-rank positive semidefinite (PSD ... [more ▼]

In this paper, we adopt a differential-geometry viewpoint to tackle the problem of learning a distance online. As this prob- lem can be cast into the estimation of a fixed-rank positive semidefinite (PSD) matrix, we develop algorithms that ex- ploits the rich geometry structure of the set of fixed-rank PSD matrices. We propose a method which separately updates the subspace of the matrix and its projection onto that subspace. A proper weighting of the two iterations enables to continu- ously interpolate between the problem of learning a subspace and learning a distance when the subspace is fixed. [less ▲]

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See detailFrom synchronous to asynchronous communication
Gribomont, Pascal ULg

in Specification and Verification of Concurrent Systems (1990)

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See detailFrom taboo to commodity: history and current situation of cavy culture in the Democratic Republic of the Congo
Maass; Metre, TK; Tsongo, F et al

in Livestock Research for Rural Development (2014), 26

For the first time, the status of cavy culture in the Democratic Republic of the Congo (DRC) is reviewed with emphasis on Sud-Kivu province. Cavy culture, as discussed in this paper, is the raising ... [more ▼]

For the first time, the status of cavy culture in the Democratic Republic of the Congo (DRC) is reviewed with emphasis on Sud-Kivu province. Cavy culture, as discussed in this paper, is the raising, production and utilization of the domestic cavy (i.e., Guinea pig, Cavia porcellus) for consumption. Many sources were used in the review, but published scientific research literature is extremely scarce. Nevertheless, it can be estimated that more than 2 million cavies are kept in DRC, contributing significantly to nutrition security, especially animal protein, and income generation of some hundreds of thousands of poor rural and urban households. The largest cavy populations are in the Kivu provinces, which is probably partly due to the inclusion of cavies in ‘rehabilitation kits’ of humanitarian NGOs and in the agricultural portfolio of development agencies who seek to address the challenges of widespread hunger and malnutrition in the area. The review covers the history of cavy culture in Sud-Kivu since colonial times based on oral tradition; it describes the current ‘cavy status’ in the country and identifies research and capacity building needs. We suggest that cavy culture in DRC is likely to become more widespread and important due to the activities of a new project on ‘Harnessing husbandry of domestic cavy for alternative and rapid access to food and income in Cameroon and the eastern Democratic Republic of the Congo’. Given the dimension, cavies should be included in livestock census as well as research and development agenda, honoring their role in the livelihoods of less endowed people, especially women. [less ▲]

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See detailFrom the Annales de la régie directe to Annals of Public and Cooperative Economics: 100 years of Transformations in an International Economic Journal
Geerkens, Eric ULg

in Annals of Public and Cooperative Economics = Annales de l'Economie Publique, Sociale et Coopérative (2008), 79(3/4), 417-460

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See detailFrom the Clinics to the Bench and back to the Clinics: design of a medical treatment for Cervical Intraepithelial Neoplasia (CIN)
Jost, Maud; Frankenne, Francis; Maillard, Catherine ULg et al

Conference (2011, May 20)

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See detailFrom the curriculum framework to its dissemination: the accompaniment of educational practices in care facilities for children under three years
Pirard, Florence ULg

in European Early Childhood Education Research Journal (2011), 19(2), 255-268

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See detailfrom the deepest mud mound to the shallowest palaeosoils: correlations and sequence stratigraphy
Da Silva, Anne-Christine ULg; Boulvain, Frédéric ULg

in Abstract book 13th Bathurst meeting of carbonate sedimentologists (2007)

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See detailFrom the design to the clinical application of thromboxane modulators
Dogné, Jean-Michel ULg; Hanson, Julien ULg; de Leval, Xavier et al

in Current Pharmaceutical Design (2006), 12(8), 903-923

Arachidonic acid (AA) metabolites are key mediators involved in the pathogenesis of numerous cardiovascular, pulmonary, inflammatory, and thromboembolic diseases. One of these bioactive metabolites of ... [more ▼]

Arachidonic acid (AA) metabolites are key mediators involved in the pathogenesis of numerous cardiovascular, pulmonary, inflammatory, and thromboembolic diseases. One of these bioactive metabolites of particular importance is thromboxane A(2) (TXA(2)). It is produced by the action of thromboxane synthase on the prostaglandin endoperoxide H-2 (PGH(2)) which results from the enzymatic transformation of AA by the cyclooxygenases. It is a potent inducer of platelet aggregation, vasoconstriction and bronchoconstriction, and has been involved in a series of major pathophysiological conditions. Therefore, TXA(2) receptor antagonists, thromboxane synthase inhibitors and drugs combining both properties have been developed by different laboratories since the early 1980s. Several Compounds have been launched on the market and others are tinder clinical evaluation. In the first part of this review. we will describe the physiological properties of TXA(2), thromboxane synthase and thromboxane receptors. The second part is dedicated to a description of each class of thromboxane modulators with the advantages and disadvantages they offer. In the third part. we aim to describe recent studies performed with the most interesting thromboxane modulators in major pathologies: myocardial infarction and thrombosis, atherosclerosis, diabetes, pulmonary embolism, septic shock.. preeclampsia, and asthma. Each pathology will be systematically reviewed. Finally, in the last part we will highlight the latest perspectives in drug design of thromboxane modulators and in their future therapeutic applications such as cancer, metastasis and angiogenesis. [less ▲]

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See detailFrom the germinal cells to the newborn animal: the transmission of genes and life through the generations
Drion, Pierre ULg; Scenzi, Otto; Ectors Francis et al

(1999, May)

During the last decade, the technology of reproduction progressed considerably leading to a certain availability of in vitro methods for fertilization, maturation of the oocyte and culture system for the ... [more ▼]

During the last decade, the technology of reproduction progressed considerably leading to a certain availability of in vitro methods for fertilization, maturation of the oocyte and culture system for the embryos. The most spectacular manipulations are cloning and transgenesis… This review focuses on the early appearance of the germinal cells precursors and the longstanding destiny of the gametes in mammals. The evident complexity and long-term programmation of events in gametes and early embryo explain the difficulties to succeed in in-vitro methods and the occurrence of unexpected alterations of development, e.g. embryonic or fetal mortalities, large weight newborn syndrome and other dys-regulations in imprinting or DNA transmission. “Studying and teaching the reproductive physiology in mammals, we sometimes imagine that a newborn animal survived two pregnancies: the first one would be a high risk pregnancy that represents the oocyte development and survival inside the follicle with a tetraploïd genome and the zona pellucida & cumulus cells as placenta-like structures. Around the first birth (ovulation), oocytes (individuals) accept in vitro conditions for maturation, fertilization and culture. Afterwards, a second pregnancy will be necessary in the mother or in the recipient uterus; a low risk pregnancy depending on the oocyte competence acquisition and on the conditions or length of exposure in vitro. “ [less ▲]

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See detailFrom the germinal cells to the newborn animal: The transmission of genes and life through the generations
Drion, Pierre ULg; Szenci, Otto; Ectors, Fabien ULg et al

in Acta Veterinaria Hungarica (2003), 51(3), 371-384

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most ... [more ▼]

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most spectacular manipulations are cloning and transgenesis. This review focuses on the early appearance of germinal cell precursors and the long-standing fate of gametes in mammals. The evident complexity and long-term programming of events in gametes and early embryos explain part of the difficulties encountered during the development of in vitro and in vivo methods such as multiple Ovulation and embryo transfer (MOET), oestrus synchronisation, ovulation induction, superovulation, in vitro maturation and fertilisation, cryopreservation, transgenesis, nuclear transfer and cloning) and the occurrence of unexpected alterations of development, e.g. embryonic or fetal mortality, large-weight newborn syndrome and other dysregulations ill imprinting or DNA transmission. [less ▲]

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See detailFrom the Guiding Principles on Internal Displacement to the Nansen Initiative: What the Governance of Environmental Migration Can Learn from the Governance of Internal Displacement
Gemenne, François ULg; Brücker, Pauline

in International Journal of Refugee Law (2015), 27(2), 245-263

Environmental migration is often presented as one of the gravest consequences of environmental disruptions – climate change in particular, and is already a reality in many parts of the world. Yet the ... [more ▼]

Environmental migration is often presented as one of the gravest consequences of environmental disruptions – climate change in particular, and is already a reality in many parts of the world. Yet the protection of these migrants is not adequately addressed in the international normative frameworks on migration. As a result, a growing number of scholars and advocacy groups have sought to create a special convention and/or an ad hoc status for these migrants, while others have contended that such a legal status is not the answer. As a result, the protection of environmental migrants is currently the subject of vigorous debates amongst scholars and policy-makers, and no clear solution is yet in sight. Research however has little considered the debates that surrounded the protection of those displaced within their countries (IDPs) in the 1990s. Both phenomena have sometimes overlapped, especially as environmental displacement is often internal. Yet, the debate on IDPs has had some significant success, in particular, the adoption of the Guiding Principles on Internal Displacement in 1998, and the signature of the Organization for African Unity’s Kampala Convention in 2009. This article argues that important lessons can be drawn from the protection of IDPs in order to inform the current debates on the protection of environmental migrants, as the political contexts and policy challenges associated with both crises of the migration regime are often similar. The article identifies such lessons and assesses the opportunities and caveats of applying a similar approach of soft law to environmental migration – and what would be needed to achieve it. [less ▲]

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See detailFrom the Gymnasium to the Agora: Hermes and his Cult-Epithets
Paul, Stéphanie ULg

Conference (2014, March 29)

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See detailFrom the Herat of the Bayous- Fernest ARCENEAUX - JSP Records- LP sleeve notes & photos
Sacré, Robert ULg

Diverse speeche and writing (1983)

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