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See detailFive years of denosumab exposure in women with postmenopausal osteoporosis: Results from the first two years of the FREEDOM extension.
Papapoulos, S.; Chapurlat, R.; Libanati, C. et al

in Journal of Bone and Mineral Research (2012), 27(3), 694-701

The 3-year FREEDOM trial assessed the efficacy and safety of 60 mg denosumab every 6 months for treatment of postmenopausal women with osteoporosis. Participants who completed FREEDOM were eligible to ... [more ▼]

The 3-year FREEDOM trial assessed the efficacy and safety of 60 mg denosumab every 6 months for treatment of postmenopausal women with osteoporosis. Participants who completed FREEDOM were eligible to enter an extension to continue the evaluation of denosumab efficacy and safety for up to 10 years. For the extension results presented here, women from the FREEDOM denosumab group had 2 more years of denosumab treatment (long-term group) and those from the FREEDOM placebo group had 2 years of denosumab exposure (cross-over group). We report results for bone turnover markers (BTMs), bone mineral density (BMD), fractures rates, and safety. A total of 4550 women enrolled in the extension (2343 long-term; 2207 cross-over). Reductions in BTMs were maintained (long-term group) or occurred rapidly (cross-over group) following denosumab administration. In the long-term group, lumbar spine and total hip BMD increased further, resulting in 5-year gains of 13.7% and 7.0%, respectively. In the cross-over group, BMD increased at the lumbar spine (7.7%) and total hip (4.0%) during the 2-year denosumab treatment. Yearly fracture incidences for both groups were below rates observed in the FREEDOM placebo group and below rates projected for a "virtual untreated twin" cohort. Adverse events did not increase with long-term denosumab administration. Two adverse events in the cross-over group were adjudicated as consistent with osteonecrosis of the jaw (ONJ). Five-year denosumab treatment of women with postmenopausal osteoporosis maintained BTM reduction and increased BMD, and was associated with low fracture rates and a favorable risk/benefit profile. (c) 2011 American Society for Bone and Mineral Research. [less ▲]

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See detailFive years of experience for the promotion of a better nutritional environment in schools : The programme "Je mange bien à l'école" (I eat well at school) an innovatie project developed in the French-speaking Community of Belgium
Vandoorne, Chantal ULiege

in Bouwman, L. I.; Boonekamp, G. M. M.; Koelen, M. A. (Eds.) Proceedings of the International conference on Health Promotion and Nutrition (1996)

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See detailFive years on for Fukushima's IDPs: Life with radiological risk and without a community safety net
Hasegawa, Reiko ULiege

E-print/Working paper (2016)

On the fifth anniversary of the Fukushima nuclear accident, the article analyses what are at stake in the communities affected by the disaster, based on the result of the field interviews conducted in ... [more ▼]

On the fifth anniversary of the Fukushima nuclear accident, the article analyses what are at stake in the communities affected by the disaster, based on the result of the field interviews conducted in Fukushima. [less ▲]

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See detailFive years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age.
Seeman, Ego; Boonen, Steven; Borgstrom, Frederik et al

in BONE (2010), 46(4), 1038-42

INTRODUCTION: Longevity has resulted in a greater proportion of the population entering a time of life when increasing bone fragility and falls predispose to fractures, particularly nonvertebral fractures ... [more ▼]

INTRODUCTION: Longevity has resulted in a greater proportion of the population entering a time of life when increasing bone fragility and falls predispose to fractures, particularly nonvertebral fractures. Women over 80 years of age constitute 10% of the population but contribute 30% of all fractures and 60% of all nonvertebral fractures. Despite this, few studies have examined antifracture efficacy of treatments in this high-risk group and none has provided evidence for benefits beyond 3 years. MATERIALS AND METHODS: To determine whether strontium ranelate reduces the risk of vertebral and nonvertebral fractures during 5 years, we analyzed a subgroup of 1489 female patients over 80 years of age (mean 83.5+/-3.0 years) with osteoporosis from the SOTI (spinal osteoporosis therapeutic intervention) and TROPOS (treatment of peripheral osteoporosis) studies randomized to strontium ranelate 2 g/d or placebo. All received a supplement of calcium plus vitamin D. RESULTS: By intention to treat, vertebral fracture risk was reduced by 31% (relative risk, RR=0.69; 95% confidence interval, CI 0.52-0.92), nonvertebral fracture risk by 27% (RR=0.73; 95% CI 0.57-0.95), major nonvertebral fracture risk by 33% (RR=0.67; 95% CI 0.50-0.89) and hip fracture risk by 24% (RR=0.76; 95% CI 0.50-1.15, not significant). Treatment was cost-saving as it decreased cost and increased QALYs and life-years. DISCUSSION: Strontium ranelate safely produced a significant reduction in vertebral and nonvertebral fracture risk during 5 years in postmenopausal women over 80 years of age and was cost saving. [less ▲]

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See detailFive-spring model for complete shear behaviour of deep beams
Mihaylov, Boyan ULiege

in Structural Concrete (2015), 16(1), 71-83

This paper presents a five-spring model capable of predicting the complete pre- and post-peak shear behaviour of deep beams. The model stems from a two-parameter kinematic theory (2PKT) for the shear ... [more ▼]

This paper presents a five-spring model capable of predicting the complete pre- and post-peak shear behaviour of deep beams. The model stems from a two-parameter kinematic theory (2PKT) for the shear strength and displacement capacity of deep beams under single curvature. Four of the springs of the model represent the shear resistance mechanisms of the beam, while the fifth spring models the flexural behaviour. The model predicts not only the load–displacement response, but also the deformation patterns of the beam and how these patterns change with increasing load. Validation studies are performed by using 28 tests from the literature, showing excellent results. The model is used to interpret the tests and to draw conclusions about the behaviour of deep beams. It is shown that shear strength variations of up to 60 % between nominally identical specimens can be caused by variations in the path of the critical shear cracks. It is also demonstrated that loss of bond of large reinforcing bars increases the shear capacity of deep beams. Finally, the five-spring model is shown to predict the post-peak shear behaviour effectively, which is important for the analysis of structures under extreme loading. [less ▲]

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See detailFive-year Denosumab treatment of postmenopausal women with osteoporosis: results from the first two years of the freedom trial extension
Papapoulos, S.; Man, Z.; Mellstrom, D. et al

in Osteoporosis International (2011, March), 22(Suppl.1), 107-108

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See detailFive-year follow-up of patients from a previous 3-year randomised, controlled trial of glucosamine sulfate in knee osteoarthritis
Bruyère, Olivier ULiege; Compere, Stephanie; Rovati, Lucio C et al

in Arthritis and Rheumatism (2003, September), 48(number 9 (suppl.)), 80

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See detailFive-year follow-up of patients from a previous 3-year randomised, controlled trial of glucosamine sulfate in knee osteoarthritis
Bruyère, Olivier ULiege; Compere, S.; Rovati, Lucio C et al

in Osteoarthritis and Cartilage (2003, October), 11(Suppl.1), 10-11

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See detailFive-year follow-up patients issued from a previous 3-year randomised, controlled trial of glucosamine sulfate in knee osteoarthritis
Bruyère, Olivier ULiege; Compère, S.; Gathy, C. et al

in Osteoporosis International (2003, November), 14(Suppl 7), 9

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See detailFixation chirurgicale d'un volet thoracique: a propos d'une premiere procedure encourageante.
TONGLET, Martin ULiege; DESIRON, Quentin ULiege; Marechal, Hugues et al

in Revue Médicale de Liège (2016), 71

We report the case of a young woman who suffered from a severe traffic accident with major thoracic trauma consisting of hemopneumothorax and flail chest. At day 5 of mechanical ventilation, a surgical ... [more ▼]

We report the case of a young woman who suffered from a severe traffic accident with major thoracic trauma consisting of hemopneumothorax and flail chest. At day 5 of mechanical ventilation, a surgical reduction and fixation of the fractured ribs were performed; the patient was liberated from mechanical ventilation the next day and discharged from the intensive care unit two days later. The success of this local first case incites us to further a similar approach in such challenging trauma cases. [less ▲]

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See detailFixation de ferritine cationisee a la surface des cretes palatines du rat.
Renard, Ariane ULiege; Heinen, Ernst ULiege; Baeckeland, E.

in Bulletin de l'Association des Anatomistes (1982), 66(192), 117-25

Recently, we suggested that the cell coat of the surface epithelial cells of the palatal shelves and especially its sialyl groups are implied in the adhesion process which initiates the constitution of ... [more ▼]

Recently, we suggested that the cell coat of the surface epithelial cells of the palatal shelves and especially its sialyl groups are implied in the adhesion process which initiates the constitution of the secondary palate. In this work, use of cationized ferritin which interacts with anionic receptors of the plasma membrane give us the possibility to render these sialic acids visible. After five minutes incubation in presence of cationized ferritin, the labeling particles are distributed in monolayer over the plasmalemma of epithelial cells. Subsequent incubation in cationized ferritin free medium results in clustering of the marker followed by the detachment of the labeled patches. Otherwise, incubation in the presence of neuraminidase from Clostridium perfringens before the polycationic ligand contact prevents labeling. We think that lateral migration modifications of the anionic receptor could be associated with changes of the shelves capacity to adhere. [less ▲]

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See detailLa fixation de la frontière linguistique au parlement
Verjans, Pierre ULiege

in Ubac, Pierre (Ed.) Génération Fourons (1993)

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See detailFixation du CO2 dans les blocs de béton à base de granulats recyclés
Parmentier, Véronique; Michel, Frédéric ULiege; Courard, Luc ULiege

in Gagné, Richard (Ed.) Actes de la 14ème édition des Journées Scientifiques (2013)

A l’heure où l’industrie cimentière est majoritairement responsable de la production de CO2 dans le secteur de la construction, il s’avère utile de compenser cette production par un phénomène inverse: la ... [more ▼]

A l’heure où l’industrie cimentière est majoritairement responsable de la production de CO2 dans le secteur de la construction, il s’avère utile de compenser cette production par un phénomène inverse: la captation du CO2. Ce processus d’absorption de CO2, appelé carbonatation, améliore certaines propriétés du béton lors de la conversion du dioxyde de carbone CO2 en carbonate de calcium CaCO3. Les préoccupations environnementales actuelles motivent l’étude de la carbonatation dans le but de maximiser l'absorption du dioxyde de carbone. Les granulats recyclés, produits à base de déchets de béton concassés mécaniquement, peuvent prendre place dans de nouvelles applications en béton. Ils peuvent remplacer les granulats naturels en tout ou en partie, épargnant ainsi l’extraction des matières premières naturelles. La combinaison des deux approches vise à élaborer un produit dont l’impact environnemental est réduit au minimum. [less ▲]

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See detailLa fixation du prix par un tiers désigné sur la base de l’article 1592 du Code civil
Caprasse, Olivier ULiege

in Journal des Tribunaux (2014)

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See detailFixation of oxoglutarate on the external face of the internal minochondrial membrane of rat hearts (proceedings)
Sluse, Francis ULiege; Sluse-Goffart, Claudine; Duyckaerts, Claire ULiege et al

in Archives Internationales de Physiologie et de Biochimie (1978), 86

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See detailFixed discrimination factors in diet reconstruction?
Caut, Stéphane; Das, Krishna ULiege

Conference (2008, August 25)

Detailed reference viewed: 7 (1 ULiège)