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See detailHigh-dimensional probability density estimation with randomized ensembles of tree structured bayesian networks
Ammar, Sourour; Leray, Philippe; Defourny, Boris ULg et al

in Proc. of the 4th European Workshop on Probabilistic Graphical Models (PGM08) (2008)

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See detailHigh-dispersion infrared spectroscopic observations of comet 8P/Tuttle with VLT/CRIRES
Kobayashi, H.; Bockelée-Morvan, D.; Kawakita, H. et al

in Astronomy and Astrophysics (2010), 509

We report on the composition of the Halley-family comet (HFC) 8P/Tuttle investigated with high-dispersion near-infrared spectroscopic observations. The observations were carried out at the ESO VLT (Very ... [more ▼]

We report on the composition of the Halley-family comet (HFC) 8P/Tuttle investigated with high-dispersion near-infrared spectroscopic observations. The observations were carried out at the ESO VLT (Very Large Telescope) with the CRIRES instrument as part of a multi-wavelength observation campaign of 8P/Tuttle performed in late January and early February 2008. Radar observations suggested that 8P/Tuttle is a contact binary, and it was proposed that these components might be heterogeneous in chemistry. We determined mixing ratios of organic volatiles with respect to H[SUB]2[/SUB]O and found that mixing ratios were consistent with previous near infrared spectroscopic observations obtained in late December 2007 and in late January 2008. It has been suggested that because 8P/Tuttle is a contact binary, it might be chemically heterogeneous. However, we find no evidence for chemical heterogeneity within the nucleus of 8P/Tuttle. We also compared the mixing ratios of organic molecules in 8P/Tuttle with those of both other HFCs and long period comets (LPCs) and found that HCN, C[SUB]2[/SUB]H[SUB]2[/SUB], and C[SUB]2[/SUB]H[SUB]6[/SUB] are depleted whereas CH[SUB]4[/SUB] and CH[SUB]3[/SUB]OH have normal abundances. This may indicate that 8P/Tuttle was formed in a different region of the early solar nebula than other HFCs and LPCs. We estimated the conversion efficiency from C[SUB]2[/SUB]H[SUB]2[/SUB] to C[SUB]2[/SUB]H[SUB]6[/SUB] by hydrogen addition reactions on cold grains by employing the C[SUB]2[/SUB]H[SUB]6[/SUB]/(C[SUB]2[/SUB]H[SUB]6[/SUB]+C[SUB]2[/SUB]H[SUB]2[/SUB]) ratio. The C[SUB]2[/SUB]H[SUB]6[/SUB]/(C[SUB]2[/SUB]H[SUB]6[/SUB]+C[SUB]2[/SUB]H[SUB]2[/SUB]) ratio in 8P/Tuttle is consistent with the ratios found in other HFCs and LPCs within the error bars. We also discuss the source of C[SUB]2[/SUB] and CN based on our observations and conclude that the abundances of C[SUB]2[/SUB]H[SUB]2[/SUB] and C[SUB]2[/SUB]H[SUB]6[/SUB] are insufficient to explain the C[SUB]2[/SUB] abundances in comet 8P/Tuttle and that the abundance of HCN is insufficient to explain the CN abundances in the comet, so at least one additional parent is needed for each species, as pointed out in previous study. Based on observations collected at the European Southern Observatory, Paranal, Chile (ESO Prog. 080.C-0615 and 280.C-5053).We regret to note the death of Dr. J. -M. Zucconi in 2009 May. [less ▲]

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See detailHigh-dispersion Spectroscopic Observations Of 8P/Tuttle With VLT/CRIRES
Kobayashi, Hitomi; Bockelee-Morvan, D.; Dello Russo, N. et al

in Bulletin of the American Astronomical Society (2008, September 01), 40

We present near-infrared observations of organic molecules in comet 8P/Tuttle. Comet 8P/Tuttle is a Halley-type comet and its last perihelion was in early January 2008. Our observations were carried out ... [more ▼]

We present near-infrared observations of organic molecules in comet 8P/Tuttle. Comet 8P/Tuttle is a Halley-type comet and its last perihelion was in early January 2008. Our observations were carried out on January 28 and February 4 using CRIRES (CRyogenic high-resolution InfraRed Echelle Spectrograph) at the Very Large Telescope (VLT). We used a 0.2" slit which provided a spectral resolving power of 80,000. We detected H[SUB]2[/SUB]O, OH, HCN, C[SUB]2[/SUB]H[SUB]2[/SUB] on Jan 28, and H[SUB]2[/SUB]O, OH, CH[SUB]4[/SUB], C[SUB]2[/SUB]H[SUB]6[/SUB], and CH[SUB]3[/SUB]OH on Feb 4. We find that 8P/Tuttle is depleted in HCN, C[SUB]2[/SUB]H[SUB]2[/SUB] and C[SUB]2[/SUB]H[SUB]6[/SUB] relative to H[SUB]2[/SUB]O compared with most other Oort cloud comets studied to date. Perhaps these depletions suggest that 8P/Tuttle formed in a different region from most Oort cloud comets, but it is also possible that the depletions are caused by repeated passages through the inner solar system. [less ▲]

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See detailHigh-Dispersion Spectroscopic Observations of Comet C/2012 S1 (ISON) with the Subaru Telescope
Shinnaka, Yoshiharu; Kawakita, Hideyo; Nagashima, Masayoshi et al

in Bulletin of the American Astronomical Society (2014, November 01), 46

Comet C/2012 S1 (ISON) was one of the Oort cloud comets and dynamically new. This comet was broken at its perihelion passage on UT 2013 November 28.1 (at Rh ~ 17 solar radius). We observed the comet C ... [more ▼]

Comet C/2012 S1 (ISON) was one of the Oort cloud comets and dynamically new. This comet was broken at its perihelion passage on UT 2013 November 28.1 (at Rh ~ 17 solar radius). We observed the comet C/2012 S1 (ISON) on UT 2013 November 15 with the High Dispersion Spectrograph (HDS) mounted on the Subaru Telescope atop Mauna Kea, Hawaii. Its heliocentric and geocentric distances were 0.601 and 0.898 AU, respectively. We selected the slit size of 0”.5 x 9”.0 on the sky to achieve the spectral resolution of R = 72,000 from 550 to 830 nm. The total exposure time of comet C/2012 S1 (ISON) was 1200 seconds. We detected many emission lines caused from radicals (e.g., CN, C2, NH2), ions (H2O+), atoms ([OI] and Na I) and also many unidentified lines in the spectra. We report the (1) the ortho-to-para abundance ratios (OPRs) of water and ammonia estimated from the high-dispersion spectra of H2O+ and NH2, (2) the green-to-red line ratio of forbidden oxygen emissions, (3) the isotopic ratios of C2 (the carbon isotopic ratio from Swan band) and CN (the carbon and nitrogen isotopic ratios from red band), (4) the sodium-to-continuum ratio of comet C/2012 S1 (ISON). </PRE></BODY></HTML> [less ▲]

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See detailHigh-dispersion spectroscopic observations of comet C/2013 R1 (Lovejoy) with the Subaru Telescope on 2013 November 15
Shinnaka, Y.; Kawakita, H.; Nagashima, M. et al

in Muinonen, Karri (Ed.) Asteroids, Comets, Meteors - Book of Abstracts (2014, July 01)

Comet C/2013 R1 (Lovejoy) probably originates from the Oort Cloud. Comet Lovejoy provided us with great opportunities to investigate the chemical composition of the comet thanks to its brightness and ... [more ▼]

Comet C/2013 R1 (Lovejoy) probably originates from the Oort Cloud. Comet Lovejoy provided us with great opportunities to investigate the chemical composition of the comet thanks to its brightness and elongation angle from October 2013 to March 2014. We observed comet C/2013 R1 (Lovejoy) on 2013 November 15 UT using the High Dispersion Spectrograph (HDS) mounted on the Subaru Telescope on Mauna Kea. Its heliocentric and geocentric distances were 1.066 and 0.412 au, respectively. The obtained spectra cover the wavelength region from 360 to 830 nm with the resolving power of R = λ/Δλ = 72,000 for the slit size of 0''.5 × 9''.0 (360-520 nm) and 0''.5 × 9''.0 (550-830 nm) on the sky. Exposure time was 130 minutes in total (100 minutes for shorter and 30 minutes for longer wavelength regions). We could identify many species such as the radicals (CN, CH, C_{3}, C_{2}, NH_{2}, etc.), ions (CH^{+}, H_{2}O^{+}), and atoms ([OI] and NaI) in the spectra and many unidentified lines were also detected. Here we discuss the chemical reaction in cometary coma and the origin of icy materials of comet C/2013 R1 (Lovejoy), based on the high-dispersion spectra in the optical wavelength regions. We present (1) the ortho-to-para abundance ratios (OPRs) of water and ammonia inferred from the high-dispersion spectra of H_{2}O^{+} and NH_{2}, (2) the green-to-red line ratio of forbidden oxygen emissions, (3) the nitrogen and the carbon isotopic ratios of CN, and (4) spatial distributions of radicals, atoms, and dust continuum in the inner coma. [less ▲]

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See detailHigh-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery
Janssens, Marc ULg; Joris, Jean ULg; David, Jean-Louis et al

in Anesthesiology (1994), 80

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See detailHigh-Dose Cytarabine in Induction Treatment Improves the Outcome of Adult Patients Younger Than Age 46 Years With Acute Myeloid Leukemia: Results of the EORTC-GIMEMA AML-12 Trial
Willemze, Roelof; Suciu, Stefan; Meloni, Giovanna et al

in Journal of Clinical Oncology (2014), 32(3), 219-228

Purpose : Cytarabine plays a pivotal role in the treatment of patients with acute myeloid leukemia (AML). Most centers use 7 to 10 days of cytarabine at a daily dose of 100 to 200 mg/m2 for remission ... [more ▼]

Purpose : Cytarabine plays a pivotal role in the treatment of patients with acute myeloid leukemia (AML). Most centers use 7 to 10 days of cytarabine at a daily dose of 100 to 200 mg/m2 for remission induction. Consensus has not been reached on the benefit of higher dosages of cytarabine. Patients and Methods : The European Organisation for Research and Treatment of Cancer (EORTC) and Gruppo Italiano Malattie Ematologiche dell’ Adulto (GIMEMA) Leukemia Groups conducted a randomized trial (AML-12; Combination Chemotherapy, Stem Cell Transplant and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia) in 1,942 newly diagnosed patients with AML, age 15 to 60 years, comparing remission induction treatment containing daunorubicin, etoposide, and either standard-dose (SD) cytarabine (100 mg/m2 per day by continuous infusion for 10 days) or high-dose (HD) cytarabine (3,000 mg/m2 every 12 hours by 3-hour infusion on days 1, 3, 5, and 7). Patients in complete remission (CR) received a single consolidation cycle containing daunorubicin and intermediate-dose cytarabine (500 mg/m2 every 12 hours for 6 days). Subsequently, a stem-cell transplantation was planned. The primary end point was survival. Results : At a median follow-up of 6 years, overall survival was 38.7% for patients randomly assigned to SD cytarabine and 42.5% for those randomly assigned to HD cytarabine (log-rank test P = .06; multivariable analysis P = .009). For patients younger than age 46 years, survival was 43.3% and 51.9%, respectively (P = .009; multivariable analysis P = .003), and for patients age 46 to 60 years, survival was 33.9% and 32.9%, respectively (P = .91). CR rates were 72.0% and 78.7%, respectively (P = .001) and were 75.6% and 82.4% for patients younger than age 46 years (P = .01) and 68.3% and 74.8% for patients age 46 years and older (P = .03). Patients of all ages with very-bad-risk cytogenetic abnormalities and/or FLT3-ITD (internal tandem duplication) mutation, or with secondary AML benefitted from HD cytarabine. Conclusion : HD cytarabine produces higher remission and survival rates than SD cytarabine, especially in patients younger than age 46 years. [less ▲]

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See detailHigh-dose oral intake of serotonin induces valvular heart disease in rabbits.
Lancellotti, Patrizio ULg; NCHIMI LONGANG, Alain ULg; Hego, Alexandre ULg et al

in International Journal of Cardiology (2015), 197

Carcinoid tumors are rare neuroendocrine malignancies, often originating from enterochromaffin cells in the gastrointestinal tract. They can secrete serotonin (5-hydroxytryptamine, 5-HT), which is largely ... [more ▼]

Carcinoid tumors are rare neuroendocrine malignancies, often originating from enterochromaffin cells in the gastrointestinal tract. They can secrete serotonin (5-hydroxytryptamine, 5-HT), which is largely inactivated by the liver. Carcinoid heart disease occurs when tumor cells metastasize to the liver, as the vasoactive substances produced are able to reach the systemic circulation via the hepatic vein, causing deposition of fibrous tissue on the endocardial surfaces of the heart. It is predominantly manifested by right-sided valvular heart disease (VHD). Scavenging enzymes in the pulmonary endothelium may explain why left-sided cardiac involvement is unusual. The severity of cardiac damage is correlated with the plasmatic levels of serotonin, but the lowspecificity of serotonin for cardiac damage suggests that serotonin may be necessary but not sufficient to induce cardiac lesions. Therefore, other factors combined with serotonin might be required to induce VHD. However, recent animal studies confirmed the development of carcinoid-like valvular deposits in rats after 3 months of daily subcutaneous/intraperitoneal serotonin injections to avoid the liver first-pass clearance.Whether oral administration of serotonin can also induce VHD is unknown. We hypothesized that long-term oral serotonin overload in rabbits can lead to VHD, mimicking serotonin-induced lesions of carcinoid heart disease. We demonstrate, for the first time that high dose long-term oral administration of serotonin can lead to VHD in rabbits. [less ▲]

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See detailHigh-Dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study
Schoenen, Jean ULg; Lenaerts, M.; Bastings, E.

in Cephalalgia : An International Journal of Headache (1994), 14(5), 328-9

If the brain of migraineurs is characterized between attacks by a reduction of mitochondrial phosphorylation potential, riboflavin, which has the potential of increasing mitochondrial energy efficiency ... [more ▼]

If the brain of migraineurs is characterized between attacks by a reduction of mitochondrial phosphorylation potential, riboflavin, which has the potential of increasing mitochondrial energy efficiency, might have prophylactic effects in migraine. In this preliminary open pilot study, 49 patients suffering from migraine (45 without aura, 4 with aura) were treated with 400 mg of riboflavin as a single oral dose for at least 3 months. Twenty-three patients received in addition 75 mg of aspirin. Mean global improvement after therapy was 68.2% and there was no difference between the two groups of patients. With the exception of one patient in the riboflavin plus aspirin group who withdrew because of gastric intolerance, no drug-related side effects were reported. High-dose riboflavin could thus be an effective, low-cost prophylactic treatment of migraine devoid of short-term side effects. A placebo-controlled trial of its efficacy seems worthwhile. [less ▲]

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See detailHigh-efficiency biolistic transformation of Chlamydomonas mitochondria can be used to insert mutations in complex I genes
Remacle, Claire ULg; Cardol, Pierre ULg; Coosemans, Nadine ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2006), 103(12), 4771-4776

Mitochondrial transformation of Chlamydomonas reinhardtii has been optimized by using a particle-gun device and cloned mitochondrial DNA or PCR fragments. A respiratory-deficient strain lacking a 1.2-kb ... [more ▼]

Mitochondrial transformation of Chlamydomonas reinhardtii has been optimized by using a particle-gun device and cloned mitochondrial DNA or PCR fragments. A respiratory-deficient strain lacking a 1.2-kb mitochondrial DNA region including the left telomere and part of the cob gene could be rescued as well as a double-frameshift mutant in the mitochondrial cox1 and nd1 genes. High transformation efficiency has been achieved (100-250 transformants per microgram of DNA), the best results being obtained with linearized plasmid DNA. Molecular analysis of the transformants suggests that the right telomere sequence can be copied to reconstruct the left telomere by recombination. In addition, both nondeleterious and deleterious mutations could be introduced. Myxothiazol-resistant transformants have been created by introducing a nucleotide substitution into the cob gene. Similarly, an in-frame deletion of 23 codons has been created in the nd4 mitochondrial gene of both the deleted and frameshift recipient strains. These 23 codons are believed to encode the first transmembrane segment of the ND4 protein. This Delta nd4 mutation causes a misassembly of complex 1, with the accumulation of a subcomplex that is 250-kDa smaller than the wild-type complex 1. The availability of efficient mitochondrial transformation in Chlamydomonas provides an invaluable tool for the study of mitochondrial biogenesis and, more specifically, for site-directed mutagenesis of mitochondrially encoded subunits of complex 1, of special interest because the yeast Saccharomyces cerevisiae, whose mitochondrial genome can be manipulated virtually at will, is lacking complex 1. [less ▲]

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See detailHigh-Efficiency Liquid-Liquid Phase Separation Using Internals
Chatterjee, M; Franken, H; Hülswitt, N et al

Conference (2003)

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See detailHigh-energy forward scattering and the pomeron: Simple pole versus unitarized models
Cudell, Jean-René ULg; Ezhela, V.; Kang, K. et al

in Physical Review. D : Particles and Fields (2000), 61

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See detailHigh-energy hadron spin-flip amplitude at small momentum transfer and new A(N) data from RHIC
Cudell, Jean-René ULg; Predazzi, E.; Selyugin, Oleg Viktorovich

in European Physical Journal A -- Hadrons & Nuclei (2004), 21(3), 479-486

In the case of elastic high-energy hadron-hadron scattering, the impact of the large-distance contributions on the behaviour of the slopes of the spin-non-flip and of the spin-flip amplitudes is analysed ... [more ▼]

In the case of elastic high-energy hadron-hadron scattering, the impact of the large-distance contributions on the behaviour of the slopes of the spin-non-flip and of the spin-flip amplitudes is analysed. It is shown that the long tail of the hadronic potential in impact parameter space leads to a value of the slope of the reduced spin-flip amplitude larger than that of the spin-non-flip amplitude. This effect is taken into account in the calculation of the analysing power in proton-nucleus reactions at high energies. It is shown that the preliminary measurement of A(N) (for p 12C obtained by the E950 Collaboration indeed favours a spin-flip amplitude with a large slope. Predictions for A)(N) (at P)(L) = 250 GeV/c are given. [less ▲]

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See detailHigh-Energy Physics with Particles Carrying Non-Zero Orbital Angular Momentum
Ivanov, Igor ULg

in Few-Body Systems (2011)

Thanks to progress in optics in the past two decades, it is possible to create photons carrying well-defined non-zero orbital angular momentum (OAM). Boosting these photons into high-energy range ... [more ▼]

Thanks to progress in optics in the past two decades, it is possible to create photons carrying well-defined non-zero orbital angular momentum (OAM). Boosting these photons into high-energy range preserving their OAM seems feasible. Intermediate energy electrons with OAM have also been produced recently. One can, therefore, view OAM as a new degree of freedom in high-energy collisions and ask what novel insights it can bring. Here we discuss generic features of scattering processes involving twisted particles in the initial state. We show that they make it possible to perform a Fourier analysis of a plane wave cross section with respect to the azimuthal angles of the initial particles, and to probe the autocorrelation function of the amplitude, a quantity inaccessible in plane wave collisions. [less ▲]

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See detailHigh-energy X-ray tomography analysis of a metal packing biofilm reactor for the production of lipopeptides by Bacillus subtilis
Zune, Quentin ULg; Soyeurt, Delphine; Toye, Dominique ULg et al

in Journal of Chemical Technology & Biotechnology (2014), 89

BACKGROUND: Whereas multi-species biofilm reactors are commonly used for the treatment of liquid and solid wastes, new strategies are progressing for the development of single species biofilm for the ... [more ▼]

BACKGROUND: Whereas multi-species biofilm reactors are commonly used for the treatment of liquid and solid wastes, new strategies are progressing for the development of single species biofilm for the production of high-value metabolites. Technically, this new concept relies on the design of bioreactors able to promote biofilm formation and on the identification of the key physico-chemical parameters involved in biofilm formation. RESULTS: An experimental setting comprising a liquid continuously recirculated on a metal structured packing has been used to promote Bacillus subtilis GA1 biofilm formation. The colonization of the packing has been visualized non-invasively by X-ray tomography. This analysis revealed an uneven, conical, distribution of the biofilm inside the packing. Compared with a submerged culture carried out in a stirred tank reactor, significant modification of the lipopeptide profile has been observed in the biofilm reactorwith the disappearance of fengycin and iturin fractions and an increase of the surfactin fraction. In addition, considering the biofilm reactor design, no foam formation has been observed during the culture. CONCLUSIONS: The configuration of this biofilm reactor set-up allows for a higher surfactin production by comparison with a submerged culture while avoiding foam formation. Additionally, scale-up could easily be performed by increasing the number of packing elements. [less ▲]

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See detailHigh-field magnetization of U2T2X compounds (T = Co, Ni, Rh, Pd, Ir, Pt and X = In, Sn)
Nakotte, Heinz; Prokes, Karel; Brück, E. et al

Poster (1993, November)

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See detailHigh-field magnetization of U2T2X compounds (T = Co, Rh, Ni, Pd, Ir, Pt and X = In, Sn)
Nakotte, Heinz; Prokes, Karel; Brück, E. et al

in Physica B: Condensed Matter (1994), 201

Structure parameters and magnetization in quasistatic fields up to 38 T at 4.2 K are reported for U2T2X compounds with T = Co, Rh, Ni, Pd, Ir, Pt and X = In, Sn, which crystalline in the tetragonal U3Si2 ... [more ▼]

Structure parameters and magnetization in quasistatic fields up to 38 T at 4.2 K are reported for U2T2X compounds with T = Co, Rh, Ni, Pd, Ir, Pt and X = In, Sn, which crystalline in the tetragonal U3Si2 structure. Even the highest applied fields are not sufficient to achieve saturation of the magnetization in any of these compounds of which the majority is antiferromagnetic and some are Pauli paramagnets. The importance of 5f-ligand hybridization for the magnetism in these compounds is discussed. [less ▲]

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See detailHigh-frequency A-type pulsators discovered using SuperWASP
Holdsworth, Daniel L.; Smalley, B.; Gillon, Michaël ULg et al

in Monthly Notices of the Royal Astronomical Society (2014)

We present the results of a survey using the WASP archive to search for high-frequency pulsations in F-, A- and B-type stars. Over 1.5 million targets have been searched for pulsations with amplitudes ... [more ▼]

We present the results of a survey using the WASP archive to search for high-frequency pulsations in F-, A- and B-type stars. Over 1.5 million targets have been searched for pulsations with amplitudes greater than 0.5 millimagnitude. We identify over 350 stars which pulsate with periods less than 30 min. Spectroscopic follow-up of selected targets has enabled us to confirm 10 new rapidly oscillating Ap stars, 13 pulsating Am stars and the fastest known δ Scuti star. We also observe stars which show pulsations in both the high-frequency domain and the low-frequency δ Scuti range. This work shows the power of the WASP photometric survey to find variable stars with amplitudes well below the nominal photometric precision per observation. [less ▲]

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See detailHigh-frequency correction method for CO2 and water vapour fluxes: an application on Walloon Terrestrial Observatories data
De Ligne, Anne ULg

Report (2015)

High frequency concentration fluctuations are attenuated by the eddy covariance (EC) sensors system. This is due to an inability of the EC system to process eddies of small size and induces an ... [more ▼]

High frequency concentration fluctuations are attenuated by the eddy covariance (EC) sensors system. This is due to an inability of the EC system to process eddies of small size and induces an underestimation of the fluxes. The two main reasons are the fluid frictions through the inlet tube of the gas analyzer and the separation of the sensors position between the center of the anemometer and the inlet tube. A correction factor is then needed for CO2 and H2O fluxes. In this study, we describe a new procedure for the high frequency correction (HFC). This new HFC is applied for the CO2 and H2O fluxes measured at Vielsalm and Lonzée since their setup. Finally, we compare the former and updated corrected fluxes of these two sites which are part of the Terrestrial Observatories of Belgium. Both Observatories are included in the European ecosystem network of ICOS. [less ▲]

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