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See detailHigh prevalence of pituitary adenomas: A cross-sectional study in the province of Liege, Belgium
Daly, Adrian ULg; Rixhon, M.; Adam, Christelle et al

in Journal of Clinical Endocrinology and Metabolism (2006), 91(12), 4769-4775

Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. Objective: The objective of the study was to ... [more ▼]

Context: Prevalence data are important for assessing the burden of disease on the health care system; data on pituitary adenoma prevalence are very scarce. Objective: The objective of the study was to measure the prevalence of clinically relevant pituitary adenomas in a well-defined population. Design: This was a cross-sectional, intensive, case-finding study performed in three regions of the province of Liège, Belgium, to measure pituitary adenoma prevalence as of September 30, 2005. Setting: The study was conducted in specialist and general medical practitioner patient populations, referral hospitals, and investigational centers. Methods: Three demographically and geographically distinct districts of the province of Liège were delineated precisely using postal codes. Medical practitioners in these districts were recruited, and patients with pituitary adenomas under their care were identified. Diagnoses were confirmed after retrieval of clinical, hormonal, radiological, and pathological data; full demographic and therapeutic follow-up data were collected in all cases. Results: Sixty-eight patients with clinically relevant pituitary adenomas were identified in a population of 71,972 individuals; the mean (± SD) prevalence was 94 ± 19.3 cases per 100,000 population (95% confidence interval, 72.2 to 115.8). The group was 67.6% female and had a mean age at diagnosis of 40.3 yr; 42.6% had macroadenomas and 55.9% underwent surgery. Prolactinomas comprised 66% of the group, with the rest having nonsecreting tumors (14.7%), somatotropinomas (13.2%), or Cushing’s disease (5.9%); 20.6% had hypopituitarism. Conclusion: The prevalence of pituitary adenomas in the study population (one case in 1064 individuals) was more than 3.5–5 times that previously reported. This increased prevalence may have important implications when prioritizing funding for research and treatment of pituitary adenomas. [less ▲]

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See detailHigh prevalence of risk factors for cardiovascular diseases in postmenopausal women being prescribed an antiosteoporotic treatment
Bosio Le Goux, B.; Augendre-Ferrante, B.; Tancredi, Annalisa ULg et al

in Osteoporosis International (2003, November), 14(Suppl. 7), 87

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See detailHigh production of SPARC/osteonectin/BM-40 in mouse metastatic B16 melanoma cell lines
Kato, Y.; Frankenne, F.; Noël, Agnès ULg et al

in Pathology Oncology Research (2000), 6(1), 24-26

Abstract Production of SPARC/osteonectin/BM-40 was determined in mouse B16 melanoma clones BL6 and F10 (high metastatic) and F1 (low metastatic). SPARC was produced greater amount in BL6 and F10 than in ... [more ▼]

Abstract Production of SPARC/osteonectin/BM-40 was determined in mouse B16 melanoma clones BL6 and F10 (high metastatic) and F1 (low metastatic). SPARC was produced greater amount in BL6 and F10 than in F1 cells, showing a good agreement with their metastatic potentials. Moreover, SPARC production was not influenced by culture pH, even in the acidic conditions (= pH 5.9). Although tumor tissues show often low pH due to excessive amount of acidic metabolites such as lactate, most studies have been done in neutral pH. High SPARC production in the acidic medium, therefore, is thought to be an important potential for tumor invasive behaviour. [less ▲]

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See detailHigh protein intake affects lean body mass but not energy expenditure in nonobese neutered cats
Nguyen, Patrick; Leray, Véronique; Dumon, Henri et al

in Journal of Nutrition (2004), 134(8, Suppl. S), 2084-2086

Dietary composition affects body composition; the role of fat and carbohydrates is well documented. Proteins are more satiating than carbohydrates, may produce different effects on glycemia , and are more ... [more ▼]

Dietary composition affects body composition; the role of fat and carbohydrates is well documented. Proteins are more satiating than carbohydrates, may produce different effects on glycemia , and are more thermogenic. Indeed the efficiency of cellular conversion of energy to high-energy yielding phosphate bonds from fatty acids is 90%, from carbohydrates 75%, but only 55% for amino acids. High-protein diets produced greater weight loss in some studies of obese humans but not others. Other human studies found that although the high-protein diet did not promote weight loss in excess of control diets, it did preserve lean tissue mass and promoted the loss of fat tissue . Companion animals also suffer from obesity , and a high-protein, energy-restricted diet was successful in reducing the body weight and body fat of overweight dogs and cats , and in conserving lean body mass of dogs . However, there have been few studies of the effects of protein intake on the body composition in normal-weight individuals of any species. The current study aimed to determine the effect of a limited energy intake of a high-protein diet on the body composition and least observed metabolism (LOM)5 of adult neutered cats. [less ▲]

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See detailHigh quality meshing based on harmonic mappings for biomedical simulation
Remacle, J.-F.; Marchandise, E.; Willemet, M. et al

in Proceedings of the 1st International Conference on Mathematical and Computational Biomedical Engineering (CMBE2009) (2009)

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See detailHigh quality meshing with harmonic maps
Marchandise, E.; Remacle, J.-F.; Geuzaine, Christophe ULg

in Proceedings of the IVth European Conference on Computational Mechanics (ECCM 2010) (2010)

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See detailHigh Quality Surface Meshing using Harmonic Maps
Geuzaine, Christophe ULg

Scientific conference (2010, June 09)

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See detailHigh Quality Surface Remeshing Using Harmonic Maps. Part II: Surfaces with High Genus and of Large Aspect Ratio
Marchandise, E.; Carton de Wiart, C.; Vos, W. et al

in International Journal for Numerical Methods in Engineering (2011), 86(11), 1303-1321

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See detailHigh Quality Surface Remeshing Using Harmonic Maps. Surfaces with High Genus and of Large Aspect Ratio
Remacle, J.-F.; Geuzaine, Christophe ULg; Marchandise, E.

in 19th International Meshing Roundtable (2010)

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See detailHigh Quality Surface Remeshing Using Harmonic Maps: Surfaces with High Genus and of Large Aspect Ratio
Remacle, J.-F.; Geuzaine, Christophe ULg; Marchandise, E.

in Proceedings of the Third Workshop on Grid Generation for Numerical Computations, Tetrahedron III (2010, September)

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See detailHigh reactive oxygen species in fibrotic and non-fibrotic skin of Patients with diffuse cutaneous systemic sclerosis
BOURJI, Khalil; MEYER, Alain; CHATELUS, Emmanuel et al

in Free Radical Biology & Medicine (2015), 87

Systemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil the pathogenic ... [more ▼]

Systemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil the pathogenic mechanisms of SSc, they are still unclear. High levels of Reactive Oxygen Species (ROS) in affected patients have been shown, and ROS are suggested to play a role in fibrosis pathogenesis. In this study we evaluate ROS levels in non-fibrotic and fibrotic skin of patients with SSc and we compare them with those obtained from healthy controls. Patients and Methods We enrolled 9 SSc patients fulfilling the EULAR/ACR classification criteria and 7 healthy controls. Patients included were 4 men and 5 women with mean age of 46 ±10 yrs. Controls were matched by sex and age. All patients were affected by diffuse cutaneous form of SSc and the ANA pattern anti-Scl70. Mean disease duration was 7.5±5 yrs. Skin involvement was evaluated by modified Rodnan Skin Score (mRSS). Skin samples (4 mm punch biopsy) were taken from fibrotic skin and non-fibrotic skin of patients and from healthy controls as well. To detect ROS, specimens were analyzed immediately after sampling by electron paramagnetic resonance spectroscopy. Blood samples have been drawn from all patients and controls to assess oxidative stress biomarkers. Results ROS levels (expressed as median and range, unit of measurement was nmol/l/min/mg of dry weight) were 24.7 (10.9– 47.0) in fibrotic skin, 18.7 (7.3–34.0) in non-fibrotic skin and 7.7 (3.5–13.6) in healthy controls skin. ROS levels in Fibrotic and Non-fibrotic skin of SSc patients were significantly higher than in Healthy Controls (p=0.002 and p=0.009, respectively). ROS levels in fibrotic skin were raised in comparison to non-fibrotic skin, when samples related to each patient were compared (p=0.01). ROS levels in fibrotic skin were correlated with forced vital capacity (r= -0.75, p=0.02) and erythrocyte sedimentation rate (r=0.70, p=0.04). All other clinical and lab parameters showed no significant correlation. When compared to controls, blood from SSc patients showed lower ascorbate (vitamin C) levels (8 [3.8-9.8] vs. 10.5 [9-19.1] mg/L, p=0.004) and higher lipid peroxides (873.5 [342-1973] vs. 422 [105-576] μmol/L, p=0.004). Conclusion Our results indicate the presence of high oxidative stress both in non-fibrotic skin and fibrotic skin of SSc patients, but with higher tendency in the latter. Raised ROS levels in non-fibrotic skin of SSc patients might be a hint of early involvement in skin fibrogenesis. However, a longitudinal prospective study is necessary for such proof. [less ▲]

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See detailThe high redshift of quasars
Surdej, Jean ULg

in Kleczek, J. (Ed.) Exercises in astronomy.. Revised and extended edition of "Practical work in elementary astronomy" by M. G. J. Minnaert. D. ReidelPublishing Co., Dordrecht, The Netherlands. 24+339 pp. Price Dfl. 140.00, US 64.00, £ 49.50 cloth; Dfl. 59.00, US 19.50, £ 18.00 paper (1987). ISBN 90-277-2409-1 cloth, ISBN 90-277-2423-7 paper. (1987)

This book is an updated and considerably extended version of Minnaert's work published in 1969 (01.003.051).Many new exercises referring to new observational techniques and methods have been incorporated ... [more ▼]

This book is an updated and considerably extended version of Minnaert's work published in 1969 (01.003.051).Many new exercises referring to new observational techniques and methods have been incorporated by the editor in collaboration with the contributing authors D. A. Allen, Z. Ceplechka, S. Ferraz Mello, K. J. Gordon, L. Houziaux, C. Jaschek, Z. Kopal, J. Manfroid, J. Palous, J. Podolský, G. R. Quast, J. Surdej, A. B. Underhill, J. M. Vreux, D. G. Wentzel.The exercises are organized in the following sections:A. The planetary system: 1. Space and time, instruments. 2. The motions of celestial bodies. 3. Planets and satellites.B. The stars: 1. The Sun. 2. Stars and nebulae. 3. Stellar systems. [less ▲]

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See detailHigh resolution 16 row computed tomography examination of the canine thorax
De Busscher; Bolen, Géraldine ULg; Cavrenne et al

Poster (2007)

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See detailHigh resolution 3-D imaging of void networks in plant tissues
Verboven, Pieter; Kerckhofs, Greet ULg; Cloetens, Peter et al

in Abstract book SkyScan User Meeting 2008 (2008)

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See detailHigh resolution characterization of the soil organic carbon depth profile in a soil landscape affected by erosion
Jague, Emilien; Sommer, Michael; Saby, Nicolas et al

in Soil & Tillage Research (2016), 156

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See detailHigh Resolution Electron Energy Loss Spectroscopy Investigation of the Vibrational Structure and Order of an Octadecanethiol Monolayer on Gold Substrates
Duwez, Anne-Sophie ULg; Yu, Li-Ming; Riga, Joseph et al

in Journal of Physical Chemistry B (2000), 104

The vibrational spectra induced by electron beam from octadecanethiol monolayers adsorbed on gold are reported as a contribution to study in detail the structure of the layers, through an analysis of the ... [more ▼]

The vibrational spectra induced by electron beam from octadecanethiol monolayers adsorbed on gold are reported as a contribution to study in detail the structure of the layers, through an analysis of the interaction mechanisms between the electrons and these organic ultrathin films. To show the different spatial distribution of scattered electrons from dipole and impact interactions with the monolayer, angular distributions of elastic and inelastic scattered electrons were measured for various primary energies. The absolute electron scattering loss probabilities from both dipole and impact interactions were estimated for different vibrational modes. The study of these different mechanisms was first hampered by the poor order of the layers adsorbed on evaporated gold. It became therefore highly desirable to perform the experiments on a single-crystal substrate. Using Au(111) and Au(100) single crystals as substrates, it was possible to separate the spectral response from impact and dipole interacting electrons. A negative ion resonant behavior has been observed in the energy dependence of the electron scattering differential cross sections [less ▲]

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See detailHigh Resolution Frequency Analysis as Applied ti the Singing Voice
Morsomme, Dominique ULg; Remacle, Marc; Millet, Benoite et al

Conference (1992, August 14)

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See detailHigh Resolution Frequency Analysis as applied to the singing voice
Morsomme, Dominique ULg; Remacle, Marc; Millet, Benoite

in Folia Phoniatrica (1993), 45

We have applied high-resolution vocal frequential analysis to a population of singing voices. Two important elements have become apparent: (1) Confirmation that the singing formant originates in the ... [more ▼]

We have applied high-resolution vocal frequential analysis to a population of singing voices. Two important elements have become apparent: (1) Confirmation that the singing formant originates in the resonators. This is observed especially on a low fundamental, and it is acquired through technical skill and experience (2)Observation of the vibrato, which, isolated from the clinical study, regarding only its graphic presentation, could habe been interpreted as "abnormal". [less ▲]

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