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See detailIs there any interest in combining treatments in osteoporosis?
Rabenda, Véronique ULg; Hanssens, Linda; De Ceulaer, Frédéric et al

in Current Rheumatology Reviews (2005), 1

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See detailIs There Any Place for Salmon Calcitonin in Prevention of Postmenopausal Bone Loss?
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Denis, D. et al

in Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology (1988), 2(3), 195-204

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See detailIs there any rationale for prescribing hormone replacement therapy (HRT) to prevent or to treat osteoarthritis?
Kvasz, Angela ULg; Bruyère, Olivier ULg; Neuprez, Audrey ULg et al

in Osteoporosis International (2002, November), 13(Suppl.3), 59

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See detailis there any rationale for prescribing hormone replacement therapy (HTR) to prevent or to treat osteoarthritis?
Reginster, Jean-Yves ULg; Kvasz, Angela ULg; Bruyère, Olivier ULg et al

in Osteoarthritis and Cartilage (2003), 11(2), 87-91

Background: During the last two decades of the 20th century, hormone replacement therapy (HRT) has been considered as the sole pharmacological approach for counterbalancing or mitigating the effects of ... [more ▼]

Background: During the last two decades of the 20th century, hormone replacement therapy (HRT) has been considered as the sole pharmacological approach for counterbalancing or mitigating the effects of estrogens deprivation in post-menopausal women. Subsequently, HRT has been widely recommended for the management of chronic diseases occurring, in women during the second half of their life. The overall risk/benefit ratio of estrogens has been recently reassessed in the light of long-term prospective studies failing to demonstrate the expected benefit of HRT on cardiovascular diseases incidence. Osteoarthritis (OA) is one of the chronic conditions for which HRT has been suggested to provide beneficial outcomes. Results: The presence of estrogen receptors in human cartilage is no longer debated. However, cellular or animal models of OA do not provide an unequivocal pathway for the influence of gonadal steroids on cartilage. Similarly, studies attempting to correlate serum or urinary levels of sex steroids to the onset or progression of OA gave conflicting results. No randomized, prospective, controlled trial was designed to specifically assess the impact of hormone replacement therapy on symptomatic or structural progression of OA. Large-scale observational studies or trials designed to assess other potential benefits of estrogens suggest that HRT use does not provide symptomatic relief in OA but may interfere with its long-term structural progression, particularly in the lower limbs. Conclusion: Based on the recent results of the Women Health Initiative suggesting that HRT health risks may outweigh benefits, one can hardly recommend, with the current level of evidence, HRT as a first-line treatment against progression of OA. (C) 2003 OsteoArthritis Research Society International. Published by Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailIs there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?
Henrotin, Yves ULg; Mobasheri, Ali; Marty, Marc

in Arthritis Research & Therapy (2012), 14(1), 201

ABSTRACT: Glucosamine in its acetylated form is a natural constituent of some glycosaminoglycans (for example, hyaluronic acid and keratan sulfate) in the proteoglycans found in articular cartilage ... [more ▼]

ABSTRACT: Glucosamine in its acetylated form is a natural constituent of some glycosaminoglycans (for example, hyaluronic acid and keratan sulfate) in the proteoglycans found in articular cartilage, intervertebral disc and synovial fluid. Glucosamine can be extracted and stabilized by chemical modification and used as a drug or a nutraceutical. It has been approved for the treatment of osteoarthritis (OA) in Europe to promote cartilage and joint health and is sold over the counter as a dietary supplement in the United States. Various formulations of glucosamine have been tested, including glucosamine sulfate and glucosamine hydrochloride. In vitro and in vivo studies have uncovered glucosamine's mechanisms of action on articular tissues (cartilage, synovial membrane and subchondral bone) and justified its efficacy by demonstrating structure-modifying and anti-inflammatory effects at high concentrations. However, results from clinical trials have raised many concerns. Pharmacokinetic studies have shown that glucosamine is easily absorbed, but the current treatment doses (for example, 1,500 mg/day) barely reach the required therapeutic concentration in plasma and tissue. The symptomatic effect size of glucosamine varies greatly depending on the formulation used and the quality of clinical trials. Importantly, the effect size reduces when evidence is accumulated chronologically and evidence for the structure-modifying effects of glucosamine are sparse. Hence, glucosamine was at first recommended by EULAR and OARSI for the management of knee pain and structure improvement in OA patients, but not in the most recent NICE guidelines. Consequently, the published recommendations for the management of OA require revision. Glucosamine is generally safe and although there are concerns about potential allergic and salt-related side effects of some formulations, no major adverse events have been reported so far. This paper examines all the in vitro and in vivo evidence for the mechanism of action of glucosamine as well as reviews the results of clinical trials. The pharmacokinetics, side effects and differences observed with different formulations of glucosamine and combination therapies are also considered. Finally, the importance of study design and criteria of evaluation are highlighted as new compounds represent new interesting options for the management of OA. [less ▲]

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See detailIs there anybody in there? Detecting awareness in disorders of consciousness.
Demertzi, Athena; Vanhaudenhuyse, Audrey ULg; Bruno, Marie-Aurelie et al

in Expert Review of Neurotherapeutics (2008), 8(11), 1719-30

The bedside detection of awareness in disorders of consciousness (DOC) caused by acquired brain injury is not an easy task. For this reason, differential diagnosis using neuroimaging and ... [more ▼]

The bedside detection of awareness in disorders of consciousness (DOC) caused by acquired brain injury is not an easy task. For this reason, differential diagnosis using neuroimaging and electrophysiological tools in search for objective markers of consciousness is being employed. However, such tools cannot be considered as diagnostic per se, but as assistants to the clinical evaluation, which, at present, remains the gold standard. Regarding therapeutic management in DOC, no evidence-based recommendations can be made in favor of a specific treatment. The present review summarizes clinical and paraclinical studies that have been conducted with neuroimaging and electrophysiological techniques in search of residual awareness in DOC. We discuss the medical, scientific and ethical implications that derive from these studies and we argue that, in the future, the role of neuroimaging and electrophysiology will be important not only for the diagnosis and prognosis of DOC but also in establishing communication with these challenging patients. [less ▲]

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See detailIs there anything to expect from 3D views in sketching support tools ?
Darses, Françoise; Mayeur, Anaïs; Elsen, Catherine ULg et al

in Gero, John S.; Goel, Ashok K. (Eds.) Design Computing and Cognition '08 : Proceedings of the Third International Conference on Design Computing and Cognition. (2008)

This paper describes a research project which aims at studying the ergonomic and cognitive value of EsQUIsE, a freehand design environment for architects. This sketch-based modeling software is ... [more ▼]

This paper describes a research project which aims at studying the ergonomic and cognitive value of EsQUIsE, a freehand design environment for architects. This sketch-based modeling software is implemented on a Tablet PC. The EsQUIsE software provides architects with the possibility to generate automatically 3D views from the freehand drawings. The first part of the paper deals with the usability of such a digital environment for sketching, and especially the use of the drawing areas. The second part of the paper is dedicated to the analysis of how 3D views are generated and used for exploring alternative solutions. Although in interviews architects rate 3D highly, in fact they do not produce a large volume of 3D sketches. Issues about visual and spatial reasoning in design are thus highlighted. Finally, the benefit of such a tool for creativity is questioned. [less ▲]

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See detailIs there potential for strontium ranelate in the management of osteoarthritis ?
Reginster, Jean-Yves ULg; Pelousse, Franz; Bruyère, Olivier ULg

in Clinical Practice (2013), 10(2), 201-207

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See detailIs there really an Azores diversity enigma? Insights from the phylogeography of the heather Erica scoparia s.l.
Desamore, Aurélie ULg

Poster (2011)

The Azorean flora, in contrast to that of other archipelagos, is characterized by a paucity of evolutionary radiations and the widespread distribution of most endemics. Several hypotheses, including ... [more ▼]

The Azorean flora, in contrast to that of other archipelagos, is characterized by a paucity of evolutionary radiations and the widespread distribution of most endemics. Several hypotheses, including isolation from the continent, recent age, ecological homogeneity, and limited paleoclimatic variations, have been proposed to account for this pattern. These hypotheses are tested here within the context of the molecular phylogeography of the heather Erica scoparia s.l., a Mediterraneo-Atlantic species complex distributed across Macaronesia, North Africa and southwestern Europe. The marked molecular radiation of this species in the Azores, including an array of single-island endemics, suggests that the apparent homogeneity of the Azorean flora might, in fact, conceal undetected patterns of endemism that are similar to those observed in the Canarian flora for morphological data. Haplotype richness was higher in the Azores than in the Canaries and extensive dispersal mediated allopatry is apparent at the molecular level. The Azores were colonized at least twice independently by E. scoparia, whereas the Canarian haplotypes are monophyletic, suggesting that the greater distance between the Azores and the continent does not necessarily hamper the chances of successful colonization. [less ▲]

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See detailIs there value in maintaining small populations ? Example of the Dual-Purpose Belgian Blue breed.
Gengler, Nicolas ULg; Soyeurt, Hélène ULg; Bastin, Catherine ULg et al

Conference (2011, July 13)

Current status of thinking on genomic selection in dairy cattle is mostly major breed centric (e.g., Holstein) and only for traditional traits (e.g., milk yields). Once you depart from this, it becomes ... [more ▼]

Current status of thinking on genomic selection in dairy cattle is mostly major breed centric (e.g., Holstein) and only for traditional traits (e.g., milk yields). Once you depart from this, it becomes obvious that different, often related, issues appear (e.g., lack of large training populations, need for expensive recording of new phenotypes). Also, there is an urgent need to rethink issues that are important for sustainability of dairy production (e.g., added value foods, animal robustness). In this context, small populations (breeds/lines) could represent a potential source of extra information to justify their maintenance. As marker densities increase, efficient dissection of different selection histories of divergent breeds or lines, potentially identifying pockets of unexploited variability will increase. A current example from the Belgian (Walloon) perspective is the Dual Purpose (DP) line of the Belgian Blue Breed (BBB), with presently around 4500 breeding females, for historical reason of which only 1500 have good pedigrees, and which is present in Belgium and northern France. Recent research, done on this line, showed its tendency to produce less saturated milk fat and to have better fertility. Results indicated that it could stay competitive in specific markets, especially because of largely increased meat value. Currently, the myostatin mutation is largely used for breeding purposes. To assess the genetic diversity of the breed, recently, over 200 genotypes (SNP50K) for nearly all breeding bulls of the last 20 years became available. HD genotypes should be available in the near future, also allowing to access selection history of this breed as being in between the 2 extreme breeds: Beef BBB (with which it shares a recent history) and Holstein-Friesian (which is related through its geographic proximity over centuries). Finally, genomic selection for DP-BBB will need to consider a single step type approach without the need of reference population and potentially relying heavily on SNP3K of cows, also with the objective to recreate relationships between animals of interest. [less ▲]

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See detailIs there value in maintaining small populations ? Example of the Dual-Purpose Belgian Blue breed.
Gengler, Nicolas ULg; Soyeurt, Hélène ULg; Bastin, Catherine ULg et al

in Journal of Dairy Science (2011), 94(E-suppl.1), 664

Current status of thinking on genomic selection in dairy cattle is mostly major breed centric (e.g., Holstein) and only for traditional traits (e.g., milk yields). Once you depart from this, it becomes ... [more ▼]

Current status of thinking on genomic selection in dairy cattle is mostly major breed centric (e.g., Holstein) and only for traditional traits (e.g., milk yields). Once you depart from this, it becomes obvious that different, often related, issues appear (e.g., lack of large training populations, need for expensive recording of new phenotypes). Also, there is an urgent need to rethink issues that are important for sustainability of dairy production (e.g., added value foods, animal robustness). In this context, small populations (breeds/lines) could represent a potential source of extra information to justify their maintenance. As marker densities increase, efficient dissection of different selection histories of divergent breeds or lines, potentially identifying pockets of unexploited variability will increase. A current example from the Belgian (Walloon) perspective is the Dual Purpose (DP) line of the Belgian Blue Breed (BBB), with presently around 4500 breeding females, for historical reason of which only 1500 have good pedigrees, and which is present in Belgium and northern France. Recent research, done on this line, showed its tendency to produce less saturated milk fat and to have better fertility. Results indicated that it could stay competitive in specific markets, especially because of largely increased meat value. Currently, the myostatin mutation is largely used for breeding purposes. To assess the genetic diversity of the breed, recently, over 200 genotypes (SNP50K) for nearly all breeding bulls of the last 20 years became available. HD genotypes should be available in the near future, also allowing to access selection history of this breed as being in between the 2 extreme breeds: Beef BBB (with which it shares a recent history) and Holstein-Friesian (which is related through its geographic proximity over centuries). Finally, genomic selection for DP-BBB will need to consider a single step type approach without the need of reference population and potentially relying heavily on SNP3K of cows, also with the objective to recreate relationships between animals of interest. [less ▲]

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See detailIs thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs ?
Robert, S.; Ghiotto, J.; Pirotte, Bernard ULg et al

in Pharmacological Research (2009), 59

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See detailIs thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?
Robert, S.; Ghiotto, J.; Pirotte, Bernard ULg et al

Conference (2009, November)

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See detailIs transforming growth factor- beta 1 involved in the pathogenesis of IPF in dogs ?
Krafft, Emilie ULg; Heikkilä, H. P.; De Lorenzi, D. et al

in Proceedings of the 20th Annual Congress of the ECVIM-CA (2010)

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See detailIs ultra-short cold ischemia the key to IBDL avoidance in DCD-LT?
DETRY, Olivier ULg; DE ROOVER, Arnaud ULg; Ledinh, Hieu et al

Poster (2013, February 08)

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See detailIS ULTRA-SHORT COLD ISCHEMIA THE KEY TO ISCHEMIC CHOLANGIOPATHY AVOIDANCE IN DCD- LT?
DETRY, Olivier ULg; DE ROOVER, Arnaud ULg; Cheham, Samir et al

in Transplant International (2013, December), 26(S2), 53-98

Introduction: Donation after circulatory death (DCD) donors have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of ischemic ... [more ▼]

Introduction: Donation after circulatory death (DCD) donors have been proposed to partially overcome the organ donor shortage. DCD-LT remains controversial, with reported increased risk of ischemic cholangiopathy leading to graft loss. The authors retrospectively reviewed a single centre experience with DCD-LT in a 9-year period. Patients and Methods: 70 DCD-LT were performed from 2003 to November 2012. All DCD procedures were performed in operative rooms. Median donor age was 59 years. Most grafts were flushed with HTK solution. Allocation was centre-based. Median total DCD warm ischemia was 19.5 min. Mean follow-up was 36 months. No patient was lost to follow-up. Results: Median MELD score at LT was 15. Median cold ischemia was 235 min. Median peak AST was 1,162 U/L. Median peak bilirubin was 31.2 mg/dL. Patient and graft survivals were 92.8% and 91.3% at one year and 79% and 77.7% at 3 years, respectively. One graft was lost due to hepatic artery thrombosis. No PNF or graft loss due to ischemic cholangiopathy was observed in this series. Causes of death were malignancies in 8 cases. Discussion: In this series, DCD LT appears to provide results equal to classical LT. Short cold ischemia and recipient selection with low MELD score may be the keys to good results in DCD LT, in terms of graft survival and avoidance of ischemic cholangiopathy. [less ▲]

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See detailIs ultra-short cold ischemia the key to ischemic cholangiopathy avoidance in DCD-LT?
DETRY, Olivier ULg; DE ROOVER, Arnaud ULg; Cheham, S et al

in Acta Chirurgica Belgica (2013, May), Supplement 113(3), 6729

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See detailIs volition the missing link in the management of low back pain?
Broonen, Jean-Paul ULg; Marty, Marc; Legout, Virgine et al

in Joint Bone Spine (2011), 78

Patients with nonspecific chronic low back pain are typically prescribed a regimen of regular physical exercises to improve pain and function, increase workability, and prevent pain recurrence. However ... [more ▼]

Patients with nonspecific chronic low back pain are typically prescribed a regimen of regular physical exercises to improve pain and function, increase workability, and prevent pain recurrence. However, adherence to home exercise programs is often partial at best. Patients often fail to translate their intention to exercise (motivation) into action (implementation). Volition is the mental activity by which intentions are implemented. In this review, we argue that volition may be crucial to the successful rehabilitation of patients with low back pain. Obstacles to the implementation of intentions are described, as well as factors that promote implementation, most notably the conscious formation of implementation intentions. [less ▲]

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See detailIs wild boar heading towards movement ecology? A review of trends and gaps
Morelle, Kevin ULg; Lehaire, François ULg; Lejeune, Philippe ULg

in Wildlife Biology (2014), 20(4), 196-205

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See detailIs your company oriented toward strategic intelligence?
Brandt, Céline ULg; Gretry, Anaïs ULg; Gruslin, Claire ULg

Article for general public (2012)

If you wonder if your company is active in the different fields of strategic intelligence and which are its strengths and weaknesses, this questionnaire will help you to do so.

Detailed reference viewed: 27 (5 ULg)