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See detailInvestigating a two-level dynamic estimation algorithm for large-scale electric power systems
Rousseaux, Patricia ULg; Van Cutsem, Thierry ULg; Ribbens-Pavella, Mania

in Proceedings of the 1st European Workshop on the Real Time Control of Large Scale Systems (1984)

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See detailInvestigating apical adverse effects of four endocrine active substances in the freshwater gastropod Lymnaea stagnalis
Giusti, Arnaud ULg; Lagadic, Laurent; Barsi, Alpar et al

in Science of the Total Environment (2014), 493

The hermaphroditic gastropod Lymnaea stagnalis is proposed as a candidate species for the development of OECD guidelines for testing of the reprotoxicity of chemicals, including endocrine active ... [more ▼]

The hermaphroditic gastropod Lymnaea stagnalis is proposed as a candidate species for the development of OECD guidelines for testing of the reprotoxicity of chemicals, including endocrine active substances (EASs). Up to now, only a few putative EASs have been tested for their reproductive toxicity in this species. In this study, we investigate the effects of four EASs with different affinities to the vertebrate estrogen and androgen receptors (chlordecone as an estrogen; cyproterone acetate, fenitrothion and vinclozolin as anti-androgens) on the reproduction of L. stagnalis in a 21-day semi-static test. Testosterone and 17α-ethinylestradiol (EE2) were used as the reference compounds. The tested EASs had no significant effect on growth and survival at the tested concentration ranges (ng to μg/L). Classical reproduction endpoints (i.e., oviposition and fecundity) were not responsive to the tested chemicals, except for chlordecone and 17α-ethinylestradiol, which hampered reproduction from 19.6 μg/L and 17.6 μg/L, respectively. The frequency of polyembryonic eggs, used as an additional endpoint, demonstrated the effects of all compounds except EE2. The molecular pathways, which are involved in such reproduction impairments, remain unknown. Our results suggest that egg quality is a more sensitive endpoint as compared to other reproductive endpoints commonly assessed in mollusk toxicity tests. [less ▲]

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See detailInvestigating Circumferential Non-Uniformities in Throughflow Calculations using an Harmonic Reconstruction
Thomas, Jean-Philippe ULg; Léonard, Olivier ULg

in Proceedings of the ASME Turbo Expo 2008 (2008, June)

The flow field in a multistage turbomachine is very complex. It is 3D, unsteady and turbulent. Even if modern simulation tools can describe most of the flow features, the computation time needed and the ... [more ▼]

The flow field in a multistage turbomachine is very complex. It is 3D, unsteady and turbulent. Even if modern simulation tools can describe most of the flow features, the computation time needed and the extraction of useful information remain severe drawbacks to systematic use of URANS codes in a design procedure. In this context the throughflow simulation proved to be more convenient. Nevertheless the need for empiricism limits the potential of throughflow solvers. As an alternative, Admaczyck (1984) proposed three averaging operators (ensemble, time and passage) that lead to the average-passage model, linking the unsteady turbulent flow field to a steady flow field in a typical blade passage. This model involves additional terms that respectively bring back the mean effect of turbulence, deterministic unsteadiness and aperiodicity on the mean periodic flow. These terms need to be modelled; it is the closure problem. Harmonic closure, which consists in solving a linearized perturbation system in the frequency domain, revealed to be an efficient method to approximate deterministic stresses (He and Ning, 1998, Stridh, 2005, Vilmin, 2006). A fourth averaging can be performed, a circumferential averaging, giving rise to the throughflow model. Additional terms appear: the so-called circumferential stresses. It has been proven that these terms play an important role in the description of the flow (Jennions, 1986, Perrin, 1995), being at least as considerable as deterministic stresses. Introducing these terms in a throughflow simulation allows to reproduce the averaged 3D steady flow field (Simon, 2007). The aim of the present contribution is to prove that harmonic method can potentially be used to reconstruct circumferential stresses. The importance of circumferential stresses in a throughflow simulation is first highlighted on a single stage low speed compressor testcase, for viscous and non-viscous flow fields. The second step is the characterization of the frequency spectrum of the circumferential perturbation field. Next are compared the stresses associated to a Fourier reconstruction of the perturbation field with the real ones. Finally the approximated circumferential stresses are injected into a throughflow simulation tool to analyse and demonstrate their capability to reproduce a 3D averaged flow field. [less ▲]

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See detailInvestigating Depth-Fanout Trade-Off in WiMAX Mesh Networks
Nahle, Salim; Iannone, Luigi; Donnet, Benoît ULg et al

in 1st WEIRD Workshop on WiMAX, Wireless and Mobility (2007, May)

In the last years, Wireless Mesh Networks (WMNs) have been an emerging technology for providing cost/effective broadband Internet access. The research done insofar usually assumes that the wireless ... [more ▼]

In the last years, Wireless Mesh Networks (WMNs) have been an emerging technology for providing cost/effective broadband Internet access. The research done insofar usually assumes that the wireless backbone of a WMN is built using IEEE 802.11 technologies. Such an approach has the drawback of leading to dense and sub-optimal deployments, due to the short transmission range of this standard. Recently standardized, the WiMAX technology is supposed to transcend this limitation by a transmission range of several miles. In particular, the mesh mode of the WiMAX standard enables direct communications between subscriber stations and, hence, reduces dead zones while increasing the global throughput. In this paper, we investigate the throughput capacity of a WiMAX mesh tree. More specifically, we are interested in balancing the impact of the depth of the tree with its fanout. We provide a traffic model and evaluate the WiMAX mesh tree by simulations. [less ▲]

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See detailInvestigating Effect of Holidays on Daily Traffic Counts: Time Series Approach
Cools, Mario ULg; Moons, Elke; Wets, Geert

in Transportation Research Record: Journal of the Transportation Research Board (2007), 2019

In this paper, different modeling philosophies are explored in order to explain and forecast daily traffic counts. The main objectives of this study are the analysis of the impact of holidays on daily ... [more ▼]

In this paper, different modeling philosophies are explored in order to explain and forecast daily traffic counts. The main objectives of this study are the analysis of the impact of holidays on daily traffic, and the forecasting of future traffic counts. Data coming from single inductive loop detectors, collected in 2003, 2004 and 2005, were used for the analysis. The different models that were investigated showed that the variation in daily traffic counts could be explained by weekly cycles. The Box-Tiao modeling approach was applied to quantify the effect of holidays on daily traffic. The results showed that traffic counts were significantly lower for holiday periods. When the different modeling techniques were compared with respect to forecasting with a large forecast horizon, Box-Tiao modeling clearly outperformed the other modeling strategies. Simultaneous modeling of both the underlying reasons of travel, and revealed traffic patterns, certainly is a challenge for further research. [less ▲]

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See detailInvestigating Effect of Holidays on Daily Traffic Counts: Time Series Approach
Cools, Mario ULg; Moons, Elke; Wets, Geert

in Proceedings of the 86th Annual Meeting of the Transportation Research Board (CD-ROM) (2007)

In this paper, different modeling philosophies are explored in order to explain and forecast daily traffic counts. The main objectives of this study are the analysis of the impact of holidays on daily ... [more ▼]

In this paper, different modeling philosophies are explored in order to explain and forecast daily traffic counts. The main objectives of this study are the analysis of the impact of holidays on daily traffic, and the forecasting of future traffic counts. Data coming from single inductive loop detectors, collected in 2003, 2004 and 2005, were used for the analysis. The different models that were investigated showed that the variation in daily traffic counts could be explained by weekly cycles. The Box-Tiao modeling approach was applied to quantify the effect of holidays on daily traffic. The results showed that traffic counts were significantly lower for holiday periods. When the different modeling techniques were compared with respect to forecasting with a large forecast horizon, Box-Tiao modeling clearly outperformed the other modeling strategies. Simultaneous modeling of both the underlying reasons of travel, and revealed traffic patterns, certainly is a challenge for further research. [less ▲]

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See detailInvestigating Expertise, Flexibility and Resilience in Socio-technical Environments : A Case Study in Robotic Surgery.
Nyssen, Anne-Sophie ULg; Blavier, Adelaïde ULg

in Hollnagel, Erik; Braithwaite, Jeffrey; Wears, Robert (Eds.) Resilient Health Care (2013)

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See detailInvestigating Hardy-Weinberg equilibrium in case-control or cohort studies or meta-analysis.
Ziegler, Andreas; Van Steen, Kristel ULg; Wellek, Stefan

in Breast Cancer Research and Treatment (2011), 128(1), 197-201

Yu et al. (Breast Cancer Res Treat 117:675-677, 2009) recently stated that testing for deviation from Hardy-Weinberg equilibrium (HWE) is necessary to identify systematic genotyping errors in case-control ... [more ▼]

Yu et al. (Breast Cancer Res Treat 117:675-677, 2009) recently stated that testing for deviation from Hardy-Weinberg equilibrium (HWE) is necessary to identify systematic genotyping errors in case-control studies. They criticized a meta-analytic study for the deviation from HWE in the case group of one study. The aim of this article is twofold. First, we derive recommendations on how to test for deviations from HWE in different study designs. Second, we develop a meta-analytic framework for assessing compatibility with HWE or measuring deviation from HWE. The authors sketch the possible reasons behind deviation from HWE and provide guidelines for proper investigation of HWE deviations in different study designs. The authors argue that the standard HWE chi(2) lack of fit test is logically flawed and provide a logically unflawed approach for measuring deviation from HWE using confidence intervals. The proposed method is applicable to meta-analyses of both case-control or cohort association studies. The proposed approach is illustrated using the meta-analysis criticized by Yu et al. Heterogeneity between studies can be assessed. The critique of Yu et al. to the article of Frank et al. (Breast Cancer Res Treat 111:139-144, 2008) can be refuted. Even more, validity of HWE can be proven for the pooled control sample. The authors advocate the use of a confidence interval-based approach to assess HWE. The latter should only be investigated in control populations. In multicenter studies or meta-analysis, deviation from HWE should be analyzed using a meta-analytic approach. [less ▲]

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See detailInvestigating iron and organic matter incorporation in growing sea ice
Janssens, J.; Delille, Bruno ULg; de Jong et al

Conference (2014, March)

High concentration of exopolysacharides (EPS) and iron have been found in sea ice surrounding the Antarctic continent. However, the mechanisms leading to that enrichment remain unclear. Scavenging of iron ... [more ▼]

High concentration of exopolysacharides (EPS) and iron have been found in sea ice surrounding the Antarctic continent. However, the mechanisms leading to that enrichment remain unclear. Scavenging of iron by organic matter in seawater and entrainment during sea ice formation are thought to be responsible for the accumulation of iron in sea ice. EPS could also play a role in the iron passive chelative scavenging process in sea ice and in the increase of iron bioavailability. Our study investigates the processes responsible for the accumulation of iron (dissolved, particulate and total dissolvable iron), EPS, dissolved and particulate organic matter, macro-nutrients (silicic acid, nitrate and nitrite, phosphoric acid and ammonium), chlorophyll a and sea ice algae in young sea ice during an Australian-lead spring voyage off East Antarctica (SIPEX II September – November 2012) and a German-lead winter voyage to the Weddell Sea (AWECS June – August 2013). We used a combination of field- (“in situ”) and laboratory- based sea ice growth time-series experiments. In addition different types of newly formed sea ice as pancake ice, grey ice, frost flowers and slush were collected during both voyages as a means to compare and validate the experimental data. To our knowledge, this is the first report on the biogeochemical properties of newly formed Antarctic pack ice samples in the winter. Ice temperature, salinity and textures are also presented to support the biogeochemical observations at the onset of sea ice formation. [less ▲]

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See detailInvestigating Prostaglandin E2 activation of the p38 pathway of oesophageal squamous cell carcinoma
Rambout, Xavier ULg

Master's dissertation (2008)

Background, aim and objectives: Oesophageal squamous cell carcinoma (OSCC) is an endemic disease. Epidemiologic studies driven by investigation of Sammon in a region with one of the highest prevalence ... [more ▼]

Background, aim and objectives: Oesophageal squamous cell carcinoma (OSCC) is an endemic disease. Epidemiologic studies driven by investigation of Sammon in a region with one of the highest prevalence, linked a predisposition to develop OSCC to a high consumption of maize via reflux disease and chronic oesophagitis. In that context, it was postulated that prostaglandin E2 (PGE2), a hormone derived from a main component of maize, continuously triggers activation of proliferation and inflammation pathways. This work aimed at assessing the role of p38, a mitogen-activated protein kinase (MAPK), in the potential of PGE2 to trigger cellular proliferation, transcription and expression of proliferative (Cyclin D1) and inflammatory (IL-6) mediators in a human epithelial oesophageal cell line (Het1a). Methods: The proliferation potential of PGE2 via p38 was assessed by MTT assay on Het1a. The effect of H2O2 treatments was also assessed as a positive control. Then, RNA and protein samples were extracted from that cell line previously PGE2-treated. Transcription and expression profiles were studied over time respectively by quantitative polymerase chain reaction (qPCR) and western blot. The role of p38 was assessed by addition of a specific inhibitor, SB203580, to the cells under investigation. Results and Discussion: It was shown that PGE2 alone could not trigger proliferation of the Het1a cell line. Though, the effect of p38 might be positive. Acute H2O2 treatments turned out encouraging in the development of a model of p38 activation. Regulation of Cyclin D1 and IL-6 transcription was suggested to occur through PGE2 and via the p38 pathway. The Cyclin D1 and IL-6 transcripts were respectively overexpressed and downregulated in a bimodal manner, the second peak relying exclusively on p38 activation. Both observations could be supported by a positive feedback theory involving cyclooxygenase (COX)-2. Conclusions: Even though PGE2 was shown not to be sufficient to promote Het1a proliferation, regulation of Cyclin D1 and IL-6 transcription via p38 was observed. Furthermore, the expression profile might support the Sammon-Pink theory. [less ▲]

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See detailInvestigating relationships between Landsat ETM+ data and LAI in a semi-arid grassland of northwest China
Lu, L; Li, X; Ma, M G et al

in Geoscience and Remote Sensing Symposium, 2004. Proceedings IGARSS '04. (2004)

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See detailInvestigating rock-slope failures in the Tien Shan: State-of-the-art and perspectives of international cooperation (M111).
Strom, A.; Korup, O.; Abdrakhmatov, K. et al

Scientific conference (2005)

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See detailInvestigating State Reconstruction from Scarce Synchronized Phasor Measurements
Glavic, Mevludin; Van Cutsem, Thierry ULg

in Proceedings of the IEEE Trondheim Power Tech 2011 conference (2011, June)

Synchronized phasor measurements can potentially track the system dynamics between two classical state estimations. However, in the PMU configurations available nowadays and in the near future, those ... [more ▼]

Synchronized phasor measurements can potentially track the system dynamics between two classical state estimations. However, in the PMU configurations available nowadays and in the near future, those measurements are too scarce for the whole system state to be estimated. Therefore, we investigate the possibility to reconstruct coherent, time-synchronized system states from the available PMU data. State reconstruction is formulated as an optimization problem. The objective is to minimize, in the space of bus powers, the distance between the reconstructed state and the last state estimate provided by a standard state estimator. PMU data are imposed as equality constraints. Furthermore, the placement of PMUs near generators is advocated for higher accuracy of state reconstruction. The performance and potential benefits of the approach are illustrated by processing snapshots obtained from detailed time simulation of a test system subject to a disturbance and corrective actions. [less ▲]

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See detailInvestigating the Effects of Training and Techno-Pedagogical Support
Lecomte, Béatrice ULg; Van de Poël, Jean-François ULg; Verpoorten, Dominique ULg et al

Conference (2013, December)

This communication presents a quantitative-qualitative research conducted among 225 teachers and teaching assistants who have benefited from the education technologies training program provided by our ... [more ▼]

This communication presents a quantitative-qualitative research conducted among 225 teachers and teaching assistants who have benefited from the education technologies training program provided by our eCampus department at IFRES (University of Liege, Belgium) since 2011. The data collected are used to a) describe and characterize the public who attended these training sessions, b) identify the types of training programs chosen by the attendees, and c) to explore the influence of those sessions on the techno-pedagogical development of teachers. That effect is manifested by a change of mental representations or by "acting out" in terms of integrating technology into teaching practices. [less ▲]

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See detailInvestigating the factors for fermentative biohydrogen improvement: original bioreactors design and hydrogen partial pressure effect
Beckers, Laurent ULg; Hiligsmann, Serge ULg; Hamilton, Christopher ULg et al

in WHEC 2012, Toronto June 3rd - 7th (2012, June 05)

The anaerobic production of hydrogen from biomass offers the potential production of usable biogas from a variety of renewable resources. However, in order to produce hydrogen at high yields and ... [more ▼]

The anaerobic production of hydrogen from biomass offers the potential production of usable biogas from a variety of renewable resources. However, in order to produce hydrogen at high yields and production rates the biotechnological process needs to be further optimized and efficient bioreactors must be designed [1]. At the CWBI, a continuous horizontal rotating cylinder bioreactor has been designed and investigated to produce biohydrogen from glucose by the strain Clostridium butyricum [2] at good yields (1,9molH2•molglucose-1) and production rates (48,6mmolH2•Lmilieu-1.molhexose-1•h-1). This reactor has an internal volume of 2.3L and a small working volume (300ml) (fig.1). It enhances the hydrogen production rates (by about three times more than a completely stirred bioreactor) by partially immobilizing the bacteria on the porous support. Moreover, the rotating cylinder design enables efficient H2 gas transfer from the liquid phase increasing hydrogen yields by about 25% compared to a completely stirred bioreactor [3-4]. Other original bioreactors, such as a trickle bed, have been built with the same aim of lowering the hydrogen partial pressure and led to similar results. Our work shows the importance of a good liquid to gas transfers in the biohydrogen-producing reactors to reach higher performances. [less ▲]

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See detailInvestigating the Impact of Different Thermal Comfort Models for Zero Energy Buildings in Hot Climates
Attia, Shady ULg; Hensen, JLM

in Proceeding of: Conference on Energy and Indoor Environment for Hot Climates (2014, February 24)

The selection of a thermal comfort model has a major impact on energy consumption of Net Zero Energy Buildings (NZEBs) in hot climates. The objective of this paper is to compare the influence of using ... [more ▼]

The selection of a thermal comfort model has a major impact on energy consumption of Net Zero Energy Buildings (NZEBs) in hot climates. The objective of this paper is to compare the influence of using different comfort models for zero energy buildings in hot climates. The paper compares the impact of applying Givoni’s model, ASHRAE 55 adaptive comfort standard, EN 15251 adaptive comfort standard and EN ISO 7730 on energy consumption and comfort. Using ZEBO and EnergyPlus for energy simulation, an existing prototype of a residential apartment module will be used to evaluate energy performance and thermal comfort in two parametric series. The first one is the result of coupling natural ventilation and mechanical cooling and the second one is guided coupling natural ventilation, mechanical cooling and ceiling fans. Results show a significant difference of cooling loads and total energy generation for the compared comfort models. However, the study remains theoretical and requires post occupancy evaluation for a better reliability of the results. [less ▲]

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See detailInvestigating the intraspecific biodiversity of the threatened rodent Leopoldamys neilli in Southeast Asia
Latinne, Alice ULg; Waengsothorn, Surachit; Herbreteau, Vincent et al

Conference (2010, September 23)

We study the phylogeography of Leopoldamys neilli, a threatened murine rodent species endemic to limestone karsts of Thailand, in order to assess the influence of its endemicity to karstic habitat on its ... [more ▼]

We study the phylogeography of Leopoldamys neilli, a threatened murine rodent species endemic to limestone karsts of Thailand, in order to assess the influence of its endemicity to karstic habitat on its intraspecific biodiversity and phylogeographic pattern. Samples of L. neilli were collected in limestone karsts from 20 localities in seven provinces of Thailand. Two mitochondrial markers, the cytochrome b gene (cytb) and the cytochrome c oxydase subunit I gene (COI), were sequenced for 115 L. neilli individuals. A nuclear fragment, the β-fibrinogen intron 7 (bfibr), was amplified in a subset of 65 samples. Phylogenetic reconstructions and median joining networks were used to explore relationships between haplotypes of the studied populations. Haplotype and nucleotide diversities of the main lineages were estimated for each locus. Divergence times of the main lineages of L. neilli were estimated using Bayesian inference. The demographic histories of the main lineages of L.neilli were also examined. Our study gave evidence of a strong geographic structure of the genetic diversity for L. neilli. Six highly differentiated genetic lineages were observed in the phylogenetic and phylogeographic analyses. These lineages are allopatric and correspond to particular regions of Thailand. They exhibit very high degree of genetic divergence and gene flows between them are extremely low. Within each lineage, the levels of haplotype and nucleotide diversities are very low for each gene. These results suggest a severe fragmentation of L. neilli’s populations, correlated to the fragmented distribution of its habitat and highlight its high endemicity to limestone karsts. The strong phylogeographic pattern of L. neilli and the very ancient separation of some lineages could be explained by the geological history of Thailand during Tertiary and Quaternary era. In conclusion, this study revealed an unexpectedly high level of intraspecific biodiversity within the species L. neilli. These results consolidate the importance to strengthen the protection of limestone habitats and to preserve not only their huge interspecific but also intraspecific biodiversity. [less ▲]

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