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See detailJijé : l'effervescence désinvolte
Dejasse, Erwin ULg

in Toussaint, Jacques (Ed.) Jijé, un artiste wallon au service de la bande dessinée (2010)

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See detailJl 13, a Potential Successor to Clozapine, Is Less Sensitive to Oxidative Phenomena
Liégeois, Jean-François ULg; Mouithys-Mickalad, Ange ULg; Bruhwyler, J. et al

in Biochemical and Biophysical Research Communications (1997), 238(1), 252-5

The oxidation behaviour of JL 13, a promising antipsychotic, was investigated in comparison with clozapine and loxapine, by measuring their direct "radical scavenging" abilities and their efficacies in ... [more ▼]

The oxidation behaviour of JL 13, a promising antipsychotic, was investigated in comparison with clozapine and loxapine, by measuring their direct "radical scavenging" abilities and their efficacies in inhibiting the lipid peroxidation. In the lipid peroxidation system, the reactivity of these compounds with free radicals produced by gamma-irradiation of linoleic acid may be presented as follows: JL 13 = loxapine < clozapine. In two enzymatic systems (HRP/GSH and HRP/H2O2/ GSH) which generate the thiyl free radicals, clozapine produces a strong enhancement of the thiyl-radical EPR signal intensity while JL 13 and loxapine exhibit no or minimal effect on this signal. The redox potential values for the three derivatives confirm the spectro-photometric and EPR results. Following this study, we show that JL 13, although presenting a preclinical clozapine-like profile, appears less sensitive to oxidation than clozapine. [less ▲]

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See detailJL 13, a pyridobenzoxazepine compound with potential atypical antipsychotic activity: a review of its behavioral properties
Bruhwyler, J.; Liégeois, Jean-François ULg; Bergman, J. et al

in Pharmacological Research (1997), 36

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See detailJL 13, an atypical antipsychotic: A preclinical review
Ellenbroek, B. A.; Liégeois, Jean-François ULg

in Cns Drug Reviews (2003), 9(1, Spring), 41-56

The extensive pharmacological evaluation of JL 13 as an atypical antipsychotic drug has revealed a close similarity to clozapine, however with some major advantages. JL 13 was characterized as a weak D-2 ... [more ▼]

The extensive pharmacological evaluation of JL 13 as an atypical antipsychotic drug has revealed a close similarity to clozapine, however with some major advantages. JL 13 was characterized as a weak D-2 antagonist, both in vitro and in vivo, with a strong affinity for the D-4 and the 5-HT2A receptors. It has no affinity for the 5-HT2C receptor. In vivo microdialysis experiments in rat showed that JL 13, like clozapine, preferentially increased extracellular dopamine concentrations in the prefrontal cortex compared to nucleus accumbens or striatum. Behavioral studies showed that JL 13, like clozapine, has the profile of an atypical antipsychotic. Thus, JL 13 did not antagonize apomorphine-induced stereotypy nor did it produce catalepsy, but it antagonized apomorphine-induced climbing in rodents. It was inactive against d-amphetamine-induced stereotypy but antagonized d-amphetamine-induced hyperactivity in the mouse. Likewise, in the paw test, it was more effective in prolonging hindlimb retraction time than prolonging forelimb retraction time. Like other antipsychotic drugs, JL 13 reversed the apomorphine- and amphetamine-induced disruption of prepulse inhibition. In a complex temporal regulation schedule in the dog, JL 13 showed a high resemblance with clozapine without inducing sialorrhea, palpebral ptosis or any significant motor side effects. In rats and squirrel monkeys JL 13 induced a high degree of generalization (70%) to clozapine. Regarding behavioral toxicology, JL 13 did not produce dystonia or Parkinsonian symptoms in haloperidol-sensitized monkeys. After acute administration, again like clozapine, JL 13 induced only a transient increase in circulating prolactin. Last but not the least, regarding a possible hematological toxicity, unlike clozapine, JL 13 did not present sensitivity to peroxidase-induced oxidation. Moreover, its electrooxidation potential was close to that of loxapine and far from that of clozapine. Taking all these preclinical data into account, it appears that JL 13 is a promising atypical antipsychotic drug. [less ▲]

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See detailJob characteristics and work engagement: multiple-group analyses of flexibility practices
Travaglianti, Fabrice ULg; De Zanet, Fabrice ULg; Vandenberghe, Christian et al

Poster (2014, May 16)

Detailed reference viewed: 36 (14 ULg)
See detailJob control in changing work environments
Hansez, Isabelle ULg; De Keyser, Véronique ULg

in Avallone, F.; Caetano, A.; Sinangil, H. (Eds.) Identity and diversity in organizations (2003)

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See detailjob day
Bruyère, Eric ULg

Speech (2013)

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See detailjob day
Bruyère, Eric ULg

Speech (2012)

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See detailThe job Demands-Resources Model and management commitment to safety applied to safe behaviour.
Hansez, Isabelle ULg; Chmiel, N.

Conference (2007, May 12)

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See detailJob satisfaction and self-efficacy to manage dementia in home caregivers: Effects of a three-day intervention
Marquet, Manon ULg; Missotten, Pierre ULg; Charlot, Valentine ULg et al

Poster (2013, July)

There is a growing need for interventions designed to help professionals who care for people with dementia. Nevertheless, most existing programs are developed for professionals working in institutional ... [more ▼]

There is a growing need for interventions designed to help professionals who care for people with dementia. Nevertheless, most existing programs are developed for professionals working in institutional settings. Thus, the objectives of our study are to evaluate the effectiveness of a three-day program aimed at training home help services (n=19). This intervention is targeted to enhance knowledge about dementia and help professionals to develop problem-solving strategies applicable to their everyday practice. Statistical analyses were based on self-report questionnaires administered before and after the intervention. Results indicate that participants find focused-problem coping to be more helpful after training and have better knowledge about dementia. Moreover, the program produces enhancement of job satisfaction and lower ageism scores. These findings are promising and suggest that a brief program can be effective to help caregivers of home-based services dealing with dementia problems. [less ▲]

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See detailLa "Joconde" de Léonard de Vinci et sa description par Giorgio Vasari
Fagnart, Laure ULg

Conference (2008, August 28)

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See detailLa "Joconde", plus divine qu'humaine ?
Fagnart, Laure ULg

in Catalogue de l'exposition La passion Léonard, comprendre et créer (Réfectoire des Cordeliers) (2007)

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See detailLa "Joconde", une histoire, un parcours
Fagnart, Laure ULg

in Fagnart, Laure (Ed.) Catalogue de l'exposition La Joconde inattendue (Château du Clos Lucé) (2007)

Detailed reference viewed: 64 (16 ULg)
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See detailJoe G. Pinelli, dans le no man’s land de la bande dessinée
Paques, Frédéric ULg

in Textyles : Revue des Lettres Belges de Langue Française (2010), 36-37

Detailed reference viewed: 52 (12 ULg)
See detailJohann Wolfgang Goethe: Gedichte
Witte, Bernd; Viehöver, Vera ULg; Reinlein, Tanja

Book published by Reclam (2001)

Edition critique de 365 poèmes de Johann Wolfgang Goethe

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See detailJohann Wolfgang Goethe: Gedichte. Studienausgabe
Witte, Bernd; Reinlein, Tanja; Viehöver, Vera ULg

Book published by Reclam - 2. Auflage (2008)

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See detailJohannes Arnoldus Bergellanus, De chalcographiae inventione poema encomiasticum
Adam, Renaud ULg

in De Schepper, Marcus; Kelders, Ann; Pauwels, Jan (Eds.) In de ban van boeken. Grote verzamelaars uit de negentiende eeuw in de Koninklijke Bibliotheek van België (2008)

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See detailJohannes Arnoldus Bergellanus, De chalcographiae inventione poema encomiasticum
Adam, Renaud ULg

in De Schepper, Marcus; Kelders, Ann; Pauwels, Jan (Eds.) Les seigneurs du livre. Les grands collectionneurs du XIXème siècle à la Bibliothèque royale de Belgique (2008)

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See detailJohannes de Sancto Laurentio, Postillae evangeliorum totius anni et aliquorum festorum
Adam, Renaud ULg

in De Schepper, Marcus; Kelders, Ann; Pauwels, Jan (Eds.) In de ban van boeken. Grote verzamelaars uit de negentiende eeuw in de Koninklijke Bibliotheek van België (2008)

Detailed reference viewed: 25 (2 ULg)