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See detailIrritation cutanee et vitesse de propagation d'ondes ultrasonores.
Uhoda, Emmanuelle ULg; Pierard, Gérald ULg

in International Journal of Cosmetic Science (2003), 25(1-2), 31-5

Cutaneous irritation is a stereotyped response of the skin to any physical or chemical insult. Its main manifestations encompass inflammatory erythema and an alteration of the cutaneous microrelief ... [more ▼]

Cutaneous irritation is a stereotyped response of the skin to any physical or chemical insult. Its main manifestations encompass inflammatory erythema and an alteration of the cutaneous microrelief showing increased roughness, dehydration and erratic desquamation. Several instrumental methods can indirectly assess the issues of cutaneous irritation on human stratum corneum. The aim of the present study was to measure the speed of propagation of ultrasound shear waves in the skin irritated by anionic surfactants. The study was performed in 25 healthy subjects of both sexes. Occlusive patches of a 10% solution of anionic surfactants were applied to a forearm of each volunteer. The other forearm served as an untreated control site. Patches remained in place for 24 h. Three hours later, another patch was placed again for 21 h. Resonance running time measurements (RRTM) of the ultrasound shear wave were performed using a Reviscometer((R)) RVM 600. Measurements were performed at entry in the study and 2 days after removing the second patch. Desquamative xerosis was obvious at the sites patched with the surfactant solution. RRTM values were significantly (P < 0.0001) lower than those at the control site. Hence, the speed of propagation of ultrasound shear waves was shown to be increased at an irritated site compared to an intact site. In conclusion, this study shows that the propagation speed of ultrasounds is influenced by the skin surface nature, being considerably increased in skin altered by surfactants. [less ▲]

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See detailIrvin Yalom : satire et thérapie
Saint-Amand, Denis ULg

Article for general public (2010)

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See detailIs "translational research" reshaping health policy ?
Fallon, Catherine ULg

Conference (2012, July 08)

Biomedical research is an area of fast evolving development. Although biomedical research occurs in internationally nested research laboratories, application development occurs in local settings, such as ... [more ▼]

Biomedical research is an area of fast evolving development. Although biomedical research occurs in internationally nested research laboratories, application development occurs in local settings, such as hospitals, which are central instruments for health policies. Much translation work occurs to build new forms of cooperation between biomedical researchers and medical doctors. The first group works in an international competitive environment, acting as research entrepreneurs with connection to the pharmaceutical industry in the logics of "open innovation". Members of the second group are embedded in hospital systems, within a web of constrains, being accountable as well to their patients as to their managers, and to their professional constrains which are most of the time defined within specific institutions at national level, in close relation to public health authorities. These links at micro-meso-macro levels between medics and their environment are put under constrains by biomedical innovations (as was shown in Europe during the controversy around the breast cancer products from Myriad Genetics). In order to organise new forms of cooperation and to dismantle frontiers between the "bench world" and the "bed world", a new concept was put at the fore : "translational research" which is supporting new forms of cooperation "from bench to bed" with all associated partners, ensuring enrolment of the individual patient and the policy makers. Starting with the presentation of the new science production regime in French speaking Belgium, the paper proposes to deconstruct the conditions of emergence of the new instruments of science production in biomedical research to understand institutional reorganisation and new power balances. [less ▲]

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See detailIs 3 '-deoxy-3 '-[F-18] fluorothymidine ([F-18]-FLT) the next tracer for routine clinical PET after R [F-18]-FDG?
Couturier, Olivier; Léost, Françoise; Campone, Mario et al

in Bulletin du Cancer (2005), 92(9), 789-798

Positron emission tomography (PET) with {F-18}-FDG is nowfirmly established as a clinical tool in oncology. Its applications are however limited in some indications, due to the lack of specificity of its ... [more ▼]

Positron emission tomography (PET) with {F-18}-FDG is nowfirmly established as a clinical tool in oncology. Its applications are however limited in some indications, due to the lack of specificity of its uptake mechanism for tumors, or the low avidity of some cancer types such as prostate. Alternative tracers are thus being developed, in order to fill up this void. Proliferation as a biological target is particularly attractive in cancer imaging. From that perspective, fluorothymidine ({F-18}-FLT or FLT) has generated a strong interest among the scientific community, especially since the radiosynthesis process has been improved and simplified, thus making possible to envision a routine use for the tracer. This article aims at summarizing the status of the current scientific data regarding FLT The uptake mechanism of FLT is well known, relying on the thymidine kinase 1 (TK1) enzymatic activity, and thus on DNA synthesis, Preclinical studies have shown a clear relationship between tracer accumulation and level of tumor proliferation, even though DNA salvage pathwayss intervene in the process and may complicate the interpretation of the results. Several clinical studies suggest a good specificity for tumor, albeit with a lower sensitivity than with FDG. In all likelihood however, the future of FLT lies in the evaluation of antitumor response and possibly the pretherapeutic prognostic characterization, rather than in the diagnosis and staging of malignancies. Although the scientific data regarding this issue remain limited, initial results are encouraging. Further significant work remains to he done in order to fully assess the clinical performances of the tracer, on the one hand, and to determine its place relative to FDG and other emerging tracers, on the other hand. Until these studies are completed, FLT should he considered as a promising tracer, hut remaining at an experimental stage of its development. [less ▲]

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See detailIs 5-Hydroxytryptamine (serotonin) involved in the pathogenesis of idiopathic pulmonary fibrosis in dogs ?
Krafft, Emilie ULg; Roels, Elodie ULg; Laurila et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailIs a low-mass top quark ruled out?
Cudell, Jean-René ULg; Halzen, F.; He, X. G. et al

in Physics Letters B (1987), 196

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See detailIs a renal abnormality of sodium excretion the marker of genetic predisposition to hypertension?
Krzesinski, Jean-Marie ULg; Goffard, A.; Warling, X. et al

in Clinical & Experimental Hypertension (1989), A11(7), 1391

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See detailIs Aggregation Of Beta-Amyloid Peptides A Mis-Functioning Of A Current Interaction Process?
Festy, F.; Lins, Laurence ULg; Peranzi, G. et al

in Biochimica et Biophysica Acta-Protein Structure and Molecular Enzymology (2001), 1546(2), 356-64

In a previous study, Hughes et al. [Proc. Natl. Acad. Sci. USA 93 (1996) 2065-2070] demonstrated that the amyloid peptide is able to interact with itself in a two-hybrid system and that interaction is ... [more ▼]

In a previous study, Hughes et al. [Proc. Natl. Acad. Sci. USA 93 (1996) 2065-2070] demonstrated that the amyloid peptide is able to interact with itself in a two-hybrid system and that interaction is specific. They further supported that the method could be used to define the sequences that might be important in nucleation-dependent aggregation. The sequence of the amyloid peptide can be split into four clusters, two hydrophilic (1-16 and 22-28) and two hydrophobic (17-21 and 29-42). We designed by molecular modeling and tested by the two-hybrid approach, series of mutations spread all over the sequence and changing the distribution of hydrophobicity and/or the spatial hindrance. In the two-hybrid assay, interaction of native Abeta is reproduced. Screening of mutations demonstrates that the C-domain (residues 29-40 (42)), the median domain (residues 17-22) and the N-domain (1-16) are all crucial for interaction. This demonstrates that almost all fragments of the amyloid peptide but a loop (residues 23-28) and the C-term amino acid are important for the native interaction. We support that the folded three-dimensional (3D) structure is the Abeta-Abeta interacting species, that the whole sequence is involved in that 3D fold which has a low secondary structure propensity and a high susceptibility to mutations and thus should have a low stability. The native fold of Abeta could be stabilized in Abeta-Abeta complexes which could in other circumstances facilitate the nucleation event of aggregation that leads to the formation of stable senile plaques. [less ▲]

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See detailIs Alzheimer's disease a disconnection syndrome? Evidence from a crossmodal audio-visual illusory experiment
Delbeuck, Xavier; Collette, Fabienne ULg; Van der Linden, Martial ULg

in Neuropsychologia (2007), 45(14), 3315-3323

In Alzheimer's disease (AD), loss of connectivity in the patient's brain has been evidenced by a range of electrophysiological and neuroimaging studies. However, few neuropsychological research projects ... [more ▼]

In Alzheimer's disease (AD), loss of connectivity in the patient's brain has been evidenced by a range of electrophysiological and neuroimaging studies. However, few neuropsychological research projects have sought to interpret the cognitive modifications following the appearance of AD in terms of a disconnection syndrome. In this paper, we sought to investigate brain connectivity in AD via the study of a crossmodal effect. More precisely, we examined the integration of auditory and visual speech information (the McGurk effect) in AD patients and matched control subjects. Our results revealed impaired crossmodal integration during speech perception in AD, which was not associated with disturbances in the separate processing of auditory and visual speech stimuli. In conclusion, our data suggest the occurrence of a specific, audio-visual integration deficit in AD, which might be the consequence of a connectivity breakdown and corroborate the observation from other studies of crossmodal deficits between the auditory and visual modalities in this population. (C) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailIs an alcoholic fixative fluid used for manual liquid-based cytology accurate to perform HPV tests?
Garbar, Christian; Mascaux, Corinne; De Graeve, Philippe et al

in Pathology and Laboratory Medicine International (2012), 4

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See detailIs an evidence-based approach unrealistic in NSCLC?
Coucke, Philippe ULg; Barthelemy, Nicole ULg; Bosquee, Léon ULg et al

in Belgian Journal of Medical Oncology [=BJMO] (2008), volume 2(6), 326-333

Summary Non-small cell lung cancer (NSCLC) is a heterogeneous tumour. A wide variety of treatment options is currently available. Surgery remains the mainstay of curative treatment and an operative ... [more ▼]

Summary Non-small cell lung cancer (NSCLC) is a heterogeneous tumour. A wide variety of treatment options is currently available. Surgery remains the mainstay of curative treatment and an operative approach will be selected in function of disease stage, tumour resectability and performance status of the patient. Adjuvant chemotherapy is considered standard at least for stage II and III disease. In stage III disease, resectability should be decided in function of the cytological/histological confirmation of N2 disease. If N2-disease cannot be highlighted at work-up, the patients are submitted to surgery followed by adjuvant chemotherapy. If patients are staged pN0-pN1 after surgery, ostoperative radiotherapy should not be given. However, if pN2 is discovered at surgery, there might be a place for postoperative radiotherapy but this still needs confirmation. In case of cytological/histological confirmation of pN2 disease prior to surgery, patients should not be operated but treated with a combination of oncomitant chemoradiotherapy. This treatment algorithm will be evaluated by reviewing the published evidence issued from randomized controlled trials. [less ▲]

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See detailIs Anosognosia in Alzheimer disease also observed for behavioural and personality changes?
Feyers, Dorothée ULg; Bastin, Christine ULg; Jaspar, Mathieu ULg et al

Poster (2010, May 28)

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously ... [more ▼]

Anosognosia is a frequent manifestation in Alzheimer disease (AD) but its extent is not yet clearly established. While anosognosia for memory deficit has been widely reported, no study has simultaneously explored anosognosia for personality and behaviour changes. We have tackled this question with 20 AD patients and 20 matched elderly subjects (ES). Participants (AD and ES) assessed their personality and their reactions in social situation both in current (S1) and past (S1_bef) time period. Assessment of these characteristics was also performed by relatives of the participants (R2 and R2_bef). Mann-Whitney test (p<0.05) were performed between discrepancy scores (calculated by comparing answers of subjects and relatives) obtained for AD and ES. A specific measure of anosognosia was also calculated by comparing S1 and R2. Statistical analyses demonstrated (1) that relatives of AD patients report more personality and behavioural changes across time (S1-S1_bef) than relatives of ES (R2–R2_bef); (2) that self-reported changes were not significantly different between AD patients and ES; (3) that anosognosia (S1-R2) was observed in AD patients for personality changes only. Results obtained support the hypothesis that anosognosia does not affect all domain in AD. Indeed, even if AD patients are no more able to assess their current personality, they perceive adequately their current reactions in social situations. [less ▲]

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See detailIs anthracene cofactor or spectator for the thermolysis of anthracenyl acylnitroso cycloadducts in the presence of a diene?
Monbaliu, Jean-Christophe ULg; Marchand-Brynaert, Jacqueline; Peeters, Daniel

in Tetrahedron Letters (2009), 50

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See detailIs aprotinin worth the risk in total hip replacement?
Janssens, Marc ULg; Joris, Jean ULg

in Anesthesiology (1994), 81(2), 518-519

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See detailIs artemisinin the only antiplasmodial compound in the Artemisia annua tea infusion? An in vitro study.
Mouton, Julia; Jansen, Olivia ULg; Frederich, Michel ULg et al

in Planta Medica (2013), 79(6), 468-70

In our ongoing investigation into Artemisia annua for the treatment of malaria, we decided to study the possibility that synergism might enhance the efficacy of artemisinin. Our main objective was to test ... [more ▼]

In our ongoing investigation into Artemisia annua for the treatment of malaria, we decided to study the possibility that synergism might enhance the efficacy of artemisinin. Our main objective was to test tea infusions and nonpolar extracts prepared from different A. annua varieties against Plasmodium falciparum in vitro in order to determine if synergism will increase the effectiveness of artemisinin in the samples as compared to pure artemisinin. We found that the IC50 of artemisinin in the tea and nonpolar extracts was not significantly different to the IC50 of pure artemisinin. We could show that the year and country of harvest or storage conditions did not have any influence on the activity and that it narrowly followed the concentration of artemisinin in all the extracts. In conclusion, based on these in vitro results, artemisinin seems to be the only active antiplasmodial compound in A. annua. [less ▲]

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See detailIs automatic disinfection between each endoscopy mandatory? Jury opinion
Delwaide, Jean ULg; Pelckmans, P.; Defrance, P. et al

in Acta Gastro-Enterologica Belgica (1998), 61(4), 429-430

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See detailIs bad group climate between girls a risky factor of aggression?
Mathys, Cécile ULg; Lanctôt, Nadine

Conference (2012)

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See detailIs behavior still a relevant variable ?
Richelle, Marc ULg

in Psychiatry, the state of the art. Vol.1. clinical psychopathology : nomenclature and classification (1985)

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