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See detailIntegrating axle weight restrictions in a two-dimensional vehicle routing problem with sequence based loading
Pollaris, Hanne; Braekers, Kris; Caris, An et al

Scientific conference (2014, June)

A mixed integer linear programming model for a two-dimensional capacitated vehicle routing problem (2L-CVRP) with sequence based loading and axle weight restrictions is provided. To the authors’ knowledge ... [more ▼]

A mixed integer linear programming model for a two-dimensional capacitated vehicle routing problem (2L-CVRP) with sequence based loading and axle weight restrictions is provided. To the authors’ knowledge, it is the first time that axle weight restrictions are incorporated in a VRP. Axle weight limits impose a great challenge for transportation companies. Trucks with overloaded axles represent a significant threat for traffic safety and may cause serious damage to the road surface. Transporters face high fines when violating these limits. The problem is based on a real-world problem from a Belgian logistics service provider. The demand of the customers consists of europallets. Pallets can be placed in two horizontal rows inside the vehicle. No vertical stacking is allowed. The center of gravity of the pallets inside the vehicle is calculated to determine the axle weights. Results of the model are compared to results of a 2L-CVRP with sequence based loading without axle weight restrictions. Numerical experiments demonstrate that the model performs adequately and that the integration of axle weight constraints in vehicle routing models is necessary for a feasible route planning. [less ▲]

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See detailIntegrating biological information in genome-wide association interaction (GWAI) studies.
Gusareva, Elena ULg; Van Steen, Kristel ULg

Poster (2012, May 30)

Genome-wide association (GWA) studies of Crohn's disease have identified numerous genes. However, a substantial portion of the heritability of this disease remains unexplained. Some gene variants, not ... [more ▼]

Genome-wide association (GWA) studies of Crohn's disease have identified numerous genes. However, a substantial portion of the heritability of this disease remains unexplained. Some gene variants, not detectable via main effects GWA study, may manifest themselves only in interaction with other variants. To search for interacting genes involved in the regulation of Crohn's disease, we performed GWA epistasis screening in a large human cohort (1851 cases/2938 controls) belonging to the Wellcome Trust Case Control Consortium (WTCCC). All subjects were genotyped with the GeneChip 500K Mapping Array Set (Affymetrix chip). SNPs that passed our quality control (359,479 SNPs) were processed in Biofilter (a software package that looks for candidate epistatic genes contributing to disease risk) giving rise to 14,185 SNPs. Subsequent MB-MDR epistasis screening, highlighted evidence for statistical epistasis for 6 SNP pairs. Four of these pairs involve interaction on between the HTR3B and USP28 genes (chromosome 11). One pair involves an interaction between the SLED1 and ACSL1 genes (chromosome 4). Another pair involves an interaction between PTPN22 (chromosome 1) and a SNP located between USPL1 and ALOX5AP (chromosome 13). Notably, when mapped to the same genomic regions, the interacting SNPs were not in linkage disequilibrium (r^2 < 0.11). All results were corrected for potential main SNP effects and were corrected for multiple testing on 7072 SNPs (i.e., 25,003,056 pairs). We investigated the consistency of these findings using different methodologies, including information-based, LD comparison-based and regression-based approaches. We also investigated the utility of using prior information from biological interaction data bases in novel epistasis discoveries, as well as the utility of biological data bases in interpreting a posterior identified statistical epistasis pairs. Our findings may provide new leads on important pathways involved in Crohn's disease. [less ▲]

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See detailIntegrating coarse-scale uncertain soil moisture data into a fine-scale hydrological modelling scenario
Vernieuwe, H.; De Baets, B.; Minet, Julien ULg et al

in Hydrology and Earth System Sciences (2011), 15

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See detailIntegrating cognitive and collective aspects of work in evaluating technology
Nyssen, Anne-Sophie ULg

in IEEE Transactions on Systems Man and Cybernetics Part A-Systems and Humans (2004), 34(6), 743-748

Ergonomic criteria are receiving increasing attention from designers but their applications do not ensure that technology matches the user's abilities, needs, and work constraints. In this paper, we used ... [more ▼]

Ergonomic criteria are receiving increasing attention from designers but their applications do not ensure that technology matches the user's abilities, needs, and work constraints. In this paper, we used two series of studies conducted in the healthcare system to illustrate how important work analysis is in evaluating new technology in order to identify critical dimensions of work and anticipate the impact of the devices on these dimensions: one looking at a new automatic drug device for anesthetists and one at a new robotic surgery system. Given the results, we developed a methodology for evaluation of new technology in complex systems. The aim is to insist to assess the impacts of technology on all the dimensions of work: technical, performance, cognitive, organizational, and economic. Which dimensions and criteria will be developed more in detail depends on the results of the work analysis. [less ▲]

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See detailIntegrating collective work aspects in the design process: An analysis case study of the robotic surgery. Using communication as a sign of fundamental change
Nyssen, Anne-Sophie ULg; Blavier, Adelaïde ULg

in Palanque, Philippe; Vanderdonck; Winckler (Eds.) Human Error, Safety and System Development (2010)

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See detailIntegrating Experimental and Computational Fluid Dynamics approaches using Proper Orthogonal Decomposition Techniques
Andrianne, Thomas ULg; Yasue, Kanako; Guissart, Amandine ULg et al

in Progress in Aerospace Sciences (2013)

The concept of Proper Orthogonal Decomposition (POD) is used to integrate Experimental Fluid Dynamics (EFD) and Computational Fluid Dynamics (CFD) approaches. The key idea is to take advantage of the ... [more ▼]

The concept of Proper Orthogonal Decomposition (POD) is used to integrate Experimental Fluid Dynamics (EFD) and Computational Fluid Dynamics (CFD) approaches. The key idea is to take advantage of the optimality of the POD technique and its capability to extract the most energetic patterns of complex aerodynamic flow fields. First, the concept of Modal Assurance Criterion (MAC) is used to obtain a simple quantitative criterion to compare EFD measurements to CFD results. The comparison is based on the POD modes, extracted from each set of data. The analysis of the energy content of the modes allows to draw important conclusions about the role of the latter. The method is applied in the study of the flow field around a rectangular cylinder, which is either static or oscillating in a low-speed flow field. The second EFD/CFD integration technique deals with the reconstruction of a flow field from measured data, making use of CFD simulation results. The POD modes are first extracted from several CFD data sets, using a snapshot POD approach. Then the entire flow field of measured data can be reconstructed using a gappy POD method. The technique is applied to the transonic flow around a civil aircraft type wind tunnel model. The EFD measurements consist in pressure coefficient data from pressure ports or pressure-sensitive paint. It is shown that the complete flow field can be reconstructed from the pressure data with satisfactory accuracy and at relatively low computational cost. The work demonstrates the potential of the POD technique to integrate EFD and CFD data, leading to a combined, validated and complete analysis of the flow under consideration. [less ▲]

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See detailIntegrating functional MRI information into radiotherapy planning of CNS tumors-early experiences.
Árpád Kovács; Lilla Tóth; Csaba Glavák et al

in Pathology Oncology Research (2011), 17(2), 207-17

The purpose of our study was to examine the integration of functional MRI (fMRI) information into 3D based planning process of the central nervous system (CNS) malignancies. Between 01.01.2008 and 01.12 ... [more ▼]

The purpose of our study was to examine the integration of functional MRI (fMRI) information into 3D based planning process of the central nervous system (CNS) malignancies. Between 01.01.2008 and 01.12.2008 four patients with astrocytoma were enrolled to this study. Before the planning process conventional planning CT, postoperative MR and individual functional MRI examinations were delivered. For the functional MRI examination the following four types of stimulus were applied: acoustic, visual, somatosensory and numeral. Three different theoretical planning situations were applied and compared: 3D conformal plan without fMRI information, 3D conformal plan with fMRI information and IMRT plan with fMRI information. For plan comparison DVH analysis, and NTCP model were used. fMRI based OR definition resulted in 4 additional OR's in the contouring process. As these cases demonstrate, an average of 50% dose reduction was achieved in OR, OR2 and OR3 with IMRT and fMRI based 3D planning, especially in case of midline localization and big tumor extent. IMRT provides additional sparing effect in the optic tract and brainstem, especially for localizations close to the midline. Our results demonstrated that using fMRI information in conventional 3D based treatment planning potentially benefits significant dose reduction in critical organs, with no compromise in PTV coverage. fMRI can be widely used even in low grade cases (long life expectancies, lower acute and late toxicity in radiotherapy) and in cases with high grade astrocytomas or metastases (higher dose to PTV with better risk organ sparing in radiotherapy). [less ▲]

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See detailIntegrating geophysical and tracer test data for accurate solute transport modelling in heterogeneous porous media
Rentier, Céline; Brouyère, Serge ULg; Dassargues, Alain ULg

in Groundwater Quality: Natural and Enhanced Restoration of Groundwater Pollution (GQ’2001) (2002)

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See detailIntegrating hydraulic and economic analysis for selecting flood protection measures in the context of climate change
Ernst, Julien ULg; Dewals, Benjamin ULg; Giron, E. et al

in Proceedings of the 4th Int. Symp. on Flood Defence (pp. 133-1-133-9) (2008)

In order to protect our societies from damaging impacts of climate change (floods, heat waves, droughts…), the most cost-effective adaptation strategies must be selected among a wide range of options ... [more ▼]

In order to protect our societies from damaging impacts of climate change (floods, heat waves, droughts…), the most cost-effective adaptation strategies must be selected among a wide range of options (including structural and non-structural protection measures). The Belgian national project “ADAPT” aims to provide guidance for this choice by developing a decision-support system (DSS) for the selection of protection measures against increased risk resulting from climate change, and more specifically from floods. The DSS is based on a combination of cost-benefit analysis (CBA) and multi-criteria analysis (MA), taking into consideration hydraulic, economic, social and ecological indicators. For the purpose of demonstrating the relevance and efficiency of the DSS, the approach is applied for two case studies located in the two main Belgian river basins (Meuse and Scheldt). Within this global framework, the present paper covers the description of the hydrodynamic modeling component and the economic analysis, focusing on their interactions and on their integration within the DSS. The paper also details the case study of the Meuse Basin (river Ourthe), for which the hydraulic simulations are conducted by means of the two-dimensional numerical model WOLF 2D, based on a finite volume scheme and entirely developed at the University of Liege. High resolution Digital Surface Models and geographic database are exploited, enabling to represent streets, buildings and parcels individually. Relevant damage functions are validated and refined based on the analysis of four recent major flood events, for which a relationship may established between simulated local water depths (and possibly velocities or flow duration) and actual damage costs. Consequently, the combined hydrodynamic and economic analysis described in the paper may be judged as a valuable tool for assessing the effectiveness of specific flood protection measures. [less ▲]

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See detailIntegrating hydrological features and 1 genetically validated occurrence data in occupancy 2 modeling of an endemic and endangered semi‐aquatic mammal species, Galemys pyrenaicus. 3 4
Charbonnel, Anaïs; Buisson, Laetitia; Biffi, Marjorie et al

in Biological Conservation (2015), Sous Presse

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See detailIntegrating lexis, gesture and discourse in spatial descriptions
Lemmens, Maarten; Perrez, Julien ULg

Conference (2014, October 01)

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See detailIntegrating phylogenetic and environmental niche models to explore speciation mechanisms in the Erythrophleum genus in tropical Africa
Gorel, Anaïs ULg; Fayolle, Adeline ULg; Doucet, Jean-Louis ULg et al

Conference (2014, December 10)

In the context of global climate change, it is of primary importance to understand the species response to climate (habitat tracking or adaptation). In this study we investigated the evolutionary history ... [more ▼]

In the context of global climate change, it is of primary importance to understand the species response to climate (habitat tracking or adaptation). In this study we investigated the evolutionary history of the climatic niche between and within closely related tropical tree species of the Erythrophleum genus (Fabaceae, Caesalpinioideae): E. ivorense, E. suaveolens and E. africanum. Two major hypotheses, the refuge theory and the ecological gradient hypothesis, have been developed to explain the current distribution of tree clades across tropical Africa. To identify the speciation mechanisms, we used a combination of geographic data and environmental factors to quantify the degree of niche conservatism (or divergence). We used two sets of distribution data for the purpose of this study. Species distribution data for the whole of tropical Africa were gathered from herbarium records. Distribution data of the two sister species E. ivorense and E. suaveolens assigned to genetic cluster were available for the lowland tropical forests of western and central Africa. Using a Species Distribution Model (SDM) approach based on MaxEnt algorithm, we tested for the environmental differences (BIOCLIM data) between species and genetic clusters within species. We developed SDMs for each of the three Erythrophleum species (over the whole range) and for each of the five genetic clusters. We quantified the niche overlap using new niche similarity metrics. At species level, the climatic niches differed significantly and overlapped only sligthly, suggesting a parapatric speciation along a climatic gradient. Within the two sister species, the niche of the parapatric central African clusters strongly overlapped, suggesting a secondary contact following the recolonization from different forest refugia. The west African cluster however showed contrasted climatic niches possibly due to either recent (< 100 yrs) climate change in west Africa, or ongoing differentiation on the dry part of the climatic gradient. [less ▲]

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See detailIntegrating phytohormone metabolism and action with primary biochemical pathways. I. Interrelationships between auxins, cytokinins, ethylene and polyamines in growth and development processes
Gaspar, Thomas ULg; Kevers, Claire ULg; Hausman, Jean-François et al

in Greppin, Hubert; Penel, Claude; Broughton, Walter (Eds.) et al Integrated Plant Systems (2000)

The paper begins with a review of the phytohormone (plant hormone) concept vs the sense of the mammalian hormones. The term "plant growth regulators" including new naturally occurring substances is ... [more ▼]

The paper begins with a review of the phytohormone (plant hormone) concept vs the sense of the mammalian hormones. The term "plant growth regulators" including new naturally occurring substances is discussed in regard to their effects on both growth and development processes, and possible different mechanisms of action in two different physiological directions. Mutual interactions between auxins, cytokinins, ethylene and polyamines are examined in several growth and development processes, showing the complexity of approach of the hormonal actions in plants . The indissociability of some hormonal relationships, and their obligatory integration with primary biochemical pathways is finally shown. [less ▲]

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See detailIntegrating phytohormone metabolism and action with primary biochemical pathways. II. Interrelationships between disturbed nitrogen and carbon metabolism and changes in hormonal concentrations and sensitivities in tissue cultures
Gaspar, Thomas ULg; Bisbis, Badia; Kevers, Claire ULg et al

in Greppin, Hubert; Penel, Claude; Broughton, Walter (Eds.) et al Integrated Plant Systems (2000)

The paper begins with a review of the concept of neoplastic progressions in plant tissue cultures, with the progressive acquisition of (a relative) independence to the hormones auxins and cytokinins. It ... [more ▼]

The paper begins with a review of the concept of neoplastic progressions in plant tissue cultures, with the progressive acquisition of (a relative) independence to the hormones auxins and cytokinins. It takes advantage of the deviations of carbon and nitrogen metabolisms shown in these particular cases, to illustrate the interdependence with the metabolisms of the hormones (and increased sensitivities to) polyamines and ethylene. These results provide additional examples of the changing concepts in hormonology. [less ▲]

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See detailIntegrating soil and plant knowledge at different scales to better understand the dynamics of water in SPAC.
Lobet, Guillaume ULg; Chaumont, F.; Javaux, M. et al

Conference (2008)

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See detailIntegrating structural and input design of a 2-DOF high-speed parallel manipulator: A flexible model-based approach
da Silva, M. M.; de Oliveira, L. P. R.; Bruls, Olivier ULg et al

in Mechanism & Machine Theory (2010), 45

This paper discusses the integrated design of parallel manipulators, which exhibit varying dynamics. This characteristic affects the machine stability and performance. The design methodology consists of ... [more ▼]

This paper discusses the integrated design of parallel manipulators, which exhibit varying dynamics. This characteristic affects the machine stability and performance. The design methodology consists of four main steps: (i) the system modeling using flexible multibody technique, (ii) the synthesis of reduced-order models suitable for control design, (iii) the systematic flexible model-based input signal design, and (iv) the evaluation of some possible machine designs. The novelty in this methodology is to take structural flexibilities into consideration during the input signal design; therefore, enhancing the standard design process which mainly considers rigid bodies dynamics. The potential of the proposed strategy is exploited for the design evaluation of a two degree-of-freedom high-speed parallel manipulator. The results are experimentally validated. [less ▲]

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See detailIntegrating Succession and Gender Issues from the Perspective of the Daughter of Family Enterprise across the U.S. and EU
Constantinidis, Christina ULg; Nelson, Teresa

in Management International = International Management = Gestión Internacional (2009), 14(1), 43-54

We engage a gender analysis, including consideration of the social phenomena of separation and hierarchy, to consider the role, condition and aspirations of daughters of family enterprise as they consider ... [more ▼]

We engage a gender analysis, including consideration of the social phenomena of separation and hierarchy, to consider the role, condition and aspirations of daughters of family enterprise as they consider the option of family entrepreneurship. From this perspective we examine the extant literature and present findings from two exploratory empirical research efforts, one in Belgium and one in the U.S., to better understand internationally how daughters perceive their leadership paths in the family business. We take into consideration growing social acceptance of women’s leadership, and women’s own career-mindedness, which influence traditional views of the opportunities for daughters inside and outside of the family business. Research avenues and practical recommendations to support successful succession of daughters are discussed. [less ▲]

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See detailIntegrating Succession and Gender Issues from the Perspective of the Daughter of Family Enterprise across the U.S. and EU
Constantinidis, Christina ULg; Nelson, Teresa

Conference (2008, November 04)

We engage a gender analysis, including consideration of the social phenomena of separation and hierarchy, to consider the role, condition and aspirations of daughters of family enterprise. From this ... [more ▼]

We engage a gender analysis, including consideration of the social phenomena of separation and hierarchy, to consider the role, condition and aspirations of daughters of family enterprise. From this perspective we examine the extant literature and present findings from two exploratory empirical research efforts, one in the EU and one in the U.S., to better understand how daughters perceive their leadership paths in the family business internationally. We take into consideration growing social acceptance of women’s leadership, and women’s own career-mindedness, which influence traditional views of the opportunities for daughters inside and outside of the family business. Research avenues and practical recommendations to support successful succession of daughters are discussed. [less ▲]

Detailed reference viewed: 83 (8 ULg)