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See detailMulti-level dynamic state estimation for electric power systems
Rousseaux, Patricia ULg; Van Cutsem, Thierry ULg; Ribbens-Pavella, Mania

in Proceedings of the 8th Power System Computation Conference (PSCC) (1984)

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See detailThe multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5.
Hofland, Leo J.; van der Hoek, Joost; Feelders, Richard et al

in European Journal of Endocrinology (2005), 152(4), 645-654

Objective: Currently, there is no effective medical treatment for patients with pituitary-dependent Cushing’s disease. A novel somatostatin (SS) analogue, named SOM230, with high binding affinity to SS ... [more ▼]

Objective: Currently, there is no effective medical treatment for patients with pituitary-dependent Cushing’s disease. A novel somatostatin (SS) analogue, named SOM230, with high binding affinity to SS receptor subtypes sst1, sst2, sst3 and sst5 was recently introduced. We compared the in vitro effects of the sst2-preferring SS analogue octreotide (OCT) and the multi-ligand SOM230 on ACTH release by human and mouse corticotroph tumour cells. Methods: By quantitative RT-PCR the sst subtype expression level was determined in human corticotroph adenomas. In vitro, the inhibitory effect of OCT and SOM230 on ACTH release by dispersed human corticotroph adenoma cells and mouse AtT20 corticotroph adenoma cells was determined. In addition, the influence of dexamethasone on the responsiveness to OCT and SOM230 was studied. Results: Corticotroph adenomas expressed predominantly sst5 mRNA (six out of six adenomas), whereas sst2 mRNA expression was detected at significantly lower levels. In a 72 h incubation with 10 nmol/l SOM230, ACTH release was inhibited in three out of five cultures (range –30 to –40%). Ten nmol/l OCT slightly inhibited ACTH release in only one of five cultures (– 28%). In AtT20 cells, expressing sst2, sst3 and sst5, SOM230 inhibited ACTH secretion with high potency (IC50 0.2 nmol/l). Dexamethasone (10 nmol/l) pre-treatment did not influence the sensitivity of the cells to the inhibitory effect of SOM230, suggesting that sst5 is relatively resistant to negative control by glucocorticoids. Conclusions: The selective expression of sst5 receptors in corticotroph adenomas and the preferential inhibition of ACTH release by human corticotroph adenoma cells by SOM230 in vitro, suggest that SOM230 may have potential in the treatment of patients with pituitary-dependent Cushing’s disease. [less ▲]

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See detailMulti-method monitoring of odor emissions in agricultural biogas facilities.
Nicolas, Jacques ULg; Adam, Gilles ULg; Ubeda, Yolanda et al

in Proceedings of the 5th IWA conference on odours and air emissions, San Francisco, USA, March, 4-7, 2013 (2013, March)

The production of farm-based biogas and electricity is an area of alternative-energy interest to many livestock producers. However, it is still insignificant in comparison to the maximum potential of ... [more ▼]

The production of farm-based biogas and electricity is an area of alternative-energy interest to many livestock producers. However, it is still insignificant in comparison to the maximum potential of farms all over the world. Market penetration should involve better confidence in the technique and better understanding of its possible assets and limits. For instance, is the environmental impact of biomethanation positive or negative? What are the possible ways to avoid or to control process imbalances? In the context of a European project, the research group attempted to tackle those questions under the angle of gas emission and more particularly of odor annoyance. A multi-method approach was applied to monitor biogas and odor emissions, both at the laboratory level on pilot plants and at real scale in 4 agricultural biogas facilities, in Belgium, Luxembourg, France and Germany. Results show that digested material is generally less odorant than crude manure or slurry, while preserving all the amendment and fertilizing qualities of the original material. Possible annoyance of agricultural biogas facilities in the surroundings remains limited and can be solved through simple techniques. [less ▲]

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See detailMulti-Months Cycles Observed in Climatic Data
Nicolay, Samuel ULg; Mabille, Georges ULg; Fettweis, Xavier ULg et al

in Simard, Suzanne (Ed.) Climate Change and Variability (2010)

Climatic variations happen at all time scales and since the origins of these variations are usually of very complex nature, climatic signals are indeed chaotic data. The identification of the cycles ... [more ▼]

Climatic variations happen at all time scales and since the origins of these variations are usually of very complex nature, climatic signals are indeed chaotic data. The identification of the cycles induced by the natural climatic variability is therefore a knotty problem, yet the knowing of these cycles is crucial to better understand and explain the climate (with interests for weather forecasting and climate change projections). Due to the non-stationary nature of the climatic time series, the simplest Fourier-based methods are inefficient for such applications (see e.g. Titchmarsh (1948)). This maybe explains why so few systematic spectral studies have been performed on the numerous datasets allowing to describe some aspects of the climate variability (e.g. climatic indices, temperature data). However, some recent studies (e.g. Matyasovszky (2009); Paluš & Novotná (2006)) show the existence of multi-year cycles in some specific climatic data. This shows that the emergence of new tools issued from signal analysis allows to extract sharper information from time series. Here, we use a wavelet-based methodology to detect cycles in air-surface temperatures obtained from worldwide weather stations, NCEP/NCAR reanalysis data, climatic indices and some paleoclimatic data. This technique reveals the existence of universal rhythms associated with the periods of 30 and 43 months. However, these cycles do not affect the temperature of the globe uniformly. The regions under the influence of the AO/NAO indices are influenced by a 30 months period cycle, while the areas related to the ENSO index are affected by a 43 months period cycle; as expected, the corresponding indices display the same cycle. We next show that the observed periods are statistically relevant. Finally, we consider some mechanisms that could induce such cycles. This chapter is based on the results obtained in Mabille & Nicolay (2009); Nicolay et al. (2009; 2010). [less ▲]

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See detailMulti-national, Multi-cultural and Multi-levelled Brussels : National and Ethnic Politics in the « Capital of Europe »
Martiniello, Marco ULg; Favell, Adrian

in Fonseca, Maria-Lucinda (Ed.) Cities in Movement : Migrants and Urban Change (2008)

Detailed reference viewed: 42 (2 ULg)
See detailMulti-national, multi-cultural and multi-levelled Brussels: national and ethnic politics in the "Capital of Europe"
Martiniello, Marco ULg; Favell, A.

Book published by The Transnational Communities Programme, University of Oxford (1999)

Detailed reference viewed: 13 (2 ULg)
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See detailMulti-Objective Optimization of a Fan Blade by Coupling a Genetic Algorithm and a Parametric Flow Solver
Kelner, Vincent ULg; Grondin, Gilles; Léonard, Olivier ULg et al

in Proceedings of EUROGEN'05 (2005, September)

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See detailMulti-party Arbitration under the UNCITRAL Rules
Kohl, Benoît ULg

Conference given outside the academic context (2008)

Detailed reference viewed: 45 (1 ULg)
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See detailMulti-period vehicle loading with stochastic release dates
Arda, Yasemin ULg; Crama, Yves ULg; Kronus, David ULg et al

E-print/Working paper (2012)

This paper investigates a multi-period vehicle loading problem with stochastic information regarding the release dates of items to be transported. The deterministic version of the problem can be ... [more ▼]

This paper investigates a multi-period vehicle loading problem with stochastic information regarding the release dates of items to be transported. The deterministic version of the problem can be formulated as a large-scale set covering problem. Several heuristic algorithms are proposed to generate decision policies for the stochastic optimization model over a long rolling horizon. The resulting policies have been extensively tested on instances which display the main characteristics of the industrial case-study that motivated the research. The tests demonstrate the benefits of the multi-period stochastic model over simple myopic strategies. A simple and efficient heuristic is shown to deliver good policies and to be robust against errors in the estimation of the probability distribution of the release dates. [less ▲]

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See detailMulti-physical processes in geomechanics – an introduction to constitutive modelling and coupling aspects
Charlier, Robert ULg; Dizier, Arnaud ULg; Laloui, Lyesse et al

in European Journal of Environmental and Civil Engineering [=EJECE] (2009), 7-8

This paper is the basis for a course dedicated to the geomechanics modelling, taking into account multiphysics couplings. A number of different coupling are discussed, with respectively the fluid flow ... [more ▼]

This paper is the basis for a course dedicated to the geomechanics modelling, taking into account multiphysics couplings. A number of different coupling are discussed, with respectively the fluid flow (saturated and unsaturated) and the thermal transfers in deformable porous media. Eventually some aspects on the numerical modelling with the finite element method are discussed. [less ▲]

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See detailMulti-physics modeling
Terrapon, Vincent ULg

Scientific conference (2010, February)

Detailed reference viewed: 10 (2 ULg)
See detailMulti-Residue Screening and Confirmatory Analysis of Anabolic Steroids in Urine by Gas Chromatography Coupled with Tandem Mass Spectrometry
Van Vyncht, G.; Gaspar, P.; De Pauw, Edwin ULg et al

in Journal of Chromatography. A (1994), 683(1), 67-74

The diversity of substances used illegally as growth promoters in meat production requires the development of multi-analyte methods of analysis involving a sample pretreatment step that is as rapid and as ... [more ▼]

The diversity of substances used illegally as growth promoters in meat production requires the development of multi-analyte methods of analysis involving a sample pretreatment step that is as rapid and as easy as possible, followed by a specific and sensitive determination of several residues within the same run. A general strategy for the screening and confirmatory analysis of fifteen artificial anabolic compounds in urine samples is described. It is based on solid-phase extraction on C18 Empore discs and amino-bonded columns followed, after derivatization (trimethylsilyl or methyloxime-trimethylsilyl derivatives), by gas chromatography coupled with collisionally activated dissociation tandem mass spectrometry. [less ▲]

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See detailMulti-row approaches to cutting plane generation
Poirrier, Laurent ULg

Doctoral thesis (2012)

This thesis focuses on the use of cutting-plane techniques to improve general-purpose mixed-integer linear programming solvers. The first topic covered here is a fast separation method for two-row cuts ... [more ▼]

This thesis focuses on the use of cutting-plane techniques to improve general-purpose mixed-integer linear programming solvers. The first topic covered here is a fast separation method for two-row cuts. Two-row cuts are intersection cuts from two rows of a simplex tableau describing the LP relaxation of the problem. This type of cuts recently gathered a lot of attention from the scientific community following a paper by Andersen, Louveaux, Weismantel and Wolsey describing the facets of the underlying two-row model and providing an intuitive geometric classification the the derived cuts. The specificity of the approach adopted here is that it does not rely on an "infinite relaxation" point of view and generate intersection cuts from fixed lattice-free sets. Instead, given a fractional point, it aims at always finding a most violated facet-defining inequality for the two-row model. This can be achieved by optimizing over the polar set of the integer hull of the model. A fast way of performing this is provided, by means of a polyhedron that is equivalent to the polar for that purpose, but has a more compact representation. Moreover, a row-generation algorithm is developed in order to avoid the costly computations of integer hulls of two-dimensional cones. An implementation of the resulting algorithm performs separation of two-row cuts in a few milliseconds on average, on the standard MIPLIB 3 and 2003 testsets. While this two-row separator is quick, the measurements of the computational usefulness of the cuts do not yield satisfactory results. Since all the cuts generated are facet-defining, this might suggest that the underlying two-row models are too weak. This observation prompted the second part of this thesis, an attempt to evaluate the strength of various multi-row relaxations, on small instances, using a generic separator. To that end, a separator is developed, which is able to compute facet-defining inequalities from arbitrary (yet reasonably small) mixed-integer sets. A row-generation approach is again adopted, but this time the slave part consists in the resolution of a mixed-integer problem instead of a closed-form oracle. Some interesting computational tricks are developed, in order to speedup the inherently hard computations. [less ▲]

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See detailMulti-scale analysis of carbon stocks and deforestation monitoring. Case of the Eastern tropical humid forest of Madagascar.
Ratsimba, H; Rajoulison, L G; Rabenilalana, F M et al

in Azevedo, J C; Feliciano, M; Castro, J (Eds.) et al Forest landscapes and Global Change (2010)

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See detailA multi-scale approach to facultative paedomorphosis of European newts (Salamandridae) in the Montenegrin karst: Distribution pattern, environmental variables, and conservation
Denoël, Mathieu ULg; Ficetola, Gentile Francesco; Cirovic, Ruza et al

in Biological Conservation (2009), 142(3), 509-517

Facultative paedomorphosis, a process in which newt larvae can opt for reproduction before or after metamorphosis, is geographically heterogeneous. Despite numerous ecological studies and recent evidence ... [more ▼]

Facultative paedomorphosis, a process in which newt larvae can opt for reproduction before or after metamorphosis, is geographically heterogeneous. Despite numerous ecological studies and recent evidence of declines in paedomorphic populations, however, no attempt to model environmental variables that explain the presence of paedomorphs has been made at a multi-scale level. Our aim was to fill this gap in studying three newt species (Lissotriton vulgaris, Mesotriton alpestris, and Triturus macedonicus) of the Montenegrin karst as model species. To this end, we used multivariate analysis on three scales of habitat: the breeding pond, the land use and the climatologic features. Results show that the study area is both an important hotspot for paedomorphosis and where intraspecific diversity is quickly disappearing (20-47% extirpation) because of fish introductions. Other habitat variables (water permanency, PH or the habitat origin) were shown to act on paedomorphosis but not consistently across species, confirming complexity of the evolutionary and ecological processes. This study appeals for more long-term and detailed landscape studies of polyphenisms, a neglected but promising topic, to better understand and protect alternative modes of development. Particularly, measures should be taken to identify hotspots of intraspecific diversity at a global scale and stop fish introductions before we reach a point of no-return. (C) 2008 Elsevier Ltd. All rights reserved. [less ▲]

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See detailA multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship.
Pironet, Antoine ULg; Desaive, Thomas ULg; Kosta, Sarah ULg et al

in BioMedical Engineering OnLine (2013), 12(1), 8

ABSTRACT: BACKGROUND: The end-systolic pressure-volume relationship is often considered as a load-independent property of the heart and, for this reason, is widely used as an index of ventricular ... [more ▼]

ABSTRACT: BACKGROUND: The end-systolic pressure-volume relationship is often considered as a load-independent property of the heart and, for this reason, is widely used as an index of ventricular contractility. However, many criticisms have been expressed against this index and the underlying time-varying elastance theory: first, it does not consider the phenomena underlying contraction and second, the end-systolic pressure volume relationship has been experimentally shown to be load-dependent. METHODS: In place of the time-varying elastance theory, a microscopic model of sarcomere contraction is used to infer the pressure generated by the contraction of the left ventricle, considered as a spherical assembling of sarcomere units. The left ventricle model is inserted into a closed-loop model of the cardiovascular system. Finally, parameters of the modified cardiovascular system model are identified to reproduce the hemodynamics of a normal dog. RESULTS: Experiments that have proven the limitations of the time-varying elastance theory are reproduced with our model: (1) preload reductions, (2) afterload increases, (3) the same experiments with increased ventricular contractility, (4) isovolumic contractions and (5) flow-clamps. All experiments simulated with the model generate different end-systolic pressure-volume relationships, showing that this relationship is actually load-dependent. Furthermore, we show that the results of our simulations are in good agreement with experiments. CONCLUSIONS: We implemented a multi-scale model of the cardiovascular system, in which ventricular contraction is described by a detailed sarcomere model. Using this model, we successfully reproduced a number of experiments that have shown the failing points of the time-varying elastance theory. In particular, the developed multi-scale model of the cardiovascular system can capture the load-dependence of the end-systolic pressure-volume relationship. [less ▲]

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See detailMulti-scale computational homogenization analysis of foams with micro-buckling
Nguyen, Van Dung ULg; Noels, Ludovic ULg

Conference (2012, July)

When studying the behavior of foams by multi-scale computational homogenization procedure, the micro-buckling may occur at the cell walls and edges and reduces the effective stiffness of the structures at ... [more ▼]

When studying the behavior of foams by multi-scale computational homogenization procedure, the micro-buckling may occur at the cell walls and edges and reduces the effective stiffness of the structures at macro-scale. This instability can be enhanced by plastic deformation at micro-scale. At sufficiently large value of macro-strain, even if the micro-tangent moduli of micro-material is still elliptic, the homogenized tangent moduli at macro-scale can lose its ellipticity that implies the localization occurs at macro-scale. When localization occurs, the characteristic size of macro- scopic deformation is the same order of the microscopic size. The assumption of material action in standard multi-scale computational homogenization approach where the stress only depends on the strain at this point is no-longer suitable. And the material behavior at given point depends also on the neighborhood of this point. To cover this problem, the second-order multi-scale computational homogenization is suitably used. At macroscopic problem, the high-order stress and the high-order strain are enhanced to the standard formulation by using the Discontinuous-Galerkin formulation while at the micro-scale, the standard continuum formulation is still used. By this procedure, the influence of micro-buckling of foams on structural behaviour is studied. [less ▲]

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See detailMulti-scale computational homogenization for structured shells
Kouznetsova, Varvara; Coenen, Erica; Fioole, Joost et al

Conference (2010)

Substructured and layered thin sheets can be found in a variety of structural, e.g. structured panels, as well as high-tech applications. A typical example is flexible electronics, e.g. flexible displays ... [more ▼]

Substructured and layered thin sheets can be found in a variety of structural, e.g. structured panels, as well as high-tech applications. A typical example is flexible electronics, e.g. flexible displays, where layers of different materials and interconnects are stacked to provide the necessary functionality. The resulting complex three dimensional geometry of the structured thin sheets in this type of applications prohibits the use of classical layer-wise composite shell theory. For these problems, a computational homogenization technique for thin structured sheets is proposed in this work, based on the computational homogenization concepts previously developed for the first- and second-order continua. [less ▲]

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See detailMulti-scale effect of landscape processes and habitat quality on newt abundance: Implications for conservation
Denoël, Mathieu ULg; Lehmann, Anthony

in Biological Conservation (2006), 130(4), 495-504

Recent studies in population dynamics suggest that landscape processes and habitat quality act at different scales on population abundances, but very few have modelled their simultaneous effects. However ... [more ▼]

Recent studies in population dynamics suggest that landscape processes and habitat quality act at different scales on population abundances, but very few have modelled their simultaneous effects. However, at a time of large declines in natural populations, it is essential to understand such multivariate components. We tested the hypothesis that natural populations of palmate newts (Triturus helveticus) are affected on three scales: breeding patch (pond), habitat complementation (terrestrial cover), and metapopulation. structure (density of ponds, surrounding populations). We conducted our survey in 130 ponds from southern France (Larzac) and analysed data with generalized additive models (GAM). Two main novel results emerge from these models: (1) the three landscape scales have significant effects on newt abundance, with more newts in deep, vegetated ponds, devoid of fish and surrounded by wooded areas and inhabited ponds; (2) the quality of the surrounding breeding patches is of primary importance in determining the abundance at core sites in a complex way: high abundances are associated positively with high densities of inhabited ponds, but negatively with the number of surrounding ponds. Deforestation, invasive species and abandonment of ponds all have negative impacts on the persistence of palmate newt populations. Future studies should encompass landscapes at different scales and incorporate the habitat quality in surrounding sites to better understand population dynamics and. provide adequate conservation measures. [less ▲]

Detailed reference viewed: 258 (11 ULg)