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See detailInvestigation of the fine structure of European populations with applications to disease association studies
heath, sc; gut, ivo; brennan, p et al

in European Journal of Human Genetics (2008), 16

An investigation into fine-scale European population structure was carried out using high-density genetic variation on nearly 6000 individuals originating from across Europe. The individuals were ... [more ▼]

An investigation into fine-scale European population structure was carried out using high-density genetic variation on nearly 6000 individuals originating from across Europe. The individuals were collected as control samples and were genotyped with more than 300 000 SNPs in genome-wide association studies using the Illumina Infinium platform. A major East-West gradient from Russian (Moscow) samples to Spanish samples was identified as the first principal component (PC) of the genetic diversity. The second PC identified a North-South gradient from Norway and Sweden to Romania and Spain. Variation of frequencies at markers in three separate genomic regions, surrounding LCT, HLA and HERC2, were strongly associated with this gradient. The next 18 PCs also accounted for a significant proportion of genetic diversity observed in the sample. We present a method to predict the ethnic origin of samples by comparing the sample genotypes with those from a reference set of samples of known origin. These predictions can be performed using just summary information on the known samples, and individual genotype data are not required. We discuss issues raised by these data and analyses for association studies including the matching of case-only cohorts to appropriate pre-collected control samples for genome-wide association studies. [less ▲]

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See detailInvestigation of the geomechanical aspects of a large landslide by means of a finite-element method: a case study
François, Bertrand ULg; Bonnard, Christophe; Laloui, Lyesse

in 12th IACMAG Conference (2008)

Using advanced geomechanical finite element modelling, it has been possible to simulate the mechanical behaviour of a large slope movement, namely the Triesenberg landslide. This slope is located along ... [more ▼]

Using advanced geomechanical finite element modelling, it has been possible to simulate the mechanical behaviour of a large slope movement, namely the Triesenberg landslide. This slope is located along the Rhine valley in the Principality of Liechtenstein, covering an area of around 5 km2 which includes two villages. Pore water pressure fields calculated by a separated hydrogeological model were used as an input for the geomechanical model. The results obtained through 2- and 3-dimension numerical simulations agree fairly well with field measurements of peak velocity, spatial and temporal distribution of velocity and total displacements. Such results were obtained using a Modified Cam-Clay elasto-plastic constitutive model. In addition, a parametric study has been carried out to evaluate the effect of the selected friction angle and of the range of water pressure variation on the movements during a crisis period. [less ▲]

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See detailInvestigation of the glucose metabolism of the chicken by embryonic injection of tolbutamide
Franssens, Lies; Wang, Yufeng; Willems, Els et al

in Proceedings of the XXIV World's Poultry Congress (2012)

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See detailInvestigation of the glucose metabolism of the embryonic and neonatal broiler chicks by injection of insulin
Franssens, L.; Lesuisse, J.; Koppenol, A. et al

in EAAP series (2013)

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See detailInvestigation of the glucose metabolisme of the chicken embryo by injection of insulin
Franssens, Lies; Koppenol, Astrid; Wang, Yufeng et al

Poster (2012)

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See detailInvestigation of the influence of packing geometry and of liquid viscosity on the liquid flow morphology by using X-ray tomography
Janzen, Anna; Steube, Julia; Kenig, Evgeny et al

in Proceedings of the 7th World Congress on Industrial Process Tomography (2013)

X-ray tomography is used to investigate the influence of packing geometry and of liquid viscosity on hydrodynamic quantities, as well as on the liquid flow morphology inside a packed column successively ... [more ▼]

X-ray tomography is used to investigate the influence of packing geometry and of liquid viscosity on hydrodynamic quantities, as well as on the liquid flow morphology inside a packed column successively filled with two structured metallic packing, M752Y and M500X. As expected, liquid holdup and gas-liquid interfacial area increase with liquid flow rate and viscosity. In both packings, the film flow pattern predominates, while flooded regions remain minority. The influence of liquid flow rate and viscosity on flow morphology depends on the packing geometry. In M752Y, film and flooded region flows are clearly influenced, whereas in M500X, they are not. [less ▲]

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See detailInvestigation of the influence of surface roughness modification of bone tissue engineering scaffolds
Kerckhofs, Greet ULg; Pyka, Grzegorz; Van Bael, Simon et al

in Abstract book SkyScan User Meeting 2010 (2010)

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See detailInvestigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry
Pochet, L.; Dieu, M.; Frederick, R. et al

in Tetrahedron (2003)

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See detailInvestigation of the innate immunity in the lower respiratory tract in exercising horses
Frellstedt, Linda ULg; Gosset, Philippe; Desmet, Christophe ULg et al

in Proceedings of the 1st Scientific Meeting of the Faculty of Veterinary Medicine (2011)

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See detailInvestigation of the interactions of polyvinylpyrrolidone with mixtures of anionic and nonionic surfactants or anionic and zwitterionic surfactants by pulsed field gradient NMR
Misselyn-Bauduin, Anne-Marie; Thibaut, André ULg; Grandjean, Jean ULg et al

in Journal of Colloid & Interface Science (2001), 238(1), 1-7

The interaction of polyvinylpyrrolidone (PVP) with an anionic surfactant (sodium dodecyl sulfate, SDS), a nonionic surfactant (pentaethylene glycol monodecyl ether, C(10)E(5)), and a zwitterionic ... [more ▼]

The interaction of polyvinylpyrrolidone (PVP) with an anionic surfactant (sodium dodecyl sulfate, SDS), a nonionic surfactant (pentaethylene glycol monodecyl ether, C(10)E(5)), and a zwitterionic surfactant (lauryl amido propyl betaine, LAPB) has been investigated by means of pulsed gradient spin-echo NMR (FT-PGSE NMR), allowing self-diffusion coefficients to be determined. The results confirm the strong interaction prevailing in the PVP/SDS system, whereas no association has been observed in the PVP/C(10)E(5) and PVP/LAPB systems. Mixing PVP with two surfactants, namely SDS and C(10)E(5) or SDS and LAPB, results in the formation of ternary aggregates between the polymer and the mixed micelles. [less ▲]

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See detailAn investigation of the large-scale variability of the apparently single Wolf-Rayet star WR 1
Morel, Thierry ULg; Georgiev, L. N.; Grosdidier, Y. et al

in Astronomy and Astrophysics (1999), 349

In recent years, much studies have focused on determining the origin of the large-scale line-profile and/or photometric patterns of variability displayed by some apparently single Wolf-Rayet stars, with ... [more ▼]

In recent years, much studies have focused on determining the origin of the large-scale line-profile and/or photometric patterns of variability displayed by some apparently single Wolf-Rayet stars, with the existence of an unseen (collapsed?) companion or of spatially extended wind structures as potential candidates. We present observations of <ASTROBJ>WR 1</ASTROBJ> which highlight the unusual character of the variations in this object. Our narrowband photometric observations reveal a gradual increase of the stellar continuum flux amounting to Delta v ~ 0.09 mag followed by a decline on about the same timescale (3-4 days). Only marginal evidence for variability is found during the 11 following nights. Strong, daily line-profile variations are also observed but they cannot be easily linked to the photometric variations. Similarly to the continuum flux variations, coherent time-dependent changes are observed in 1996 in the centroid, equivalent width, and skewness of He Ii lambda 4686. Despite the generally coherent nature of the variations, we do not find evidence in our data for the periods claimed in previous studies. While the issue of a cyclical pattern of variability in <ASTROBJ>WR 1</ASTROBJ> is still controversial, it is clear that this object might constitute in the future a cornerstone for our understanding of the mechanisms leading to the formation of largely anisotropic outflows in Wolf-Rayet stars. [less ▲]

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See detailInvestigation of the physics of wind interactions in colliding-wind massive binaries through XMS high resolution X-ray spectroscopy
De Becker, Michaël ULg

Conference (2011, June 14)

Binary systems made of two massive stars offer the opportunity to investigate the physics of quite extreme stellar environments. The powerful stellar winds collide, producing so-called wind interaction ... [more ▼]

Binary systems made of two massive stars offer the opportunity to investigate the physics of quite extreme stellar environments. The powerful stellar winds collide, producing so-called wind interaction regions, and the shocked gas is heated up to temperatures that can reach values as high as several tens of MK, leading to the production of copious amounts of thermal X-rays. The properties of the X-ray spectrum of such systems are intimately related to the orbitally modulated physical conditions in the wind interaction region. The study of the hydrodynamics of the colliding-wind phenomenon is a crucial issue in the sense that it constitutes the basement for the study of higher level physical processes at work in these systems, such as particle acceleration or even dust production. High-resolution X-ray spectroscopy with ATHENA/XMS is undoubtedly expected to be the most powerful tool to probe the physics of such environments over the next two decades, allowing a detailed confrontation to state-of-the-art theoretical models aiming at simulating the complex physics of colliding-wind massive binaries (CWBs). [less ▲]

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See detailInvestigation of the preparation and activity of gold catalysts in the total oxidation of n-hexane
Cellier Caroline; Lambert, Stéphanie ULg; Gaigneaux Eric et al

Poster (2005, June)

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See detailInvestigation of the preparation and activity of gold catalysts in the total oxidation of n-hexane
Cellier Caroline; Lambert, Stéphanie ULg; Gaigneaux Eric et al

in Applied Catalysis B : Environmental (2007), 70

The factors affecting the preparation of Au/TiO2 catalysts and their activity in the total oxidation of n-hexane were investigated. The mechanism of gold deposition–precipitation is discussed through ... [more ▼]

The factors affecting the preparation of Au/TiO2 catalysts and their activity in the total oxidation of n-hexane were investigated. The mechanism of gold deposition–precipitation is discussed through comparison of the samples prepared by this method and others prepared by anion adsorption method. The influence of the pH and of the origin of TiO2 support used are additionally addressed. The difference of gold dispersion observed between the two methods is attributed to a difference of mobility of the gold precursors during the thermal treatment rather than to a difference of dispersion over the uncalcined samples. The mechanism of gold deposition–precipitation actually involves the reactions of gold hydroxy-chloride species with the surface. Another part of the work, thus, concerned the use of the deposition–precipitation method to prepare a Au/MnO2 catalyst. It is shown that the activity of g-MnO2 is directly proportional to its surface area and that the deposition–precipitation procedure decreases the surface and activity of MnO2. However, the deposition of gold allows to avoid a too deep sintering of g-MnO2 and, thus, helps to somehow preserve its activity. [less ▲]

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See detailInvestigation of the preparation and activity of gold catalysts in the total oxidation of n-hexane
Cellier, Caroline; Lambert, Stéphanie ULg; Gaigneaux, Eric M. et al

in Applied Catalysis B : Environmental (2007), 70(1-4), 406-416

The factors affecting the preparation of Au/TiO2 catalysts and their activity in the total oxidation of n-hexane were investigated. The mechanism of gold deposition-precipitation is discussed through ... [more ▼]

The factors affecting the preparation of Au/TiO2 catalysts and their activity in the total oxidation of n-hexane were investigated. The mechanism of gold deposition-precipitation is discussed through comparison of the samples prepared by this method and others prepared by anion adsorption method. The influence of the pH and of the origin of TiO2 support used are additionally addressed. The difference of gold dispersion observed between the two methods is attributed to a difference of mobility of the gold precursors during the thermal treatment rather than to a difference of dispersion over the uncalcined samples. The mechanism of gold deposition-precipitation actually involves the reactions of gold hydroxy-chloride species with the surface. Another pan of the work, thus, concerned the use of the deposition-precipitation method to prepare a Au/MnO2 catalyst. It is shown that the activity of gamma-MnO2 is directly proportional to its surface area and that the deposition-precipitation procedure decreases the surface and activity of MnO2. However, the deposition of gold allows to avoid a too deep sintering of gamma-MnO2 and, thus, helps to somehow preserve its activity. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailInvestigation of the range and effective factors on protein energy malnutrition based on nutritional classification of rural zone of Arak in children less than five years
Jafarinia; Faraz, Alireza ULg; Akhoundzadeh, Sh. et al

in Arak Medical University Journal (2003), 6(2(23)), 7-13

Introduction: The protein-energy malnutrition is the most prevalent cause of malnutrition and always occures in infants and children under 5 years old. According to the harmful effects of malnutrition ... [more ▼]

Introduction: The protein-energy malnutrition is the most prevalent cause of malnutrition and always occures in infants and children under 5 years old. According to the harmful effects of malnutrition, such as high mortality, inability of learning and decrease of mental and physical ability, reconnoite and study of malnutrition qualification is very important. Material and Methods: This analytic cross-sectional study was carried out on 811 children under 5 years old who were living in rural zone of Arak. Based on health files; clinical inspections and interview with mothers a checklist was fulfilled for every child. Data were analysed by EPI6 software. Results: In this study, none of the children had stricken with Kwashiorkor or Marasmic-Kwashiorkor. Undernourished were seen in 7.39% and Marasmus were also seen in 1.1 % of subjects. The prevalence of malnutrition was 7.5% in Wellcome, 33.55% in Waterlow-Stunting, 23.05% in Waterlow-Wasting and 30.94% in Gomez classification. There was statistically correlation between malnutririon and respiratory infection rate, milstones, birthweight, maturity and begning of helpfood (P<0.05). Conclusion: Considering the results, the most rate of malnutrition in each classification was mild. It is suggested that increasing of familial awareness is an important factor for preventing from next damages and additional treatment costs. [less ▲]

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See detailInvestigation of the Relationship between Osteoporosis and the Collagenase Gene by Means of Polymorphism of the 5'upstream Region of This Gene
Thiry-Blaise, L. M.; Taquet, A. N.; Reginster, Jean-Yves ULg et al

in Calcified Tissue International (1995), 56

Osteoporosis is a slowly progressing disease resulting from an imbalance between bone accretion and degradation. As interstitial collagenase is a key enzyme in the degradation of bone matrix, we ... [more ▼]

Osteoporosis is a slowly progressing disease resulting from an imbalance between bone accretion and degradation. As interstitial collagenase is a key enzyme in the degradation of bone matrix, we investigated a possible relationship between the collagenase gene and osteoporosis. Analysis of an amplified genomic DNA fragment from -524 to +52 by denaturing gradient gel electrophoresis and sequencing allowed us to detect three dimorphic sites upstream of base -300, one of them leading to a BanI restriction site. None of the sites could be directly associated with osteoporosis. The allele frequencies of the three dimorphic sites were estimated. The interallelic ratios were high, thus providing new useful genetic markers for linkage analysis. When comparing these ratios in osteoporotic and nonosteoporotic subjects, no significant differences could be observed. [less ▲]

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