IS EPIZOOTIC RABBIT ENTEROPATHY (ERE) A BACTERIAL DISEASE?
Huybens, Nathalie ; Houeix, Julien ; Szalo, Ioan Mihai et al
in Proceeding of the 9th World Rabbit Congress (2008, June 12)
The etiology of epizootic rabbit enteropathy (ERE) is still unknown despite ten years of continuous research. A putative bacterial etiology is at the basis of current research. The fractionation of the ... [more ▼]
The etiology of epizootic rabbit enteropathy (ERE) is still unknown despite ten years of continuous research. A putative bacterial etiology is at the basis of current research. The fractionation of the reference inoculum (TEC4) is a major step to find the potential bacterial agent(s). In this study, TEC4 was fractionated with two techniques: centrifugation on discontinuous sucrose gradient then cell adhesion. Two selected fractions were inoculated to SPF rabbits and analyzed with classical bacteriological techniques. ERE was reproduced with both fractions. The 16S rDNA gene was amplified in all fractions and in three negative controls and subsequently analyzed with Restriction Fragment Length Polymorphism (RFLP) and Denaturating Gradient Gel Electrophoresis (DGGE). A difference in bacterial DNA composition was found between virulent and non-virulent fractions which reinforce the potential role of bacteria in the etiology of ERE. [less ▲]Detailed reference viewed: 174 (42 ULg)
Is ethanol a pro-drug? Acetaldehyde contribution to brain ethanol effects
Quertemont, Etienne ; ; et al
in Alcoholism, Clinical & Experimental Research (2005), 29(8), 1514-1521
This article presents the proceedings of a symposium at the 2004 meeting of the International Society for Biomedical Research on Alcoholism, held in Mannheim, Germany. The symposium was organized by ... [more ▼]
This article presents the proceedings of a symposium at the 2004 meeting of the International Society for Biomedical Research on Alcoholism, held in Mannheim, Germany. The symposium was organized by Etienne Quertemont and chaired by C. J. Peter Eriksson. The presentations were (1) Brain ethanol metabolism and its behavior consequences, by Sergey M. Zimatkin and P. S. Pronko; (2) Acetaldehyde increases dopaminergic neuronal activity: a possible mechanism for acetaldehyde reinforcing effects, by Marco Diana and Milena Pisano; (3) Contrasting the reinforcing actions of acetaldehyde and ethanol within the ventral tegmental area (VTA) of alcohol-preferring (P) rats, by Zachary A. Rodd and Richard R. Bell; (4) Molecular and biochemical changes associated with acetaldehyde toxicity, by Roberta J. Ward; and (5) Role of acetaldehyde in human alcoholism and alcohol abuse, by C. J. Peter Eriksson [less ▲]Detailed reference viewed: 35 (5 ULg)
Is ethanol a pro-drug? The role of acetaldehyde in the central effects of ethanol
Quertemont, Etienne ; Tambour, Sophie
in Trends in Pharmacological Sciences (2004), 25(3), 130-134
Acetaldehyde, the first product of ethanol metabolism, has been speculated to be involved in many behavioral effects of ethanol. However, its precise role remains a matter of debate, with some researchers ... [more ▼]
Acetaldehyde, the first product of ethanol metabolism, has been speculated to be involved in many behavioral effects of ethanol. However, its precise role remains a matter of debate, with some researchers suggesting that acetaldehyde has no role in the effects of ethanol and others contending that ethanol is a pro-drug whose pharmacological action is mediated by acetaldehyde. Recent studies support a role for acetaldehyde in the stimulant, reinforcing, hypnotic and amnesic effects of ethanol, and, in particular, alcohol abuse and alcoholism. However, current evidence indicates that acetaldehyde is not involved in some of the major neurochemical effects of ethanol. It is therefore likely that ethanol and acetaldehyde molecules act synergistically to determine the multiple neurochemical and behavioral effects of alcohol consumption. [less ▲]Detailed reference viewed: 32 (3 ULg)
Is evidence-based medicine so evident in veterinary research and practice? History, obstacles and perspectives.
Vandeweerd, Jean-Michel ; ; et al
in Veterinary Journal (2012), 191(1), 28-34
Evidence-based medicine (EBM) refers to the conscientious, explicit and judicious use of current best evidence from research for the care of an individual patient. The concept of EBM was first described ... [more ▼]
Evidence-based medicine (EBM) refers to the conscientious, explicit and judicious use of current best evidence from research for the care of an individual patient. The concept of EBM was first described in human medicine in the early 1990s and was introduced to veterinary medicine 10 years later. However, it is not clear that the EBM approach promulgated in human medicine can be applied to the same extent to veterinary medicine. EBM has the potential to help veterinarians to make more informed decisions, but obstacles to the implementation of EBM include a lack of high quality patient-centred research, the need for basic understanding of clinical epidemiology by veterinarians, the absence of adequate searching techniques and accessibility to scientific data bases and the inadequacy of EBM tools that can be applied to the busy daily practise of veterinarians. This review describes the development of EBM in the veterinary profession, identifies its advantages and disadvantages and discusses whether and how veterinary surgeons should further adopt the EBM approach of human medicine. [less ▲]Detailed reference viewed: 50 (11 ULg)
Is extended or continuous infusion of Carbapenems the obvious solution to improve clinical outcomes and reduce mortality?
FRIPPIAT, Frédéric ; VERCHEVAL, Christelle ; LAMBERMONT, Bernard et al
in Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America (2013), 57(2), 324-325Detailed reference viewed: 20 (8 ULg)
Is FDG bowel uptake modified by oral spasmolytic premedication ?
; DAENEN, Frédéric ; et al
in Journal of Nuclear Medicine (The) (2002), 43Detailed reference viewed: 8 (0 ULg)
Is FDG-PET/CT an early indicator of the clinical response to rituximab in rheumatoid arthritis ?
NAMUR, Gauthier ; KAISER, Marie-Joëlle ; et al
in Journal of Nuclear Medicine (The) (2008), 49(SUPPL), 10Detailed reference viewed: 7 (0 ULg)
Is FE(NO50) useful diagnostic tool in suspected asthma?
SCHLEICH, FLorence ; ASANDEI, Raluca ; Manise, Maïté et al
in International Journal of Clinical Practice (2012), 66(2), 158-65
Background: Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of ... [more ▼]
Background: Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of 50 ml/s (FE(NO50) ) remains a controversial diagnostic tool. Aim: To assess the ability of FE(NO50) to identify bronchial hyperresponsiveness (BHR) to methacholine (provocative concentration of methacholine causing a 20% fall in FEV(1) ; PC20M </= 16 mg/ml) and to establish whether or not symptoms relate to FE(NO50) and PC20M in patients with no demonstrated reversibility to beta(2) -agonist. Methods: We conducted a prospective study on 174 steroid naive patients with respiratory symptoms, forced expiratory volume in 1 s (FEV(1) ) >/= 70% predicted and no demonstrated reversibility to beta(2) -agonist. Patients answered to a standardised symptom questionnaire and underwent FE(NO50) and methacholine challenge. Receiver-operating characteristic (ROC) curve and logistic regression analysis assessed the relationship between PC20M and FE(NO50) , taking into account covariates (smoking, atopy, age, gender and FEV(1) ). Results: A total of 82 patients had a PC20M </= 16 mg/ml and had significantly higher FE(NO50) (19 ppb vs. 15 ppb; p < 0.05). By constructing ROC curve, we found that FE(NO50) cut-off value of 34 ppb was able to identify not only BHR with high specificity (95%) and positive predictive value (88%) but low sensitivity (35%) and negative predictive value (62%). When combining all variables into the logistic model, FE(NO50) (p = 0.0011) and FEV(1) (p < 0.0001) were independent predictors of BHR whereas age, gender, smoking and atopy had no influence. The presence of diurnal and nocturnal wheezing was associated with raised FE(NO50) (p < 0.001 and p < 0.05, respectively). Conclusion: The value of FE(NO50) > 34 ppb has high predictive value of PC20M < 16 in patients with suspected asthma in whom bronchodilating test failed to demonstrate reversibility or was not indicated. However, FE(NO50) </= 34 ppb does not rule out BHR and should prompt the clinician to ask for a methacholine challenge. [less ▲]Detailed reference viewed: 38 (11 ULg)
Is Fractal Geometry Useful in Medicine and Biomedical Sciences?
; Fissette, Jean ; et al
in Medical Hypotheses (2000), 54(3), 360-6
Fractal geometry has become very useful in the understanding of many phenomena in various fields such as astrophysics, economy or agriculture and recently in medicine. After a brief intuitive introduction ... [more ▼]
Fractal geometry has become very useful in the understanding of many phenomena in various fields such as astrophysics, economy or agriculture and recently in medicine. After a brief intuitive introduction to the basis of fractal geometry, the clue is made about the correlation between Df and the complexity or the irregularity of a structure. However, fractal analysis must be applied with certain caution in natural objects such as bio-medical ones. The cardio-vascular system remains one of the most important fields of application of these kinds of approach. Spectral analysis of the R-R interval, morphology of the distal coronary arteries constitute two examples. Other very interesting applications are founded in bacteriology, medical imaging or ophthalmology. In our institution, we apply fractal analysis in order to quantitate angiogenesis and other vascular processes. [less ▲]Detailed reference viewed: 12 (0 ULg)
Is Geometallurgy Teachable? A challenge for the new Erasmus Mundus EMerald
Conference (2014, September 05)
designate any kind of advanced ore characterisation prior to mineral processing operations while in fact it should clearly refer to a multidisciplinary integration of geological, mining, metallurgical ... [more ▼]
designate any kind of advanced ore characterisation prior to mineral processing operations while in fact it should clearly refer to a multidisciplinary integration of geological, mining, metallurgical, environmental and economic information into a single orebody model. In order to instil the best available geometallurgical practices in the professional world, it seems essential to break the traditional cleavages among disciplines and educate a new generation of engineers. The Erasmus Mundus EMerald “Master in Georesources Engineering” program initiated by four European universities under the coordination of University of Liege, has been designed to exactly tackle this challenge. It is not surprising that this program has been set up by universities having a long tradition in mixing a double perspective of geology and engineering (Nancy; Lulea; Liege and Freiberg). Geometallurgy requires both an excellent understanding of the natural variability and complexity of an ore and a comprehensive overview of the techniques available to extract and concentrate any valuable material. The course program has been designed to achieve a right balance between knowledge of mineral resources (geology, resource characterisation, reserve estimation, modelling) and processing (comminution, preconcentration, leaching, waste disposal,...). It also includes a broader view on life cycle analysis and urban mining. A series of professional seminars, suggested by an industrial advisory board, shed light on strategic issues, economic and environmental challenges, corporate social responsibilities, etc. Mobility and multicultural experience is an added-value of the Erasmus Mundus experience which definitely contributes to breeding engineers for tomorrow. [less ▲]Detailed reference viewed: 7 (0 ULg)
Is global left ventricular afterload has an impact on left atrial function in patients with aortic stenosis?
; Magne, Julien ; MOONEN, Marie et al
Conference (2010)Detailed reference viewed: 2 (0 ULg)
Is group climate a protective factor of substance use for Canadian girls with problem behaviors?
Mathys, Cécile ;
Conference (2012)Detailed reference viewed: 13 (2 ULg)
Is HD 163899 really a supergiant star?
Godart, Mélanie ; Dupret, Marc-Antoine ; Noels-Grötsch, Arlette
in Communications in Asteroseismology (2008), 157
According to its spectral type B2 Ib/I I (Klare & Neckel 1977; Schmidt & Carruthers 1996), HD163899 is a supergiant star. The star presents p and g-mode pulsations (Saio et al. 2006). In such a post-main ... [more ▼]
According to its spectral type B2 Ib/I I (Klare & Neckel 1977; Schmidt & Carruthers 1996), HD163899 is a supergiant star. The star presents p and g-mode pulsations (Saio et al. 2006). In such a post-main sequence (post MS) star, the helium core is radiative with a very large Brunt-Väisälä frequency which produces a strong damping. The presence of excited g-modes is however possible thanks to an intermediate convective zone (ICZ) which prevents some g-modes from entering the radiative damping core (Saio et al. 2006). We have investigated an alternative solution. We show that MS evolutionary tracks could cross the error box of HD 163899 if a sufficiently large amount of overshooting is taken into account. However, in that case, the spectrum of unstable modes is different from the spectrum of a supergiant star since the Brunt-Väisälä frequency is much smaller. [less ▲]Detailed reference viewed: 5 (0 ULg)
Is HIF-1alpha a pro- or an anti-apoptotic protein?
; Mottet, Denis ; et al
in Biochemical Pharmacology (2002), 64(5-6), 889-92
Hypoxia-inducible factor-1 (HIF-1) is the major transcription factor specifically activated by hypoxia. It induces the expression of different genes whose products play an adaptive role for hypoxic cells ... [more ▼]
Hypoxia-inducible factor-1 (HIF-1) is the major transcription factor specifically activated by hypoxia. It induces the expression of different genes whose products play an adaptive role for hypoxic cells and tissues. Besides these protective responses, HIF-1 and/or hypoxia have also been shown to be either anti-apoptotic or pro-apoptotic, according to the cell type and experimental conditions. More severe or prolonged hypoxia rather induces apoptosis that is, at least in part, initiated by the direct association of HIF-1alpha and p53 and p53-induced gene expression. On the other hand, HIF-1alpha dimerized with ARNT, as an active transcription factor, can protect cells from apoptosis induced by several conditions. This review is aimed to describe the different mechanisms that account for these opposite effects of HIF-1alpha. [less ▲]Detailed reference viewed: 19 (3 ULg)
Is hypoxia-inducible factor 1 an actor in migraine pathogenesis ? An experimental study of possible metabolic facets including hypoxia and mitochondrial impairment
Multon, Sylvie ; ; Schoenen, Jean
Poster (2008, September)Detailed reference viewed: 10 (0 ULg)