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See detailIRF3 is required for induction of allergic airway inflammation by dendritic cells
Marichal, Thomas ULg; Bedoret, Denis; Goriely, M. et al

Conference (2009)

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Peer Reviewed
See detailIRF3 is required for induction of allergic airway inflammation by dendritic cells
Marichal, Thomas ULg; Bedoret, Denis; Goriely, S et al

Poster (2009)

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See detailIRF3 is required for the induction of allergic airway inflammation by lung dendritic cells in a mouse model of house dust mite-induced atopic asthma
Marichal, Thomas ULg; Bedoret, Denis; Goriely, M. et al

in Abstracts of the 17th Annual European Respiratory Society Congress, Vienna, Austria (2009)

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See detailIRF6 Screening of Syndromic and a priori Non-Syndromic Cleft Lip and Palate Patients: Identification of a New Type of Minor VWS Sign.
Desmyter, L.; Ghassibe, M.; Revencu, N. et al

in Molecular Syndromology (2010), 1(2), 67-74

Van der Woude syndrome (VWS), caused by dominant IRF6 mutation, is the most common cleft syndrome. In 15% of the patients, lip pits are absent and the phenotype mimics isolated clefts. Therefore, we ... [more ▼]

Van der Woude syndrome (VWS), caused by dominant IRF6 mutation, is the most common cleft syndrome. In 15% of the patients, lip pits are absent and the phenotype mimics isolated clefts. Therefore, we hypothesized that some of the families classified as having non-syndromic inherited cleft lip and palate could have an IRF6 mutation. We screened in total 170 patients with cleft lip with or without cleft palate (CL/P): 75 were syndromic and 95 were a priori part of multiplex non-syndromic families. A mutation was identified in 62.7 and 3.3% of the patients, respectively. In one of the 95 a priori non-syndromic families with an autosomal dominant inheritance (family B), new insights into the family history revealed the presence, at birth, of lower lip pits in two members and the diagnosis was revised as VWS. A novel lower lip sign was observed in one individual in this family. Interestingly, a similar lower lip sign was also observed in one individual from a 2nd family (family A). This consists of 2 nodules below the lower lip on the external side. In a 3rd multiplex family (family C), a de novo mutation was identified in an a priori non-syndromic CL/P patient. Re-examination after mutation screening revealed the presence of a tiny pit-looking lesion on the inner side of the lower lip leading to a revised diagnosis of VWS. On the basis of this data, we conclude that IRF6 should be screened when any doubt rises about the normality of the lower lip and also if a non-syndromic cleft lip patient (with or without cleft palate) has a family history suggestive of autosomal dominant inheritance. [less ▲]

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See detailIRM interventionnelle : vers une neuronavigation en temps reel
Martin, Didier ULg

Conference (2008, October 11)

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See detailIRM interventionnelle : vers une neuronavigation en temps réel.
Martin, Didier ULg; Nguyen Khac, Minh-Tuan ULg; Scholtes, Félix ULg et al

in Revue Médicale de Liège (2008), 63

La neuronavigation est un outil neurochirurgical qui peut être comparé au GPS. Elle sert à guider la procédure neurochirurgicale en visualisant les déplacements des instruments chirurgicaux sur les images ... [more ▼]

La neuronavigation est un outil neurochirurgical qui peut être comparé au GPS. Elle sert à guider la procédure neurochirurgicale en visualisant les déplacements des instruments chirurgicaux sur les images préopératoires. En augmentant la précision du geste, elle permet d’atteindre des lésions parfois très petites ou difficiles d’accès tout en réduisant la morbidité et en augmentant l’efficacité. Elle présente cependant un écueil majeur. L’image utilisée par le système de navigation est obtenue avant l’intervention et ne peut être corrigée durant celle-ci. En raison des modifications anatomiques inhérentes à l’opération (modification du volume du liquide céphalo-rachidien, résection de la tumeur,…), il apparaît progressivement une discordance entre la réalité chirurgicale et l’imagerie. Les informations pertinentes se périment ainsi peu à peu et la précision se perd. L’IRM interventionnelle est le moyen de réactualiser la neuronavigation par des images de haute définition. De plus, elle permet de réaliser des contrôles intra-opératoires de la qualité du geste chirurgical. [less ▲]

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See detailIron and FRP materials
Ly, Dong Phuong Lam ULg; Demonceau, Jean-François ULg; Jaspart, Jean-Pierre ULg

Report (2008)

Numerical investigations are very helpful to prepare and to plan experimental investigations. The numerical investigations presented within the present section deals with the experimental tests conducted ... [more ▼]

Numerical investigations are very helpful to prepare and to plan experimental investigations. The numerical investigations presented within the present section deals with the experimental tests conducted on iron elements reinforced by FRP in tension, i.e.: - first, to determine the anchorage length requested for the FRP (zone A of the figure 1.1 1) to insure a good stress transfer from the iron member to FRP sheets through bonds without any debonding problem; - and secondly, to predict the effects of FRP sheets on iron elements in tension. [less ▲]

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See detailIron and the anaemia of chronic disease: a review and strategic recommendations.
Cavill, Ivor; Auerbach, Michael; Bailie, George R et al

in Current Medical Research & Opinion (2006), 22(4), 731-7

BACKGROUND: The incidence of anaemia is high in many chronic conditions, yet it often receives little attention. SCOPE/METHODS: A panel of international experts with experience in haematology, nephrology ... [more ▼]

BACKGROUND: The incidence of anaemia is high in many chronic conditions, yet it often receives little attention. SCOPE/METHODS: A panel of international experts with experience in haematology, nephrology, oncology, rheumatology and pharmacy was convened to prepare strategic guidelines. A focused literature search was conducted after key issues had been identified. A series of recommendations was agreed, backed, wherever possible, by published evidence which is included in the annotations. RECOMMENDATIONS: Anaemia is a critical issue for patients with chronic diseases. Healthcare professionals need to recognise that anaemia is a frequent companion of cancer and chronic conditions such as rheumatoid arthritis and heart failure. It reduces patients' quality of life and can increase morbidity and mortality. Anaemia should be considered as a disordered process in which the rate of red cell production fails to match the rate of destruction which leads eventually to a reduction in haemoglobin concentration; this process is common to all chronic anaemias. The aim of anaemia management should be to restore patient functionality and quality of life by restoring effective red cell production. Blood transfusion can elevate haemoglobin concentration in the short term but does nothing to address the underlying disorder; red cell transfusion is, therefore, not an appropriate treatment for chronic anaemia. Patients with anaemia of chronic disease may benefit from iron therapy and/or erythropoiesis stimulating agents (ESAs). Intravenous iron should be considered since this can be given safely to patients with chronic diseases while intramuscular iron causes unacceptable adverse effects and oral iron has limited efficacy in chronic anaemia. CONCLUSION: The management of anaemia calls for the development of a specialist service together with education of all healthcare professionals and transfer of skills from areas of good practice. Improvement in the management of anaemia requires a fundamental change of attitude from healthcare professionals. [less ▲]

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See detailIron availability for erythropoiesis
Fillet, Georges ULg; Beguin, Yves ULg

in Drewienkiewicz, C. (Ed.) The potential use of erythropoietin to diminish the need for homologous blood in surgery (1992)

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See detailIron bacterial and fungal mats, Bajocian stratotype (Mid-Jurassic, northern Normandy, France)
Préat; Mamet, B.; De Ridder, C. et al

in Sedimentary Geology (2001), 137

The Oolithe ferrugineuse de Bayeux Formation is located at the historical Bajocian stratotype of Sainte-Honorine-des-Pertes, north of Bayeux, Normandy. The condensed formation ranges from the base of the ... [more ▼]

The Oolithe ferrugineuse de Bayeux Formation is located at the historical Bajocian stratotype of Sainte-Honorine-des-Pertes, north of Bayeux, Normandy. The condensed formation ranges from the base of the Humphriesianum Zone to the Parkinsoni Zone and is divided into four beds of decimetric scale. Three main microfacies are present: (1) oncoid rudstones, (2) ooid bioclastic packstones and (3) silty burrowed wackestones/ packstones. Sedimentation took place in a very quiet environment, below the photic zone and below or near the storm wave base. The general setting is a distal carbonate ramp, its lower part characterized by hemipelagic sedimentation indicated by the presence of planktonic foraminifers. The inferred depth is around 100 m. Free oxygen concentration was low. Dysaerobic conditions are indicated by a scarcity of benthic macrofauna. Ferruginous structures are numerous in the first two microfacies, and absent in the last. Hematite staining is not uniform and follows many sedimentary patterns. Among the more widespread Fe structures are perforation infillings with endolithic microorganisms, microstromatolites, oncoids, ooids, blisters, coatings and hardgrounds. These structures can be associated and none are mutually exclusive. Hematite-coated filaments of different sizes and shapes are observed in the micrite matrix: the walls of various organisms; the calcite crystals associated with the Fe cortical laminations; the perforations and burrow; the hardgrounds; and microstromatolites. Petrographical and SEM examinations suggest that the laminated crusts (oncoids and hardgrounds) are formed by microbial iron mats dominated by filamentous bacteria and fungi. Seven types of microbes are recognized: filaments (five morphotypes), spheroidal bodies and stalked bodies. Filamentous microfossils of type 1 to 4 resemble the present-day filamentous bacteria (Beggiatoales and Cytophagaceae). Because of their large diameter and their branching nature, filaments of type 5 are possibly filamentous fungi. Another argument in favor of fungi is the presence of stalked and spheroidal bodies that resemble zoosporangia and oogonia of some Oomycota. In deep, calm and dysaerobic waters, many interfaces (e.g. between aerobic and dysaerobic waters) are present in the sediments. The stability of the soluble reduced state of iron (Fe2+) is higher at such interfaces, and many ferric iron-encrusted microbial fossils are observed. Iron could thus serve as an electron donor for microbial iron-oxidation processes. Other microbial iron deposition pathways are also possible. It appears that, regardless of geological age (Paleozoic, Mesozoic) and geographical location, the same microbiological mechanisms are probably responsible for the red color in calcareous stratified or unstratified bodies. The presence of fossilized iron-encrusted bacteria and fungi at interfaces may therefore serve as an indicator of anoxic to dysaerobic conditions in various paleo(micro)environments. [less ▲]

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Peer Reviewed
See detailIron chelation decreases NF-kappaB and HIV-1 activation due to oxidative stress
Sappey, Christine; Boelaert, J. R.; Legrand-Poels, Sylvie ULg et al

in AIDS Research and Human Retroviruses (1995)

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See detailIron columns reinforced by FRP under axial compression
Ly, Dong Phuong Lam ULg; Jaspart, Jean-Pierre ULg; Demonceau, Jean-François ULg

Report (2008)

Slender iron column reinforced by FRP is sensitive to buckling phenomenon, taking place obviously at a cross-section within the middle segment. An equivalent FRP-iron cross-section can be used to derive ... [more ▼]

Slender iron column reinforced by FRP is sensitive to buckling phenomenon, taking place obviously at a cross-section within the middle segment. An equivalent FRP-iron cross-section can be used to derive the buckling resistance of the composite member by using buckling formulation previously defined for column members. [less ▲]

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Peer Reviewed
See detailIron content in human alveolar macrophages.
CORHAY, Jean-Louis ULg; Weber, Georges ULg; Bury, Thierry ULg et al

in European Respiratory Journal (1992), 5(7), 804-9

Intracellular iron can be estimated semi-quantitatively by histochemical determination using the ferrocyanide reagent's score. Particle-induced X-ray emission (PIXE) allows accurate determination of ... [more ▼]

Intracellular iron can be estimated semi-quantitatively by histochemical determination using the ferrocyanide reagent's score. Particle-induced X-ray emission (PIXE) allows accurate determination of various elements including iron in cells and biological fluids. Both techniques have been used to measure iron in alveolar macrophages gathered by bronchoalveolar lavage. The purpose of this study was to investigate the clinical usefulness of the PIXE technique in occupational respiratory medicine and in various pulmonary diseases. Using the PIXE method, we measured the iron content of alveolar macrophages in healthy subjects, with and without occupational exposure to iron dust, and in patients with pulmonary diseases (chronic obstructive pulmonary disease (COPD), lung cancer, Goodpasture's syndrome). Our results were then compared with those obtained with the ferrocyanide reagent. Intramacrophagic iron was 0.33 +/- 0.21 micrograms.10(-6) (mean +/- SD) cells in healthy non-smoking subjects without occupational exposure. Intramacrophagic iron was increased in smokers, iron-steelworkers, and in patients with COPD or lung cancer even in the absence of pulmonary haemorrhage. The two patients with Goodpasture's syndrome had high intramacrophagic iron content. About 80% of the whole bronchoalveolar lavage fluid iron content was in the cells. Mean iron content of blood monocytes, lymphocytes and neutrophils of eight healthy subjects was significantly lower than that of alveolar macrophages. A significant correlation was found between iron determination by the PIXE method and the ferrocyanide reagent's score (r = 0.89). We conclude that intramacrophagic iron may be increased in steelworkers and subjects with pulmonary haemorrhage, but also in asymptomatic smokers, in COPD and lung cancer patients without occupational exposure to iron dust. [less ▲]

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See detailIron deficiency
Beguin, Yves ULg; Estatiev, R.

in Gasche, C. (Ed.) Anemia in inflammatory bowel disease (2008)

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See detailIron distribution in a sea ice environment
Lannuzel, D.; de Jong, J.; Schoemann, V. et al

Poster (2004, October)

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See detailIron Distribution in Antarctic Pack Ice
Lannuzel, Delphine; Schoemann, Véronique; de Jong, Jeroen et al

Poster (2006, February)

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See detailIron distribution in sea ice
Lannuzel, Delphine; De Jong, Johannes Jeroen; Schoemann, Véronique et al

Poster (2005, March)

Detailed reference viewed: 3 (0 ULg)