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See detailFDC : origin and function
Heinen, Ernst ULiege; Bosseloir, A.; Bouzahzah, F. et al

in Current topics in Microbiology and Immunology (1995)

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See detailFDC-B1, a new monoclonal antibody directed against bovine follicular dendrititic cells.
Defaweux, Valérie ULiege; Mélot, France ULiege; Jolois, Olivier ULiege et al

Poster (2003, March)

Follicular dendritic cells (FDCs) are unique immunological accessory cells located in the light and dark zones of the germinal centres in lymph follicles. Characterized by long branching processes forming ... [more ▼]

Follicular dendritic cells (FDCs) are unique immunological accessory cells located in the light and dark zones of the germinal centres in lymph follicles. Characterized by long branching processes forming a three-dimensional network, FDCs create particular microenvironments for germinal centre B and T cells and contribute to the maturation of B cells into memory cells. An involvement of the FDCs is suspected in various disorders affecting lymphoid tissues, malignant lymphoma or in some viral diseases. Moreover, in prion diseases, FDCs seem to be the major sites of extraneuronal cellular prion protein expression and the principal sites of the infectious agent accumulation in lymph organs. Because no antibody commercially available was specific to bovine FDCs, a new monoclonal antibody directed against bovine FDCs (FDC-B1) has been produced and characterized in our laboratory. The antigen detected by FDC-B1 is expressed on FDC surfaces in ruminant (bovine, ovine and caprine) lymphoid organs. This protein seems to be a membrane glycoprotein of more or less 28 kDa whose sequence will be soon determined. Moreover, FDC-B1 can be used in various applications: immunofluorescence, immunoperoxidase, immunogold labellings and western blotting. FDCs are potential targets for therapy or prophylaxis in natural TSEs, such as bovine spongiform encephalopathies and scrapie. Thus, it appears of great interest to identify bovine and ovine FDCs in routine lymphoid tissues sections. An other application of this antibody to immunofluorescence histochemistry techniques will enable the study of possible direct contacts between bovine FDCs and nerve endings and thus clarify prions neuroinvasion scheme in the case of BSE and scrapie. [less ▲]

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See detailFDC-B1: a new monoclonal antibody directed against bovine follicular dendritic cells
Defaweux, Valérie ULiege; Mélot, France ULiege; Jolois, Olivier ULiege et al

in Veterinary Immunology and Immunopathology (2004), 97(1-2), 1-9

Follicular dendritic cells (FDCs) are a unique population of accessory cells located in the light zone of the germinal centres of lymphoid follicles. Their involvement in the generation of Immoral immune ... [more ▼]

Follicular dendritic cells (FDCs) are a unique population of accessory cells located in the light zone of the germinal centres of lymphoid follicles. Their involvement in the generation of Immoral immune responses implies a potential role for these cells in many disorders. Indeed, in prion diseases, FDCs seem to be the major sites of extraneuronal cellular prion protein expression and the principal sites of the infectious agent accumulation in lymphoid organs. The identification of FDC is useful for the analysis of their distribution in reactive lymphoid tissue as well as in pathological conditions. The production and characterisation of a new mouse monoclonal antibody directed against bovine follicular dendritic cells (FDC-B1) is reported. The antigen detected by FDC-B1 is expressed exclusively on the surface of FDCs in ruminant lymphoid organs. The antigen has an approximate molecular weight of 28 kDa. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailLe FDF dans les provinces et les entités fédérées
Lanneau, Catherine ULiege

in Dujardin, Vincent; Delcorps, Vincent (Eds.) FDF. 50 ans d’engagement politique (2014)

Cette contribution analyse l’action du FDF, parti « communautaire » essentiellement bruxellois, dans les entités fédérées. Quel rôle a-t-il joué, seul ou en partenariat avec le RW puis les libéraux, à la ... [more ▼]

Cette contribution analyse l’action du FDF, parti « communautaire » essentiellement bruxellois, dans les entités fédérées. Quel rôle a-t-il joué, seul ou en partenariat avec le RW puis les libéraux, à la Communauté française ? Comment s’est articulé son combat pour une région bruxelloise et dans quelle mesure y a-t-il appliqué son programme depuis 1989 ? Quelle est l’action de son seul député au Parlement flamand ? Le FDF a-t-il réussi à dépasser son image de parti protestataire, focalisé sur les thématiques linguistiques, pour se positionner en mouvement « urbain et culturel », se définissant comme « réformateur social » ? Nous nous appuyons sur les archives du parti, ses publications internes, les sources officielles émanant des régions et communautés mais également la presse quotidienne et magazine. [less ▲]

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See detailFDG PET/CT for diagnostic arterial prosthetic graft infection : preliminary report.
NAMUR, Gauthier ULiege; VAN DAMME, Hendrik ULiege; BECKERS, Catherine ULiege et al

in PROCEEDINGS OF XIIIth SYMPOSIUM OF THE BELGIAN SOCIETY OF NUCLEAR MEDICINE (2007, May)

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See detailFDG PET/CT for rectal carcinoma radiotherapy treatment planning : Comparison of functional volume delineation algorithms and clinical challenges.
WITHOFS, Nadia ULiege; BERNARD, Claire ULiege; VAN DER REST, Catherine ULiege et al

in Journal of Applied Clinical Medical Physics (2014), 15(5), 216-228

PET/CT imaging could improve delineation of rectal carcinoma gross tumor volume (GTV) and reduce interobserver variability. The objective of this work was to compare various functional volume delineation ... [more ▼]

PET/CT imaging could improve delineation of rectal carcinoma gross tumor volume (GTV) and reduce interobserver variability. The objective of this work was to compare various functional volume delineation algorythms. [less ▲]

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See detailFDG PET/CT in Crohn's disease : correlation of quantitative FDG PET/CT parameters with clinical and endoscopic surrogate markers of disease activity
SABOURY, BABAK; SALAVATI, ALI; BROTHERS, ALEX et al

in European Journal of Nuclear Medicine and Molecular Imaging (2014), 41

PURPOSE: The aim of this study was to determine the feasibility and potential clinical utility of assessment of Crohn's disease (CD) activity by 18F-fluorodeoxyglucose (FDG) positron emission tomography ... [more ▼]

PURPOSE: The aim of this study was to determine the feasibility and potential clinical utility of assessment of Crohn's disease (CD) activity by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT employing a new quantitative approach. METHODS: A total of 22 subjects (mean age 37) with CD who had undergone FDG PET/CT followed by ileocolonoscopy within 1 week were included in this analysis. The CD endoscopy index of severity (CDEIS) for various bowel segments was calculated. The CD activity index (CDAI) was evaluated, and fecal calprotectin was measured. On PET, regions with increased FDG uptake in large bowel were segmented with an adaptive contrast-oriented thresholding algorithm, and metabolically active volume (MAV), uncorrected mean standardized uptake value (SUVmean), partial volume-corrected SUVmean (PVC-SUVmean), SUVmax, uncorrected total lesion glycolysis (TLG = MAV x SUVmean), and PVC total lesion glycolysis (PVC-TLG = MAV x PVC-SUVmean) were measured. Global CD activity score (GCDAS) was calculated as the sum of PVC-TLG over all clinically significant FDG-avid regions in each subject. Correlations between regional PET quantification measures (SUVs, TLGs) and CDEIS were calculated. Correlations between the global PET quantification measure (GCDAS, global SUVs) with CDAI, fecal calprotectin, CDEIS, and CRP level were also calculated. RESULTS: SUVmax, PVC-SUVmean, and PVC-TLG significantly correlated with segment CDEIS subscores (r = 0.50, r = 0.69, and r = 0.31, respectively; p < 0.05). GCDAS significantly correlated with CDAI and fecal calprotectin (r = 0.64 and r = 0.51, respectively; p < 0.05). CONCLUSION: By employing this new quantitative approach, we were able to calculate indices of regional and global CD activity, which correlated well with both clinical and pathological disease activity surrogate markers. This approach may be of clinical importance in measuring both global disease activity and treatment response in patients with CD. [less ▲]

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See detailFDG PET/CT radiomics for predicting the outcome of locally advanced rectal cancer.
LOVINFOSSE, Pierre ULiege; POLUS, Marc ULiege; VAN DAELE, Daniel ULiege et al

in European Journal of Nuclear Medicine and Molecular Imaging (2017)

PURPOSE: The aim of this study was to investigate the prognostic value of baseline 18F-FDG PET/CT textural analysis in locally-advanced rectal cancer (LARC). METHODS: Eighty-six patients with LARC ... [more ▼]

PURPOSE: The aim of this study was to investigate the prognostic value of baseline 18F-FDG PET/CT textural analysis in locally-advanced rectal cancer (LARC). METHODS: Eighty-six patients with LARC underwent 18F-FDG PET/CT before treatment. Maximum and mean standard uptake values (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), histogram-intensity features, as well as 11 local and regional textural features, were evaluated. The relationships of clinical, pathological and PET-derived metabolic parameters with disease-specific survival (DSS), disease-free survival (DFS) and overall survival (OS) were assessed by Cox regression analysis. Logistic regression was used to predict the pathological response by the Dworak tumor regression grade (TRG) in the 66 patients treated with neoadjuvant chemoradiotherapy (nCRT). RESULTS: The median follow-up of patients was 41 months. Seventeen patients (19.7%) had recurrent disease and 18 (20.9 %) died, either due to cancer progression (n = 10) or from another cause while in complete remission (n = 8). DSS was 95% at 1 year, 93% at 2 years and 87% at 4 years. Weight loss, surgery and the texture parameter coarseness were significantly associated with DSS in multivariate analyses. DFS was 94 % at 1 year, 86 % at 2 years and 79 % at 4 years. From a multivariate standpoint, tumoral differentiation and the texture parameters homogeneity and coarseness were significantly associated with DFS. OS was 93% at 1 year, 87% at 2 years and 79% after 4 years. cT, surgery, SUVmean, dissimilarity and contrast from the neighborhood intensity-difference matrix (contrastNGTDM) were significantly and independently associated with OS. Finally, RAS-mutational status (KRAS and NRAS mutations) and TLG were significant predictors of pathological response to nCRT (TRG 3-4). CONCLUSION: Textural analysis of baseline 18F-FDG PET/CT provides strong independent predictors of survival in patients with LARC, with better predictive power than intensity- and volume-based parameters. The utility of such features, especially coarseness, should be confirmed by larger clinical studies before considering their potential integration into decisional algorithms aimed at personalized medicine. [less ▲]

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See detailFDG PET/CT texture analysis for predicting the outcome of lung cancer treated by stereotactic body radiation therapy.
LOVINFOSSE, Pierre ULiege; Janvary, Zsolt Levente; COUCKE, Philippe ULiege et al

in European journal of nuclear medicine and molecular imaging (2016)

INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume ... [more ▼]

INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume or heterogeneity could predict the outcome in patients with non-small cell lung cancers (NSCLC) treated by stereotactic body radiation therapy (SBRT). METHODS: Sixty-three patients with NSCLC treated by SBRT underwent a 18F-FDG PET/CT before treatment. Maximum and mean standard uptake value (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), as well as 13 global, local and regional textural features were analysed. The predictive value of these parameters, along with clinical features, was assessed using univariate and multivariate analysis for overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS). Cutoff values were obtained using logistic regression analysis, and survivals were compared using Kaplan-Meier analysis. RESULTS: The median follow-up period was 27.1 months for the entire cohort and 32.1 months for the surviving patients. At the end of the study, 25 patients had local and/or distant recurrence including 12 who died because of the cancer progression. None of the clinical variables was predictive of the outcome, except age, which was associated with DFS (HR 1.1, P = 0.002). None of the 18F-FDG PET/CT or clinical parameters, except gender, were associated with OS. The univariate analysis showed that only dissimilarity (D) was associated with DSS (HR = 0.822, P = 0.037), and that several metabolic measurements were associated with DFS. In multivariate analysis, only dissimilarity was significantly associated with DSS (HR = 0.822, P = 0.037) and with DFS (HR = 0.834, P < 0.01). CONCLUSION: The textural feature dissimilarity measured on the baseline 18F-FDG PET/CT appears to be a strong independent predictor of the outcome in patients with NSCLC treated by SBRT. This may help selecting patients who may benefit from closer monitoring and therapeutic optimization. [less ▲]

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See detailFDG-PET and lung cancer: evaluation of solitary pulmonary nodule and mediastinal staging.
PAULUS, P.; HUSTINX, Roland ULiege; BURY, Thierry ULiege et al

in Proceedings of the VIIth International PET Conference, Institute for Clinical PET (1996)

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See detailFDG-PET for the routine follow-up in NHL: First prospective evaluation
Jerusalem, Guy ULiege; Silvestre, R.; Beguin, Yves ULiege et al

in Journal of Clinical Oncology (2006, June 20), 24(18, Part 1 Suppl. S), 439

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See detailFDG-PET imaging for assessing pleural malignancy : a semi-quantitative analysis.
LAROCK, Marie-Paule ULiege; DUYSINX, Bernard ULiege; NGUYEN, D. et al

in Journal of Nuclear Medicine (The) (2005), 46(SUPPL), 426

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See detailFDG-PET imaging for diagnosing bone infection.
LETESSON, G.; FOIDART-WILLEMS, Jacqueline ULiege; HUSTINX, Roland ULiege

in Journal of Nuclear Medicine (The) (2005), 46(SUPPL), 323

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See detailFDG-PET imaging for monitoring rheumatoid arthritis treated by infliximab injections.
BECKERS, Catherine ULiege; RIBBENS, Clio ULiege; ANDRE, Béatrice ULiege et al

in Journal of Nuclear Medicine (The) (2002), 43

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See detailFe and Mg Isotope Fractionation in Olivine from the NWA 1068 Shergottite
Collinet, Max ULiege; Charlier, Bernard ULiege; Namur, Olivier et al

Conference (2014, June 09)

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See detailFE modeling of the cooling and tempering steps of bimetallic rolling mill rolls
Neira Torres, Ingrid; Gilles, Gaëtan ULiege; Tchuindjang, Jérôme Tchoufack ULiege et al

in International Journal of Material Forming (2017), Volume 10,(Issue 3), 287305

Numerical simulations enable the analysis of the stress and strain histories of bimetallic rolling mill rolls. The history of rolling mill rolls is simulated by thermo-mechanical metallurgical finite ... [more ▼]

Numerical simulations enable the analysis of the stress and strain histories of bimetallic rolling mill rolls. The history of rolling mill rolls is simulated by thermo-mechanical metallurgical finite element code while considering two steps: post-casting cooling and subsequent tempering heat treatment. The model requires a notably large set of material parameters. For different phases and temperatures, Young modulus, yield limit and tangent plastic modulus are determined through compression tests. Rupture stresses and strains are obtained by tensile tests. Thermo-physical parameters are measured by such experimental methods as dilatometry, DSC (Differential Scanning Calorimetry) and Laser Flash methods. Such parameters as the transformation plasticity coefiicients for the ferrite, pearlite and martensite phases are identified through an inverse method. From the simulation results, the profile of the stresses evolution at different critical times is presented. An analysis of the potential damage is proposed by comparing the predicted axial stress \vith rupture stresses. The perspective of the Ghosh and McClintock damage criteria is also investigated. [less ▲]

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See detailFE modelling of anorthosite diapirism: the Egersund-Ogna massif, South Norway
Hoffer, B.; Barnichon, J.-D.; Charlier, Robert ULiege et al

in Proc. of the Int. Meeting on Deformation Mechanisms in nature and experiments (1997, March)

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See detailFe XXV line profiles in colliding wind binaries
Rauw, Grégor ULiege; Mossoux, Enmanuelle; Nazé, Yaël ULiege

in New Astronomy (2016), 43

Strong wind-wind collisions in massive binaries generate a very hot plasma that frequently produces a moderately strong iron line. The morphology of this line depends upon the properties of the wind ... [more ▼]

Strong wind-wind collisions in massive binaries generate a very hot plasma that frequently produces a moderately strong iron line. The morphology of this line depends upon the properties of the wind interaction zone and its orientation with respect to the line of sight. As the binary components revolve around their common centre of mass, the line profiles are thus expected to vary. With the advent of the next generation of X-ray observatories (Astro-H, Athena) that will offer high-resolution spectroscopy above 6 keV, it will become possible to exploit these changes as the most sensitive probe of the inner parts of the colliding wind interaction. Using a simple prescription of the wind-wind interaction in an early-type binary, we have generated synthetic line profiles for a number of configurations and orbital phases. These profiles can help constrain the properties of the stellar winds in such binary systems. [less ▲]

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