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See detailIntermediate report on the development of the Geer hydrological model (surface and subsurface water) for climatic change scenario on that sub-catchment
Goderniaux, Pascal ULg; Orban, Philippe ULg; Dassargues, Alain ULg et al

Report (2007)

In the framework of Workpackage BASIN R3 Meuse, the Hydrology Group of the University of Liège (Belgium) is developing a hydrological model of the Geer sub-catchment, in order to assess climate change ... [more ▼]

In the framework of Workpackage BASIN R3 Meuse, the Hydrology Group of the University of Liège (Belgium) is developing a hydrological model of the Geer sub-catchment, in order to assess climate change impacts on groundwater reserves. This report describes the calculation code used, the general hypotheses chosen to develop the model, the conceptual model, the climate change scenarios and the final objectives of the study. [less ▲]

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See detailLes intermittences du corps filmique: Pathologies et blessures de l’image dans la pratique contemporaine du found footage
Thonon, Jonathan ULg

in André, Emmanuelle; Lioult, Jean-Luc (Eds.) Penser la création audiovisuelle (2008)

Depuis un demi-siècle et de manière exponentielle ces vingt dernières années, le champ de l’art contemporain et celui du cinéma n’ont cessé d’engendrer des processus mutuels d’hybridation, par ... [more ▼]

Depuis un demi-siècle et de manière exponentielle ces vingt dernières années, le champ de l’art contemporain et celui du cinéma n’ont cessé d’engendrer des processus mutuels d’hybridation, par contamination(s), échange(s) et transfert(s), rendant à la fois tangible et poreuse la frontière qui semblait s’être définitivement érigée entre l’art de masse et l’art d’élite. Il est une pratique assez symptomatique de cette interrogation muséale qui naît de l’exposition de cinéma. Pratique historiquement ancrée dans cet espace plastique charnière que constitue le cinéma expérimental, le cinéma de found footage nous offre le terrain idéal qui nous permet, à la fois, de penser l’histoire (du cinéma et des formes cinématographiques) au moyen de films qui en constituent, en quelque sorte, la pensée en acte, mais aussi, au regard de l’histoire même de cette pratique et de son évolution et à partir d’objets contemporains qui en réactualisent la forme et le discours, de repenser le rapport « cinéma – art contemporain » à la lueur de formes filmiques renouvelées. [less ▲]

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See detail"Les intermittences du visible. Reprises de vue dans le cinéma expérimental américain"
Belloi, Livio ULg

in Recherches Anglaises et Nord-Américaines [= RANAM] (2012), 45

After a brief historical and theoretical survey of the found footage film tradition, this text discusses the issue of reprise in the field of contemporary experimental cinema, focusing on two films by ... [more ▼]

After a brief historical and theoretical survey of the found footage film tradition, this text discusses the issue of reprise in the field of contemporary experimental cinema, focusing on two films by American filmmaker Bill Morrison. In "The Death Train" (1993), Morrison takes up again three series of distinct images in a gesture that tends to foreground the mechanical dimensions of the cinematic spectacle. In "Decasia" (2002), the filmmaker capitalizes on fragments of decaying nitrate film, thus exploring film as materiality. However different they may seem, both works seem to address the same visual theme, that of visible intermittencies, in so far as they can be considered as an act of definition of a modernity ingrained in the very mechanics of the gaze. [less ▲]

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See detail"Les intermittences du visible. Reprises de vue dans le cinéma expérimental américain"
Belloi, Livio ULg

Scientific conference (2010, October 18)

Approche historique et théorique du procédé de la reprise de vue dans le cinéma expérimental américain, abordé à l'aune d'un schème structurant et particulièrement récursif : celui des intermittences du ... [more ▼]

Approche historique et théorique du procédé de la reprise de vue dans le cinéma expérimental américain, abordé à l'aune d'un schème structurant et particulièrement récursif : celui des intermittences du visible. [less ▲]

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See detailIntermittent bisphosphonate therapy in postmenopausal osteoporosis - Progress to date
Reginster, Jean-Yves ULg; Malaise, Olivier ULg; Neuprez, A. et al

in Drugs & Aging (2007), 24(5), 351-359

Bisphosphonates are the most widely prescribed drugs in osteoporosis today. They have unequivocally shown their ability to reduce fracture rate at the spine (alendronic acid, risedronic acid, ibandronic ... [more ▼]

Bisphosphonates are the most widely prescribed drugs in osteoporosis today. They have unequivocally shown their ability to reduce fracture rate at the spine (alendronic acid, risedronic acid, ibandronic acid) and at the hip (alendronic acid and risedronic acid). However, their dosage and administration procedures and the adverse reactions induced by their oral intake are responsible for low adherence. Therefore, intermittent regimens have been developed. Weekly alendronic acid and risedronic acid provide similar benefits, in terms of bone mineral density (BMD) and changes in biochemical markers, as those seen with their daily formulations. Ibandronic acid has been shown to reduce vertebral fractures when given intermittently. Ibandronic acid given orally monthly and intravenously every 2 or 3 months provides increases in BMD similar to the daily formulation. Yearly intravenous infusions of zoledronic acid are currently being evaluated for their ability to reduce fractures. If the efficacy and safety of bisphosphonates given at administration intervals longer than weekly are confirmed, this might significantly improve patient adherence and long-term outcomes of bisphosphonate treatment in postmenopausal osteoporosis. [less ▲]

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See detailIntermittent Cyclic Tiludronate in the Treatment of Osteoporosis
Reginster, Jean-Yves ULg; Christiansen, C.; Roux, C. et al

in Osteoporosis International (2001), 12(3), 169-77

The objective of the study was to determine the efficacy and safety of tiludronate in the treatment of postmenopausal osteoporosis. Two placebo-controlled, randomized, double-masked, multicenter, cyclical ... [more ▼]

The objective of the study was to determine the efficacy and safety of tiludronate in the treatment of postmenopausal osteoporosis. Two placebo-controlled, randomized, double-masked, multicenter, cyclical, intermittent, dose-ranging studies including 1805 women with low vertebral bone mineral density and prevalent vertebral fractures and 488 women with low bone mineral density and no prevalent fracture were conducted. Patients were randomized to either tiludronate 50 mg/day, tiludronate 200 mg/day or placebo, given orally for the first 7 days of each month. A supplement of 500 mg elemental calcium was provided daily from day 8 to the end of the month. Both studies demonstrated no statistically or clinically relevant trends in the incidence of adverse effects across the three treatment groups. However, tiludronate administered at these two doses in a cyclic intermittent regimen was not effective in reducing the incidence of vertebral fractures or increasing spinal bone mineral density. Thus, tiludronate, administered at these doses in a cyclic intermittent regimen, cannot be considered an appropriate treatment of postmenopausal osteoporosis, notwithstanding a high safety profile. [less ▲]

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See detailIntermittent intravenous (i.v.) ibandronate injections are more effective than an established daily oral regimen: DIVA 2-year results
Czerwinski, E.; Reginster, Jean-Yves ULg; Jonkanski, I. et al

in Osteoporosis International (2007, March), 18(Suppl.1), 127

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See detailIntermittent intravenous ibandronate injections and daily oral ibandronate provide at least equivalent increases in bone mineral density: 1-year results from DIVA
Delmas, P. D.; Sambrook, P.; Recker, R. et al

in Osteoporosis International (2005, March), 16(Suppl.3), 7

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See detailIntermittent madantory ventilation (IMV)
Lamy, Maurice ULg

in Lawin, Peter; Klaus, Peter; Scherer, Ralf (Eds.) Maschinelle beatmung gestern-heute-morgen (1984)

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See detailIntermittent peripheral weakness as the presenting feature of pyruvate dehydrogenase deficiency.
DEBRAY, François-Guillaume ULg; Lambert, Marie; Vanasse, Michel et al

in European journal of pediatrics (2006), 165(7), 462-466

Two unrelated children presenting with episodic isolated peripheral weakness were found to have pyruvate dehydrogenase (PDH) deficiency (OMIM 312170) due to previously undescribed mutations (Pro250Thr ... [more ▼]

Two unrelated children presenting with episodic isolated peripheral weakness were found to have pyruvate dehydrogenase (PDH) deficiency (OMIM 312170) due to previously undescribed mutations (Pro250Thr, Arg88Cys) in the gene for the E1alpha subunit (PDHA1). Taken in context with the literature, these patients suggest that acute weakness initially resembling Guillain-Barre syndrome is a potentially reversible and probably underdiagnosed manifestation of PDH deficiency and that peripheral nerve function should be evaluated in PDH-deficient patients. [less ▲]

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See detailIntermittent positive pressure ventilation with either positive end-expiratory pressure or high frequency jet ventilation (HFJV), or HFJV alone in human acute respiratory failure.
Brichant, Jean-François ULg; Rouby, J. J.; Viars, P.

in Anesthesia and Analgesia (1986), 65(11), 1135-42

Continuous Positive Pressure Ventilation (CPPV), High-Frequency Jet Ventilation (HFJV), and a combination of HFJV with Intermittent Positive Pressure Ventilation (CV) were randomly compared in 13 ... [more ▼]

Continuous Positive Pressure Ventilation (CPPV), High-Frequency Jet Ventilation (HFJV), and a combination of HFJV with Intermittent Positive Pressure Ventilation (CV) were randomly compared in 13 critically ill patients with severe acute respiratory failure. Ventilatory settings were chosen in order to apply the same mean airway pressure (Paw) during the three modes. Respiratory frequencies were adjusted during CPPV (16 +/- 2 breaths/min) and HFJV (235 +/- 32 breaths/min) to achieve the same level of PaCO2 and were then combined during CV. All patients were heavily sedated during the study and had had peripheral and balloon-tipped pulmonary arterial catheters previously inserted. After a steady state at FIO2 1 in each mode of ventilation, hemodynamic and respiratory parameters were measured. A Paw of 13.8 +/- 2.9 mm Hg was applied to each patient by using a PEEP of 7.4 mm Hg during CPPV; a driving pressure of 2.9 +/- 0.2 bars and an I/E ratio of 0.43 during HFJV; and by combining HFJV, using a driving pressure of 1.2 +/- 0.3 bars with intermittent positive pressure ventilation during CV. There were no significant differences in any of the hemodynamic or respiratory parameters measured, except for a significant decrease in PaCO2 during CV when compared to CPPV or HFJV. We concluded that 1) arterial oxygenation and cardiac output depend mainly on Paw independent of the method used to increase Paw and 2) CV can improve CO2 elimination without increasing Paw.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailIntermittent thermal manipulations of broiler embryos during late incubation and their immediate and long-lasting effects
Willemsen, Hilke; Li, Yue; Witters, Anouck et al

Conference (2010)

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See detailIntermittent thermal manipulations of broiler embryos during late incubation and their immediate effect on the embryonic development and hatching process.
Willemsen, H.; Li, Yongzhen ULg; Willems, E. et al

in Poultry science (2011), 90(6), 1302-12

Intermittent high (+3 degrees C) and low (-3 degrees C) temperature treatments for 4 h on embryonic day (E) 16, E17, and E18 showed differential effects on embryonic metabolism, without influencing ... [more ▼]

Intermittent high (+3 degrees C) and low (-3 degrees C) temperature treatments for 4 h on embryonic day (E) 16, E17, and E18 showed differential effects on embryonic metabolism, without influencing embryonic growth or hatchability. Embryos in the high-temperature group shifted to a more anaerobic metabolism, as indicated by a lower partial pressure of O(2) and a higher partial pressure of CO(2) in the air cell, lower blood pH, and higher lactic acid production. Three hours after the end of the high-temperature treatment, a decrease in metabolism was observed, as indicated by the lower partial pressure of CO(2) and higher partial pressure of O(2) in the air cell and increased plasma triglyceride levels. The embryos in the low-temperature group responded by temporarily slowing down their metabolism, especially the metabolism of carbohydrates and lipids, as indicated by altered air cell gases, a higher relative yolk weight, higher plasma triglyceride level, and higher liver glycogen level. Three hours after the end of the temperature treatment, the metabolism of embryos in the low-temperature treatment had increased to the level of the control temperature group. However, for both temperature treatments, during the hatching process, all the shortages and excesses created were restored to control levels, which would explain the lack of change in embryo growth and hatchability and the slight delay in the hatching process. These mild consequences of the intermittent temperature treatment indicate that the different metabolic shifts made by the embryos seem to be efficient in overcoming the challenges of the intermittent high- or low-temperature treatment during late incubation. [less ▲]

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See detailIntermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo
Uebelhart, D.; Malaise, Michel ULg; Marcolongo, R. et al

in Osteoarthritis and Cartilage (2004), 12(4), 269-276

Objective: To investigate the efficacy and tolerability of a 3-month duration, twice a-year, intermittent treatment with oral chondroitin sulfate (CS) in knee osteoarthritis (OA) patients. Design: A total ... [more ▼]

Objective: To investigate the efficacy and tolerability of a 3-month duration, twice a-year, intermittent treatment with oral chondroitin sulfate (CS) in knee osteoarthritis (OA) patients. Design: A total of 120 patients with symptomatic knee OA were randomized into two groups receiving either 800 mg CS or placebo (PBO) per day for two periods of 3 months during 1 year. Primary efficacy outcome was Lequesne's algo-functional index (AFI); secondary outcome parameters included VAS, walking time, global judgment, and paracetamol consumption. Radiological progression was assessed by automatic measurement of medial femoro-tibial joint space width on weight-bearing X-rays of both knees. Clinical and biological tolerability was assessed. Results: One hundred and ten of 120 patients were included in the ITT analysis. AFI decreased significantly by 36% in the CS group after 1 year as compared to 23% in the PBO group. Similar results were found for the secondary outcomes parameters. Radiological progression at month 12 showed significantly decreased joint space width in the PBO group with no change in the CS group. Tolerability was good with only minor adverse events identically observed in both groups. Conclusion: This study provides evidences that oral CS decreased pain and improved knee function. The 3-month intermittent administration of 800 mg/day of oral CS twice a year does support the prolonged effect known with symptom-modifying agents for OA. The inhibitory effect of CS on the radiological progression of the medial femoro-tibial joint space narrowing could suggest further evidence of its structure-modifying properties in knee OA. (C) 2004 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved. [less ▲]

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See detailIntermittent versus continuous renal replacement therapy for acute kidney injury patients admitted to the intensive care unit: results of a randomized clinical trial.
Lins, Robert L; Elseviers, Monique M; Van der Niepen, Patricia et al

in Nephrology Dialysis Transplantation (2009), 24(2), 512-8

BACKGROUND: There is uncertainty on the effect of different dialysis modalities for the treatment of patients with acute kidney injury (AKI), admitted to the intensive care unit (ICU). This controlled ... [more ▼]

BACKGROUND: There is uncertainty on the effect of different dialysis modalities for the treatment of patients with acute kidney injury (AKI), admitted to the intensive care unit (ICU). This controlled clinical trial performed in the framework of the multicentre SHARF 4 study (Stuivenberg Hospital Acute Renal Failure) aimed to investigate the outcome in patients with AKI, stratified according to severity of disease and randomized to different treatment options. METHODS: This was a multicentre prospective randomized controlled trial with stratification according to severity of disease expressed by the SHARF score. ICU patients were eligible for inclusion when serum creatinine was >2 mg/dL, and RRT was initiated. The selected patients were randomized to intermittent (IRRT) or continuous renal replacement therapy (CRRT). RESULTS: A total of 316 AKI patients were randomly assigned to IRRT (n = 144) or CRRT (n = 172). The mean age was 66 (range 18-96); 59% were male. Intention-to-treat analysis revealed a mortality of 62.5% in IRRT compared to 58.1% in CRRT (P = 0.430). No difference between IRRT and CRRT could be observed in the duration of ICU stay or hospital stay. In survivors, renal recovery at hospital discharge was comparable between both groups. Multivariate analysis, including the SHARF score, APACHE II and SOFA scores for correction of disease severity, showed no difference in mortality between both treatment modalities. This result was confirmed in pre-specified subgroup analysis (elderly, patients with sepsis, heart failure, ventilation) and after exclusion of possible confounders (early mortality, delayed ICU admission). CONCLUSIONS: Modality of RRT, either CRRT or IRRT, had no impact on the outcome in ICU patients with AKI. Both modalities need to be considered as complementary in the treatment of AKI (Clinical Trial: SHARF 4, NCT00322933, http://ClinicalTrials.gov). [less ▲]

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See detailIntermittent Versus Continuous Total Androgen Blockade in the Treatment of Patients with Advanced Hormone-Naive Prostate Cancer: Results of a Prospective Randomized Multicenter Trial
De Leval, Jean ULg; Boca, Philippe; Yousef, Enis et al

in Clinical Prostate Cancer (2002), 1(3), 163-71

The aim of this study was to compare the efficacy of total intermittent androgen deprivation (IAD) versus total continuous androgen deprivation (CAD) for treating patients with advanced prostate cancer in ... [more ▼]

The aim of this study was to compare the efficacy of total intermittent androgen deprivation (IAD) versus total continuous androgen deprivation (CAD) for treating patients with advanced prostate cancer in a phase III randomized trial. A total of 68 evaluable patients with hormone-naive advanced or relapsing prostate cancer were randomized to receive combined androgen blockade according to a continuous (n = 33) or intermittent (n = 35) regimen. Therapeutic monitoring was assessed by use of serum prostate-specific antigen (PSA) measurements. Patients in the CAD and IAD groups were equally stratified for age, biopsy Gleason score, and baseline serum PSA levels. The outcome variable was time to androgen-independence of the tumor, which was defined as increasing serum PSA levels despite androgen blockade. Mean follow-up was 30.8 months. The 35 IAD-treated patients completed 91 cycles, and 19 of them (54.3%) completed > or = 3 cycles. Median cycle length and percentage of time off therapy were 9.0 months and 59.5, respectively. The estimated 3-year progression rate was significantly lower in the IAD group (7.0% +/- 4.8%) than in the CAD group (38.9% +/- 11.2%, P = 0.0052). Our data suggest that IAD treatment may maintain the androgen-dependent state of advanced human prostate cancer, as assessed by PSA measurements, at least as long as CAD treatment. Further studies with longer follow-up times and larger patient cohorts are needed to determine the comparative impacts of CAD and IAD on survival. [less ▲]

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See detailIntermodal network design for freight transportation in Belgium - location of rail/road and road/inland waterway terminals
Mostert, Martine ULg; Limbourg, Sabine ULg

Conference (2013, February 07)

In the recent years, growing concerns about environmental, societal and economic issues have emerged in the society. The improvement and the expansion of the multimodal network is one way of solving those ... [more ▼]

In the recent years, growing concerns about environmental, societal and economic issues have emerged in the society. The improvement and the expansion of the multimodal network is one way of solving those kinds of problems. The objective of this work is therefore the integration of inland waterway, rail and road transport into the linear modeling of intermodal terminal location problems, based on transportation costs functions which are nonlinear with the distance traveled. The model should also take into account the capacity constraints linked to the different modes of transport. [less ▲]

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