Is evidence-based medicine so evident in veterinary research and practice? History, obstacles and perspectives.
Vandeweerd, Jean-Michel ; ; et al
in Veterinary Journal (2012), 191(1), 28-34
Evidence-based medicine (EBM) refers to the conscientious, explicit and judicious use of current best evidence from research for the care of an individual patient. The concept of EBM was first described ... [more ▼]
Evidence-based medicine (EBM) refers to the conscientious, explicit and judicious use of current best evidence from research for the care of an individual patient. The concept of EBM was first described in human medicine in the early 1990s and was introduced to veterinary medicine 10 years later. However, it is not clear that the EBM approach promulgated in human medicine can be applied to the same extent to veterinary medicine. EBM has the potential to help veterinarians to make more informed decisions, but obstacles to the implementation of EBM include a lack of high quality patient-centred research, the need for basic understanding of clinical epidemiology by veterinarians, the absence of adequate searching techniques and accessibility to scientific data bases and the inadequacy of EBM tools that can be applied to the busy daily practise of veterinarians. This review describes the development of EBM in the veterinary profession, identifies its advantages and disadvantages and discusses whether and how veterinary surgeons should further adopt the EBM approach of human medicine. [less ▲]Detailed reference viewed: 50 (11 ULg)
Is extended or continuous infusion of Carbapenems the obvious solution to improve clinical outcomes and reduce mortality?
FRIPPIAT, Frédéric ; VERCHEVAL, Christelle ; LAMBERMONT, Bernard et al
in Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America (2013), 57(2), 324-325Detailed reference viewed: 20 (8 ULg)
Is FDG bowel uptake modified by oral spasmolytic premedication ?
; DAENEN, Frédéric ; et al
in Journal of Nuclear Medicine (The) (2002), 43Detailed reference viewed: 8 (0 ULg)
Is FDG-PET/CT an early indicator of the clinical response to rituximab in rheumatoid arthritis ?
NAMUR, Gauthier ; KAISER, Marie-Joëlle ; et al
in Journal of Nuclear Medicine (The) (2008), 49(SUPPL), 10Detailed reference viewed: 7 (0 ULg)
Is FE(NO50) useful diagnostic tool in suspected asthma?
SCHLEICH, FLorence ; ASANDEI, Raluca ; Manise, Maïté et al
in International Journal of Clinical Practice (2012), 66(2), 158-65
Background: Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of ... [more ▼]
Background: Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of 50 ml/s (FE(NO50) ) remains a controversial diagnostic tool. Aim: To assess the ability of FE(NO50) to identify bronchial hyperresponsiveness (BHR) to methacholine (provocative concentration of methacholine causing a 20% fall in FEV(1) ; PC20M </= 16 mg/ml) and to establish whether or not symptoms relate to FE(NO50) and PC20M in patients with no demonstrated reversibility to beta(2) -agonist. Methods: We conducted a prospective study on 174 steroid naive patients with respiratory symptoms, forced expiratory volume in 1 s (FEV(1) ) >/= 70% predicted and no demonstrated reversibility to beta(2) -agonist. Patients answered to a standardised symptom questionnaire and underwent FE(NO50) and methacholine challenge. Receiver-operating characteristic (ROC) curve and logistic regression analysis assessed the relationship between PC20M and FE(NO50) , taking into account covariates (smoking, atopy, age, gender and FEV(1) ). Results: A total of 82 patients had a PC20M </= 16 mg/ml and had significantly higher FE(NO50) (19 ppb vs. 15 ppb; p < 0.05). By constructing ROC curve, we found that FE(NO50) cut-off value of 34 ppb was able to identify not only BHR with high specificity (95%) and positive predictive value (88%) but low sensitivity (35%) and negative predictive value (62%). When combining all variables into the logistic model, FE(NO50) (p = 0.0011) and FEV(1) (p < 0.0001) were independent predictors of BHR whereas age, gender, smoking and atopy had no influence. The presence of diurnal and nocturnal wheezing was associated with raised FE(NO50) (p < 0.001 and p < 0.05, respectively). Conclusion: The value of FE(NO50) > 34 ppb has high predictive value of PC20M < 16 in patients with suspected asthma in whom bronchodilating test failed to demonstrate reversibility or was not indicated. However, FE(NO50) </= 34 ppb does not rule out BHR and should prompt the clinician to ask for a methacholine challenge. [less ▲]Detailed reference viewed: 38 (11 ULg)
Is Fractal Geometry Useful in Medicine and Biomedical Sciences?
; Fissette, Jean ; et al
in Medical Hypotheses (2000), 54(3), 360-6
Fractal geometry has become very useful in the understanding of many phenomena in various fields such as astrophysics, economy or agriculture and recently in medicine. After a brief intuitive introduction ... [more ▼]
Fractal geometry has become very useful in the understanding of many phenomena in various fields such as astrophysics, economy or agriculture and recently in medicine. After a brief intuitive introduction to the basis of fractal geometry, the clue is made about the correlation between Df and the complexity or the irregularity of a structure. However, fractal analysis must be applied with certain caution in natural objects such as bio-medical ones. The cardio-vascular system remains one of the most important fields of application of these kinds of approach. Spectral analysis of the R-R interval, morphology of the distal coronary arteries constitute two examples. Other very interesting applications are founded in bacteriology, medical imaging or ophthalmology. In our institution, we apply fractal analysis in order to quantitate angiogenesis and other vascular processes. [less ▲]Detailed reference viewed: 12 (0 ULg)
Is global left ventricular afterload has an impact on left atrial function in patients with aortic stenosis?
; Magne, Julien ; MOONEN, Marie et al
Conference (2010)Detailed reference viewed: 2 (0 ULg)
Is group climate a protective factor of substance use for Canadian girls with problem behaviors?
Mathys, Cécile ;
Conference (2012)Detailed reference viewed: 13 (2 ULg)
Is HD 163899 really a supergiant star?
Godart, Mélanie ; Dupret, Marc-Antoine ; Noels-Grötsch, Arlette
in Communications in Asteroseismology (2008), 157
According to its spectral type B2 Ib/I I (Klare & Neckel 1977; Schmidt & Carruthers 1996), HD163899 is a supergiant star. The star presents p and g-mode pulsations (Saio et al. 2006). In such a post-main ... [more ▼]
According to its spectral type B2 Ib/I I (Klare & Neckel 1977; Schmidt & Carruthers 1996), HD163899 is a supergiant star. The star presents p and g-mode pulsations (Saio et al. 2006). In such a post-main sequence (post MS) star, the helium core is radiative with a very large Brunt-Väisälä frequency which produces a strong damping. The presence of excited g-modes is however possible thanks to an intermediate convective zone (ICZ) which prevents some g-modes from entering the radiative damping core (Saio et al. 2006). We have investigated an alternative solution. We show that MS evolutionary tracks could cross the error box of HD 163899 if a sufficiently large amount of overshooting is taken into account. However, in that case, the spectrum of unstable modes is different from the spectrum of a supergiant star since the Brunt-Väisälä frequency is much smaller. [less ▲]Detailed reference viewed: 5 (0 ULg)
Is HIF-1alpha a pro- or an anti-apoptotic protein?
; Mottet, Denis ; et al
in Biochemical Pharmacology (2002), 64(5-6), 889-92
Hypoxia-inducible factor-1 (HIF-1) is the major transcription factor specifically activated by hypoxia. It induces the expression of different genes whose products play an adaptive role for hypoxic cells ... [more ▼]
Hypoxia-inducible factor-1 (HIF-1) is the major transcription factor specifically activated by hypoxia. It induces the expression of different genes whose products play an adaptive role for hypoxic cells and tissues. Besides these protective responses, HIF-1 and/or hypoxia have also been shown to be either anti-apoptotic or pro-apoptotic, according to the cell type and experimental conditions. More severe or prolonged hypoxia rather induces apoptosis that is, at least in part, initiated by the direct association of HIF-1alpha and p53 and p53-induced gene expression. On the other hand, HIF-1alpha dimerized with ARNT, as an active transcription factor, can protect cells from apoptosis induced by several conditions. This review is aimed to describe the different mechanisms that account for these opposite effects of HIF-1alpha. [less ▲]Detailed reference viewed: 19 (3 ULg)
Is hypoxia-inducible factor 1 an actor in migraine pathogenesis ? An experimental study of possible metabolic facets including hypoxia and mitochondrial impairment
Multon, Sylvie ; ; Schoenen, Jean
Poster (2008, September)Detailed reference viewed: 10 (0 ULg)
Is hypoxia-inducible factor 1 an actor in migraine pathogenesis?
TRUONG, Julie ; ; Schoenen, Jean et al
Poster (2009, May)Detailed reference viewed: 10 (0 ULg)
Is IL-6 capable to modify chondrocyte metabolism ?
Henrotin, Yves ; ; et al
in Clinical Rheumatology (1996), 15Detailed reference viewed: 3 (2 ULg)
Is isokinetic eccentric exercise dangerous for the heart?
LE GOFF, Caroline ; Kaux, Jean-François ; LAURENT, Terry et al
in Isokinetics & Exercise Science (2014), 22(2), 131-136
BACKGROUND: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order ... [more ▼]
BACKGROUND: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order to perform these very intensive exercises; otherwise an acute myocardial dysfunction could theoretically appear in predisposed patients. OBJECTIVE: Our study aimed to observe the cardiovascular impact of a maximal intense isokinetic eccentric exercise performed by a population of sedentary young men. METHODS: Resting and post-exercise (just after, 3 hours and 24 hours after the exercise) blood samples were taken from 12 young male sedentary healthy subjects. These subjects performed an intense maximal eccentric isokinetic exercise of the quadriceps muscle.We evaluated markers of cardiovascular risk (troponin I, highly sensitive troponin T, NT-proBNP,myoglobin), of inflammation (hsCRP) and of oxidative stress (myeloperoxydase, lipidic peroxides, reduced and oxidized glutathione). RESULTS: The following observations were made: no significant increase in cardiac (NT-proBNP, troponins) or inflammation (hsCRP) biomarkers; a significant increase in myoglobin, myeloperoxidase, lipidic peroxides, oxidised glutathione just after the exercise. CONCLUSIONS: No modification in cardiac biomarkers were observed after the maximal eccentric isokinetic exercise. We were thus able to prove that the exercise could be performed without any risk to cardiac function in young sedentary subjects. However, a significant level of oxidative stress was induced by this exercise. [less ▲]Detailed reference viewed: 13 (3 ULg)
Is it necessary to change the classification of ß-lactamases?
Frère, Jean-Marie ; Galleni, Moreno ; et al
in Journal of Antimicrobial Chemotherapy (2005), 55(6), 1051-1053Detailed reference viewed: 6 (0 ULg)
Is It Possible to Define a European Total Merit Index?
Vanderick, Sylvie ; Faux, Pierre ; Gengler, Nicolas
in Interbull Bulletin (2012), 44
Developing a common European bull list is an objective of the PROTEJE (PROduction Traits European Joint Evaluation) workgroup started in 2001 as an initiative of the European Holstein herdbooks. Six Total ... [more ▼]
Developing a common European bull list is an objective of the PROTEJE (PROduction Traits European Joint Evaluation) workgroup started in 2001 as an initiative of the European Holstein herdbooks. Six Total Merit Indexes were compared to define a common breeding goal across Europe. A principal component analysis was used to observe the direction of the largest common variation among the studied Total Merit Indexes. Results showed that the considered indexes had a lot in common. The first principal component explained 86% of the total variation. Based on previous researches establishing combined proofs on a European phantom scale for most traits and trait groups and using a multiple regression for this European Total Merit Index, relative emphases on production and functionality of 37% and on conformation of 26% could be established. [less ▲]Detailed reference viewed: 32 (10 ULg)