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See detailItracoanzole in human aspergillosis revisited.
Pierard, Gérald ULg; Kharfi, M.; Salomon-Neira, M. D. et al

in Journal de Mycologie Médicale (2004), 14

Itraconazole is a broad spectrum antifungal agent of the bis-triazole class. The drug is an important option in the management of many human mycoses including various clinical presentations of ... [more ▼]

Itraconazole is a broad spectrum antifungal agent of the bis-triazole class. The drug is an important option in the management of many human mycoses including various clinical presentations of aspergillosis. Indeed, the compound exhibits potent in vitro antifungal activity against Aspergillus spp. and shows variable fungicidal effect against the different species and strains. After amphotericin B, itraconazole has been the very first agent, and the first azole antifungal to have demonstrated clinical efficacy in aspergillosis. In vivo, the antifungal efficacy of itraconazole has been demonstrated in several types of aspergillosis both in immunocompetent and immunocompromised animal models. The drug administered in its oral or intravenous formulations displays non-linear plasma pharmacokinetics. Despite best current therapies, the outcome of invasive aspergillosis may remain dismal. Fungal cells can induce enormous damage on a background of immunosuppression. Medical help comes often too slow or is too weak. It will be a long time before the ideal strategy is found for an effective prophylaxis or for the optimal therapy of disseminated and invasive aspergillosis. In spite of this limitation, itraconazole has a definite chemotherapeutic effect in experimental aspergillosis. Non-comparative clinical data of itraconazole in the treatment of suspected or proven invasive aspergillosis indicate response rates at least similar and possibly superior to those of amphotericin B. Itraconazole has clearly improved the clinical outcome in some of the less immunosuppressed patients with invasive aspergillosis. The experience with itraconazole for induction therapy of invasive aspergillosis is more limited in profoundly neutropenic patients. Itraconazole has an important role for consolidation and maintenance therapy of patients with invasive aspegillosis. Itraconazole oral cyclodextrin solution is particularly suitable in these indications. Novel combination and sequential therapies involving itraconazole with other antifungals are promising. Itraconazole is usually well tolerated, but a potential for drug interactions exists, mediated through the cytochrome P450 3A4 system. This possibility should be considered when itraconazole is used as part of a multi-drug regimen. [less ▲]

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See detailItraconazole corneofungimetry bioassay on Malassezia species.
Pierard, Gérald ULg; Arrese Estrada, Jorge ULg; Pierard, Claudine ULg

in Mycoses (2004), 47(9-10), 418-21

Yeasts of the genus Malassezia are part of the normal skin biocenosis and are involved in a series of distinct skin disorders and specific dermatomycoses in man and animals. Several species are currently ... [more ▼]

Yeasts of the genus Malassezia are part of the normal skin biocenosis and are involved in a series of distinct skin disorders and specific dermatomycoses in man and animals. Several species are currently distinguished. Their relative in vitro susceptibility to antifungals appears different according to the species and to the nature and route of administration of the drug. Corneofungimetry is an ex vivo bioassay allowing to test the fungal response on human stratum corneum following oral intake of a given antifungal by volunteers. Two series of cyanoacrylate skin surface strippings (CSSS) were harvested from the volar forearm of 30 volunteers before and after a 2-week treatment with itraconazole 200 mg daily. They were coated by olive oil and inoculated with suspensions of seven different Malassezia spp. After a 1-week culture on CSSS, the amount of viable yeasts was assessed using neutral red staining assisted by computerized image analysis. Growth of the seven species was not similar on the CSSS from untreated stratum corneum. The ranking order from the most proliferative to the least was M. restricta, M. sympodialis, M. globosa, M. furfur, M. obtusa, M. slooffiae and M. pachydermatis. Their growth was abated to almost the same level after itraconazole treatment. It is concluded that in vivo treatment with itraconazole is highly active against all Malassezia spp. colonizing the human stratum corneum. [less ▲]

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See detailThe iturin and fengycin families of lipopeptides are key factors in antagonism of Bacillus subtilis toward Podosphaera fusca
Romero, D.; de Vicente, A.; Rakotoaly, R. H. et al

in Molecular Plant-Microbe Interactions [=MPMI] (2007), 20(4), 430-440

Podosphaera fusca is the main causal agent of cucurbit powdery mildew in Spain. Four Bacillus subtilis strains, UMAF6614, UMAF6619, UMAF6639, and UMAF8561, with proven ability to suppress the disease on ... [more ▼]

Podosphaera fusca is the main causal agent of cucurbit powdery mildew in Spain. Four Bacillus subtilis strains, UMAF6614, UMAF6619, UMAF6639, and UMAF8561, with proven ability to suppress the disease on melon in detached leaf and seedling assays, were subjected to further analyses to elucidate the mode of action involved in their biocontrol performance. Cell-free supernatants showed antifungal activities very close to those previously reported for vegetative cells. Identification of three lipopeptide antibiotics, surfactin, fengycin, and iturin A or bacillomycin, in butanolic extracts from cell-free culture filtrates of these B. subtilis strains pointed out that antibiosis could be a major factor involved in their biocontrol ability. The strong inhibitory effect of purified lipopeptide fractions corresponding to bacillomycin, fengycin, and iturin A on P fusca conidia germination, as well as the in situ detection of these lipopeptides in bacterial-treated melon leaves, provided interesting evidence of their putative involvement in the antagonistic activity. Those results were definitively supported by site-directed mutagenesis analysis, targeted to suppress the biosynthesis of the different lipopeptides. Taken together, our data have allowed us to conclude that the iturin and fengycin families of lipopeptides have a major role in the antagonism of B. subtilis toward P fusca. [less ▲]

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See detailIUE and other new observations of the slow nova RR Tel
Penston, M. V.; Benvenuti, P.; Cassatella, A. et al

in Monthly Notices of the Royal Astronomical Society (1983), 202

IUE satellite UV spectra of RR Tel covering 1150-3200 A at high and low dispersion through both large and small apertures are reported, and a list of 431 lines is presented which gives measured wavelength ... [more ▼]

IUE satellite UV spectra of RR Tel covering 1150-3200 A at high and low dispersion through both large and small apertures are reported, and a list of 431 lines is presented which gives measured wavelength, intensity, and full width at half maximum. Over three-quarters of the lines are identified, and a correlation is noted between line width and ionization energy. The lines identified, which include common species ionized from one to four times, are generally resonance, forbidden or semiforbidden lines but also include the recombination lines for C, O and Ne. Many Fe II lines are present. Forbidden line wavelengths are used to define intersystem separations of energy levels in some species. The continuum energy distribution yielded by low dispersion data is not due to a simple recombination of gaseous emission processes and a hot star or accretion disk, but the very high ratio of the energy in the lines to that in the continuum of 2.4 indicates that a high temperature source must be present. [less ▲]

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See detailIUE and other new observations of the slow nova RR Tel.
Penston, M. V.; Benvenuti, P.; Cassatella, A. et al

in NASA Conference Publication (1981)

Not Available

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See detailIUFRO guidelines for designing multipurpose resource inventories: a project of IUFRO Research group 4.02.02 Vienna
Rondeux, Jacques ULg

in LUND, H. Gyde (Ed.) IUFRO Guidelines for designing multipurpose resource inventories: a project of IUFRO Research group 4.02.02 Vienna: IUFRO World Series (1998)

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See detailIUG-/ZOUG- dans une inscription latine écrite en lettres grecques (CIJ I 215)
Rochette, Bruno ULg

in Zeitschrift für Papyrologie und Epigraphik (1997), 115

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See detailThe IUGS Devonian-Carboniferous Working Group: a report on activities, 1978-1984
Paproth, e; Streel, Maurice ULg

in Courier Forschungsinstitut Senckenberg (1984), 67

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See detailIVA. I soggetti passivi dell’imposta : La nozione di attività economica, i diversi tipi di attività economica e professionale
Bourgeois, Marc ULg; Greggi, Marco

in Di Pietro, A. (Ed.) Lo stato della fiscalità nell’Unione europea. L’esperienza e l’efficacia dell’armonizzazione (2003)

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See detailLes ivoires liégeois
Van den Bossche, Benoît ULg

in Van den Bossche, Benoît (Ed.) L’Art mosan: Liège et son pays à l’époque romane (du XIe au XIIIe siècle) (2007)

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See detailIxodes ricinus Tick Lipocalins: Identification, Cloning, Phylogenetic Analysis and Biochemical Characterization
Beaufays, Jérôme ULg; Adam, Benoit; Decrem, Yves et al

in PLoS ONE (2008), 3(12), 3941

Background: During their blood meal, ticks secrete a wide variety of proteins that interfere with their host's defense mechanisms. Among these proteins, lipocalins play a major role in the modulation of ... [more ▼]

Background: During their blood meal, ticks secrete a wide variety of proteins that interfere with their host's defense mechanisms. Among these proteins, lipocalins play a major role in the modulation of the inflammatory response. Methodology/Principal Findings: Screening a cDNA library in association with RT-PCR and RACE methodologies allowed us to identify 14 new lipocalin genes in the salivary glands of the Ixodes ricinus hard tick. A computational in-depth structural analysis confirmed that LIRs belong to the lipocalin family. These proteins were called LIR for ``Lipocalin from I. ricinus'' and numbered from 1 to 14 (LIR1 to LIR14). According to their percentage identity/similarity, LIR proteins may be assigned to 6 distinct phylogenetic groups. The mature proteins have calculated pM and pI varying from 21.8 kDa to 37.2 kDa and from 4.45 to 9.57 respectively. In a western blot analysis, all recombinant LIRs appeared as a series of thin bands at 50-70 kDa, suggesting extensive glycosylation, which was experimentally confirmed by treatment with N-glycosidase F. In addition, the in vivo expression analysis of LIRs in I. ricinus, examined by RT-PCR, showed homogeneous expression profiles for certain phylogenetic groups and relatively heterogeneous profiles for other groups. Finally, we demonstrated that LIR6 codes for a protein that specifically binds leukotriene B4. Conclusions/Significance: This work confirms that, regarding their biochemical properties, expression profile, and sequence signature, lipocalins in Ixodes hard tick genus, and more specifically in the Ixodes ricinus species, are segregated into distinct phylogenetic groups suggesting potential distinct function. This was particularly demonstrated by the ability of LIR6 to scavenge leukotriene B4. The other LIRs did not bind any of the ligands tested, such as 5-hydroxytryptamine, ADP, norepinephrine, platelet activating factor, prostaglandins D2 and E2, and finally leukotrienes B4 and C4. [less ▲]

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See detailIxodes ticks belonging to the Ixodes ricinus complex encode a family of anticomplement proteins.
Daix, Virginie ULg; Schroeder, Hélène ULg; Praet, N. et al

in Insect Molecular Biology (2007), 16(2), 155-66

The alternative pathway of complement is an important innate defence against pathogens including ticks. This component of the immune system has selected for pathogens that have evolved countermeasures ... [more ▼]

The alternative pathway of complement is an important innate defence against pathogens including ticks. This component of the immune system has selected for pathogens that have evolved countermeasures. Recently, a salivary protein able to inhibit the alternative pathway was cloned from the American tick Ixodes scapularis (Valenzuela et al., 2000; J. Biol. Chem. 275, 18717-18723). Here, we isolated two different sequences, similar to Isac, from the transcriptome of I. ricinus salivary glands. Expression of these sequences revealed that they both encode secreted proteins able to inhibit the complement alternative pathway. These proteins, called I. ricinus anticomplement (IRAC) protein I and II, are coexpressed constitutively in I. ricinus salivary glands and are upregulated during blood feeding. Also, we demonstrated that they are the products of different genes and not of alleles of the same locus. Finally, phylogenetic analyses demonstrate that ticks belonging to the Ixodes ricinus complex encode a family of relatively small anticomplement molecules undergoing diversification by positive Darwinian selection. [less ▲]

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See detailIy and iw as a single morphological and semantic entity
Winand, Jean ULg

Conference (1990, October 18)

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See detailIy et iw: unité morphologique et sémantique
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (1991), 1

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See detailL’Iynge dans le discours mythique et les procédures magiques
Pirenne-Delforge, Vinciane ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1993), 6

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See detailİzmir Gezisi: Antoine Galland'ın Bir Elyazması (1678)
Galland, Antoine; Bauden, Frédéric ULg; Üyepazarcı, Erol

Book published by İzmir Büyükşehir Belediyesi Kültür Yayını (2003)

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See detailIZOARD Jacques
Purnelle, Gérald ULg

in Blanchaud, Corinne (Ed.) Dictionnaire des écrivains francophones classiques. Belgique, Canada, Québec, Luxembourg, Suisse romande (2013)

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See detailJ dependence in the LSDA plus U treatment of noncollinear magnets
Bousquet, Eric ULg; Spaldin, Nicola

in Physical Review. B, Condensed Matter and Materials Physics (2010), 82(22),

We re-examine the commonly used density-functional theory plus Hubbard U (DFT+U) method for the case of noncollinear magnets. While many studies neglect to explicitly include the exchange-correction ... [more ▼]

We re-examine the commonly used density-functional theory plus Hubbard U (DFT+U) method for the case of noncollinear magnets. While many studies neglect to explicitly include the exchange-correction parameter J, or consider its exact value to be unimportant, here we show that in the case of noncollinear magnetism calculations the J parameter can strongly affect the magnetic ground state. We illustrate the strong J dependence of magnetic canting and magnetocrystalline anisotropy by calculating trends in the magnetic lithium orthophosphate family LiMPO(4) (M=Fe and Ni) and difluorite family MF(2) (M=Mn, Fe, Co, and Ni). Our results can be readily understood by expanding the usual DFT+U equations within the spinor scheme, in which the J parameter acts directly on the off-diagonal components which determine the spin canting. [less ▲]

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See detail"J'ai deux ‘amours’…"
Dejasse, Erwin ULg

in Art&Fact (2000), 19

The representations of Paris into the comic "Adèle Blanc-Sec" by Jacques Tardi.

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