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See detailGamma-Ray Spectrometry: Experimental Measurement and Monte Carlo Simulation using GEANT4 toolkit
Guembou Shouop, Cébastien Joel ULg; Ndontchueng Moyo, Maurice; Chene, Grégoire ULg et al

Poster (2016, July 13)

Nowadays the precision in the measurement has become a challenge for physicists. That is why in recent decades, the interest is very granted to simulation. Since 1940, the method Monte Carlo is more ... [more ▼]

Nowadays the precision in the measurement has become a challenge for physicists. That is why in recent decades, the interest is very granted to simulation. Since 1940, the method Monte Carlo is more useful for validation and even for prediction of the results of the experiment. The aim of this study is to validate experimental models. Our laboratories are equipped with HPGe gamma spectrometers for measuring the natural radioactivity, it becomes interesting to compare and even to improve the performance of our system. Geant4 is used for the construction of the geometry of detection, the physics processes and the primary particles. First and prliminary result was prsented in this paper. [less ▲]

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See detailA gammaherpesvirus infection protects against allergic asthma.
Machiels, Bénédicte ULg; Dourcy, Mickael ULg; Sabatel, Catherine ULg et al

Poster (2014, December 12)

The “hygiene hypothesis” proposes that the augmentation of allergic diseases in developed countries could be linked to a reduced exposure to infections during childhood. Surprisingly, the potential ... [more ▼]

The “hygiene hypothesis” proposes that the augmentation of allergic diseases in developed countries could be linked to a reduced exposure to infections during childhood. Surprisingly, the potential protective role of herpesvirus infections against allergy development has never been addressed directly. In this study, we used the Murid herpesvirus 4 (MuHV-4) to study the impact of a persistent gammaherpesvirus infection on the development of House Dust Mites (HDM)-induced allergic asthma. Our results revealed that MuHV-4 infection affects both the sensitization and the challenging phases of HDM-induced airway allergy. In particular, we highlighted that MuHV-4 infection strongly impacts the lung innate immune response. Indeed, while the dendritic cells remained competent to uptake antigens and to migrate to the draining lymph nodes, MuHV-4 infection impaired their ability to trigger HDM sensitization. In the future, these results could allow us to develop strategies to prevent the development of TH2-skewed responses against respiratory allergens. [less ▲]

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See detailgammaMAXT: a fast multiple-testing correction algorithm
Van Lishout, François ULg; Gadaleta, Francesco; Moore, Jason H. et al

in BioData Mining (2015), 8(36),

Background: The purpose of the maxT algorithm is to provide a significance test algorithm that controls the family-wise error rate (FWER) during simultaneous hypothesis testing. However, the requirements ... [more ▼]

Background: The purpose of the maxT algorithm is to provide a significance test algorithm that controls the family-wise error rate (FWER) during simultaneous hypothesis testing. However, the requirements in terms of computing time and memory of this procedure are proportional to the number of investigated hypotheses. The memory issue has been solved in 2013 by Van Lishout’s implementation of MaxT, which makes the memory usage independent from the size of the dataset. This algorithm is implemented in MBMDR-3.0.3, a software that is able to identify genetic interactions, for a variety of SNP-SNP based epistasis models effectively. On the other hand, that implementation turned out to be less suitable for genome-wide interaction analysis studies, due to the prohibitive computational burden. Results: In this work we introduce gammaMAXT, a novel implementation of the maxT algorithm for multiple testing correction. The algorithm was implemented in software MBMDR-4.2.2, as part of the MB-MDR framework to screen for SNP-SNP, SNP-environment or SNP-SNP-environment interactions at a genome-wide level. We show that, in the absence of interaction effects, test-statistics produced by the MB-MDR methodology follow a mixture distribution with a point mass at zero and a shifted gamma distribution for the top 10 % of the strictly positive values. We show that the gammaMAXT algorithm has a power comparable to MaxT and maintains FWER, but requires less computational resources and time. We analyze a dataset composed of 106 SNPs and 1000 individuals within one day on a 256-core computer cluster. The same analysis would take about 104 times longer with MBMDR-3.0.3. Conclusions: These results are promising for future GWAIs.However, the proposed gammaMAXT algorithm offers a general significance assessment and multiple testing approach, applicable to any context that requires performing hundreds of thousands of tests. It offers new perspectives for fast and efficient permutation-based significance assessment in large-scale (integrated) omics studies. [less ▲]

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See detailgammaMAXT: a fast multiple-testing correction algorithm
Van Lishout, François ULg; Gadaleta, Francesco ULg; Moore, Jason H. et al

in ERCIM 2014 Abstract Book (2014, November 12)

The purpose of the maxT algorithm (1993) is to control the family-wise error rate (FWER) when assessing significance of multiple tests jointly. However, the requirements in terms of computing time and ... [more ▼]

The purpose of the maxT algorithm (1993) is to control the family-wise error rate (FWER) when assessing significance of multiple tests jointly. However, the requirements in terms of computing time and memory of this procedure are proportional to the number of investigated hypothesis. The memory issue has been solved by Van Lishout’s implementation of maxT (2013), which makes the memory usage independent from the size of the dataset. This algorithm is implemented in MBMDR-3.0.3, a software that is able to identify genetic interactions, for a variety of SNP-SNP based epistasis model,s in an effective way. However, that implementation turned out to be less suitable for genome-wide interaction analysis studies, due to the prohibitive computational burden. Here, we present gammaMAXT, a novel algorithm which is part of MBMDR-4.2.2. We show that, in the abscence of interaction effects, test-statistics produced by the MB-MDR methodology follow a mixture distribution with a point mass at zero and a shifted gamma distribution for the top 10% of the strictly positive values. We show that the gammaMAXT algorithm has a power comparable to maxT and maintains FWER, but requires less computational resources and time. MBMDR-4.2.2 can be downloaded at http://www.statgen.ulg.ac.be. [less ▲]

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See detailGammapathie monoclonale d'origine indéterminée et myélome
Bury, Jean; Salmon, Jean ULg; Fillet, Georges ULg

in Revue Médicale de Liège (1988), 43

La découverte d'une gammapathie monoclonale n'implique pas nécessairement le diagnostic de myélome multiple. Le myélome est une prolifération maligne d'un clone plasmocytaire dont l'évolution sans ... [more ▼]

La découverte d'une gammapathie monoclonale n'implique pas nécessairement le diagnostic de myélome multiple. Le myélome est une prolifération maligne d'un clone plasmocytaire dont l'évolution sans traitement est toujours fatale. Les traitements chimiothérapiques instaurés actuellement, tout en prolongeant la survie des patients, améliorent de façon nette la qualité de vie. En dehors de la greffe de moelle osseuse allogénique, la rémission complète n'est jamais synonyme de guérison. Récemment, l'interféron alpha 2 recombinant a complété positivement l'arsenal thérapeutique utilisé chez les malades souffrant de myéolme, de même que certains nouveaux protocoles chimiothérapiques. [less ▲]

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See detailGammapathie monoclonale de signification indéterminée : information destinée aux médecins référents
CAERS, Jo ULg; Binsfeld, Marilène ULg; Muller, Joséphine ULg et al

in Revue Médicale de Liège (2014), 69

Monoclonal gammopathies of undetermined significance (MGUS) are frequently diagnosed in the global population. Because of its possible transformation into a hematological malignancy, the identiÏlCation of ... [more ▼]

Monoclonal gammopathies of undetermined significance (MGUS) are frequently diagnosed in the global population. Because of its possible transformation into a hematological malignancy, the identiÏlCation of a MGUS requires a regular and generaDy long follow-up. However, tbis risk of transformation differs between the individuals and different laboratory criteria have bee. identiOed as predictive factors for progression and were combined in scoring systems that alIow correct classification of individuals. The management of the se patients needs to be adapted according to the cakulated risk profile. [less ▲]

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See detailGammapathies monoclonales de signification indéterminée
Vekemans, Marie-Christiane; CAERS, Jo ULg; Doyen, Chantal et al

in Louvain Medical (2013), 132(2), 51-62

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See detailGangliocytome dysplasique du cervelet ou maladie de LhermitteDuclos (A propos de 2 cas opérés)
Milbouw, G.; Martin, Didier ULg; Born, J. et al

Conference (1986, December)

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See detailGanglion sentinelle et sentibras: pour un "staging" axillaire sur mesure
Cusumano, P.; BLERET, Valerie ULg; Nos, C. et al

in Revue Médicale de Liège (2011), 66(5-6), 336-40

The status of the axillary lymph nodes is one of the most important prognostic factors in women with early stage breast cancer. Histologic examination of removed lymph nodes is the most accurate method ... [more ▼]

The status of the axillary lymph nodes is one of the most important prognostic factors in women with early stage breast cancer. Histologic examination of removed lymph nodes is the most accurate method for assessing spread of disease to these nodes. Axillary lymph node dissection (ALND) remains the standard approach for women who have clinically palpable axillary nodes. The benefits of ALND include its impact on disease control (axillary recurrence and survival), its prognostic value, and its role in treatment selection. However, the anatomic disruption caused by ALND may result in lymphedema, nerve injury, and shoulder dysfunction, which compromise functionality and quality of life. For patients who have clinically negative axillary lymph nodes, sentinel lymph node (SLN) biopsy offers a less morbid method to determine if there are positive nodes, in which case axillary node dissection would be necessary. Patients who are SLN-positive should undergo complete ALND. Axillary reverse mapping (ARM) is a recent improvement of ALND which, like the biopsy of the GS, would reduce morbidity. [less ▲]

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See detailUne gangrène digitale humide traitée de façon conservatrice
Janssen, Aurélie; STERGIOPOULOU, Theodouli ULg; NYAMUGABO MUNYERE NKANA, Kindja ULg et al

in Tijdschrift van de Belgische Kinderarts = Journal du Pédiatre Belge (2015, January), 17(1), 64

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See detailGangrene gazeuse: importance du diagnostic precoce et de l'oxygenotherapie hyperbare.
Lamy, Maurice ULg; Lejeune, G.; Noel, F. X. et al

in Revue Médicale de Liège (1977), 32(19), 589-93

Detailed reference viewed: 138 (1 ULg)
See detailThe Ganymede aurora …
Gérard, Jean-Claude ULg; Shematovich, Valery; Bisikalo, Dmitry et al

Poster (2013, September)

In this Report we present the Monte Carlo model for calculation of oxygen UV and IR emissions due to the electron precipitation in the Ganymede polar regions. These techniques will provide column ... [more ▼]

In this Report we present the Monte Carlo model for calculation of oxygen UV and IR emissions due to the electron precipitation in the Ganymede polar regions. These techniques will provide column densities of atmospheric species at better than or equal to 1 km spatial resolution, and will constrain the amount of some specific compounds from limb scans and during stellar occultation. This investigation also needs characterization of the vertical temperature profile from ground up to about 400 km altitude with ~5 km vertical resolution as well as mapping of water vapour concentration. This can be performed by multiple water line observations in the 200-600 μm wavelength range. It shall be complemented by ion and neutral mass spectrometry of plasma particles, radio occultations to measure structures of the neutral atmosphere and ionosphere, and plasma wave measurements to constrain plasma density and temperature of the ionosphere. [less ▲]

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See detailThe Ganymede auroral footprint: implications of the spots’ multiplicity
Bonfond, Bertrand ULg; Hess, Sébastien; Bagenal, Fran et al

Conference (2013, September 10)

We report here the finding of a secondary spot for the Ganymede auroral footprint on Jupiter. Moreover, we characterize the evolution of the Ganymede footprint morphology with longitude and time. Finally ... [more ▼]

We report here the finding of a secondary spot for the Ganymede auroral footprint on Jupiter. Moreover, we characterize the evolution of the Ganymede footprint morphology with longitude and time. Finally, we discuss the implications of these results with respect to the morphology of the other satellite footprints. [less ▲]

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See detailGap analysis on robustness of tubular structures
Jaspart, Jean-Pierre ULg; Huvelle, Clara ULg; Demonceau, Jean-François ULg

Report (2012)

Recent events such as natural catastrophes (tsunami, hurricane, …) or terrorism attacks have highlighted the necessity of ensuring the structural integrity of buildings under exceptional events with the ... [more ▼]

Recent events such as natural catastrophes (tsunami, hurricane, …) or terrorism attacks have highlighted the necessity of ensuring the structural integrity of buildings under exceptional events with the objective to save the life of the occupants and of the safety services (fireman, ambulance man, …) and also to avoid collateral damages to the adjoining buildings. The partial collapse of the Ronan Point Tower in 1968 in UK is considered as the starting point of the interest in the structural integrity of buildings but more recent catastrophes in the last decade such as the terrorist attack of the World Trade Center towers in 2001 or the earthquake/tsunami in Fukushima in 2011 have increased the interest of the engineering community and also of the population in this topic. According to different national and international design codes, the structural integrity of civil engineering structures should be ensured through appropriate measures but, in most of the cases, no precise practical guidelines on how to achieve this goal are provided. In the present report, some definitions are first given. Existing codes and standards are then reviewed and main conclusions are drawn on their adequacy to the present needs of practitioners. From this analysis, general and specific research needs within CIDECT are identified. These ones are detailed in two dedicated sections respectively on buildings and trusses. A summary table draws the main conclusions in terms of future required CIDECT investments. Finally some references to literature are listed. [less ▲]

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See detailThe Gap Concept as a Quality of Life Measure: Validation Study of the Child Quality of Life Systemic Inventory
Etienne, Anne-Marie ULg; Dupuis, Gilles; Spitz, Elisabeth et al

in Social Indicators Research (2011), 100(2), 241-257

The objective was to determine the interest and psychometric properties of a new QOL self-assessment questionnaire suitable for children 8–12 years old measuring alpha, beta and gamma changes: the ... [more ▼]

The objective was to determine the interest and psychometric properties of a new QOL self-assessment questionnaire suitable for children 8–12 years old measuring alpha, beta and gamma changes: the ‘‘Inventaire Syste´mique de Qualite´ de vie pour Enfants’’ (ISQV-E ). This was a cross-sectional validation study. 288 children have completed the ISQV-E. Other tools were used: The ‘‘Autoquestionnaire de Qualite´ de Vie Enfants Image´’’ (AUQUEI), the State-Trait Anxiety Inventory for Children (STAIC), the Children’s Depression Inventory (CDI). The internal consistency of the four scores of the ISQV-E (state, goal, rank and gap) is satisfactory. All scores have their own specificity. The data show the convergent validity, sensitivity and applicability of the ISQV-E. On the other hand, no satisfactory factorial structure was found although a multidimensional theoretical perspective was applied. The feasibility of the ISQV-E seems clearly demonstrated and the value of this new tool seems evident in contexts of physical, psychological or social problems. The validation study was promising but certain points such as test–retest reliability remain to be studied. [less ▲]

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See detailGap Filling Strategies For Defensible Annual Sums Of Net Ecosystem Exchange
Falge, E.; Baldocchi, D.; Olson, R. et al

in Agricultural and Forest Meteorology (2001), 107(1),

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See detailGap Filling Strategies For Long Term Energy Flux Data Sets
Falge, E.; Baldocchi, D.; Olson, R. et al

in Agricultural and Forest Meteorology (2001), 107(1),

Detailed reference viewed: 19 (2 ULg)