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See detailIrregular earthquake cycle along the southern Tianshan front, China (Aksu area)
Hubert, Aurelia ULg; Suppe, J.; Van Der Woerd, J. et al

in Journal of Geophysical Research (2005), 110(10.1029/2003JB002603),

A long deformation record (􏰩16.5 ka) showing nonsteady earthquake recurrence is established for the Aksu thrust (Tianshan, China) on the basis of cosmogenic 10Be dating of faulted surfaces. Topographic ... [more ▼]

A long deformation record (􏰩16.5 ka) showing nonsteady earthquake recurrence is established for the Aksu thrust (Tianshan, China) on the basis of cosmogenic 10Be dating of faulted surfaces. Topographic leveling across the Aksu fault scarp indicates up to 􏰩10 m uplift across a moraine abandoned 􏰩16.5 ka and similar uplift of 􏰩6 m across two inset surfaces yielding ages of 􏰩12.5 and 􏰩5 ka. Successively smaller uplifts of terraces younger than 5 ka indicate that three or more major earthquakes occurred during this period. These data show that the Aksu thrust fault was quiet for at least 7500 years and active in the last 􏰩5000 years and probably in the interval 16.5–12.5 ka. The seismic cycle along the Aksu thrust fault over the last 􏰩16,500 years was thus strongly irregular showing long quiescence and clustering, which is a challenge for paleoseismology and hazard assessment. This irregularity also makes it more difficult to estimate long-term shortening rates. Nevertheless, we are able to constrain a minimum total shortening rate (>7 mm/yr) across the southern Tianshan front for the last 12,500 years that is about a third of the total geodetic rate for the western Tianshan (􏰩20 mm/yr). [less ▲]

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See detailThe irresistible need for educational research
De Landsheere, Gilbert ULg

Conference (1976, June)

The function of research is to perfect the tools of education and to manufacture new ones. Research opens up perspectives and informs teachers. The whole of the education system and all its components ... [more ▼]

The function of research is to perfect the tools of education and to manufacture new ones. Research opens up perspectives and informs teachers. The whole of the education system and all its components should be investigated if research is to be comprehensive and successful. Highly qualified teams of researchers are essential, bringing a variety of interests, knowledge, and points of view. Education is a human venture and also a realm of contingencies; it is important that educational research take into account the teacher's cultural background, intellectual limitations, needs, frustrations, and the real problems faced in the classroom. Full understanding and communication between researchers and teachers must exist if change and action are to result from educational exploration, evaluation, and future planning. (JD) [less ▲]

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See detailThe irresistible quest for new concepts, theories and paradigms
Martiniello, Marco ULg

in RC‐31 Newsletter (2012), (Autumn 2012), 1-2

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See detailIrreversible dynamics of the phase boundary in U(Ru(0.96)Rh(0.04))(2)Si(2) and implications for ordering
Silhanek, Alejandro ULg; Jaime, M.; Harrison, N. et al

in Physical Review Letters (2006), 96(13),

We report measurements and analysis of the specific heat and magnetocaloric effect-induced temperature changes at the phase boundary into the single magnetic field-induced phase (phase II) of U(Ru(0.96)Rh ... [more ▼]

We report measurements and analysis of the specific heat and magnetocaloric effect-induced temperature changes at the phase boundary into the single magnetic field-induced phase (phase II) of U(Ru(0.96)Rh(0.04))(2)Si(2), which yield irreversible properties similar to those at the valence transition of Yb(1-x)Y(x)InCu(4). To explain these similarities, we propose a bootstrap mechanism by which lattice parameter changes caused by an electric quadrupolar order parameter within phase II become coupled to the 5f-electron hybridization, giving rise to a valence change at the transition. [less ▲]

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See detailIrreversible magnetization under rotating fields and lock-in effect on a ErBa2Cu3O7-delta single crystal with columnar defects
Avila, M. A.; Civale, L.; Silhanek, Alejandro ULg et al

in Physical Review. B : Condensed Matter (2001), 64(14),

We have measured the irreversible magnetization (M-i) of an ErBa2Cu3O7-delta single crystal with columnar defects (CD), using a technique based on sample rotation under a fixed magnetic field H. This ... [more ▼]

We have measured the irreversible magnetization (M-i) of an ErBa2Cu3O7-delta single crystal with columnar defects (CD), using a technique based on sample rotation under a fixed magnetic field H. This method is valid for samples whose magnetization vector remains perpendicular to the sample surface over a wide angle range-which is the case for platelets and thin films-and presents several advantages over measurements of M-L(H) loops at fixed angles. The resulting M-i(Theta) curves for several temperatures show a peak in the CD direction at high fields. At lower fields, a very well defined plateau indicative of the vortex lock-in to the CD develops. The H dependence of the lock-in angle phi (L) follows the H-1 theoretical prediction, while the temperature dependence is in agreement with entropic smearing effects corresponding to long range vortex-defects interactions. [less ▲]

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See detailIrreversible passive energy transfer in coupled oscillators with essential nonlinearity
Kerschen, Gaëtan ULg; Lee, Young Sup; Vakakis, Alexander F. et al

in SIAM Journal on Applied Mathematics (2006), 66(2), 648-679

We study numerically and analytically the dynamics of passive energy transfer from a damped linear oscillator to an essentially nonlinear end attachment. This transfer is caused by either fundamental or ... [more ▼]

We study numerically and analytically the dynamics of passive energy transfer from a damped linear oscillator to an essentially nonlinear end attachment. This transfer is caused by either fundamental or subharmonic resonance capture, and in some cases is initiated by nonlinear beat phenomena. It is shown that, due to the essential nonlinearity, the end attachment is capable of passively absorbing broadband energy at both high and low frequencies, acting, in essence, as a passive broadband boundary controller. Complicated transitions in the damped dynamics can be interpreted based on the topological structure and bifurcations of the periodic solutions of the underlying undamped system. Moreover, complex resonance capture cascades are numerically encountered when we increase the number of degrees of freedom of the system. The ungrounded essentially nonlinear end attachment discussed in this work can find application in numerous practical settings, including vibration and shock isolation of structures, seismic isolation,. utter suppression, and packaging. [less ▲]

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See detailIrreversible passive TEF in the damped response of coupled oscillators with nonlinearity
Kerschen, Gaëtan ULg; Lee, Young S.; Vakakis, Alexander F. et al

in ASME International Design Engineering Technical Conferences & Computers and Information in Engineering Conference, Long Beach, 2005 (2005, September)

We study, numerically and analytically the dynamics of passive energy transfer from a damped linear oscillator to an essentially nonlinear end attachment. This transfer is caused either by fundamental or ... [more ▼]

We study, numerically and analytically the dynamics of passive energy transfer from a damped linear oscillator to an essentially nonlinear end attachment. This transfer is caused either by fundamental or subharmonic resonance capture, and in some cases is initiated by nonlinear beat phenomena. It is shown that, due to the essential nonlinearity, the end attachment is capable of passively absorbing broadband energy both at high and low frequencies, acting, in essence, as a passive broadband boundary controller. Complicated transitions in the damped dynamics can be interpreted based on the topological structure and bifurcations of the periodic solutions of the underlying undamped system. Moreover, complex resonance capture cascades are numerically encountered when we increase the number of degrees of freedom of the system. The grounded, essentially nonlinear end attachment discussed in this work can find application in numerous practical settings, including vibration and shock isolation of structures, seismic isolation, flutter suppression and packaging. [less ▲]

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See detailIrrigation avec les eaux usées traitées : manuel d'utilisation.
Bazza, M.; Xanthoulis, Dimitri ULg

Conference (2003, September)

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See detailIrritation cutanee et vitesse de propagation d'ondes ultrasonores.
Uhoda, Emmanuelle ULg; Pierard, Gérald ULg

in International Journal of Cosmetic Science (2003), 25(1-2), 31-5

Cutaneous irritation is a stereotyped response of the skin to any physical or chemical insult. Its main manifestations encompass inflammatory erythema and an alteration of the cutaneous microrelief ... [more ▼]

Cutaneous irritation is a stereotyped response of the skin to any physical or chemical insult. Its main manifestations encompass inflammatory erythema and an alteration of the cutaneous microrelief showing increased roughness, dehydration and erratic desquamation. Several instrumental methods can indirectly assess the issues of cutaneous irritation on human stratum corneum. The aim of the present study was to measure the speed of propagation of ultrasound shear waves in the skin irritated by anionic surfactants. The study was performed in 25 healthy subjects of both sexes. Occlusive patches of a 10% solution of anionic surfactants were applied to a forearm of each volunteer. The other forearm served as an untreated control site. Patches remained in place for 24 h. Three hours later, another patch was placed again for 21 h. Resonance running time measurements (RRTM) of the ultrasound shear wave were performed using a Reviscometer((R)) RVM 600. Measurements were performed at entry in the study and 2 days after removing the second patch. Desquamative xerosis was obvious at the sites patched with the surfactant solution. RRTM values were significantly (P < 0.0001) lower than those at the control site. Hence, the speed of propagation of ultrasound shear waves was shown to be increased at an irritated site compared to an intact site. In conclusion, this study shows that the propagation speed of ultrasounds is influenced by the skin surface nature, being considerably increased in skin altered by surfactants. [less ▲]

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See detailIrvin Yalom : satire et thérapie
Saint-Amand, Denis ULg

Article for general public (2010)

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See detailIs "translational research" reshaping health policy ?
Fallon, Catherine ULg

Conference (2012, July 08)

Biomedical research is an area of fast evolving development. Although biomedical research occurs in internationally nested research laboratories, application development occurs in local settings, such as ... [more ▼]

Biomedical research is an area of fast evolving development. Although biomedical research occurs in internationally nested research laboratories, application development occurs in local settings, such as hospitals, which are central instruments for health policies. Much translation work occurs to build new forms of cooperation between biomedical researchers and medical doctors. The first group works in an international competitive environment, acting as research entrepreneurs with connection to the pharmaceutical industry in the logics of "open innovation". Members of the second group are embedded in hospital systems, within a web of constrains, being accountable as well to their patients as to their managers, and to their professional constrains which are most of the time defined within specific institutions at national level, in close relation to public health authorities. These links at micro-meso-macro levels between medics and their environment are put under constrains by biomedical innovations (as was shown in Europe during the controversy around the breast cancer products from Myriad Genetics). In order to organise new forms of cooperation and to dismantle frontiers between the "bench world" and the "bed world", a new concept was put at the fore : "translational research" which is supporting new forms of cooperation "from bench to bed" with all associated partners, ensuring enrolment of the individual patient and the policy makers. Starting with the presentation of the new science production regime in French speaking Belgium, the paper proposes to deconstruct the conditions of emergence of the new instruments of science production in biomedical research to understand institutional reorganisation and new power balances. [less ▲]

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See detailIs 3 '-deoxy-3 '-[F-18] fluorothymidine ([F-18]-FLT) the next tracer for routine clinical PET after R [F-18]-FDG?
Couturier, Olivier; Léost, Françoise; Campone, Mario et al

in Bulletin du Cancer (2005), 92(9), 789-798

Positron emission tomography (PET) with {F-18}-FDG is nowfirmly established as a clinical tool in oncology. Its applications are however limited in some indications, due to the lack of specificity of its ... [more ▼]

Positron emission tomography (PET) with {F-18}-FDG is nowfirmly established as a clinical tool in oncology. Its applications are however limited in some indications, due to the lack of specificity of its uptake mechanism for tumors, or the low avidity of some cancer types such as prostate. Alternative tracers are thus being developed, in order to fill up this void. Proliferation as a biological target is particularly attractive in cancer imaging. From that perspective, fluorothymidine ({F-18}-FLT or FLT) has generated a strong interest among the scientific community, especially since the radiosynthesis process has been improved and simplified, thus making possible to envision a routine use for the tracer. This article aims at summarizing the status of the current scientific data regarding FLT The uptake mechanism of FLT is well known, relying on the thymidine kinase 1 (TK1) enzymatic activity, and thus on DNA synthesis, Preclinical studies have shown a clear relationship between tracer accumulation and level of tumor proliferation, even though DNA salvage pathwayss intervene in the process and may complicate the interpretation of the results. Several clinical studies suggest a good specificity for tumor, albeit with a lower sensitivity than with FDG. In all likelihood however, the future of FLT lies in the evaluation of antitumor response and possibly the pretherapeutic prognostic characterization, rather than in the diagnosis and staging of malignancies. Although the scientific data regarding this issue remain limited, initial results are encouraging. Further significant work remains to he done in order to fully assess the clinical performances of the tracer, on the one hand, and to determine its place relative to FDG and other emerging tracers, on the other hand. Until these studies are completed, FLT should he considered as a promising tracer, hut remaining at an experimental stage of its development. [less ▲]

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See detailIs 5-Hydroxytryptamine (serotonin) involved in the pathogenesis of idiopathic pulmonary fibrosis in dogs ?
Krafft, Emilie ULg; Roels, Elodie ULg; Laurila et al

in Proceedings of the 23th ECVIM Meeting (2013, September)

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See detailIs a low-mass top quark ruled out?
Cudell, Jean-René ULg; Halzen, F.; He, X. G. et al

in Physics Letters B (1987), 196

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See detailIs a renal abnormality of sodium excretion the marker of genetic predisposition to hypertension?
Krzesinski, Jean-Marie ULg; Goffard, A.; Warling, X. et al

in Clinical & Experimental Hypertension (1989), A11(7), 1391

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See detailIs Aggregation Of Beta-Amyloid Peptides A Mis-Functioning Of A Current Interaction Process?
Festy, F.; Lins, Laurence ULg; Peranzi, G. et al

in Biochimica et Biophysica Acta-Protein Structure and Molecular Enzymology (2001), 1546(2), 356-64

In a previous study, Hughes et al. [Proc. Natl. Acad. Sci. USA 93 (1996) 2065-2070] demonstrated that the amyloid peptide is able to interact with itself in a two-hybrid system and that interaction is ... [more ▼]

In a previous study, Hughes et al. [Proc. Natl. Acad. Sci. USA 93 (1996) 2065-2070] demonstrated that the amyloid peptide is able to interact with itself in a two-hybrid system and that interaction is specific. They further supported that the method could be used to define the sequences that might be important in nucleation-dependent aggregation. The sequence of the amyloid peptide can be split into four clusters, two hydrophilic (1-16 and 22-28) and two hydrophobic (17-21 and 29-42). We designed by molecular modeling and tested by the two-hybrid approach, series of mutations spread all over the sequence and changing the distribution of hydrophobicity and/or the spatial hindrance. In the two-hybrid assay, interaction of native Abeta is reproduced. Screening of mutations demonstrates that the C-domain (residues 29-40 (42)), the median domain (residues 17-22) and the N-domain (1-16) are all crucial for interaction. This demonstrates that almost all fragments of the amyloid peptide but a loop (residues 23-28) and the C-term amino acid are important for the native interaction. We support that the folded three-dimensional (3D) structure is the Abeta-Abeta interacting species, that the whole sequence is involved in that 3D fold which has a low secondary structure propensity and a high susceptibility to mutations and thus should have a low stability. The native fold of Abeta could be stabilized in Abeta-Abeta complexes which could in other circumstances facilitate the nucleation event of aggregation that leads to the formation of stable senile plaques. [less ▲]

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See detailIs Alzheimer's disease a disconnection syndrome? Evidence from a crossmodal audio-visual illusory experiment
Delbeuck, Xavier; Collette, Fabienne ULg; Van der Linden, Martial ULg

in Neuropsychologia (2007), 45(14), 3315-3323

In Alzheimer's disease (AD), loss of connectivity in the patient's brain has been evidenced by a range of electrophysiological and neuroimaging studies. However, few neuropsychological research projects ... [more ▼]

In Alzheimer's disease (AD), loss of connectivity in the patient's brain has been evidenced by a range of electrophysiological and neuroimaging studies. However, few neuropsychological research projects have sought to interpret the cognitive modifications following the appearance of AD in terms of a disconnection syndrome. In this paper, we sought to investigate brain connectivity in AD via the study of a crossmodal effect. More precisely, we examined the integration of auditory and visual speech information (the McGurk effect) in AD patients and matched control subjects. Our results revealed impaired crossmodal integration during speech perception in AD, which was not associated with disturbances in the separate processing of auditory and visual speech stimuli. In conclusion, our data suggest the occurrence of a specific, audio-visual integration deficit in AD, which might be the consequence of a connectivity breakdown and corroborate the observation from other studies of crossmodal deficits between the auditory and visual modalities in this population. (C) 2007 Elsevier Ltd. All rights reserved. [less ▲]

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See detailIs an alcoholic fixative fluid used for manual liquid-based cytology accurate to perform HPV tests?
Garbar, Christian; Mascaux, Corinne; De Graeve, Philippe et al

in Pathology and Laboratory Medicine International (2012), 4

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See detailIs an evidence-based approach unrealistic in NSCLC?
Coucke, Philippe ULg; Barthelemy, Nicole ULg; Bosquee, Léon ULg et al

in Belgian Journal of Medical Oncology [=BJMO] (2008), volume 2(6), 326-333

Summary Non-small cell lung cancer (NSCLC) is a heterogeneous tumour. A wide variety of treatment options is currently available. Surgery remains the mainstay of curative treatment and an operative ... [more ▼]

Summary Non-small cell lung cancer (NSCLC) is a heterogeneous tumour. A wide variety of treatment options is currently available. Surgery remains the mainstay of curative treatment and an operative approach will be selected in function of disease stage, tumour resectability and performance status of the patient. Adjuvant chemotherapy is considered standard at least for stage II and III disease. In stage III disease, resectability should be decided in function of the cytological/histological confirmation of N2 disease. If N2-disease cannot be highlighted at work-up, the patients are submitted to surgery followed by adjuvant chemotherapy. If patients are staged pN0-pN1 after surgery, ostoperative radiotherapy should not be given. However, if pN2 is discovered at surgery, there might be a place for postoperative radiotherapy but this still needs confirmation. In case of cytological/histological confirmation of pN2 disease prior to surgery, patients should not be operated but treated with a combination of oncomitant chemoradiotherapy. This treatment algorithm will be evaluated by reviewing the published evidence issued from randomized controlled trials. [less ▲]

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