Glucosamine sulfate slows-down osteoarthritis progression in postmenopausal women: pooled analysis of two large, independent, randomised, placebo-controlled, double-blind, prospective 3-year trials
Reginster, Jean-Yves ; ; Deroisy, Rita et al
in Osteoporosis International (2002, November), 13(Suppl.3), 60Detailed reference viewed: 22 (0 ULg)
Glucosamine sulphate in osteoarthritis: from symptoms to structure modification
Reginster, Jean-Yves ; LECART, Marie-Paule ; Bruyère, Olivier et al
in Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (2005), 4
Several chemical entities have been carefully investigated for the symptomatic and structural management of osteoarthritis. The most compelling evidence of a potential for inhibiting the structural ... [more ▼]
Several chemical entities have been carefully investigated for the symptomatic and structural management of osteoarthritis. The most compelling evidence of a potential for inhibiting the structural progression of osteoarthritis has been obtained with glucosamine sulfate. At any rate, this compoind has clearly demonstrated a symptomatic action, mainly in osteoarthritis of the lower limbs, on pain relief an improvement of functional disability. An important issue is that all the conclusive studies with such chyemical entities resulted from the use of prescription medicines and not over-the-counter pills of food supplements. [less ▲]Detailed reference viewed: 33 (7 ULg)
Glucosamine sulphate in the treatment of knee osteoarthritis: cost-effectiveness comparison with paracetamol.
; Bruyère, Olivier ; et al
in International Journal of Clinical Practice (2010), 64(6), 756-62
INTRODUCTION: The aim of this study was to explore the cost-effectiveness of glucosamine sulphate (GS) compared with paracetamol and placebo (PBO) in the treatment of knee osteoarthritis. For this purpose ... [more ▼]
INTRODUCTION: The aim of this study was to explore the cost-effectiveness of glucosamine sulphate (GS) compared with paracetamol and placebo (PBO) in the treatment of knee osteoarthritis. For this purpose, a 6-month time horizon and a health care perspective was used. MATERIAL AND METHODS: The cost and effectiveness data were derived from Western Ontario and McMaster Universities Osteoarthritis Index data of the Glucosamine Unum In Die (once-a-day) Efficacy trial study by Herrero-Beaumont et al. Clinical effectiveness was converted into utility scores to allow for the computation of cost per quality-adjusted life year (QALY) For the three treatment arms Incremental Cost-Effectiveness Ratio were calculated and statistical uncertainty was explored using a bootstrap simulation. RESULTS: In terms of mean utility score at baseline, 3 and 6 months, no statistically significant difference was observed between the three groups. When considering the mean utility score changes from baseline to 3 and 6 months, no difference was observed in the first case but there was a statistically significant difference from baseline to 6 months with a p-value of 0.047. When comparing GS with paracetamol, the mean baseline incremental cost-effectiveness ratio (ICER) was dominant and the mean ICER after bootstrapping was -1376 euro/QALY indicating dominance (with 79% probability). When comparing GS with PBO, the mean baseline and after bootstrapping ICER were 3617.47 and 4285 euro/QALY, respectively. CONCLUSION: The results of the present cost-effectiveness analysis suggested that GS is a highly cost-effective therapy alternative compared with paracetamol and PBO to treat patients diagnosed with primary knee OA. [less ▲]Detailed reference viewed: 71 (15 ULg)
Glucose Control in the ICU: A Continuing Story.
; ; et al
in Journal of diabetes science and technology (2016)
In the present era of near-continuous glucose monitoring (CGM) and automated therapeutic closed-loop systems, measures of accuracy and of quality of glucose control need to be standardized for licensing ... [more ▼]
In the present era of near-continuous glucose monitoring (CGM) and automated therapeutic closed-loop systems, measures of accuracy and of quality of glucose control need to be standardized for licensing authorities and to enable comparisons across studies and devices. Adequately powered, good quality, randomized, controlled studies are needed to assess the impact of different CGM devices on the quality of glucose control, workload, and costs. The additional effects of continuing glucose control on the general floor after the ICU stay also need to be investigated. Current algorithms need to be adapted and validated for CGM, including effects on glucose variability and workload. Improved collaboration within the industry needs to be encouraged because no single company produces all the necessary components for an automated closed-loop system. Combining glucose measurement with measurement of other variables in 1 sensor may help make this approach more financially viable. [less ▲]Detailed reference viewed: 21 (0 ULg)
Glucose control: How tight? - How modeling could help?
Desaive, Thomas ;
Conference (2012)Detailed reference viewed: 4 (0 ULg)
Glucose decreases virulence gene expression of Escherichia coli O157:H7
Delcenserie, Véronique ; ; et al
in Journal of Food Protection (2012)Detailed reference viewed: 28 (5 ULg)
Glucose handling, diabetes and ageing.
; Scheen, André ; Lefebvre, Pierre
in Hormone Research (1995), 43(1-3), 52-7
The relationship between ageing and glucose homeostasis is still an open debate. In fact, the mechanisms by which glucose metabolism is progressively impaired with increasing age are not completely ... [more ▼]
The relationship between ageing and glucose homeostasis is still an open debate. In fact, the mechanisms by which glucose metabolism is progressively impaired with increasing age are not completely understood. In the present report we have reviewed the possible mechanisms (impaired insulin secretion and action, role of the environmental factors) which may lead to the impairment in glucose handling associated with ageing. We also point out that not all aged subjects are glucose intolerant; in fact, it has been suggested that only those aged subjects who present more than one pathological finding do in fact develop impaired glucose handling. [less ▲]Detailed reference viewed: 16 (1 ULg)
Glucose hypometabolism in Alzheimer's disease is not related to loss of cortical interneurons bearing 5HT2 receptors.
Salmon, Eric ; Lemaire, Christian ; Degueldre, Christian et al
in Acta Neurologica Belgica (1995), 95Detailed reference viewed: 18 (3 ULg)
Glucose inhibits human placental GH secretion, in vitro
; ; Igout, Ahmed et al
in Journal of Clinical Endocrinology and Metabolism (1995), 80(5), 1743-6
Human placenta specifically expresses the GH-V gene leading to the production of placental Growth Hormone (PGH). During pregnancy, PGH levels increase progressively in maternal blood, but its regulation ... [more ▼]
Human placenta specifically expresses the GH-V gene leading to the production of placental Growth Hormone (PGH). During pregnancy, PGH levels increase progressively in maternal blood, but its regulation remains unknown. In this study the effect of glucose on PGH secretion by human term placenta was tested, in vitro, by means of two different experimental models: organ culture of villous tissue and primary culture of isolated cytotrophoblasts. PGH was assayed in the culture medium by an immunoradiometric assay using a specific PGH monoclonal antibody. The presence of glucose (25 mmol/L) in the culture medium significantly inhibited (p < 0.001) the secretion of PGH by either placental villous explants or by cultured trophoblast cells. This inhibitory effect of glucose on PGH secretion was dose-dependent. More than 50% inhibition being observed with 5.5 mmol/L. In the same conditions, the daily production of hPL and hCG, were unmodified. Furthermore, the glucose-induced inhibition of PGH secretion was more effective when cultured trophoblast cells are differentiated into syncytiotrophoblast. This study demonstrates, for the first time, that among the gestational polypeptide hormones secreted by the human placenta, only PGH secretion is modulated by glucose, suggesting a key metabolic role for this hormone during pregnancy. [less ▲]Detailed reference viewed: 26 (2 ULg)
Glucose metabolism and invertase production in yeast : utilization of indirects gateways to control physiological conditions of growth
; ; et al
Poster (1986, March)Detailed reference viewed: 17 (0 ULg)
Glucose metabolism and the postprandial state.
Lefebvre, Pierre ; Scheen, André
in European Journal of Clinical Investigation (1999), 29 Suppl 2
Disturbances of postprandial glucose metabolism are now thought to contribute to cardiovascular disease. Postprandial glucose excursions can be affected by a number of factors, such as the types of ... [more ▼]
Disturbances of postprandial glucose metabolism are now thought to contribute to cardiovascular disease. Postprandial glucose excursions can be affected by a number of factors, such as the types of carbohydrates ingested and the way they are metabolized. In Type 2 diabetes, factors that contribute to excessive postprandial glucose excursions include disruption of insulin secretion, insufficient inhibition of hepatic glucose production and defective glucose storage in muscle. A number of measures may attenuate excessive postprandial blood glucose excursions. These include a diet high in 'low glycaemic index' foods and treatment with drugs that improve or restore the hormonal response (e.g. the sulphonylureas and the newer beta-cell mediated insulinotropic drugs such as repaglinide), that improve insulin sensitivity or that delay gastric emptying. [less ▲]Detailed reference viewed: 25 (0 ULg)
Glucose metabolism during bovine preimplantation development: analysis of gene expression in single oocytes and embryos.
Lequarré, Anne-Sophie ; ; et al
in Molecular Reproduction and Development (1997), 48(2), 216-26
Glucose metabolism of the bovine embryo is low during the first cleavages and increases sharply after the major resumption of the genome (8-16 cells). The mRNA level for genes involved in glucose ... [more ▼]
Glucose metabolism of the bovine embryo is low during the first cleavages and increases sharply after the major resumption of the genome (8-16 cells). The mRNA level for genes involved in glucose metabolism was tested by RT-PCR on individual oocytes and embryos at different stages of development. These genes were: glucose transport GLUT-1, hexokinase (HK), glucose-6-phosphatase-dehydrogenase (G6PDH), and glucose-phosphate-isomerase (GPI); actin was used as a reference transcript. RT-PCR results revealed three types of oocytes or embryos: positive with a PCR signal for each transcript considered, nul with no signal for any transcript, and heterogeneous with a PCR signal for some transcripts and none for others. The number of nul and heterogeneous samples was higher for slow than for fast-cleaving embryos (81% vs. 36%), and the proportion of positive embryos increased significantly at the 16-cell and morula stages (P < 0.002), suggesting a correlation between mRNA content and developmental capacity. In positive embryos, GLUT-1 level was reduced by half during maturation and fertilization. Actin and hexokinase mRNA levels decreased during the first cleavages, but significantly increased at the 16-cell and morula stages, respectively. GPI transcript remained stable throughout development, whereas there was a significant rise for G6PDH at the 4-cell stage, perhaps due to a polyadenylation process. Finally, the absence or decrease in intensity of several transcripts at the blastocyst stage suggests suboptimal culture conditions. [less ▲]Detailed reference viewed: 190 (6 ULg)
Glucose metabolism in obese subjects: lessons from OGTT, IVGTT and clamp studies.
Scheen, André ; Paquot, Nicolas ; Letiexhe, Michel et al
in International Journal of Obesity & Related Metabolic Disorders (1995), 19 Suppl 3
Impaired glucose tolerance and overt diabetes are more frequent in presence than in absence of obesity. In obese subjects, glucose tolerance can be maintained within the normal range by compensating for ... [more ▼]
Impaired glucose tolerance and overt diabetes are more frequent in presence than in absence of obesity. In obese subjects, glucose tolerance can be maintained within the normal range by compensating for insulin resistance by peripheral hyperinsulinism, the latter resulting from both increased insulin secretion and reduced insulin clearance. Impaired glucose tolerance is observed when insulin resistance is associated to impaired first-phase insulin response, which results in a significant increase in plasma glucose levels and a late insulin hyperresponsiveness. Both hyperinsulinaemia and hyperglycaemia are then able to overcome peripheral insulin resistance and impaired glucose disposal. When a more marked defect in insulin secretion is present, hyperglycaemia progresses, probably due to an additional participation of impaired suppression of hepatic glucose output. Overt diabetes then occurs with persistent post-absorptive hyperglycaemia. All these abnormalities can be reversed after a marked weight loss and recovery of ideal body weight, arguing for acquired rather than inherited metabolic defects in presence of morbid obesity. If a sufficient weight reduction can not be obtained, pharmacological approaches may be considered to improve insulin resistance of obese subjects, especially those with impaired glucose tolerance or overt diabetes. [less ▲]Detailed reference viewed: 46 (2 ULg)
Glucose metabolism in rheumatoid arthritis knee joints before and after anti-TNF-apha blockade : evaluation by PET with 18-FDG.
BECKERS, Catherine ; HUSTINX, Roland ; FOIDART-WILLEMS, Jacqueline et al
in IN PROCEEDINGS ANNUAL AMI MEETING 2001 (2001), P56Detailed reference viewed: 11 (0 ULg)
Glucose turnover in humans in the basal state and after intravenous glucose: a comparison of two models.
; ; et al
in American Journal of Physiology (1997), 273(2 Pt 1), 284-96
This study investigated the ability of two models to represent glucose kinetics in the basal steady state and during an intravenous glucose tolerance test (IVGTT). Six young nonobese male subjects were ... [more ▼]
This study investigated the ability of two models to represent glucose kinetics in the basal steady state and during an intravenous glucose tolerance test (IVGTT). Six young nonobese male subjects were studied after an overnight fast. Two bolus injections of [U-13C]glucose were given 150 min apart, the first without and the second together with concomitant injection of unlabeled glucose. [3-3H]glucose was constantly infused throughout the study and served to provide an independent means for evaluation of system responses. A linear time-invariant three-compartmental model and the two-compartment time-variant model proposed by Caumo and Cobelli were used to interpret measured time courses of [U-13C]glucose and to reconstruct endogenous glucose production and glucose removal. The ability of the two models to describe the glucose tracer time course was comparable. Simulation studies showed that the two-compartmental time-variant system better predicted measured [3-3H]glucose concentration profiles than did the three-compartmental time-invariant model. However, endogenous glucose production and the integral of excess glucose removal over basal during the IVGTT derived from the two models were almost identical. [less ▲]Detailed reference viewed: 15 (0 ULg)
Glucose use and lactate production by equine fresh semen in human and equine extender
Ponthier, Jérôme ; De Tullio, Pascal ; et al
in Reproduction in Domestic Animals (2014, September), 49(suppl 3), 13
This study shows that this human semen extender doesn’t support equine semen preservation. Sperm cells’ glucose consumption and lactate production seem to be negligible, as these parameters were not ... [more ▼]
This study shows that this human semen extender doesn’t support equine semen preservation. Sperm cells’ glucose consumption and lactate production seem to be negligible, as these parameters were not affected by sperm concentrations in our study. Our results suggest that spermatozoa are able to cleave complex carbohydrates as glucose concentration in INRA96 increased over time. [less ▲]Detailed reference viewed: 57 (16 ULg)
Glucose, alpha-amino nitrogen and amino acid exchange across the hindlimb in young bulls maintained at two growth rates
Hornick, Jean-Luc ; Van Eenaeme, Christian ; et al
in Canadian Journal of Animal Science (1996), 76(2), 193-202
The effect of growth rate and protein supplementation on muscle metabolism of eight bulls from the Belgian Blue breed, double-muscled type, was investigated by the arterio-venous difference technique. A ... [more ▼]
The effect of growth rate and protein supplementation on muscle metabolism of eight bulls from the Belgian Blue breed, double-muscled type, was investigated by the arterio-venous difference technique. A low growth (LG) group was maintained at a low growth rate over 36 d, and a rapid growth (RG) group for 28 d before receiving a fattening diet allowing for a rapid growth. At the end of the RG period the RG bulls received a supplement of protected soybean meal. Animals were fitted with an aortic ultrasonic blood flow probe and with catheters in the aorta and the vena cava. The blood flow in the hindlimbs of bulls varied greatly by time of the day but was higher in the RG group. The RG group had a higher arterio-venous difference (AVD) and uptake of alpha-amino nitrogen while AVD in essential amino acids was four times higher and uptake eight times higher. Significant higher AVD or uptake was observed in individual amino acids such as leucine, isoleucine and lysine. The supplementation with protected soybean meal had significant negative effect on the uptake of several amino acids. It was concluded that caution should be exercised when measuring punctually blood flow in muscle tissue, for example by dilution techniques. At high growth rate, the requirements for amino acids are larger than for glucose. Excess protein provides no additional benefit. [less ▲]Detailed reference viewed: 26 (0 ULg)
Glucose, amino acids and urea uptake by hind-limb in bulls offered different amounts of concentrate
Hornick, Jean-Luc ; Clinquart, Antoine ; Van Eenaeme, Christian et al
in Animal Production (1994), 58Detailed reference viewed: 5 (1 ULg)
Glucose, insulin and myocardial ischaemia
; ; et al
in Current Opinion in Clinical Nutrition & Metabolic Care (2006), 9(2), 131-139
Purpose of review The importance of glucose metabolism and insulin therapy during myocardial ischaemia is increasingly being investigated. Insulin is used to achieve a tight glucose control or as part of ... [more ▼]
Purpose of review The importance of glucose metabolism and insulin therapy during myocardial ischaemia is increasingly being investigated. Insulin is used to achieve a tight glucose control or as part of glucose-insulin-potassium therapy. We have reviewed (1) the physiological and physiopathological consequences of hyperglycaemia focusing on potential machanisms of myocardial ischaemia, (2) the effects of insulin on vascular tone, on the release of free fatty acids, on inflammatory pathways, on the switch of energy source and on apoptosis, and (3) clinical data reporting the effects of intensive insulin therapy and glucose-insulin-potassium solutions during myocardial ischaemia and ischaemic heart failure. Recent findings In addition to its known toxic cellular effects, hyperglycaemia increases the activity of inducible nitric oxide synthase and promotes inflammation. Conversely insulin exerts anti-inflammatory and anti-apoptotic effects. Glucose-insulin-potassium solutions could improve survival after acute myocardial infarction or after surgery, according to recent meta-analyses, but confirmation of these data is eagerly awaited. Summary Hyperglycaemia is toxic, while insulin is beneficial during acute myocardial ischaemia. Some recent evidence confirms a substantial benefit of insulin administered either alone to achieve a tight glucose control or as a component of glucose-insulin-potassium therapy. Further research is needed to confirm that tendency and to define the threshold of tight glucose control. [less ▲]Detailed reference viewed: 9 (1 ULg)