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See detailThe impact of HAART initiation on the selection and persistence of HIV-1 CTL-escape mutations
Dilernia, D.A.; Monaco, D.C.; Jones, L.R. et al

in AIDS Research and Human Retroviruses (2010, October), 26(10), 72

The impact of HAART initiation on the selection and persistence of HIV-1 CTL-escape mutations D.A. Dilernia,1 D.C. Monaco,1 L.R. Jones,2 G.D. Damilano,1 S. Rodriguez,3 H. Salomon1 1Argentinean Reference ... [more ▼]

The impact of HAART initiation on the selection and persistence of HIV-1 CTL-escape mutations D.A. Dilernia,1 D.C. Monaco,1 L.R. Jones,2 G.D. Damilano,1 S. Rodriguez,3 H. Salomon1 1Argentinean Reference Center for AIDS, Capital Federal, Argentina; 2División de Biología Molecular, Estación de Fotobiología, Playa Unión, Rawson, Chubut, Argentina; 3INTA, Castelar, Buenos Aires, Argentina Background: Immune response drives the selection of CTL escape mutations during the course of HIV infection. After initiation of HAART, antiviral drugs exert a strong selective force leading to an important limitation of viral replication. Our objective was to evaluate the impact of HAART initiation on the selection and persistence of CTL-escape mutations. Methods: Blood samples were collected from 113 newly HIV diagnosed individuals. A second sample was collected from 49 of them after 3 years. (12 of which were still drug-naı¨ve in the second sample). Dynamics of CTL-escape mutations identified in the gag gene by statistical analysis of HLA genes and viral sequences, including multiple comparison corrections (BH method) and phylogeny correction (Bayesian MCM method), were analyzed. Epitope-specific immune response was evaluated by ELISPOT against sequence-based designed peptides. Results: Immune response was evaluated on 113 individuals on an HLA-allele basis. Positive responses were detected against 6 of the 9 epitopes containing HLA-associated CTL-escape mutations.A03-restricted epitope RLRPGGKKK had the highest frequency of detection in allele-matched individuals (75%). Epitopes harboring the CTL-escape mutations identified through negative associations (i.e. escape is consensus) had lower frequency of detection: A02-restricted SLYNTVATL(25%) and A24-resctricted KYKLKHIVW(0%). Epitope sequences analysis over the second sample of 21 patients successfully sequenced showed that 38% of them did not have evidence of escape neither in the first sample nor in the second, 44% had the escape mutations in both samples and in 18%the escape mutations appeared in the second sample. Of the 7 individuals containing the epitopes of the last group, only 2 had initiated HAART (28.6%) while 64.3% (9/14) of individuals where no escape emerged, had initiated HAART. Conclusion: Accumulation of CTL-escape mutations at the population-level impaired recognition by individuals studied while initiation of HAART may prevent the selection of new escape mutations even in advanced stages of infection. [less ▲]

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See detailImpact of Harmonia axyridis (Coleoptera: Coccinellidae) on the survival rates of other aphidophagous species in semi-field conditions
Vandereycken, Axel ULg; Durieux, Delphine ULg; Joie, Emilie ULg et al

in Communications in Agricultural and Applied Biological Sciences (2011, May 24), 76(2), 219-226

The multicoloured Asian ladybird Harmonia axyridis Pallas (Coleoptera: Coccinellidae), previously introduced as a biological control agent against aphids, is now frequently considered as an intraguild ... [more ▼]

The multicoloured Asian ladybird Harmonia axyridis Pallas (Coleoptera: Coccinellidae), previously introduced as a biological control agent against aphids, is now frequently considered as an intraguild predator, consuming other aphid natural enemies. Interactions between this exotic ladybird and other aphidophagous species present in Belgian agro-ecosystems such as Coccinella septempunctata, Episyrphus balteatus and Chrysoperla carnea are asymmetric to the benefit of H. axyridis. This study focuses on the survival rate of three aphidophagous species Harmonia axyridis (Ha), Coccinella septempunctata (C7) and Episyrphus balteatus (Eb) placed in cages in biological fields of potato and sugar beet. During June and July, hermetic cages were disposed on the crops with 10 larvae (second stage) of each aphidophagous. Four types of cages were observed (1) Ha+Eb+C7+ aphids, (2) Ha+Eb+C7, (3) Eb+C7+ aphids and (4) Eb+C7. Each combination was repeated three times. In sugar beet fields, E. balteatus was the species with the highest mortality rate. The two coccinellid species had a better survival rate than E. balteatus. All aphidophagous species had higher mortality rates in absence of aphids. In potato, when aphids were present in excess, the survival rates of all aphidophagous insects were lower than in sugar beet probably because A. fabae is less adapted to the potato morphology. Nevertheless, we have observed in potato no mortality of C. 7-punctata during all its development cycle. This suggests that (1) C. 7-punctata may use aphids as food sources more efficiently than H. axyridis and (2) that interactions between aphidophagous could be less frequent (difficulty of mobility). In potato and sugar beet, H. axyridis had the longest development cycle, being still at the larval stage when C. 7-punctata and E. balteatus reached the pupae stage. We can suppose that pupae of E. balteatus and C. 7-punctata were an alternative food (intraguild prey) to H. axyridis when aphids were lacking. Pupae are immobile and therefore more sensitive to the attack of predators. [less ▲]

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See detailImpact of health professionals utilization induced by musculoskeletal disorders among active subjects
Rabenda, Véronique ULg; Manette, Christelle; Lemmens, Régine et al

in Osteoporosis International (2005, March), 16(Suppl.3), 110

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See detailImpact of Heat Stress on Production in Holstein Cattle in four EU Regions. Selection Tools
Carabaño, Maria-Jesus; Hammami, Hedi ULg; Logar, Betka et al

Conference (2014)

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See detailImpact of Heat Stress on Production in Holstein Cattle in four EU Regions. Selection Tools
Carabaño, Maria-Jesus; Hammami, Hedi ULg; Logar, Betka et al

Scientific conference (2014)

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See detailIMPACT OF HEAVY METALS ON PHYSIOLOGICAL AND PROTEOMIC RESPONSES OF WILLOWS (SALIX SP.)
Evlard, Aricia ULg; Sergeant, Kjell; Ferrandis, Salvador et al

Poster (2012)

In 2010, around 3,800 sites in Wallonia (Belgium) were identified as potentially contaminated by heavy metals, a result of their past industrial and agricultural activities [1]. The technique of using ... [more ▼]

In 2010, around 3,800 sites in Wallonia (Belgium) were identified as potentially contaminated by heavy metals, a result of their past industrial and agricultural activities [1]. The technique of using plants to remediate contaminated sites (phytoremediation) has been studied for over twenty years. In particular, the use of trees (alder, willow, poplar) has been considered because of their large biomass production [2] [3] [4] [5]. The aim of this study was to identify the potential of local willow ecotypes to grow in the presence of heavy metals using lysimeters filled with dredging sludge. Several willow ecotypes were compared realizing morphological and physiological measurements (chlorophyll fluorescence, electrolyte leakage, carbohydrate content). The plant responses to metal stress were also investigated using a proteomic approach. Heavy metals contents in leaves and stems were analysed. With this study, the potential of these trees to valorise contaminated, abandoned sites in Belgium was evaluated. [1] Cellule Etat de l'environnement wallon (2010). Tableau de bord de l'environnement wallon. SPW-DGARNE-DEMNA-DEE. [2] Dickinson N. M. (2000). Strategies for sustainable woodland on contaminated soils. Chemosphere 41(1-2): 259-263. [3] Meers E., Lamsal S., Vervaeke P., Hopgood M., Lust N. and Tack F. M. G. (2005). Availability of heavy metals for uptake by Salix viminalis on a moderately contaminated dredged sediment disposal site. Environ Pollut 137(2): 354-364. [4] Meers E., Vandecasteele B., Ruttens A., Vangronsveld J. and Tack F. M. G. (2007). Potential of five willow species (Salix spp.) for phytoextraction of heavy metals. Environ Exp Bot 60(1): 57-68. [5] Rosselli W., Keller C. and Boschi K. (2003). Phytoextraction capacity of trees growing on a metal contaminated soil. Plant Soil 256(2): 265-272. [less ▲]

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See detailImpact of helium diffusion and helium-flash-induced carbon production on gravity-mode pulsations in subdwarf B stars
Hu, Haili; Nelemans, G.; Aerts, C. et al

in Astronomy and Astrophysics (2009), 508

Context: Realistic stellar models are essential to the forward modelling approach in asteroseismology. For practicality however, certain model assumptions are also required. For example, in the case of ... [more ▼]

Context: Realistic stellar models are essential to the forward modelling approach in asteroseismology. For practicality however, certain model assumptions are also required. For example, in the case of subdwarf B stars, one usually starts with zero-age horizontal branch structures without following the progenitor evolution. <BR /> Aims: We analyse the effects of common assumptions in subdwarf B models on the g-mode pulsational properties. We investigate if and how the pulsation periods are affected by the H-profile in the core-envelope transition zone. Furthermore, the effects of C-production and convective mixing during the core helium flash are evaluated. Finally, we reanalyse the effects of stellar opacities on the mode excitation in subdwarf B stars.<BR /> Methods: We computed detailed stellar evolutionary models of subdwarf B stars, and their non-adiabatic pulsational properties. Atomic diffusion of H and He is included consistently during the evolution calculations. The number fractions of Fe and Ni are gradually increased by up to a factor of 10 around log T = 5.3. This is necessary for mode excitation and to approximate the resulting effects of radiative levitation. We performed a pulsational stability analysis on a grid of subdwarf B models constructed with OPAL and OP opacities.<BR /> Results: We find that helium settling causes a shift in the theoretical blue edge of the g-mode instability domain to higher effective temperatures. This results in a closer match to the observed instability strip of long-period sdB pulsators, particularly for l â ¤ 3 modes. We show further that the g-mode spectrum is extremely sensitive to the H-profile in the core-envelope transition zone. If atomic diffusion is efficient, details of the initial shape of the profile become less important in the course of evolution. Diffusion broadens the chemical gradients, and results in less effective mode trapping and different pulsation periods. Furthermore, we report on the possible consequences of the He-flash for the g-modes. The outer edge of a flash-induced convective region introduces an additional chemical transition in the stellar models, and the corresponding spike in the Brünt-Väisälä frequency produces a complicated mode trapping signature in the period spacings. <BR /> [less ▲]

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See detailImpact of hemodynamic load on exercise capacity in aortic stenosis
Dulgheru, Raluca Elena ULg; Magne, Julien ULg; Capoulade, R et al

in International Journal of Cardiology (2013)

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See detailImpact of heterogeneity on estimation of infectious disease parameters
Cattaert, Tom ULg

Master's dissertation (2008)

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See detailThe Impact of Higher Order Differentiability and Auxiliary Slave Nodes in Two-dimensional Contact Elements
Nguyen, Duc Tue ULg; Gaston, Rauchs; Jean Philippe, Ponthot

Scientific conference (2011, November 14)

The aim of this work is to propose new contact elements of higher order of differentiability for analysing twodimensional frictionless contact problems. Several methods were proposed in the literature to ... [more ▼]

The aim of this work is to propose new contact elements of higher order of differentiability for analysing twodimensional frictionless contact problems. Several methods were proposed in the literature to solve the problem caused by the lack of continuity resulting from the discretization. Among them are Bézier interpolation, Hermitian interpolation and splines. One of the difficulties in using Hermitian interpolation is to verify the partition of unity. Therefore, new elements that satisfy the C1 and C2 continuity at the interface are presented in this paper. These new contact elements are based on Hermitian polynomials for ensuring a higher order of continuity. The advantage is that this approach can be easily developed not only for linear elements but also for quadratic elements with higher order of differentiability. The performance of different surface representations is assessed through a comparison with a C0 surface discretization. Some numerical examples are used for assessing the accuracy and the convergence behaviour. [less ▲]

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See detailImpact of hydroelectric power releases on the morphology and the sedimentology of the bed of the Warche River (Belgium).
Assani, A. A.; Petit, François ULg

in Earth Surface Processes & Landforms (2004)

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See detailThe Impact of Illiquidity and Higher Moments of Hedge Fund Returns on Their Risk-Adjusted Performance and Diversification Potential
Cavenaile, Laurent ULg; Coen, Alain; Hübner, Georges ULg

in Journal of Alternative Investments (2011), 13(4),

This paper studies the joint impact of smoothing and fat tails on the risk-return properties of hedge fund strategies. First, we adjust risk and performance measures for illiquidity and the non-Gaussian ... [more ▼]

This paper studies the joint impact of smoothing and fat tails on the risk-return properties of hedge fund strategies. First, we adjust risk and performance measures for illiquidity and the non-Gaussian distribution of hedge funds returns. We use two risk metrics: the Modified Value-at-Risk and a preference-based measure retrieved from the linear-exponential utility function. Second, we revisit the hedge fund diversification effect with these adjustments for illiquidity. Our results report similar fund performance rankings and optimal hedge fund strategy allocations for both adjusted metrics. We also show that the benefits of hedge funds in portfolio diversification are still persistent but tend to weaken after the adjustment for illiquidity. [less ▲]

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See detailImpact of Imatinib on immune function in vitro
Pirson, Laurence ULg; Baron, Frédéric ULg; Gothot, André ULg et al

Poster (2006)

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See detailImpact of implant geometry and loading on early bone formation, Clinical Oral Implants Research
Vandamme, Katleen; Naert, Ignace; Geris, Liesbet ULg et al

in Clinical Oral Implants Research (2007), 18(5), 71-72

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See detailImpact of in vivo T-cell depletion on outcome of AML patients in first CR given peripheral blood stem cells and reduced-intensity conditioning all-SCT from a HLA-identical sibling donor : a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation
Baron, Frédéric ULg; Labopin, M.; Blaise, D. et al

in Bone Marrow Transplantation (2014)

The impact of in vivo T-cell depletion on transplantation outcomes in patients transplanted with reduced-intensity conditioning (RIC) remains controversial. This study assessed the outcome of 1250 adult ... [more ▼]

The impact of in vivo T-cell depletion on transplantation outcomes in patients transplanted with reduced-intensity conditioning (RIC) remains controversial. This study assessed the outcome of 1250 adult patients with de novo AML in first CR (CR1) given PBSC from HLA-identical siblings after chemotherapy-based RIC. A total of 554 patients did not receive any form of in vivo T-cell depletion (control group), whereas antithymocyte globulin (ATG) and alemtuzumab were given in 444 and 252 patients, respectively. The incidences of grade II-IV acute GVHD were 21.4, 17.6 and 10.2% in control, ATG and alemtuzumab patients, respectively (Po0.001). In multivariate analysis, the use of ATG and the use of alemtuzumab were each associated with a lower risk of chronic GVHD (Po0.001 each), but a similar risk of relapse, and of nonrelapse mortality, and similar leukemia-free survival and OS. Further, among patients given BU-based RIC, the use of o6 mg/kg ATG did not increase the risk of relapse (hazard ratio, HR¼1.1), whereas there was a suggestion for higher relapse risk in patients given X6 mg/kg ATG (HR¼1.4, P¼0.08). In summary, these data suggest that a certain amount of in vivo T-cell depletion can be safely used in the conditioning of AML patients in CR1 given PBSC after chemotherapy-based RIC. [less ▲]

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See detailThe impact of industrialization upon rural – urban relations in Vietnam
Nguyen Thi, Dien; Lebailly, Philippe ULg; Vu Dinh, Ton

Scientific conference (2013)

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See detailThe impact of infliximab therapy on colonic mucosal expression of barrier genes in patients with inflammatory bowel disease
Arijs, I.; Quintens, R.; Van Lommel, L. et al

in Gastroenterology (2009), 136

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See detailThe impact of infliximab therapy on colonic mucosal expression of barrier genes in patients with inflammatory bowel disease.
Arijs, I.; Quintens, R.; Van Lommel, L. et al

in Acta Gastro-Enterologica Belgica (2009)

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