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See detailGliomatose méningée cérébro-spinale diffuse chez un enfant traité par hormone de croissance dans le cadre d!un syndrome de Turner
Dacier, Ph; Leroy, P.; Ernould, Ch et al

in Société Belge de Neurologie Pédiatrique (1995)

Detailed reference viewed: 76 (2 ULg)
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See detailGliomatosis Cerebri: Clinical, Radiological and Pathological Report of a Case with a Stroke-Like Onset
Schoenen, Jean ULg; de Leval, L.; Reznik, M.

in Acta Neurologica Belgica (1996), 96(4), 294-300

A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and ... [more ▼]

A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and both CT scan and MRI irregular white matter lesion suggesting a leucoencephalopathy. His neurological deficit regressed, and he was discharged after 2 weeks. He was readmitted 6 months later because of mental confusion. MRI revealed diffuse white matter lesions extending up to the frontal lobes, these were hyperintense on T2 weighted images and suggested the diagnosis of gliomatosis cerebri (GC). The patient became progressively comatose and died 6 weeks later. At autopsy the brain looked diffusely swollen with irregular greyish areas of the white matter of both centrum ovale and brain stem. On microscopic examination the cerebrum and brain stem were diffusely and asymmetrically infiltrated by numerous neoplastic glial cells without angiogenesis or disruption of architectonic boundaries. There were no mitoses nor necrosis. Many tumour cells were GFAP- and S100-positive. A high proportion of cells contained the leucocyte antigen Leu-7. This case of gliomatosis cerebri is compared to the 9 published cases of GC with an initial focal neurological deficit and to the 19 publications reporting MRI results. The controversial nosological boundaries and etiopathogenetic hypotheses of this peculiar neoplastic disease are discussed. [less ▲]

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See detailGlipizide increases plasma insulin but not C-peptide level after a standardized breakfast in type 2 diabetic patients.
Scheen, André ULg; Lefebvre, Pierre ULg; Luyckx, A. S.

in European Journal of Clinical Pharmacology (1984), 26(4), 471-4

Peripheral blood glucose, plasma insulin and C-peptide levels were investigated after giving a standardized breakfast (500 kcal, 60 g carbohydrates) to 10 nonobese Type 2 diabetic patients previously ... [more ▼]

Peripheral blood glucose, plasma insulin and C-peptide levels were investigated after giving a standardized breakfast (500 kcal, 60 g carbohydrates) to 10 nonobese Type 2 diabetic patients previously treated by diet alone. Each patient received at random, at 1 week intervals, either 5 mg glipizide (meal + glipizide) or a placebo (meal alone) 30 min before breakfast. Basal values of blood glucose, plasma insulin and C-peptide were similar on both occasions. After meal + glipizide, the blood glucose increase was sharply limited whereas the rise in plasma insulin was steeper and reached twice as high a level. In contrast, the rise in plasma C-peptide was similar in both conditions. Consequently, the areas under the curves (0-300 min) showed a marked reduction in blood glucose after meal + glipizide (2289 +/- 149 versus 3101 +/- 169 mmol X min/1; 2p less than 0.001), associated with a significant increase in plasma insulin (14219 +/- 3261 versus 7591 +/- 1173 microU X min/ml; 2p less than 0.025) but no significant change in plasma C-peptide (342 +/- 45 versus 326 +/- 34 pmol X min/ml; N.S.). The insulin/C-peptide molar ratio was thus significantly increased after meal + glipizide (0.41 +/- 0.06 versus 0.23 +/- 0.04 at the 60th min; 2p less than 0.02). The dissociation between the responses of insulin and C-peptide suggests that a single dose of 5 mg glipizide in Type 2 diabetic subjects may enhance availability of peripheral insulin by extrapancreatic mechanism(s). This phenomenon may result in a higher circulating level of the hormone and therefore represent a further mode of action of sulphonylureas.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailGliptin versus a sulphonylurea as add-on to metformin.
SCHEEN, André ULg; Paquot, Nicolas ULg

in Lancet (2012), 380

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See detailGliptines, securite cardio-vasculaire et insuffisance cardiaque: le point apres l'etude TECOS.
Scheen, Andre ULg

in Revue medicale suisse (2015), 11(483), 1526-31

The cardiovascular safety of dipeptidyl peptidase-4 inhibitors (gliptins) has been well studied. Favourable effects of these oral antidiabetic agents have been reported in meta-analyses of phase II-III ... [more ▼]

The cardiovascular safety of dipeptidyl peptidase-4 inhibitors (gliptins) has been well studied. Favourable effects of these oral antidiabetic agents have been reported in meta-analyses of phase II-III randomised controlled trials. Three large prospective trials, which were specifically designed to investigate cardiovascular safety, showed non-inferiority of saxagliptin (SAVOR-TIMI 53), alogliptin (EXA-MINE) and sitagliptin (TECOS) versus placebo as far as major cardiovascular events are concerned, including mortality. The suspected increase in the rate of hospitalisation due to congestive heart failure reported in SAVOR-TIMI 53 was neither found in EXAMINE nor recently confirmed in TECOS. Direct comparative trials, evaluating not only safety but also efficacy, with other oral antidiabetic medications would be of major interest. [less ▲]

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See detailLes gliptines, une nouvelle mode?
SCHEEN, André ULg

in Revue du Praticien (La) (2013), 63(3), 304-5

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See detailGliptins (dipeptidyl peptidase-4 inhibitors) and risk of acute pancreatitis.
SCHEEN, André ULg

in Expert Opinion on Drug Safety (2013), 12(4), 545-57

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) play an increasing role in the management of type 2 diabetes. Such incretin-based therapies offer some advantages over other glucose ... [more ▼]

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) play an increasing role in the management of type 2 diabetes. Such incretin-based therapies offer some advantages over other glucose-lowering agents, but might be associated with an increased risk of acute pancreatitis. Areas covered: An extensive literature search was performed to analyze clinical cases of acute pancreatitis reported in the literature or to the Food and Drug Administration (FDA), in randomized clinical trials, and in observational studies with five DPP-4 inhibitors: sitagliptin, vildagliptin, saxagliptin, alogliptin, and linagliptin. Expert opinion: An increased risk of pancreatitis has been reported in diabetic versus nondiabetic patients. Several anecdotal clinical cases of pancreatitis have been reported with sitagliptin and vildagliptin and an increased relative risk reported to the FDA with sitagliptin versus other comparators, but reporting bias cannot be excluded. In rather short-term clinical trials with well-selected diabetic patients, no increased risk of acute pancreatitis has been observed with any of the five commercialized DPP-4 inhibitors: sitagliptin, vildagliptin, saxagliptin, alogliptin, and linagliptin. Similarly, real-life cohort studies showed no increased incidence of pancreatitis with gliptins compared with other glucose-lowering agents, a finding recently challenged by a case- control study. These results must be confirmed in postmarketing surveillance programs and in ongoing large prospective trials with cardiovascular outcomes. [less ▲]

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See detailGlissement progressif de l’analyse et de la gestion des risques des autorités publiques aux opérateurs industriels
Brunet, Sébastien ULg; Michel, Quentin ULg

in Revue de la Faculté de Droit de l'Université de Liège (2006), 2006/1-2

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See detailGlitazones et insuffisance cardiaque: resultats des etudes PROactive, ADOPT, DREAM et RECORD.
De Flines, Jenny ULg; Scheen, André ULg

in Revue Médicale Suisse (2007), 3(122), 18761878-83

Thiazolidinediones (TZDs) are used as insulin sensitizers in the treatment of type 2 diabetes, but are associated with an increased risk of congestive heart failure (CHF). The odds ratio of ICC was 1.43 ... [more ▼]

Thiazolidinediones (TZDs) are used as insulin sensitizers in the treatment of type 2 diabetes, but are associated with an increased risk of congestive heart failure (CHF). The odds ratio of ICC was 1.43 (pioglitazone vs placebo) in diabetic patients with high cardiovascular risk in the PROactive trial while it averaged 1.22 (rosiglitazone vs metformin) and 2.20 (rosiglitazone vs metformin) in the ADOPT study. In the interim analysis of the ongoing RECORD trial, the odds ratio averaged 2.15 (rosiglitazone vs metformin or sulfonylureas). In four real life registries, the relative risk of CHF with TZDs varied between 1.06 and 1.76 (between 1.10 and 1.44 combined with insulin) as compared to a treatment without TZDs. Such higher CHF risk should be appreciated according to the potential benefits of glitazones in the management of type 2 diabetes. [less ▲]

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See detailGlnR-mediated regulation of nitrogen metabolism in the actinomycete Saccharopolyspora erythraea
Li-Li, Yao; Cheng-Heng, Liao; Gang, Huang et al

in Applied Microbiology and Biotechnology (2014)

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See detailGLO-Roots: an imaging platform enabling multidimensional characterization of soil-grown root systems
Rellán-Álvarez, Rubén; Lobet, Guillaume ULg; Lindner, Heike et al

in eLife (2015)

Root systems develop different root types that individually sense cues from their local environment and integrate this information with systemic signals. This complex multi-dimensional amalgam of inputs ... [more ▼]

Root systems develop different root types that individually sense cues from their local environment and integrate this information with systemic signals. This complex multi-dimensional amalgam of inputs enables continuous adjustment of root growth rates, direction and metabolic activity that define a dynamic physical network. Current methods for analyzing root biology balance physiological relevance with imaging capability. To bridge this divide, we developed an integrated imaging system called Growth and Luminescence Observatory for Roots (GLO-Roots) that uses luminescence-based reporters to enable studies of root architecture and gene expression patterns in soil-grown, light-shielded roots. We have developed image analysis algorithms that allow the spatial integration of soil properties, gene expression and root system architecture traits. We propose GLO-Roots as a system that has great utility in presenting environmental stimuli to roots in ways that evoke natural adaptive responses and in providing tools for studying the multi-dimensional nature of such processes.Author keywordsResearch organism [less ▲]

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See detailGlobal adaptive stabilization of cascade nonlinear systems
Jankovic, M.; Sepulchre, Rodolphe ULg; Kokotovic, Petar V.

in Automatica (1997), 33(2), 263-368

An adaptive controller is developed for a class of nonlinear systems for which other approaches (e.g. backstepping) may fail to be applicable. The new design employs feedback passivation and an explicit ... [more ▼]

An adaptive controller is developed for a class of nonlinear systems for which other approaches (e.g. backstepping) may fail to be applicable. The new design employs feedback passivation and an explicit construction of a Lyapunov function for the zero dynamics with respect to a relative degree 1 output. As an illustration a longstanding "nonlinear benchmark problem" is solved. [less ▲]

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See detailGlobal agricultural monitoring systems by integration of earth observation and modelling techniques (globam project).
Defourny, Pierre; Bériaux, Emilie; Tychon, Bernard ULg et al

Conference (2008, February 12)

Nowadays, food security and crop production variability become a major concern. Moreover, in spite of major technological and methodological EO improvements observed since the late 1990’s, very little ... [more ▼]

Nowadays, food security and crop production variability become a major concern. Moreover, in spite of major technological and methodological EO improvements observed since the late 1990’s, very little change has been observed in the operational systems. A major gap exists between the remote sensing operationally used and the current scientific state of the art in EO crop monitoring. There is a lack of relevant field data over large areas, and these data are very much needed to gain a better understanding of potential improvements of the operational systems. [less ▲]

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See detailGlobal analysis of a continuous-time flow whith computes time-optimal switchings
Grognard, F.; Sepulchre, Rodolphe ULg

in Proceedings of the 40th IEEE Conference on Decision and Control (2001, December)

The minimum-time bounded control of linear systems is generically bang-bang and the number of switchings does not exceed the dimension of the system if the eigenvalues of the system matrix are real. This ... [more ▼]

The minimum-time bounded control of linear systems is generically bang-bang and the number of switchings does not exceed the dimension of the system if the eigenvalues of the system matrix are real. This paper proposes a synthesis method for such problems based on dynamical systems that "compute" the optimal sequence of switching times. [less ▲]

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See detailGlobal analysis of a continuum model for monotone pulse-coupled oscillators
Mauroy, Alexandre ULg; Sepulchre, Rodolphe ULg

in IEEE Transactions on Automatic Control (2013), 58(5), 1154-1166

We consider a continuum of phase oscillators on the circle interacting through an impulsive instantaneous coupling. In contrast with previous studies on related pulse-coupledmodels, the stability results ... [more ▼]

We consider a continuum of phase oscillators on the circle interacting through an impulsive instantaneous coupling. In contrast with previous studies on related pulse-coupledmodels, the stability results obtained in the continuum limit are global. For the nonlinear transport equation governing the evolution of the oscillators, we propose (under technical assumptions) a global Lyapunov function which is induced by a total variation distance between quantile densities. The monotone time evolution of the Lyapunov function completely characterizes the dichotomic behavior of the oscillators: either the oscillators converge in finite time to a synchronous state or they asymptotically converge to an asynchronous state uniformly spread on the circle. The results of the present paper apply to popular phase oscillators models (e.g., the well-known leaky integrate-and-fire model) and show a strong parallel between the analysis of finite and infinite populations. In addition, they provide a novel approach for the (global) analysis of pulse-coupled oscillators. © 2012 IEEE. [less ▲]

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See detailGlobal Analysis of Firing Maps
Mauroy, Alexandre ULg; Hendrickx, Julien; Megretski, Alexandre et al

in Proceedings of the 19th International Symposium on Mathematical Theory of Networks and Systems (2010, July)

In this paper, we study the behavior of pulse-coupled integrate-and-fire oscillators. Each oscillator is characterized by a state evolving between two threshold values. As the state reaches the upper ... [more ▼]

In this paper, we study the behavior of pulse-coupled integrate-and-fire oscillators. Each oscillator is characterized by a state evolving between two threshold values. As the state reaches the upper threshold, it is reset to the lower threshold and emits a pulse which increments by a constant value the state of every other oscillator. The behavior of the system is described by the so-called firing map: depending on the stability of the firing map, an important dichotomy characterizes the behavior of the oscillators (synchronization or clustering). The firing map is the composition of a linear map with a scalar nonlinearity. After briefly discussing the case of the scalar firing map (corresponding to two oscillators), the stability analysis is extended to the general n-dimensional firing map (for n +1 oscillators). Different models are considered (leaky oscillators, quadratic oscillators,...), with a particular emphasis on the persistence of the dichotomy in higher dimensions. [less ▲]

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See detailGlobal analysis of gene expression in the skin of mice after a 92 days journey in microgravity.
Neutelings, Thibaut ULg; Liu, Y.; Cancedda, R et al

Conference (2012)

Detailed reference viewed: 9 (2 ULg)
See detailGlobal analysis of gene expression in the skin of mice after a 92 days journey in microgravity.
Neutelings, Thibaut ULg; Liu, Y.; Cancedda, R. et al

Poster (2012, May 04)

Detailed reference viewed: 18 (6 ULg)