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See detailFamilial aggregation and antimicrobial response dose-dependently affect the risk for Crohn's disease.
Joossens, Marie; Van Steen, Kristel ULiege; Branche, Julien et al

in Inflammatory Bowel Diseases (2010), 16(1), 58-67

BACKGROUND:: An increased risk of Crohn's disease (CD) has been reported consistently in first-degree relatives of patients. Our aim was to test whether a combination of CD-associated genes involved in ... [more ▼]

BACKGROUND:: An increased risk of Crohn's disease (CD) has been reported consistently in first-degree relatives of patients. Our aim was to test whether a combination of CD-associated genes involved in innate immunity and/or antibody responses to microbial antigens may be valuable in identifying healthy relatives at risk. METHODS:: We investigated 86 families from Belgium and northern France, 45 with at least 3 first-degree relatives with CD, 24 with a single case, and 17 control families without inflammatory bowel disease (IBD). The cohort consisted of 186 CD patients, 290 healthy relatives, and 142 controls (total 618). Genetic (NOD2, NOD1, TLR4, CARD8) and serologic markers (ASCA, ACMA, ALCA, ACCA, ASigmaMA, OmpC, CBir1, I2) were determined in all subjects. All Belgian families were prospectively followed up for 54 months. RESULTS:: In multiple-affected families, an increment of affected first-degree relatives and of positive antibodies were additive risks factors for CD (P < 0.0001), independent of NOD2 mutations. When comparing subjects from multiple-affected families, having 3 additional first-degree relatives with CD and 1 additional positive antibody increased the odds for CD to 9.19 (95% confidence interval [CI]: 4.07-20.80). After a follow-up of 54 months among all Belgian families, a total of 4 new diagnoses of IBD were confirmed in the multiple-affected families only, resulting in a 57-fold increase in incidence within multiple-affected families compared to the known incidence of IBD in our region. CONCLUSIONS:: We found an additive risk increment for CD in subjects from multicase families per additional affected relative and per additional positive antibody, independent of NOD2. Furthermore, a very high disease incidence was observed in these multiple-affected families. Inflamm Bowel Dis 2010. [less ▲]

Detailed reference viewed: 57 (3 ULiège)
See detailFamilial amyloidosis caused by lysozyme mutations
Dumoulin, Mireille ULiege

in Ramirez-Alvarado, M.; Kelly, J. W.; Dobson, C. (Eds.) Protein Misfolding Diseases: Basis of Protein Misfolding, Pathophysiology, Current, and Emerging Therapies (2010)

Detailed reference viewed: 29 (5 ULiège)
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See detailFamilial and Other Conversations: Special Issue on Caryl Phillips
Ledent, Bénédicte ULiege

in Moving Worlds : A Journal of Transcultural Writings (2007), 7(1), 123

Detailed reference viewed: 67 (8 ULiège)
See detailFamilial aspects in acromegaly
Verloes, Alain ULiege; Beckers, Albert ULiege; Pétrossians, E. et al

in 26th Annual meeting of European society of Human Genetics. Abstract book (1994)

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See detailFamilial basilar migraine associated with a new mutation in the ATP1A2 gene
Ambrosini, A.; D'Onofrio, M.; Grieco, G. S. et al

in Neurology (2005), 65(11), 1826-1828

Basilar migraine (BM), familial hemiplegic migraine (FHM), and sporadic hemiplegic migraine (SHM) are phenotypically similar subtypes of migraine with aura, differentiated only by motor symptoms, which ... [more ▼]

Basilar migraine (BM), familial hemiplegic migraine (FHM), and sporadic hemiplegic migraine (SHM) are phenotypically similar subtypes of migraine with aura, differentiated only by motor symptoms, which are absent in BM. Mutations in CACNA1A and ATP1A2 have been found in FHM. The authors detected a novel mutation in the ATP1A2 gene (R548H) in members of a family with BM, suggesting that BM and FHM may be allelic disorders. [less ▲]

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See detailFamilial colloid cyst of the third ventricle: neuroendocrinological follow-up and review of the literature.
Valdes Socin, Hernan Gonzalo ULiege; Born, J.; Wallemacq, Caroline et al

in Clinical Neurology & Neurosurgery (2002), 104(4), 367-370

Colloid cysts of the third ventricle are rare, benign cysts of endodermal origin. Between 1989 and 1999, eight patients with this lesion (five females, three males), with a mean age of 40.5 years (range ... [more ▼]

Colloid cysts of the third ventricle are rare, benign cysts of endodermal origin. Between 1989 and 1999, eight patients with this lesion (five females, three males), with a mean age of 40.5 years (range 20-54), were identified out of 1354 operated for tumours of the central nervous system. Among the eight, two were familial. They were half sisters 38 and 28 years-old, who were diagnosed to have colloid cysts of the third ventricle on CT scanning. Transcortical excision yielded 10 and 15 mm sized colloid cysts, respectively. Moreover, both sisters developed a multinodular goiter associated with these congenital tumours. The second sibling developed hyperprolactinemia associated with macroprolactinemia. Pregnancy was only possible after bromocriptine treatment. These cases provide further evidences that colloid cysts probably have an autosomic recessive pattern of inheritance with variable penetrance. [less ▲]

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See detailFamilial Crohn's Disease: A Study of 18 Families
Franchimont, D.; Belaiche, Jacques ULiege; Louis, Edouard ULiege et al

in Acta Gastro-Enterologica Belgica (1997), 60(2, Apr-Jun), 134-7

The high frequency of familial Crohn's disease (CD) suggests a genetic predisposition. The most recent data from epidemiology and molecular biology are consistent with a multifactorial, polygenic ... [more ▼]

The high frequency of familial Crohn's disease (CD) suggests a genetic predisposition. The most recent data from epidemiology and molecular biology are consistent with a multifactorial, polygenic inheritance with a possible genetic heterogeneity. The aim of our study was, first to compare familial and sporadic CD on the basis of the type and location of the disease, and age at diagnosis, and second, to evaluate among families, the concordance rate for the type and location of the disease. PATIENTS AND METHODS: 18 families with 2 (n = 16) and 3 (n = 2) affected first degree relatives were studied. They were compared to a population of 154 sporadic CD coming from the same gastroenterology unit. RESULTS: Age at diagnosis was the same in sporadic and familial CD. There was an increased frequency of ileal (p = 0.02), and fibro stenotic (p = 0.005) CD and a decreased frequency of colonic (p = 0.006) and inflammatory (p = 0.02) disease, in familial CD. There was a significant increase in concordance rate for fibrostenotic disease (p < 0.001) and a decrease for inflammatory disease (p < 0.01), among the families. The observed concordance rate for the location of the disease was not significantly different from the expected one. In conclusion, these data suggest that CD may be heterogenous and that different clinical patterns may be determined either by genetic or environmental factors. [less ▲]

Detailed reference viewed: 13 (1 ULiège)
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See detailFamilial epidermolysis Bullosa in "Beaucerons" puppies
Fontaine, Jacques ULiege; Remy, Isabelle ULiege; Charlier, G. et al

in ESVD Annual Meeting, pre-congress-day of the XVII WSAVA World Congress - Rome - Italie - Septembre 1992 (1992, September)

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See detailFamilial expression of spontaneous cervical artery dissections and Ehlers-Danlos syndrome hypermobile type.
Hermanns-Lê, Trinh ULiege; Manicourt, Daniel; Pierard, Gérald ULiege

in Skin and Stem Cells (2014), 3

Detailed reference viewed: 25 (3 ULiège)
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See detailFamilial glomerulopathy in seven French Mastiff dogs.
Lavoué, Rachel ULiege; Day, MJ; Busoni, Valeria ULiege et al

in Proceedings of the 18th Annual Congress of the ECVIM-CA (2008)

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See detailFamilial history of migraine influences habituation of visual evoked potentials
Lisicki Martinez, Marco ULiege; Ruiz-Romagnoli, Emiliano; D'Ostilio, Kevin ULiege et al

in Cephalalgia : An International Journal of Headache (2017)

Background: Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation ... [more ▼]

Background: Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation pattern associated with migraine. The aim of this study was to evaluate the influence of a positive familial history of migraine on VEP amplitude and habituation. Methods: We recorded six blocks of 100 VEP during continuous pattern-reversal stimulation in 30 patients with migraine between attacks (MO) and in 30 healthy volunteers, of whom 15 had a first-degree relative suffering from migraine (HVm) and 15 had not (HV). Results: Both MO and HVm had a significant deficit of VEP habituation and similarly reduced N1-P1 first block amplitudes, compared to HV (habituation slope: MO ¼ 0.033, HVm ¼ 0.021, HV ¼ 0.025, HV vs. MO p ¼ 0.002, HV vs. HVm p ¼ 0.036; mean N1-P1 amplitude in the first block: MO ¼ 9.08 mV, HVm ¼ 9.29 mV, HV ¼ 12.19 mV. HV vs. MO p ¼ 0.041, HV vs. HVm p ¼ 0.076). The first block N1-P1 amplitude was negatively correlated with the habituation slope for both MO (r ¼ .44, p ¼ 0.015) and HVm (r ¼ .56, p ¼ 0.031) while no significant correlation was found in HV (r ¼ .17, p ¼ 0.53). There were no differences in VEP latencies between the groups. Conclusions: Our study suggests that lack of habituation of visual evoked potentials is probably a genetically determined endophenotypic trait that is associated with both migraine and migraine susceptibility. We hypothesize that genetic diversity of populations could account for some of the discrepancies between electrophysiological studies performed in migraine and for interindividual variations among the subgroups. [less ▲]

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See detailFamilial hypercholesterolaemia in Collies
Jeusette, Isabelle; Grauwels, Magda ULiege; Tonglet, C et al

in Proceedings of the 5th ESVCN Conference (2001, September)

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See detailFamilial hypocalciuric hypercalcemia : a rare cause of recurrent pancreatitis
Daniel, Sara ULiege; Potorac, Iulia ULiege; MALAISE, Olivier ULiege et al

in Abstract book - 24th Meeting of the Belgian Endocrine Society (2014, October 18)

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See detailFamilial influences on cortical evoked potentials in migraine.
Sandor, P S; Afra, J; Proietti-Cecchini, A et al

in Neuroreport (1999), 10(6), 1235-8

Cortical information processing in migraine patients is impaired between attacks, showing deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of ... [more ▼]

Cortical information processing in migraine patients is impaired between attacks, showing deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory cortical evoked potentials (IDAP). This could be a genetic trait as certain genetic patterns are known for evoked potentials in healthy subjects. We investigated VEP habituation and IDAP in 20 pairs of migraineurs made up of parents and their children. Using a Monte-Carlo statistical method, we selectively assessed vertical familial influences. VEP habituation and IDAP were abnormal in both parents and children. However, similarity was far more pronounced between related pairs than between unrelated pairs. Familial influences are highly significant in determinants of cortical information processing in migraineurs, hence supporting the important role of genetic factors. [less ▲]

Detailed reference viewed: 21 (5 ULiège)
See detailFamilial Isolated Pituitary Adenomas
Beckers, Albert ULiege

Scientific conference (2012, October)

Detailed reference viewed: 11 (0 ULiège)
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See detailFamilial Isolated Pituitary Adenomas
Beckers, Albert ULiege

in Syllabus : Canadian Diabetes association : Professional Conference and Annual Meetings (2012, October)

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See detailFamilial Isolated Pituitary Adenomas
Beckers, Albert ULiege

Scientific conference (2012, March 24)

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See detailFamilial Isolated Pituitary Adenomas
Beckers, Albert ULiege

Scientific conference (2010, June)

Detailed reference viewed: 13 (2 ULiège)
See detailFamilial Isolated Pituitary Adenomas
Beckers, Albert ULiege

Scientific conference (2009, October 24)

Detailed reference viewed: 7 (1 ULiège)