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See detailIntravenous immunoglobulins in paraneoplastic brainstem encephalitis with anti-Ri antibodies
Fumal, Arnaud ULg; Jobe, Jérôme ULg; PEPIN, Jean-Louis ULg et al

in Journal of Neurology (2006), 253(10), 1360-1361

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See detailIntravenous iron and recombinant human erythropoietin in cancer patients.
Beguin, Yves ULg

in Journal of Clinical Oncology (2005), 23(3), 651-2652-3

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See detailIntravenous iron therapy restores functional iron deficiency induced by infliximab
Katsanos, Konstantinos; Cavalier, Etienne ULg; Ferrante, Marc et al

in Journal of Crohn’s and Colitis [=JCC] (2007), 1

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See detailIntravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy
Kaba, Abdourahmane ULg; Laurent, Stanislas R; Detroz, Bernard ULg et al

in Anesthesiology (2007), 106(1), 11-85-6

BACKGROUND: Intravenous infusion of lidocaine decreases postoperative pain and speeds the return of bowel function. The authors therefore tested the hypothesis that perioperative lidocaine infusion ... [more ▼]

BACKGROUND: Intravenous infusion of lidocaine decreases postoperative pain and speeds the return of bowel function. The authors therefore tested the hypothesis that perioperative lidocaine infusion facilitates acute rehabilitation protocol in patients undergoing laparoscopic colectomy. METHODS: Forty patients scheduled to undergo laparoscopic colectomy were randomly allocated to receive intravenous lidocaine (bolus injection of 1.5 mg/kg lidocaine at induction of anesthesia, then a continuous infusion of 2 mg.kg.h intraoperatively and 1.33 mg.kg.h for 24 h postoperatively) or an equal volume of saline. All patients received similar intensive postoperative rehabilitation. Postoperative pain scores, opioid consumption, and fatigue scores were measured. Times to first flatus, defecation, and hospital discharge were recorded. Postoperative endocrine (cortisol and catecholamines) and metabolic (leukocytes, C-reactive protein, and glucose) responses were measured for 48 h. Data (presented as median [25-75% interquartile range], lidocaine vs. saline groups) were analyzed using Mann-Whitney tests. P<0.05 was considered statistically significant. RESULTS: Patient demographics were similar in the two groups. Times to first flatus (17 [11-24] vs. 28 [25-33] h; P<0.001), defecation (28 [24-37] vs. 51 [41-70] h; P=0.001), and hospital discharge (2 [2-3] vs. 3 [3-4] days; P=0.001) were significantly shorter in patients who received lidocaine. Lidocaine significantly reduced opioid consumption (8 [5-18] vs. 22 [14-36] mg; P=0.005) and postoperative pain and fatigue scores. In contrast, endocrine and metabolic responses were similar in the two groups. CONCLUSIONS: Intravenous lidocaine improves postoperative analgesia, fatigue, and bowel function after laparoscopic colectomy. These benefits are associated with a significant reduction in hospital stay. [less ▲]

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See detailIntravenous lidocaine infusion reduces bispectral index-guided requirements of propofol only during surgical stimulation.
Hans, Grégory ULg; Lauwick, Séverine ULg; Kaba, Abdourahmane ULg et al

in British Journal of Anaesthesia (2010), 105(4), 471-9

BACKGROUND: I.V. lidocaine reduces volatile anaesthetics requirements during surgery. We hypothesized that lidocaine would also reduce propofol requirements during i.v. anaesthesia. METHODS: A randomized ... [more ▼]

BACKGROUND: I.V. lidocaine reduces volatile anaesthetics requirements during surgery. We hypothesized that lidocaine would also reduce propofol requirements during i.v. anaesthesia. METHODS: A randomized controlled study of 40 patients tested the effect of i.v. lidocaine (1.5 mg kg(-1) then 2 mg kg(-1) h(-1)) on propofol requirements. Anaesthesia was maintained with remifentanil and propofol target-controlled infusions (TCI) to keep the bispectral index (BIS) around 50. Effect-site concentrations of propofol and remifentanil and BIS values were recorded before and after skin incision. Data were analysed using anova and mixed effects analysis with NONMEM. Two dose-response studies were then performed with and without surgical stimulation. Propofol TCI titrated to obtain a BIS around 50 was kept constant. Then patients were randomized into four groups: A, saline; B, 0.75 mg kg(-1) bolus then infusion 1 mg kg(-1) h(-1); C, 1.5 mg kg(-1) bolus and infusion 2 mg kg(-1) h(-1); and D, 3 mg kg(-1) bolus and infusion 4 mg kg(-1) h(-1). Lidocaine administration coincided with skin incision. BIS values and haemodynamic variables were recorded. Data were analysed using linear regression and two-way anova. RESULTS: Lidocaine decreased propofol requirements (P<0.05) only during surgery. In the absence of surgical stimulation, lidocaine did not affect BIS nor haemodynamic variables, whereas it reduced BIS increase (P=0.036) and haemodynamic response (P=0.006) secondary to surgery. CONCLUSIONS: The sparing effect of lidocaine on anaesthetic requirements seems to be mediated by an anti-nociceptive action. [less ▲]

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See detailIntravenous lidocaine reduces propofol requirement during propofol - remifentanil anaesthesia for thyroid surgery
Charlier, Vanessa ULg; Lauwick, Séverine ULg; Hans, Grégory ULg et al

in Acta Anaesthesiologica Belgica (2008, June 14), 59(3), 204

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See detailIntriguing Eigenvector-Based Methods for Object Recognition
Verly, Jacques ULg

Scientific conference (1998)

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See detailIntriguing location of myeloperoxidase in the prostate: A preliminary immunohistochemical study.
Roumeguere, Thierry; Delree, Paul; Van Antwerpen, Pierre et al

in Prostate (2012), 72(5), 507-13

BACKGROUND: Myeloperoxidase (MPO) is a member of the peroxidase-cyclooxygenase superfamily, which is secreted from stimulated leucocytes at inflammatory sites. It is well known that MPO catalyses ... [more ▼]

BACKGROUND: Myeloperoxidase (MPO) is a member of the peroxidase-cyclooxygenase superfamily, which is secreted from stimulated leucocytes at inflammatory sites. It is well known that MPO catalyses oxidation reactions via the release of reactive halogenating and nitrating species and thus induces tissue damage. Several studies have already implicated MPO in the development of neoplasia. Chronic or recurrent prostatic inflammation has long been recognized as having the potential to initiate and promote the development of prostate cancer. The objective was to investigate whether MPO is present in the prostate. METHODS: Human prostate material was obtained from biopsies, transurethral resections of the prostate (TURP), prostatic adenomectomies, and retropubic radical prostatectomies. Twenty-nine slides of normal prostate tissue, benign prostatic hyperplasia (BPH), and prostate cancer were reviewed by a pathologist. Immunohistochemical analysis using MPO-specific human antibody was performed to detect MPO in the prostate tissue. RESULTS: Immunocytohistochemistry showed cellular colocalization of MPO in the secretory epithelial cells of the prostate with staining varying from light to strong intensity. Staining in the glandular apical snouts was often reinforced although staining of basal as well as of luminal glandular cells was also present. CONCLUSIONS: We identified, for the first time, the presence of MPO at the surface of prostatic epithelial cells. In view of the pro-oxidant properties of this enzyme, further research is needed to define whether MPO contributes to the development of prostatic lesions. Prostate 72:507-513, 2012. (c) 2011 Wiley Periodicals, Inc. [less ▲]

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See detailIntrinsic and irradiation-induced tumor selectivity of liposome-based gene therapy targeting Akt activation.
Martinive, Philippe ULg; Sonveaux, Pierre; Brouet, Agnes et al

Poster (2004, September)

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See detailIntrinsic brain activity in altered states of consciousness: how conscious is the default mode of brain function?
Boly, Mélanie ULg; Phillips, Christophe ULg; Tshibanda, Luaba ULg et al

in Annals of the New York Academy of Sciences (2008), 1129

Spontaneous brain activity has recently received increasing interest in the neuroimaging community. However, the value of resting-state studies to a better understanding of brain-behavior relationships ... [more ▼]

Spontaneous brain activity has recently received increasing interest in the neuroimaging community. However, the value of resting-state studies to a better understanding of brain-behavior relationships has been challenged. That altered states of consciousness are a privileged way to study the relationships between spontaneous brain activity and behavior is proposed, and common resting-state brain activity features observed in various states of altered consciousness are reviewed. Early positron emission tomography studies showed that states of extremely low or high brain activity are often associated with unconsciousness. However, this relationship is not absolute, and the precise link between global brain metabolism and awareness remains yet difficult to assert. In contrast, voxel-based analyses identified a systematic impairment of associative frontoparieto-cingulate areas in altered states of consciousness, such as sleep, anesthesia, coma, vegetative state, epileptic loss of consciousness, and somnambulism. In parallel, recent functional magnetic resonance imaging studies have identified structured patterns of slow neuronal oscillations in the resting human brain. Similar coherent blood oxygen level-dependent (BOLD) systemwide patterns can also be found, in particular in the default-mode network, in several states of unconsciousness, such as coma, anesthesia, and slow-wave sleep. The latter results suggest that slow coherent spontaneous BOLD fluctuations cannot be exclusively a reflection of conscious mental activity, but may reflect default brain connectivity shaping brain areas of most likely interactions in a way that transcends levels of consciousness, and whose functional significance remains largely in the dark. [less ▲]

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See detailIntrinsic fasciotomy. When and why?
KHUC, Toan ULg; CARLIER, Alain ULg; Collin, B et al

in Annales de Chirurgie de la Main : Organe Officiel des Sociétés de Chirurgie de la Main (1986), 5(4), 295-300

Major trauma to the upper extremity may lead to ischemic contracture of various muscle groups, sometimes including the intrinsic muscles of the hand. The clinical consequence of such necrotic fibrosis of ... [more ▼]

Major trauma to the upper extremity may lead to ischemic contracture of various muscle groups, sometimes including the intrinsic muscles of the hand. The clinical consequence of such necrotic fibrosis of the intrinsics is clawing of the digits with marked stiffness. After a short anatomical review of the fascias of the intrinsics, indications and operative techniques are discussed, in parallel with clinical cases. Intrinsic fasciotomy thus appears to be a major step in the prevention of digital clawing, when associated with early physiotherapy. [less ▲]

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See detailIntrinsic halotolerance of the psychrophilic alpha-amylase from Pseudoalteromonas haloplanktis
Srimathi, S.; Jayaraman, G.; Feller, Georges ULg et al

in Extremophiles : Life Under Extreme Conditions (2007), 11(3), 505-515

The halotolerance of a cold adapted alpha-amylase from the psychrophilic bacterium Pseudoalteromonas haloplanktis (AHA) was investigated. AHA exhibited hydrolytic activity over a broad range of NaCl ... [more ▼]

The halotolerance of a cold adapted alpha-amylase from the psychrophilic bacterium Pseudoalteromonas haloplanktis (AHA) was investigated. AHA exhibited hydrolytic activity over a broad range of NaCl concentrations (0.01-4.5 M). AHA showed 28% increased activity in 0.5-2.0 M NaCl compared to that in 0.01 M NaCl. In contrast, the corresponding mesophilic (Bacillus amyloliquefaciens) and thermostable (B. licheniformis) alpha-amylases showed a 39 and 46% decrease in activity respectively. Even at 4.5 M NaCl, 80% of the initial activity was detected for AHA, whereas the mesophilic and thermostable enzymes were inactive. Besides an unaltered fluorescence emission and secondary structure, a 10 degrees C positive shift in the temperature optimum, a stabilization factor of > 5 for thermal inactivation and a Delta T-m of 8.3 degrees C for the secondary structure melting were estimated in 2.7 M NaCl. The higher activation energy, half-life time and T-m indicated reduced conformational dynamics and increased rigidity in the presence of higher NaCl concentrations. A comparison with the sequences of other halophilic alpha-amylases revealed that AHA also contains higher proportion of small hydrophobic residues and acidic residues resulting in a higher negative surface potential. Thus, with some compromise in cold activity, psychrophilic adaptation has also manifested halotolerance to AHA that is comparable to the halophilic enzymes. [less ▲]

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See detailIntrinsic modification of tendon structure after concentric or excentric training
Kaux, Jean-François ULg; Drion, Pierre ULg; Besançon, Benoît et al

Poster (2010, November 25)

Introduction: It is well known that eccentric training is a successful way of treating chronic tendinopathy. Although clinical results are very positive, beneficial morphological and histological effects ... [more ▼]

Introduction: It is well known that eccentric training is a successful way of treating chronic tendinopathy. Although clinical results are very positive, beneficial morphological and histological effects have not yet been elucidated. The aim of our experiment was to determine if there exist any intrinsic modifications in a tendon trained in concentric or eccentric modes, in a rat model, using an original method of measurement (cryo-jaws). Methods: 18 rats were divided into 3 groups: 6 for the control group, without physical restraint; 12 for a training of1 hour, 3 times a week, for 5 weeks, at a speed of 17m/min (1km/h), on a inclined treadmill: 6 rats running uphill at +15° for the concentric effort (group C) and 6 rats running downhill at -15° for the eccentric effort (group E). After this training period, the Achilles, patellar and tricipital tendons of both limbs were surgically removed in all 18 rats. Tendons taken from five rats of each group were subjected to a tensile test up to rupture using a “cryo” jaw. Tendons of the remaining rat of each group were subjected to a histological study. Results: The results showed significant changes in group E only: (1) an increase of the force required to rupture the patellar and tricipital tendons; (2) an improvement of the ratio between the force necessary to rupture the tricipital tendon and the body mass of the rats; (3) an increase of the surface area of the section of the tricipital tendon. No significant change was observed as far as constraint was concerned between groups. Histologically, we saw, in the group E, more peripheral blood vessels and a greater proportion of collagen. Conclusion: This study showed that the mechanical properties of tendon tissue are enhanced by eccentric training. Tendons become stronger, the amount of collagen increases and there is probably more interaction between collagen fibers (mechanotransduction). [less ▲]

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See detailIntrinsic pro-angiogenic status of cystic fibrosis airway epithelial cells
Verhaeghe, Catherine ULg; Tabruyn, Sébastien ULg; Oury, Cécile ULg et al

in Biochemical and Biophysical Research Communications (2007), 356(3), 745-749

Cystic fibrosis is a common genetic disorder characterized by a severe lung inflammation and fibrosis leading to the patient's death. Enhanced angiogenesis in cystic fibrosis (CF) tissue has been ... [more ▼]

Cystic fibrosis is a common genetic disorder characterized by a severe lung inflammation and fibrosis leading to the patient's death. Enhanced angiogenesis in cystic fibrosis (CF) tissue has been suggested, probably caused by the process of inflammation, as similarly described in asthma and chronic bronchitis. The present study demonstrates an intrinsic pro-angiogenic status of cystic fibrosis airway epithelial cells. Microarray experiments showed that CF airway epithelial cells expressed several angiogenic factors such as VEGF-A, VEGF-C, bFGF, and PLGF at higher levels than control cells. These data were confirmed by real-time quantitative PCR and, at the protein level, by ELISA. Conditioned media of these cystic fibrosis cells were able to induce proliferation, migration and sprouting of cultured primary endothelial cells. This report describes for the first time that cystic fibrosis epithelial cells have an intrinsic angiogenic activity. Since excess of angiogenesis is correlated with more severe pulmonary disease, our results could lead to the development of new therapeutic applications. (c) 2007 Elsevier Inc. All rights reserved. [less ▲]

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See detailIntrinsic structural failure of polyester (Dacron) vascular grafts. A general review.
Van Damme, Hendrik ULg; Deprez, Manuel ULg; Creemers, Etienne ULg et al

in Acta Chirurgica Belgica (2005), 105(3), 249-55

Intrinsic structural failure of Dacron prostheses is a late exceptional complication, resulting from a loss of structural integrity of the graft. The authors report six cases of non-anastomotic false ... [more ▼]

Intrinsic structural failure of Dacron prostheses is a late exceptional complication, resulting from a loss of structural integrity of the graft. The authors report six cases of non-anastomotic false aneurysms in the mid-portion of a vascular Dacron graft, observed at a mean of 12 years after insertion. It concerns four femoro-popliteal bypass grafts, one cross-over graft and a branch of a bifurcated aorto-bifemoral graft, implanted between 1980 and 1990. This represents 0.2% of all vascular Dacron grafts implanted in authors' department since 1980. The degenerated prosthesis was excised, and a new bypass graft was inserted. In three cases, histological analysis revealed a foreign body giant cell reaction against fragmented Dacron fibers. In none of the cases there was evidence of graft infection. The authors discuss the evidence and etiopathogeny of this late, unusual complication, inherent to the Dacron graft material. The most probable causative factor is material fatigue, leading to gradual breakdown and fragmentation of individual fibers, and subsequent biodegradation of the basic material. Such an intrinsic weakness of prosthetic fabric has only be observed in first and second generation Dacron grafts. [less ▲]

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See detailIntrinsic Uniformity Requirements for Pinhole Spect
Seret, Alain ULg; Bleeser, Frédéric

in Journal of Nuclear Medicine Technology (2006), 34(1), 43-47

Pinhole SPECT is a fully 3-dimensional tomography technique. Uniformity requirements for gamma-cameras have been studied for 2-dimensional SPECT performed with parallel-hole collimators. This study ... [more ▼]

Pinhole SPECT is a fully 3-dimensional tomography technique. Uniformity requirements for gamma-cameras have been studied for 2-dimensional SPECT performed with parallel-hole collimators. This study investigated reconstruction artifacts in pinhole SPECT arising from intrinsic uniformity defects of the gamma-camera in the case of a pinhole aperture (5 mm) and a rotation radius (10 cm) suitable for human studies. METHODS: A cylindric phantom was filled with water and 99mTc. The count density in the pinhole SPECT projections largely exceeded the density that would be expected in human studies. Two-dimensional gaussian-shaped positive uniformity defects of various heights and various full widths at half maximum were simulated at 5 locations on the 64 projections. All these sets of projections were reconstructed using an iterative 3-dimensional ordered-subset expectation maximization (OSEM) algorithm tailored to the pinhole geometry. The influence of the number of OSEM iterations (2, 5, or 8 for 8 subsets) was also investigated. The height of the ring artifacts generated by the uniformity defects was measured on the reconstructed transverse slices and was compared with the noise in the noncorrupted slices. The uniformity defects were also generated on a 30-megacount flood image from the camera. These images were inspected visually, and the National Electrical Manufacturers Association (NEMA) differential and integral uniformities were calculated. RESULTS: Defects centered on the line corresponding to the orthogonal projection of the camera axis of rotation onto the detector plane generated artifacts whose magnitude-to-noise ratio exceeded 1% when the defect height was larger than 5%-10%, depending on the defect full width at half maximum. These defects were clearly visible on the slices and the flood images. Defects located elsewhere on the camera detector generated ring artifacts of magnitude-to-noise ratio smaller than 1%. They were visually observable both on the reconstructed slices and on the flood images for defect heights larger than 5%. The increase in the number of OSEM iterations conducted to a decrease in the artifact magnitude-to-noise ratio. CONCLUSION: Although hardly visible on the flood images and only slightly increasing the NEMA differential or integral uniformity, a detector uniformity defect of 3% height is able to generate a visible artifact on the reconstructed transverse slices. The study was conducted on a relatively high-count pinhole SPECT acquisition. Considering that far fewer counts would accumulate in clinical practice, any camera that fulfils these uniformity requirements should not lead to the presence of visible uniformity artifacts in the reconstructed slices. [less ▲]

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See detailIntrinsic vulnerability mapping using the PI method Néblon basin (Belgium)
Lomba, Valérie; Dassargues, Alain ULg

in Zwahlen, François (Ed.) Vulnerability and risk mapping for the protection of carbonate (karst) aquifers, COST620 final report (2003)

Detailed reference viewed: 69 (3 ULg)