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See detail6,7-Disubstituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: new potent ATP-sensitive potassium channel openers
De Tullio, Pascal ULg; Boverie, S.; Becker, B. et al

Poster (2002, September)

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See detailLe 6-(acetoxymethyl)-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-chlorophényle agissant en tant qu’inhibiteur potentiel de l’invasion tumorale
Kempen, I.; Papapostolu, D.; Pochet, L. et al

Poster (2000, May)

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See detailA 6-hour nocturnal interruption of a continuous subcutaneous insulin infusion: 1. Metabolic and hormonal consequences and scheme for a prompt return to adequate control.
Krzentowski, G.; Scheen, André ULg; Castillo, M. et al

in Diabetologia (1983), 24(5), 314-8

Interruption of a continuous subcutaneous insulin infusion, most often due to technical problems occurring during the night, is a not uncommon event whose metabolic consequences have received relatively ... [more ▼]

Interruption of a continuous subcutaneous insulin infusion, most often due to technical problems occurring during the night, is a not uncommon event whose metabolic consequences have received relatively little attention until now. We have therefore investigated the changes in blood glucose, plasma non-esterified fatty acids, 3-hydroxybutyrate, glucagon and free insulin in eight C-peptide negative Type 1 diabetic patients whose pumps were deliberately stopped between 23.00 h and 05.00 h. A control test with the pump functioning normally was carried out in each patient and the studies were randomized. Considering the values at 23.00 h as reference, interruption of the insulin infusion resulted in (1) a rapid decrease in plasma free insulin significant after 1 h and reaching a nadir of 6 +/- 2 mU/l after 6 h; (2) a rise in blood glucose which was significant at hour 3 and reached 17.4 +/- 1.9 mmol/l at hour 6; (3) a moderate increase in plasma nonesterified fatty acids which remained in the range of 700-800 mumol/l; (4) an early and linear rise in plasma 3-hydroxybutyrate, significant after 1 h and averaging 1290 +/- 140 mumol/l after 6 h; (5) a late increase (hour 5) in plasma glucagon. The second aim of our study was to provide for the patient a precise scheme of insulin supplements administered via the pump and based on blood glucose monitoring (Dextrostix - Glucometer) and semi-quantitative evaluation of ketonuria (Acetest). Resetting the pump at its basal rate at 05.00 h and giving insulin supplements (2-8 U) at 06.45 h (with the usual breakfast dose) and again at 10.00 h have proved efficacious in restoring satisfactory metabolic control by noon the day after starting the experiment. These results form practical recommendations to patients undergoing this type of accident. [less ▲]

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See detailThe 6-Kilobase C-Erbb2 Promoter Contains Positive and Negative Regulatory Elements Functional in Human Mammary Cell Lines
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Dijkmans, Huguette et al

in Cancer Research (1994), 54(15), 4193-9

A 6-kilobase fragment extending at the 5'-end of the c-erbB2 protooncogene was isolated from a normal human lymphocyte genomic DNA library. The full-length fragment and five subfragments with identical 3 ... [more ▼]

A 6-kilobase fragment extending at the 5'-end of the c-erbB2 protooncogene was isolated from a normal human lymphocyte genomic DNA library. The full-length fragment and five subfragments with identical 3'-ends were obtained by progressive unidirectional deletion from the 5'-end and were cloned in front of the luciferase reporter gene. The hybrid genes were analyzed for transcriptional activity in human mammary cell lines synthesizing low (HBL-100 and T-47D), moderate (MDA-MB-453), or high (BT-474) amounts of the c-erbB2 mRNA and were also analyzed in HeLa cells. Gene-specific expression was observed, indicating the presence of multiple cis-acting sequences in the c-erbB2 promoter. A major negative element is located in the -2- to -4-kilobase region. It is flanked on both sides by positive elements that display enhanced transcriptional activity in the BT-474 tumor cells only. While predominant in the low-expressing cells, the effect of the repressor appears to be overcome by the distal transactivator in the high-expressing BT-474 cells, resulting in a 15 to 50 times increase in luciferase activity relative to the HBL-100 and T-47D cells, respectively. Cell-specific expression relies on the trans-acting factors present in the different cell lines. The formation of cell-specific protein-DNA complexes was demonstrated by gel retardation assay. [less ▲]

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See detail6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid as a core structure for selective inhibitors of human leucocyte elastase
Doucet, C.; Pochet, L.; Thierry, N. et al

in Journal of Medicinal Chemistry (1999), 42

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See detail6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of the Treatment of Cancer Cell Invasion and Metastasis
Kempen, I.; Hemmer, Marc ULg; Counerotte, Stéphane ULg et al

in European Journal of Medicinal Chemistry (2008), 43(12), 2735-50

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure ... [more ▼]

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure-activity relationships were deduced from biological results and will be used in further design of new active compounds. In particular, the acetoxymethyl substituent found at the 6-position of previously described active compounds can be replaced by an acetamidomethyl substituent without loss of potency; while the presence of an aryl ester function at the 3-position was preferred to a thioester or an amide function to induce marked biological activity. This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anti-cancer agents. [less ▲]

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See detail6-Substituted benzopyran derivatives as potent KATP channel openers: synthesis and biological in vitro evaluation
Florence, X.; De Tullio, Pascal ULg; Lebrun, P. et al

Poster (2008, May)

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See detail6. Lutte contre les maladies - 2.3. Réduire la pression des maladies: impact pratique des "leviers agronomiques"
Seutin, Benoit ULg; Vancutsem, Françoise ULg; Jacquemin, Guillaume et al

in Livre Blanc: Céréales - Gembloux (2011, February 23)

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See detail6. Lutte intégrée contre les maladies
Duvivier, Maxime; Bataille, Charlotte; Mahieu, Olivier et al

in Bodson, Bernard; Destain, Jean-Pierre (Eds.) Livre blanc céréales (2014, February 26)

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See detail6. Lutte intégrée contre les maladies
Duvivier, Maxime; Mahieu, Olivier; Heens, B. et al

in Bodson, Bernard; Destain, Jean-Pierre (Eds.) Livre Blanc - Céréales (2013, February 27)

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See detail60 h of anhepatic state without neurologic deficit
Detry, Olivier ULg; De Roover, Arnaud ULg; Delwaide, Jean ULg et al

in Transplant International (2006), 19(9), 769-769

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See detailA 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock
Kumar Kadri, Naveen; Sahana, Goutam; Charlier, Carole ULg et al

in PLoS Genetics (2014), 10(1), 1004049

In dairy cattle, the widespread use of artificial insemination has resulted in increased selection intensity, which has led to spectacular increase in productivity. However, cow fertility has ... [more ▼]

In dairy cattle, the widespread use of artificial insemination has resulted in increased selection intensity, which has led to spectacular increase in productivity. However, cow fertility has concomitantly severely declined. It is generally assumed that this reduction is primarily due to the negative energy balance of high-producing cows at the peak of lactation. We herein describe the fine-mapping of a major fertility QTL in Nordic Red cattle, and identify a 660-kb deletion encompassing four genes as the causative variant. We show that the deletion is a recessive embryonically lethal mutation. This probably results from the loss of RNASEH2B, which is known to cause embryonic death in mice. Despite its dramatic effect on fertility, 13%, 23% and 32% of the animals carry the deletion in Danish, Swedish and Finnish Red Cattle, respectively. To explain this, we searched for favorable effects on other traits and found that the deletion has strong positive effects on milk yield. This study demonstrates that embryonic lethal mutations account for a non-negligible fraction of the decline in fertility of domestic cattle, and that associated positive effects on milk yield may account for part of the negative genetic correlation. Our study adds to the evidence that structural variants contribute to animal phenotypic variation, and that balancing selection might be more common in livestock species than previously appreciated. [less ▲]

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See detailThe "666" collaboration on OGLE transits. I. Accurate radius of the planets OGLE-TR-10b and OGLE-TR-56b with VLT deconvolution photometry
Pont, F.; Moutou, C.; Gillon, Michaël ULg et al

in Astronomy and Astrophysics (2007), 465

Transiting planets are essential to study the structure and evolution of extra-solar planets. For that purpose, it is important to measure precisely the radius of these planets. Here we report new high ... [more ▼]

Transiting planets are essential to study the structure and evolution of extra-solar planets. For that purpose, it is important to measure precisely the radius of these planets. Here we report new high-accuracy photometry of the transits of OGLE-TR-10 and OGLE-TR-56 with VLT/FORS1. One transit of each object was covered in Bessel V and R filters, and treated with the deconvolution-based photometry algorithm DECPHOT, to ensure accurate millimagnitude light curves. Together with earlier spectroscopic measurements, the data imply a radius of 1.22{[SUP]+0.12[/SUP][SUB]-0.07[/SUB]} R[SUB]J[/SUB] for OGLE-TR-10b and 1.30 ± 0.05 R[SUB]J[/SUB] for OGLE-TR-56b. A re-analysis of the original OGLE photometry resolves an earlier discrepancy about the radius of OGLE-TR-10. The transit of OGLE-TR-56 is almost grazing, so that small systematics in the photometry can cause large changes in the derived radius. Our study confirms both planets as inflated hot Jupiters, with large radii comparable to that of HD 209458b and at least two other recently discovered transiting gas giants. Based on data collected with the FORS1 imager at the VLT-Kueyen telescope (Paranal Observatory, ESO, Chile) in the programme 177.C-0666E. [less ▲]

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See detail67-kD laminin receptor expression correlates with worse prognostic indicators in non-small cell lung carcinomas.
Fontanini, G.; Vignati, S.; Chine, S. et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (1997), 3(2), 227-31

Tumor samples obtained from 72 patients resected for non-small cell lung cancer were stained immunohistochemically using an immunoperoxidase method and the MLuC5 monoclonal antibody specific for the 67 ... [more ▼]

Tumor samples obtained from 72 patients resected for non-small cell lung cancer were stained immunohistochemically using an immunoperoxidase method and the MLuC5 monoclonal antibody specific for the 67-kDa laminin receptor. Sixty-one of 72 patients (84.7%) displayed a MLuC5-positive reaction, which was usually localized in both the inner surface of the plasmatic membranes and the cytoplasm of neoplastic cells. When we compared the laminin receptor expression with clinicopathological and biological parameters such as histotype, grading, T status, N status, ploidy, proliferative activity, vessel invasion, and p53 protein accumulation, the following results were observed: (a) the mean expression of the receptor was higher in the group of patients with metastatic nodal involvement than in those with uninvolved lymph nodes (P = 0.02); (b) a high Ki-67 score (>13% of positive cells) was observed in tumors with a higher mean value of laminin receptor (P = 0.004); (c) the tumors harboring neoplastic emboli in their vessels showed a higher laminin receptor immunoreactivity (P = 0.02); and (d) a borderline association was found between the high mean value of laminin receptor immunopositivity and p53 accumulation in neoplastic cell nuclei (P = 0.05). Our observations indicate that detection of high tissue levels of 67-kDa laminin receptor is associated with an invasive phenotype in non-small cell lung cancer and may provide further information in the biological characterization of this type of cancer. [less ▲]

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See detailThe 67-kDa laminin receptor originated from a ribosomal protein that acquired a dual function during evolution.
Ardini, E.; Pesole, G.; Tagliabue, E. et al

in Molecular Biology and Evolution (1998), 15(8), 1017-25

The 67-kDa laminin receptor (67LR) is a nonintegrin cell surface receptor that mediates high-affinity interactions between cells and laminin. Overexpression of this protein in tumor cells has been related ... [more ▼]

The 67-kDa laminin receptor (67LR) is a nonintegrin cell surface receptor that mediates high-affinity interactions between cells and laminin. Overexpression of this protein in tumor cells has been related to tumor invasion and metastasis. Thus far, only a full-length gene encoding a 37-kDa precursor protein (37LRP) has been isolated. The finding that the cDNA for the 37LRP is virtually identical to a cDNA encoding the ribosomal protein p40 has suggested that 37LRP is actually a component of the translational machinery, with no laminin-binding activity. On the other hand, a peptide of 20 amino acids deduced from the sequence of 37LR/p40 was shown to exhibit high laminin-binding activity. The evolutionary relationship between 23 sequences of 37LRP/p40 proteins was analyzed. This phylogenetic analysis indicated that all of the protein sequences derive from orthologous genes and that the 37LRP is indeed a ribosomal protein that acquired the novel function of laminin receptor during evolution. The evolutionary analysis of the sequence identified as the laminin-binding site in the human protein suggested that the acquisition of the laminin-binding capability is linked to the palindromic sequence LMWWML, which appeared during evolution concomitantly with laminin. [less ▲]

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See detail69 speaker 3D DOSIMETRY SYSTEMS-GELS, EPIDS AND OTHERS
Duchateau, Michael; Verellen, D.; Depuydt, T. et al

in Radiotherapy & Oncology (2011), 99

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See detailLa 6e réforme de l'Etat et quelques réflexions sur les perspectives des institutions étatiques belges par-delà la réforme
Behrendt, Christian ULg

in Revue de la Faculté de Droit de l'Université de Liège (2012)

L'article, rédigé en janvier 2012, dresse un panorama actuel de la mise en oeuvre de la 6. Réforme de l'Etat, en pointe les enjeux en termes de calendrier et les difficultés techniques lors de sa mise en ... [more ▼]

L'article, rédigé en janvier 2012, dresse un panorama actuel de la mise en oeuvre de la 6. Réforme de l'Etat, en pointe les enjeux en termes de calendrier et les difficultés techniques lors de sa mise en oeuvre. Il jette d'autre part un regard sur l'évolution possible des institutions étatiques belges à moyen et long terme. [less ▲]

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See detail6th Conference on Hot Subdwarf Stars and Related Objects
Van Grootel, Valérie ULg; Green, Elizabeth M.; Fontaine, Gilles et al

Book published by Astronomical Society of the Pacific Conference Series (2014)

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