Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailLack of Cell Wall Peptidoglycan Versus Penicillin Sensitivity: New Insights into the Chlamydial Anomaly
Ghuysen, Jean-Marie ULg; Goffin, Colette

in Antimicrobial Agents and Chemotherapy (1999), 43(10), 2339-2344

Detailed reference viewed: 7 (0 ULg)
Peer Reviewed
See detailLack of contribution of two endotelial nitric oxide synthase (eNOS) gene polymorphisms to diabetic nephropathy in type 1 diabetes
Weekers, Laurent ULg; Hadjadj, S.; Belloum, R. et al

in Diabetologia (1999), 42(Sup. 1), 226

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailLack of defective cardiac oxidative metabolism in intact dogs subjected to a prolonged low - dose infusion of E. Coli endotoxin
D'Orio, Vincenzo ULg; EL ALLAF, D; VAIRA, S et al

in Circulatory Shock (1986), 18

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailLack of efficacy of low-dose spironolactone as adjunct treatment to conventional congestive heart failure treatment in dogs
Schuller, S.; Van Israël, N.; Vanbelle, S. et al

in Journal of Veterinary Pharmacology & Therapeutics (2011)

Aldosterone plays an important role in the pathophysiology of heart failure. Aldosterone receptor blockade has been shown to reduce morbidity and mortality in human patients with advanced congestive left ... [more ▼]

Aldosterone plays an important role in the pathophysiology of heart failure. Aldosterone receptor blockade has been shown to reduce morbidity and mortality in human patients with advanced congestive left ventricular heart failure. This study was designed to assess the efficacy and tolerance of long-term low-dose spironolactone when added to conventional heart failure treatment in dogs with advanced heart failure. Eighteen client-owned dogs with advanced congestive heart failure due to either degenerative valve disease (n=11) or dilated cardiomyopathy (n=7) were included in this prospective, placebo-controlled, double-blinded, randomized clinical study. After initial stabilization including furosemide, angiotensin-converting enzyme inhibitors, pimobendan and digoxin, spironolactone at a median dose of 0.52 mg/kg (range 0.49-0.8 mg/kg) once daily (n=9) or placebo (n=9) was added to the treatment, and the dogs were reassessed 3 and 6 months later. Clinical scoring, echocardiography, electrocardiogram, systolic blood pressure measurement, thoracic radiography, sodium, potassium, urea, creatinine, alanine aminotransferase, aldosterone and aminoterminal atrial natriuretic propeptide were assessed at baseline, 3 and 6 months. Survival times were not significantly different between the two treatment groups. Spironolactone was well tolerated when combined with conventional heart failure treatment. [less ▲]

Detailed reference viewed: 19 (2 ULg)
Full Text
Peer Reviewed
See detailLack of estrogen increases pain in the trigeminal formalin model: a behavioural and immunocytochemical study of transgenic ArKO mice
Multon, Sylvie ULg; Pardutz, A.; Mosen, Jeanine ULg et al

in Pain (2005), 114(1-2), 257-265

In order to examine the effect of estrogen on facial pain, we first compared the face-rubbing evoked by a formalin injection in the lip of aromatase-knockout (ArKO) mice, lacking endogenous estrogen ... [more ▼]

In order to examine the effect of estrogen on facial pain, we first compared the face-rubbing evoked by a formalin injection in the lip of aromatase-knockout (ArKO) mice, lacking endogenous estrogen production, 17 beta-estradiol-treated ArKO mice (ArKO-E2) and wild-type (WT) littermates. During the 'acute' phase of pain the time spent rubbing was similar in the three groups, whereas during the following 'interphase' and the second phase of pain, grooming was increased ill ArKO mice. Estradiol-treatment restored a behaviour similar to WT group. To better understand estrogens modulation on pain processes, we examined changes in 5-HT and CGRP innervations of trigeminal nucleus caudalis (TNC) in ArKO, ArKO-E2 and WT groups sacrified during the interphase. Whereas serotonin and CGRP immunoreactivities were comparable in WT and ArKO non-injected control groups, our data showed that 9 min after formalin injection, the density of serotoninergic terminals increased significantly in WT, but not in ArKO mice, while that of CGRP-immunoreactive fibers was lower in WT than in ArKO mice on the injected side. Estradiol-treatment only partially reversed these changes in ArKO-E2 mice. We conclude that estrogen deprivation in ArKO mice can be responsible for increased nociceptive response and that it is accompanied by transmitter changes favouring pro- over anti-nociceptive mechanisms in TNC during interphase of the formalin model. That estradiol-treatment completely reverses the behavioural abnormality Suggests that estrogens absence produces chiefly functional activation-dependent changes. However, the fact that the immunohistochemical abnormalities were not totally normalized by estradiol-treatment suggested that some permanent developmental alterations may occur in ArKO mice. (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 79 (12 ULg)
Full Text
Peer Reviewed
See detailThe lack of expression of the peripheral benzodiazepine receptor characterises microglial response in anaplastic astrocytomas.
Takaya, Shigetoshi; Hashikawa, Kazuo; Turkheimer, Federico E et al

in Journal of neuro-oncology (2007), 85(1), 95-103

The peripheral benzodiazepine receptor (PBR) is a 18 kDa molecule mainly involved in cholesterol transport through the mitochondrial membrane. In microglia, PBR is expressed from the earliest stages of ... [more ▼]

The peripheral benzodiazepine receptor (PBR) is a 18 kDa molecule mainly involved in cholesterol transport through the mitochondrial membrane. In microglia, PBR is expressed from the earliest stages of activation and appears to exert a pro-inflammatory function. This molecule is commonly up-regulated in inflammatory, degenerative, infective and ischaemic lesions of the central nervous system but it has never been reported in glioma-infiltrating microglia. We examined two anaplastic astrocytomas showing minimal contrast-enhancement and therefore little damage of the blood brain barrier to minimise the presence of blood borne macrophages within tumour tissue. The two lesions were studied in vivo using positron emission tomography (PET) with the specific PBR ligand [(11)C](R)-PK11195 and the corresponding tumour tissue was investigated with an anti-PBR antibody. Glioma-infiltrating microglia were characterised for molecules involved in antigen presentation and cytotoxic activity. As comparison, PBR was investigated in three brains with multiple sclerosis (MS) and three with Parkinson's disease (PD). The expression profile of four anaplastic astrocytomas was also exploited and results were compared to the profile of eleven samples of normal temporal lobe and nine cases of PD. PET studies showed that [(11)C](R)-PK11195 binding was markedly lower in tumours than in the contralateral grey matter. Pathological investigation revealed that glioma-infiltrating microglia failed to express PBR and cytotoxic molecules although some cells still expressed antigen presenting molecules. PBR and cytotoxic molecules were highly represented in MS and PD. Evaluation of microarray datasets confirmed these differences. Our results demonstrated PBR suppression in glioma-infiltrating microglia and suggested that PBR may have a relevant role in modulating the anti-tumour inflammatory response in astrocytic tumours. [less ▲]

Detailed reference viewed: 8 (2 ULg)
Full Text
Peer Reviewed
See detailLack of generalization as explicative factor of morphosyntactic difficulties in children with SLI: a longitudinal study
Leroy, Sandrine ULg; Parisse, Christophe; Marchat, Aurélie et al

Poster (2013, June)

Background. Constructivist approach (Goldberg, 2006; Tomasello, 2003) postulates that children build their linguistic system from their own linguistic experience. To be productive with their language ... [more ▼]

Background. Constructivist approach (Goldberg, 2006; Tomasello, 2003) postulates that children build their linguistic system from their own linguistic experience. To be productive with their language, children have to generalize construction schemas to never heard items. Because children with SLI show limited morphosyntactic creativity and variability, we hypothesized that they would have difficulties to generalize their construction schemas, which would hinder their access to the most abstract level of the linguistic competence. Our aim was to test whether children with SLI had more difficulties than children with TLD to generalize a schema to new items. Methods. Seven children with SLI matched with 6 children TLD based on linguistic age were recorded for this study. Two steps were repeated at three different moments spread out three years. The first step consisted in a recording of a parent/child interaction at their house. All interactions were transcribed and analyzed. The second step consisted in the creation of two tasks from each child’s own productions: an utterance repetition task and a priming task. Tasks were individualized. Items were created from schemas considered as “acquired” and schemas considered as “non-acquired”. Results. Priming task. Current statistical analyses revealed a significant “Group” effect, a significant “Time” effect and a no significant “Group” by “Time” effect. Analyses revealed a significant “Structure” effect and a significant “Group” by “Structure” effect. Difference between the two groups was more marked for items with “non-acquired” schemas. Repetition task. The same results were obtained; except for “Time” variable (no significant effect). Discussion. The two groups had more difficulties to generalize non-acquired schemas to new items, but children with SLI seemed to have more difficulties, which could mean that their productivity with new schemas was more hindered. Consequently, results are compatible with our hypothesis suggesting that children with SLI have more difficulties for generalizing a schema to new items. [less ▲]

Detailed reference viewed: 47 (1 ULg)
Full Text
Peer Reviewed
See detailLack of habituation causes high intensity dependence of auditory evoked cortical potentials in migraine
Ambrosini, A.; Rossi, P.; De Pasqua, Victor ULg et al

in Brain (2003), 126(Part 9), 2009-2015

Migraineurs are characterized interictally by lack of habituation, or even potentiation, of cortical evoked potentials during repetitive stimulation and by a strong intensity dependence of auditory evoked ... [more ▼]

Migraineurs are characterized interictally by lack of habituation, or even potentiation, of cortical evoked potentials during repetitive stimulation and by a strong intensity dependence of auditory evoked potentials (IDAP). To determine whether these two features of sensory processing are interrelated, we have studied them simultaneously on the same recordings of auditory evoked potentials (AEPs). AEPs were obtained at four different stimulation intensities in 14 patients suffering from migraine without aura (MO) and 14 healthy volunteers (HV). For each intensity, 120 trials were averaged off-line globally and over four sequential blocks of 30 trials. IDAP was expressed by the amplitude/stimulus intensity function (ASF slope) for global and block averages. Habituation was calculated as the percentage amplitude variation between the first and fourth blocks for each stimulus intensity. The IDAP slope for global averages was higher in MO (1.05 +/- 0.27 muV/10 dB) than in HV (0.64 +/- 0.45 muV/10 dB) (P = 0.008), but IDAP slopes for block averages were greater in MO only at the fourth block (P = 0.048). First block amplitudes tended to be lower in MO, except at 80 dB. There was a potentiation of AEP amplitudes at every stimulus intensity in MO, contrasting with habituation in HV. IDAP slopes were negatively correlated with mean habituation percentages in pooled data from patients and controls (r = -0.610; P = 0.0006). This study confirms that IDAP is higher in migraineurs than in healthy controls. It also shows that the AEP habituation is replaced by potentiation at all stimulus intensities. The negative correlation found between IDAP and habituation suggests that the latter is able to have a strong influence on the former and perhaps even lead to it. In migraine, the habituation deficit amplifies the IDAP and may thus be the causal functional abnormality. We propose that it is due to a decreased pre-activation level of sensory cortices, a hypothesis also supported in this study by the lower amplitude of first AEP blocks in patients. [less ▲]

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailLack of habituation of visual evoked gamma band oscillations in migraine patients between attacks
Coppola, G.; Ambrosini, A.; Di Clemente, L. et al

in Cephalalgia : An International Journal of Headache (2005, October), 25(10), 885

Detailed reference viewed: 17 (0 ULg)
Peer Reviewed
See detailLack of inhibitory influence of naloxone infusion on water load excretion in female patients with subjective feeling of water retention
Geenen, Vincent ULg; Adam, Alain; Godfroi, Michel et al

in Neuroendocrinology Letters (1982), 4

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailLack of isocitrate lyase in Chlamydomonas leads to changes in carbon metabolism and in the response to oxidative stress under mixotrophic growth.
Plancke, Charlotte; Vigeolas, Hélène ULg; Hohner, Ricarda et al

in The Plant journal : for cell and molecular biology (2014), 77(3), 404-417

Isocitrate lyase is a key enzyme of the glyoxylate cycle. This cycle plays an essential role in cell growth on acetate, and is important for gluconeogenesis as it bypasses the two oxidative steps of the ... [more ▼]

Isocitrate lyase is a key enzyme of the glyoxylate cycle. This cycle plays an essential role in cell growth on acetate, and is important for gluconeogenesis as it bypasses the two oxidative steps of the tricarboxylic acid (TCA) cycle in which CO2 is evolved. In this paper, a null icl mutant of the green microalga Chlamydomonas reinhardtii is described. Our data show that isocitrate lyase is required for growth in darkness on acetate (heterotrophic conditions), as well as for efficient growth in the light when acetate is supplied (mixotrophic conditions). Under these latter conditions, reduced acetate assimilation and concomitant reduced respiration occur, and biomass composition analysis reveals an increase in total fatty acid content, including neutral lipids and free fatty acids. Quantitative proteomic analysis by 14 N/15 N labelling was performed, and more than 1600 proteins were identified. These analyses reveal a strong decrease in the amounts of enzymes of the glyoxylate cycle and gluconeogenesis in parallel with a shift of the TCA cycle towards amino acid synthesis, accompanied by an increase in free amino acids. The decrease of the glyoxylate cycle and gluconeogenesis, as well as the decrease in enzymes involved in beta-oxidation of fatty acids in the icl mutant are probably major factors that contribute to remodelling of lipids in the icl mutant. These modifications are probably responsible for the elevation of the response to oxidative stress, with significantly augmented levels and activities of superoxide dismutase and ascorbate peroxidase, and increased resistance to paraquat. [less ▲]

Detailed reference viewed: 37 (20 ULg)
Full Text
Peer Reviewed
See detailLack of LTR and ENV genetic variation during bovine leukemia virus-induced leukemogenesis.
Willems, Luc ULg; Kerkhofs, P.; Burny, A. et al

in Virology (1995), 206(1),

Detailed reference viewed: 10 (5 ULg)
Full Text
Peer Reviewed
See detailLack Of Mutation In The Waf1/Cip1 Gene During Bovine Leukemia Virus-Induced Leukemogenesis
Dequiedt, Franck ULg; Willems, Luc ULg; Kerkhofs, P. et al

in Veterinary Immunology and Immunopathology (1997), 59(3-4),

Detailed reference viewed: 8 (5 ULg)
Full Text
Peer Reviewed
See detailLack of P2X1 ion channels increases endotoxemia associated coagulation and organ damage through neutrophil hyperresponsiveness.
Lecut, Christelle ULg; Faccinetto, Céline ULg; Evans, Richard J et al

in Journal of Thrombosis and Haemostasis [=JTH] (2011), 9(suppl S2),

ATP-gated P2X1 ion channels contribute to arterial thrombosis by amplifying platelet activation. In the search for novel anti-platelet strategies, targeting P2X1 ion channels is appealing. However, in ... [more ▼]

ATP-gated P2X1 ion channels contribute to arterial thrombosis by amplifying platelet activation. In the search for novel anti-platelet strategies, targeting P2X1 ion channels is appealing. However, in this study we found that lack or inhibition of P2X1 channels enhanced neutrophil respiratory burst activity ex vivo. <br />To study the consequence of P2X1 deficiency on neutrophil function in vivo, P2X1-/- mice were used in a model of endotoxin-induced sepsis. Upon injection of lipopolysaccharides (LPS), plasma myeloperoxidase (MPO) concentrations reached higher levels in the P2X1-/- mice, and circulating neutrophils expressed higher levels of surface CD11b compared to wild-type mice. Neutrophil relocalization into the lungs of LPS-treated P2X1-/- mice was also significantly augmented, reflecting a higher activation state of P2X1-/- neutrophils under conditions of sepsis. Accordingly, more extensive lipid peroxidation was observed in the liver of LPS-treated P2X1-/- mice, indicative of exaggerated oxidative damage. Concomitantly, the levels of thrombin-antithrombin complexes were higher in the plasma of LPS-treated P2X1-/- mice and thrombocytopenia was worsened as compared to wild type mice. Elevated numbers of microthrombi were also found in the lungs of these mice. These observations coincided with a higher susceptibility of P2X1-/- mice to LPS-induced septic shock than wild type animals. <br />Our results strongly suggest that P2X1 ion channels play a protective role in sepsis by negatively regulating systemic neutrophil activation, thereby limiting oxidative damage, activation of coagulation and platelet accumulation into the lungs. Therefore, since antagonists of P2X1 ion channels may not only target platelets but also affect neutrophils, inhibiting these channels in the highly inflammatory environment of severe sepsis or of acute coronary syndromes might be detrimental. [less ▲]

Detailed reference viewed: 23 (10 ULg)
Peer Reviewed
See detailThe lack of relationship between DST nonsuppression in the dexamethasone suppression test and EEG abnormalities.
Pitchot, William ULg; Hansenne, Michel ULg; Ansseau, Marc ULg

in European Archives of Psychiatry & Clinical Neuroscience (1991), 241(3), 193-4

As a recent study suggested a relationship between cortisol escape following dexamethasone suppression test (DST) and electroencephalogram (EEG) abnormalities, we tried to replicate these findings in 52 ... [more ▼]

As a recent study suggested a relationship between cortisol escape following dexamethasone suppression test (DST) and electroencephalogram (EEG) abnormalities, we tried to replicate these findings in 52 major depressive inpatients. A total of 23 patients exhibited DST nonsuppression (44%) and 18 patients had EEG abnormalities (35%). No relationship existed between DST and EEG results. [less ▲]

Detailed reference viewed: 21 (2 ULg)
Full Text
Peer Reviewed
See detailLack of resolution in the animal phylogeny: Closely spaced cladogeneses or undetected systematic errors?
Baurain, Denis ULg; Brinkmann, Henner; Philippe, Hervé

in Molecular Biology and Evolution (2007), 24(1), 6-9

A recent phylogenomic study reported that the animal phylogeny was unresolved despite the use of 50 genes. This lack of resolution was interpreted as "a positive signature of closely spaced cladogenetic ... [more ▼]

A recent phylogenomic study reported that the animal phylogeny was unresolved despite the use of 50 genes. This lack of resolution was interpreted as "a positive signature of closely spaced cladogenetic events." Here, we propose that this lack of resolution is rather due to the mutual cancellation of the phylogenetic signal (historical) and the nonphylogenetic signal (due to systematic errors) that results from inadequate taxon sampling and/or model of sequence evolution. Starting with a data set of comparable size, we use 3 different strategies to reduce the nonphylogenetic signal: 1) increasing the number of species; 2) replacing a fast-evolving species by a slowly evolving one; and 3) using a better model of sequence evolution. In all cases, the phylogenetic resolution is markedly improved, in agreement with our hypothesis that the originally reported lack of resolution was artifactual. [less ▲]

Detailed reference viewed: 22 (7 ULg)
Full Text
Peer Reviewed
See detailLack of risk of transmission of caprine arthritis-encephalitis virus (CAEV) after an appropriate embryo transfer procedure
Ali Al Ahmad, M. Z.; Chebloune, Y.; Bouzar, Amel ULg et al

in Theriogenology (2008)

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailLack of trans-activation function for Maedi Visna virus and Caprine arthritis encephalitis virus Tat proteins
Villet, S.; Faure, C.; Bouzar, Amel ULg et al

in Virology (2003)

Detailed reference viewed: 7 (2 ULg)
Peer Reviewed
See detailLack of universality in 2-dimensional multicomponent spreading phenomena
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 52(4), 3447-3454

Magnetic entities are introduced in a two-dimensional Eden model as additional degrees of freedom in order to model multidomain spreading phenomena. The elements of the growth are "spins" taking q states ... [more ▼]

Magnetic entities are introduced in a two-dimensional Eden model as additional degrees of freedom in order to model multidomain spreading phenomena. The elements of the growth are "spins" taking q states and are coupled or not via an energy J, as in the Potts model, thus leading to a competition between species. The internal cluster spreading is found to result from a competition between growing domains. Complex mechanisms such as trapping, jamming and coalescence occur between the growing domains. A large variety of critical and nanuniversal regimes, from subcritical to self-organized critical behaviors, are obtained depending on nonuniversal parameters such as the lattice structure, the number of internal degrees of freedom q, and the coupling J. For the square lattice, the fractal dimension is 1.50 and the mass distribution exponent tau is 1.63. For the triangular lattice, the fractal dimension varies from 1.70 to 1.83 depending on the coupling value and the mass distribution exponent tau also varies from 1.67 to 1.98 depending on the coupling value. The correspondence and differences with respect to the percolation phenomenon are outlined. [less ▲]

Detailed reference viewed: 8 (0 ULg)