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See detailInsight and the sleep committee
Maquet, Pierre ULg; Ruby, P.

in Nature (2004), 427(6972), 304-305

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See detailInsight and the sleep committee
Maquet, Pierre ULg; Ruby, Perrine

in Nature (2004), 427(6972), 304-305

We all spend about a third of our lives asleep, an essential but seemingly unproductive state. Experimental evidence now emerges to support anecdotal evidence that sleep can stimulate creative thinking.

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See detailInsight in variability of apparent endoxylanase and endoxylanase inhibitor levels in wheat kernels
Dornez, Emmie; Joye, Iris J.; Gebeurs, Kurt et al

in Journal of the Science of Food and Agriculture (2006), 86(11), 1610-1617

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See detailInsight into cellular response of plant cells confined within silica-based matrices
Meunier, C. F.; Rooke, J. C.; Hajdu, K. et al

in Langmuir (2010), 26(9), 6568-6575

The encapsulation of living plant cells into materials could offer the possibility to develop new green biochemical technologies. With the view to designing new functional materials, the physiological ... [more ▼]

The encapsulation of living plant cells into materials could offer the possibility to develop new green biochemical technologies. With the view to designing new functional materials, the physiological activity and cellular response of entrapped cells within different silica-based matrices have been assessed. A fine-tuning of the surface chemistry of the matrix has been achieved by the in situ copolymerization of an aqueous silica precursor and a biocompatible trifunctional silane bearing covalently bound neutral sugars. This method allows a facile control of chemical and physical interactions between the entrapped plant cells and the scaffold. The results show that the cell-matrix interaction has to be carefully controlled in order to avoid the mineralization of the cell wall which typically reduces the bioavailability of nutrients. Under appropriate conditions, the introduction of a trifunctional silane (ca. 10%) during the preparation of hybrid gels has shown to prolong the biological activity as well as the cellular viability of plant cells. The relations of cell behavior with some other key factors such as the porosity and the contraction of the matrix are also discussed. © 2010 American Chemical Society. [less ▲]

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See detailAn insight into Ms Cambridge University Library Qq. 106-109 (Alf Layla wa-Layla - The Arabian Nights)
Franssen, Elise ULg

in Faghihi, Yasmin (Ed.) Cambridge University Library Manuscripts in Arabic Script: a New Catalogue (in press)

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See detailAn insight into normal and pathological pregnancies using large-scale microarrays: lessons from microarrays
Chaouat, G. R.; Rodde, N.; Petitbarat, M. et al

in Journal of Reproductive Immunology (2011), 89(2), 163-72

In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and large-scale microarrays in CBA ... [more ▼]

In the introduction, we briefly recall old but classic evidence that there is no tolerance to paternal alloantigens in a first pregnancy. Therefore, we performed small- and large-scale microarrays in CBA × DBA/2 and CBA × BALB/c combinations, recently described as a murine model for preeclampsia. Our results are in line with other data suggesting a very early deregulation of local immune vascular events rather than a break of immune tolerance. Other data presented at the Tioman 2010 Preeclampsia Workshop supporting this hypothesis are briefly summarised, as well as indications and caveats from a recent human microarray on implantation failure and recurrent pregnancy loss. [less ▲]

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See detailInsight into organometallic-mediated radical polymerization
Hurtgen, Marie ULg; Detrembleur, Christophe ULg; Jérôme, Christine ULg et al

in Polymer Reviews (2011), 51(2), 188-213

This review focuses on an emerging class of controlled radical polymerization named Organometallic-Mediated Radical Polymerization (OMRP). The latter is based on the temporary deactivation of the growing ... [more ▼]

This review focuses on an emerging class of controlled radical polymerization named Organometallic-Mediated Radical Polymerization (OMRP). The latter is based on the temporary deactivation of the growing radical species by a transition metal complex and the reversible formation of a carbon-metal covalent bond. Initially developed with cobalt complexes, OMRP has extended to several metals today. As highlighted here, the choice of the metal, the structure of ligands, temperature, and additives deeply affect the course of the polymerization and its mechanism. Macromolecular engineering opportunities offered by OMRP are also described, as well as practical applications sustained by the resulting polymer materials. [less ▲]

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See detailInsight into the cellular uptake mechanism of a secondary amphipathic cell penetrating peptide for siRNA delivery.
Konate, K.; Crombez, L.; Deshayes, S. et al

in Biochemistry (2010)

Delivery of siRNA remains a major limitation to their clinical application and several technologies have been proposed to improve their cellular uptake. We recently described a peptide-based nanoparticle ... [more ▼]

Delivery of siRNA remains a major limitation to their clinical application and several technologies have been proposed to improve their cellular uptake. We recently described a peptide-based nanoparticle system for efficient delivery of siRNA into primary cell lines: CADY. CADY is a secondary amphipathic peptide that forms stable complexes with siRNA and improves their cellular uptake independently of the endosomal pathway. In the present work, we have combined molecular modelling, spectroscopy and membrane interaction approaches, in order to gain further insight into CADY/siRNA particle mechanism of interaction with biological membrane. We demonstrate that CADY forms stable complexes with siRNA and binds phospholipids tightly, mainly through electrostatic interactions. Binding to siRNA or phospholipids triggers a conformational transition of CADY from an unfolded state to an -helical structure, thereby stabilizing CADY/siRNA complexes and improving their interactions with cell membranes. Therefore, we propose that CADY cellular membrane interaction is driven by its structural polymorphism which enables stabilization of both electrostatic and hydrophobic contacts with surface membrane proteoglycan and phospholipids. [less ▲]

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See detailInsight into the development of a carbonate platform through a multi-disciplinary approach - A case study from the Upper Devonian slope deposits of Mount Freikofel (Carnic Alps, Austria/Italy)
Pas, Damien ULg; Da Silva, Anne-Christine ULg; Suttner, Thomas et al

in International Journal of Earth Sciences (2014), 103

The development and behavior of Million year-scaled depositional sequences recorded within Palaeozoic carbonate platform has remained poorly examined. Therefore, the understanding of palaeoenvironmental ... [more ▼]

The development and behavior of Million year-scaled depositional sequences recorded within Palaeozoic carbonate platform has remained poorly examined. Therefore, the understanding of palaeoenvironmental changes that occur in geological past is still limited. We herein undertake a multi-disciplinary approach (sedimentology, conodont biostratigraphy, magnetic susceptibility and geochemistry) of a long-term succession in the Carnic Alps which offers new insights into the peculiar evolution of one of the best example of Palaeozoic carbonate platform in Europe. The Freikofel section, located in the central part of the Carnic Alps represents an outstanding succession in a fore-reef setting, extending from the latest Givetian (indet. falsiovalis conodont Zones) to the early Famennian (Lower crepida conodont Zone). Sedimentological analysis allowed to propose a sedimentary model dominated by distal slope and fore-reef slope deposits. The most distal setting is characterized by an autochthonous pelagic sedimentation showing local occurrence of thin-bedded turbiditic deposits. In the fore-reef slope, in a more proximal setting, there is an accumulation of various autochthonous and allochthonous fine- to coarse-grained sediments originated from the interplay of gravity-flow currents derived from the shallow-water and deeper-water area. The temporal evolution of microfacies in the Freikofel section evolves in two main steps corresponding to the Freikofel (Unit 1) and the Pal (Unit 2) Limestones. Distal slope to fore-reef lithologies and associate changes are from base to top of the section: (U1) thick bedded litho- and bioclastic breccia beds with local fining upward sequence and fine-grained mudstone intercalations corresponding, in the fore-reef setting, to the dismantlement of the Eifelian – Frasnian carbonate platform during the early to late Frasnian time (falsiovalis to rhenana superzones) with one of the causes being the Late Givetian major rift pulse; (U2) occurrence of thin-bedded red nodular and cephalopod-bearing limestones with local lithoclastic grainstone intercalations corresponding to a significant deepening of the area and the progressive withdrawal of sedimentary influxes toward the basin, in relation with late Frasnian sea-level rise. Magnetic susceptibility and geochemical analyses were also performed along the Freikofel section and demonstrate the inherent-parallel link existing between variation in magnetic susceptibility values and proxy for terrestrial input. Interpretation of magnetic susceptibility in term of palaeoenvironmental processes reflect that even though distality remains the major parameter influencing magnetic susceptibility values, carbonate production and water agitation also play an important role. [less ▲]

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See detailInsight into the ecology of Neandertals in North-West Europe: stable isotopes and their palaeobiological implications
Wissing, C.; Bocherens, H.; Crevecoeur, I. et al

Conference (2014, March 21)

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See detailInsight into the mechanisms underlying the oncogenic potential of BCL-3 through transcriptomic studies
Zhang, Xin ULg

Doctoral thesis (2013)

The abstract will be available after the corresponding papers are published. For more information, please contact Dr. Alain Chariot.

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See detailInsight into the peopling of mainland southeast Asia from thai population genetic structure.
Wangkumhang, Pongsakorn; Shaw, Philip James; Chaichoompu, Kridsadakorn ULg et al

in PloS one (2013), 8(11), 79522

There is considerable ethno-linguistic and genetic variation among human populations in Asia, although tracing the origins of this diversity is complicated by migration events. Thailand is at the center ... [more ▼]

There is considerable ethno-linguistic and genetic variation among human populations in Asia, although tracing the origins of this diversity is complicated by migration events. Thailand is at the center of Mainland Southeast Asia (MSEA), a region within Asia that has not been extensively studied. Genetic substructure may exist in the Thai population, since waves of migration from southern China throughout its recent history may have contributed to substantial gene flow. Autosomal SNP data were collated for 438,503 markers from 992 Thai individuals. Using the available self-reported regional origin, four Thai subpopulations genetically distinct from each other and from other Asian populations were resolved by Neighbor-Joining analysis using a 41,569 marker subset. Using an independent Principal Components-based unsupervised clustering approach, four major MSEA subpopulations were resolved in which regional bias was apparent. A major ancestry component was common to these MSEA subpopulations and distinguishes them from other Asian subpopulations. On the other hand, these MSEA subpopulations were admixed with other ancestries, in particular one shared with Chinese. Subpopulation clustering using only Thai individuals and the complete marker set resolved four subpopulations, which are distributed differently across Thailand. A Sino-Thai subpopulation was concentrated in the Central region of Thailand, although this constituted a minority in an otherwise diverse region. Among the most highly differentiated markers which distinguish the Thai subpopulations, several map to regions known to affect phenotypic traits such as skin pigmentation and susceptibility to common diseases. The subpopulation patterns elucidated have important implications for evolutionary and medical genetics. The subpopulation structure within Thailand may reflect the contributions of different migrants throughout the history of MSEA. The information will also be important for genetic association studies to account for population-structure confounding effects. [less ▲]

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See detailInsight into the role of catalases in salt stress in potato (Solanum tuberosum L.).
M'Hamdi, M.; Bettaieb, T.; Harbaoui, Y. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2009), 13

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See detailInsight on variables leading to burnout in cancer physicians
Bragard, Isabelle ULg; Libert, Y.; Etienne, Anne-Marie ULg et al

in Journal of Cancer Education : The Official Journal of the American Association for Cancer Education (2010), 25

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