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See detailHex-dominant meshing approach based on frame field smoothness
Bernard, P.-E.; Remacle, J.-F.; Kowalski, N. et al

in Procedia Engineering (2014), 82

Detailed reference viewed: 16 (1 ULg)
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See detailHEXAGONAL MARANGONI CONVECTION IN A RECTANGULAR BOX WITH SLIPPERY WALLS
Dauby, Pierre ULg; Lebon, Georgy ULg; COLINET, P. et al

in Quarterly Journal Of Mechanics And Applied Mathematics (1993), 46(Part 4), 683-707

Detailed reference viewed: 7 (1 ULg)
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See detailHexis
Durand, Pascal ULg

E-print/Working paper (2014)

Définition et discussion du concept d'« Hexis » dans la sociologie de Pierre Bourdieu.

Detailed reference viewed: 105 (15 ULg)
See detailHeymans Christian
Tomasovic, Dick ULg

in Moins, Philippe (Ed.) Image par image, le cinéma d’animation en communauté Wallonie-Bruxelles (2001)

Detailed reference viewed: 18 (0 ULg)
See detailHF radar observations of surface currents in the German Bight: descriptive analysis, model-data comparison and non-sequential ensemble data assimilation
Port, A.; Staneva, J.; Schulz-Stellenfleth, J. et al

Conference (2009, September)

Detailed reference viewed: 43 (2 ULg)
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See detailhGH-V gene: specific placental expression, isolation and structure of the related cDNA.
Igout, Ahmed ULg; Scippo, Marie-Louise ULg; Frankenne, Francis et al

Conference (1988)

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See detailHic et Nunc. Naevus ou melanome?
Pierard, Claudine ULg; Pierard, Gérald ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2006), 61(1), 43-7

In Wallonia, the incidence of cutaneous melanoma has steadily increased over the past decades. Hopefully, the early diagnosis made at the premetastatic stage has benefited from great advances both in the ... [more ▼]

In Wallonia, the incidence of cutaneous melanoma has steadily increased over the past decades. Hopefully, the early diagnosis made at the premetastatic stage has benefited from great advances both in the clinical and laboratory fields. Thanks to the "Groupement Oncologique Universitaire Wallonie-Liege" (GOUWL) organization, some efforts are currently made in order to better frame and normalize the management of cancer patients. Some medical staffs involved in prospective clinical research bring by their own experience further practical insights for the benefit to the patients. In this field, Belgium is not destituted. We report a brief review of the contribution of the Mosan Study Group of Pigmentary Tumors (GMETP) at the University Hospital of Liege. [less ▲]

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See detailThe hidden face of the human macrophage chitotriosidase: taking a new look at this enzyme based on the biochemical and phylogenomic analysis of its chitin binding domain
Crasson, Oscar ULg; Legrand, François; Léonard, Raphaël et al

Poster (2015, August)

Carbohydrates recognition is a critical process involved in numerous aspects of the cell biology such as inflammation, innate immune responses and proliferation. Chitin is an homopolysaccharide composed ... [more ▼]

Carbohydrates recognition is a critical process involved in numerous aspects of the cell biology such as inflammation, innate immune responses and proliferation. Chitin is an homopolysaccharide composed of β-1,4-linked N-acetylglucosamine (GlcNAc) units that is an abundant structural component of various infectious organisms like protozoans, nematodes and fungi. As there is no endogenous chitin produced by mammals, this polymer appeared to be a strategic target for innate immune agents which is why various carbohydrate binding proteins, associated or not with catalytic domains, are synthetized by plants and animals and are known to play a crucial role in innate immunity. The macrophage chitotriosidase (HCHT) is one of the three active chitinases synthetized by humans and has triggered significant attention recently due to its association with various inflammatory disorders. HCHT belongs to the Glycosyl Hydrolase family 18 (GH18) and is known to be involved in innate immunity. Nevertheless, its precise physiological function remains unclear. As numerous GHs, HCHT is a modular protein composed of a catalytic domain (GH18) associated to a Carbohydrate Binding Module (CBM) which is essential to hydrolyse crystalline chitin. If the catalytic domain GH18 is highly common in other GHs from animals, plants, fungi, bacteria, archea and viruses, its CBM (named ChBD) is much less conserved which makes the association between these two domains particularly intriguing. This work aims to demystify HCHT’s physiological function. Firstly, using competitive inhibition assays, we have highlighted the ability of ChBD to interact with chitooligosaccharides (GlcNAc1-2-4-6) which suggests that ChBD can potentially act as a lectin domain. Secondly, to better understand the molecular basis for chitin recognition, we have used homology modelling to build, with high confidence, the 3D structure model of ChBD. Based on this model, a specific set of residues has been selected for alanine scan mutagenesis which has allowed us to define the minimum chitin binding interface of the protein. Thirdly, Phylogenomic studies were performed to analyse the evolutionary history of the isolated catalytic and ChBD domains and understand how these domains were combined. Based on all these results, we discuss a new way of looking at HCHT where its ChBD would be the key determinant that has guided the catalytic domain from a basic metabolic function to a critical component of innate immunity in human. Finally, we propose a mechanism that explains how this enzyme could act at the molecular level to defend us against chitin-containing pathogens. [less ▲]

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See detailHidden faults in the Gobi Desert (Inner Mongolia, China) revealed by microtremor analysis, ground-penetrating radar and SQUID-supported transient electromagnetics
Rudersdorf, A.; Hölz, S.; Torgoev, A. et al

in EGU General Assembly Conference Abstracts (2013, April)

Abstract: The endorheic Gaxun Nur Basin (GNB, also Ejina Basin, Hei river Basin, Ruoshui Basin) in the eastern Gobi desert is situated between the northern Tibetan Plateau and the Gobi Altai mountains ... [more ▼]

Abstract: The endorheic Gaxun Nur Basin (GNB, also Ejina Basin, Hei river Basin, Ruoshui Basin) in the eastern Gobi desert is situated between the northern Tibetan Plateau and the Gobi Altai mountains. Recent fault activity is concentrated on the sinistral Altyn Tagh Fault, its eastern continuations and the Qilian Shan frontal thrust in the south, which are induced by the stress field of the India-Eurasia continental collision. In the north, the basin is bound by the Gobi Altai mountains with the major sinistral Gobi-Tien Shan Fault System. The ... [less ▲]

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See detailHidden focal abnormalities of smooth muscles in human GI motility disorders revealed by novel immunomarkers
Wedel, Théo; van Eys, G.; Glénisson, Wendy et al

Conference (2005)

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See detailThe hidden function of NIK (NF-κB-Inducing Kinase) in cell death
Boutaffala, Layla; Bertrand, Mathieu; Remouchamps, Caroline ULg et al

Conference (2011)

Detailed reference viewed: 29 (6 ULg)
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See detailThe hidden half of flowering
Bouché, Frédéric ULg; Mistiaen, Kevin ULg; D'Aloia, Maria ULg et al

Poster (2013, June)

Flowering is one of the most important developmental steps in plant life cycle and is therefore tightly controlled by environmental cues. The involvement of the aerial part of the plant in the molecular ... [more ▼]

Flowering is one of the most important developmental steps in plant life cycle and is therefore tightly controlled by environmental cues. The involvement of the aerial part of the plant in the molecular mechanisms leading to floral transition is well documented while participation of the roots received less attention. Nevertheless, the induction of flowering by photoperiod is known to involve systemic signals that move in phloem sap towards sinks, throughout the plants, including the roots. Transcriptomic analysis of roots tissues during the floral induction of flowering by a single long day of in Arabidopsis thaliana by a single long day allowed us to identify a large number of differentially expressed genes. How mutations We subsequently selected in some candidate genes affect plant development - including root architecture and flowering time - is being to analyze their flowering timefurther analyzed. Further analysis of those genes will permit us to unravel their role in the flowering induction process. [less ▲]

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See detailA hidden markov model combining linkage and linkage disequilibrium information for haplotype reconstruction and quantitative trait locus fine mapping.
Druet, Tom ULg; Georges, Michel ULg

in Genetics (2010), 184(3), 789-98

Faithful reconstruction of haplotypes from diploid marker data (phasing) is important for many kinds of genetic analyses, including mapping of trait loci, prediction of genomic breeding values, and ... [more ▼]

Faithful reconstruction of haplotypes from diploid marker data (phasing) is important for many kinds of genetic analyses, including mapping of trait loci, prediction of genomic breeding values, and identification of signatures of selection. In human genetics, phasing most often exploits population information (linkage disequilibrium), while in animal genetics the primary source of information is familial (Mendelian segregation and linkage). We herein develop and evaluate a method that simultaneously exploits both sources of information. It builds on hidden Markov models that were initially developed to exploit population information only. We demonstrate that the approach improves the accuracy of allele phasing as well as imputation of missing genotypes. Reconstructed haplotypes are assigned to hidden states that are shown to correspond to clusters of genealogically related chromosomes. We show that these cluster states can directly be used to fine map QTL. The method is computationally effective at handling large data sets based on high-density SNP panels. [less ▲]

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See detailA hidden Markov model to predict early mastitis from test-day somatic cell scores
Detilleux, Johann ULg

in Animal (2011), 5(2), 175-181

In many countries, high somatic cell scores (SCS) in milk are used as an indicator for mastitis because they are collected on a routine basis. However, individual test-day SCS are not very accurate in ... [more ▼]

In many countries, high somatic cell scores (SCS) in milk are used as an indicator for mastitis because they are collected on a routine basis. However, individual test-day SCS are not very accurate in identifying infected cows. Mathematical models may improve the accuracy of the biological marker by making better use of the information contained in the available data. Here, a simple hidden Markov model (HMM) is described mathematically and applied to SCS recorded monthly on cows with or without clinical mastitis to evaluate its accuracy in estimating parameters (mean, variance and transition probabilities) under healthy or diseased states. The SCS means were estimated at 1.96 (s.d.50.16) and 4.73 (s.d.50.71) for the hidden healthy and infected states, and the common variance at 0.83 (s.d.50.11). The probability of remaining uninfected, recovering from infection, getting newly infected and remaining infected between consecutive test days was estimated at 78.84%, 60.49%, 11.70% and 15%, respectively. Three different health-related states were compared: clinical stages observed by farmers, subclinical cases defined for somatic cell counts below or above 250 000 cells/ml and infected stages obtained from the HMM. The results showed that HMM identifies infected cows before the appearance of clinical and subclinical signs, which may critically improve the power of the studies on the genetic determinants of SCS and reduce biases in predicting breeding values for SCS. [less ▲]

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See detailThe Hidden Recess of a Global City: La République Marseille
Van Cauwenberge, Geneviève ULg

Conference (2011, August 13)

Detailed reference viewed: 14 (3 ULg)
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See detailHide-working in the Late Palaeolithic site at Rekem (Belgium): confrontation with ethnoarchaelogical observations
Caspar, Jean-Paul; Beyries, Sylvie; De Bie, Marc et al

Conference (2000)

Detailed reference viewed: 50 (1 ULg)