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See detailIntensity Dependence of the Cortical Auditory Evoked Potentials as a Surrogate Marker of Central Nervous System Serotonin Transmission in Man: Demonstration of a Central Effect for the 5ht1b/1d Agonist Zolmitriptan (311c90, Zomig)
Proietti-Cecchini, A.; Afra, J.; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1997), 17(8), 849-54799

As shown in animal studies, 5HT1B/D agonists can inhibit activity in the trigeminal nucleus caudalis, which may be advantageous for their antimigraine effect. To demonstrate a possible central nervous ... [more ▼]

As shown in animal studies, 5HT1B/D agonists can inhibit activity in the trigeminal nucleus caudalis, which may be advantageous for their antimigraine effect. To demonstrate a possible central nervous system (CNS) action of these compounds in man we studied their effect on the intensity dependence of the cortical auditory evoked potentials (IDAPs), thought to be inversely related to central serotonergic transmission. An amplitude/stimulus intensity function (ASF) slope was computed in healthy volunteers and migraine patients between attacks before and 2 h after oral 311C90 (zolmitriptan "Zomig") 10 mg (n=14), 311C90 5 mg (n=7), sumatriptan 100 mg (n=14), dexfenfluramine 15 mg (n=4), lorazepam 1.25 mg (n=4) and placebo (n=14). 311C90 10 mg and, to a lesser degree, 5 mg significantly increased the mean ASF slope (p=0.007 and 0.05 vs placebo). There was a significant positive correlation between plasma levels of 311C90 and ASF slope changes. Sumatriptan and lorazepam had little effect, but dexfenfluramine produced a significant ASF slope decrease. 311C90 is able to modify a CNS activity that is modulated by serotonin, i.e. the IDAP. This effect is probably the consequence of its superior lipophilicity compared to sumatriptan and of activation of prejunctional 5HT1B/D autoreceptors, which lowers central serotonin release and thus the preactivation level of sensory cortices. [less ▲]

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See detailIntensity distribution of non-linear scattering states
Hartmann, Timo; Urbina, Juan-Diego; Richter, Klaus et al

in Robnik, M.; Romanovski, V.G. (Eds.) LET'S FACE CHAOS THROUGH NONLINEAR DYNAMICS (2012)

We investigate the interplay between coherent effects characteristic of the propagation of linear waves, the non-linear effects due to interactions, and the quantum manifestations of classical chaos due ... [more ▼]

We investigate the interplay between coherent effects characteristic of the propagation of linear waves, the non-linear effects due to interactions, and the quantum manifestations of classical chaos due to geometrical confinement, as they arise in the context of the transport of Bose-Einstein condensates. We specifically show that, extending standard methods for non-interacting systems, the body of the statistical distribution of intensities for scattering states solving the Gross-Pitaevskii equation is very well described by a local Gaussian ansatz with a position-dependent variance. We propose a semiclassical approach based on interfering classical paths to fix the single parameter describing the universal deviations from a global Gaussian distribution. Being tail effects, rare events like rogue waves characteristic of non-linear field equations do not affect our results. [less ▲]

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See detailThe intensity of emotional facial expression and decoding accuracy
Hess, U; Blairy, Sylvie ULg; Kleck, R

in Journal of Nonverbal Behavior (1997), 21

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See detailIntensive and Prolonged Health Promotion Strategy May Increase Awareness of Osteoporosis among Postmenopausal Women
Tellier, V.; De Maeseneer, J.; De Prins, L. et al

in Osteoporosis International (2001), 12(2), 131-5

The aim of the study was to measure the results of a 15-year health promotion strategy towards osteoporosis, in an urban community of subjects over 45 years old, in terms of osteoporosis awareness and ... [more ▼]

The aim of the study was to measure the results of a 15-year health promotion strategy towards osteoporosis, in an urban community of subjects over 45 years old, in terms of osteoporosis awareness and handling. To this end an ancillary study to a large survey of the Belgian population's self-perceived health status was carried out. A rectangular sample of 4800 individuals over 45 years old was randomly selected in two Belgian cities, among the affiliates of the two main health insurance providers. One of the cities (Liege) had been, since the early 1980s, the target of a constant health promotion strategy, directed to both the medical community and the general population, aimed at increasing osteoporosis awareness in women after the menopause. During the same period, no particular steps were taken in the other city (Aalst) to increase osteoporosis awareness in the community. In our study, the participants were asked to spontaneously report any chronic, serious and/or severe disorders that they had been suffering from, for at least 6 months, during the previous 12 months. They also provided a list of drugs they were taking at the time of the survey. Osteoporosis was reported to be a disease affecting 1.5% of men in Aalst and 1.3% of men in Liege (p = 0.61). For women, osteoporosis was reported to be present in 4.8% in Aalst and 10.8% in Liege (p<0.001). Self-reporting of osteoporosis prevalence in Liege was statistically significantly higher in women aged 45-64 years, 65-74 years or over 75 years (p<0.001). Obesity, alcohol consumption or physical activity were equally distributed between women from Liege and Aalst. Prescription drugs used for osteoporosis had been delivered to a similar proportion of men in Aalst and Liege. In women, a statistically significant difference in these prescription drugs was observed between Liege and Aalst, both for the overall population (p<0.001) and in each of the age classes (p<0.001 for 45-64 years and 65-74 years; p<0.009 for over 75 years). A continuous long-term health promotion strategy, directed toward both physicians and the general population, thus appears to increase awareness about osteoporosis in women over 45 years and/or in the medical community. This is reflected by an increase in self-reported prevalence of osteoporosis and in the prescription of drugs aimed at prevention and treatment of this disorder. Whether these observations reflect an appropriate diagnosis and a proper handling of the disease remains to be evaluated by objective diagnostic tools such as bone densitometry and by an evaluation of the effectiveness of prescription practices in postmenopausal women. [less ▲]

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See detailIntensive and prolonged health promotion strategy may increase self-reported osteoporosis prevalence among postmenopausal women
Tellier, V; De Maeseneer, J; Cartier, P et al

in Annals of the Rheumatic Diseases (2000), 59(S1), 58

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See detailIntensive care unit acquired infection and organ failure
Damas, Pierre ULg; Ledoux, Didier ULg; Nys, Monique ULg et al

in Intensive Care Medicine (2008), 34

OBJECTIVE: To assess the temporal relationship between ICU-acquired infection (IAI) and the prevalence and severity of organ dysfunction or failure (OD/F). DESIGN AND SETTING: Observational, single center ... [more ▼]

OBJECTIVE: To assess the temporal relationship between ICU-acquired infection (IAI) and the prevalence and severity of organ dysfunction or failure (OD/F). DESIGN AND SETTING: Observational, single center study in a mixed intensive care unit of a university hospital. PATIENTS: We analyzed 1,191 patients hospitalized for more than 2 days during a 2-year observation period: 845 did not acquire IAI, 306 of whom had infection on admission (IOA); 346 did acquire IAI, 125 of whom had IOA. MEASUREMENTS AND RESULTS: The SOFA score was calculated daily, both SOFAmax, the sum of the worst OD/F during the ICU stay, and SOFApreinf, the sum of the worst OD/F existing before the occurrence of the first IAI. The SAPS II and SOFA score of the first 24 h were significantly higher in patients with than in those without IAI. SOFApreinf of IAI patients was also higher than the SOFAmax of patients without IAI both in patients with (12.1+/-4.6 vs. 8.9+/-4.7) and those without IOA (9.2+/-4.0 vs. 6.7+/-3.5). SOFApreinf represented 85.7% of the value of SOFAmax in patients with IAI. SOFApreinf increased significantly with the occurrence of sepsis, severe sepsis, or septic shock during ICU stay. Severe sepsis and septic shock during ICU stay as well as SOFApreinf were part of the factors associated with hospital mortality. CONCLUSIONS: IAI is significantly associated with hospital mortality; however, its contribution to OD/F is minor. Moreover, severity of IAI seems to be related to previous health status. [less ▲]

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See detailIntensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
Tilly, Hervé; Lepage, Eric; Coiffier, Bertrand et al

in Blood (2003), 102(13), 4284-4289

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide ... [more ▼]

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in previously untreated patients with poor-risk aggressive lymphoma. Patients aged 61 to 69 years who had aggressive non-Hodgkin lymphoma with at least one prognostic factor of the age-adjusted international prognostic index (IPI) were included. ACVBP consisted of an induction phase of intensified chemotherapy and central nervous system (CNS) prophylaxis followed by a sequential consolidation phase. Of the 708 patients registered for the study, 635 were eligible. The rate of complete response was 58% in the ACVBP group and 56% in the CHOP group (P =.5). Treatment-related death occurred in 13% of the ACVBP group and 7% of the CHOP group (P =.014). At 5 years, the event-free survival was 39% in the ACVBP group and 29% in the CHOP group (P =.005). The overall survival was significantly longer for patients treated with ACVBP, at 5 years it was 46% compared with 38% for patients treated with CHOP (P =.036). CNS progressions or relapses were more frequent in the CHOP group (P =.004). Despite higher toxicity, the ACVBP regimen, used as first-line treatment for patients with poor-risk aggressive lymphoma, is superior to standard CHOP with regard to both event-free survival and overall survival. (C) 2003 by The American Society of Hematology. [less ▲]

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See detailIntensive culture of juvenile and adult Eurasian perch (P. fluviatilis): effect of major biotic and abiotic factors on growth
Mélard, Charles ULg; Kestemont, P.; Grignard, J. C.

in Journal of Applied Ichthyology (1996), 12

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See detailIntensive culture of the common barbel Barbus barbus (L.) for restocking.
Philippart, Jean-Claude ULg; Melard, Ch.; Poncin, Pascal ULg

in Depauw, N;; Jaspers, E.; Ackefors, H. (Eds.) et al Aquaculture - a biotechnology in progress (1989)

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See detailIntensive Programme “Theories of International Migration”
Martiniello, Marco ULg

Scientific conference (2006, August 21)

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See detailIntensivemedizinische Probleme nach kardiochirurgischen Eingriffen in der Neugeborenenperiode
Hörnchen, H.; Dreuw, M.; Merz, U. et al

in Monatsschrift fur Kinderheilkunde (1997), 145

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See detailIntenti dimostrativi ed esemplarità nelle novelle di Maupassant
Benzoni, Pietro ULg

Scientific conference (2003, May 23)

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See detailIntentional objects and their properties : a critical appraisal of Meinongian logics
Leclercq, Bruno ULg

Scientific conference (2014, January 17)

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See detailIntentional patina of metal archaeological artefacts; a non-destructive investigation of Egyptian and Roman museum treasures
Aucouturier, Marc; Mathis, François ULg; Robcis, Dominique et al

in Corrosion Engineering, Science & Technology (2010), 45(5), 314-321

This paper describes microstructural analyses by X-ray portable diffraction and microdiffraction on intentional patina of the bronze museum objects from antique Egypt and the Roman Empire. They bring ... [more ▼]

This paper describes microstructural analyses by X-ray portable diffraction and microdiffraction on intentional patina of the bronze museum objects from antique Egypt and the Roman Empire. They bring evidence of the presence in the true black bronze patinas of metallic gold and/or silver presumably as nanoparticles. Three other Egyptian patinas not belonging to black bronze are characterised. Apparent black patination on a Roman scalpel handle is discussed. The discovery of a new patination procedure on Roman artefacts from the Louvre museum is also related, based on intentional high temperature oxidation to obtain a dark patina on a lead bronze object. A presence of lead carbonate cerussite is an important observation. [less ▲]

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See detailIntentional patina of metal archaeological artefacts; a non-destructive investigation of Egyptian and Roman museum treasures
Mathis, François ULg; Aucouturier, Marc; Robcis, Dominique et al

Conference (2009)

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See detailIntentionalisme et représentationalisme de Brentano à Crane
Boccaccini, Federico ULg

Conference (2014, March 06)

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See detailIntentionality as Disposition
Boccaccini, Federico ULg

E-print/Working paper (2014)

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See detailIntentionality as Disposition. Brentano on the Aristotelian Account of Power
Boccaccini, Federico ULg

Scientific conference (2013, May 23)

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