Foliicolous lichens: ecological and chorological data
in Botanical Journal of the Linnean Society (1986), 100Detailed reference viewed: 18 (0 ULg)
Folinic acid treatment for schizophrenia associated with folate receptor autoantibodies.
RAMAEKERS, Vincent ; ; et al
in Molecular genetics and metabolism (2014), 113(4), 307-14
BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia ... [more ▼]
BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia. Acoustic hallucinations disappeared following folinic acid treatment. Folate transport to the CNS prevents homocysteine accumulation and delivers one-carbon units for methyl-transfer reactions and synthesis of purines. The guanosine derivative tetrahydrobiopterin acts as common co-factor for the enzymes producing dopamine, serotonin and nitric oxide. METHODS: Our study selected patients with schizophrenia unresponsive to conventional treatment. Serum from these patients with normal plasma homocysteine, folate and vitamin B12 was tested for FR autoantibodies of the blocking type on serial samples each week. Spinal fluid was analyzed for MTHF and the metabolites of pterins, dopamine and serotonin. The clinical response to folinic acid treatment was evaluated. RESULTS: Fifteen of 18 patients (83.3%) had positive serum FR auto-antibodies compared to only 1 in 30 controls (3.3%) (chi(2)=21.6; p<0.0001). FRalpha antibody titers in patients fluctuated over time varying between negative and high titers, modulating folate flux to the CNS, which explained low CSF folate values in 6 and normal values in 7 patients. The mean+/-SD for CSF MTHF was diminished compared to previously established controls (t-test: 3.90; p=0.0002). A positive linear correlation existed between CSF MTHF and biopterin levels. CSF dopamine and serotonin metabolites were low or in the lower normal range. Administration of folinic acid (0.3-1mg/kg/day) to 7 participating patients during at least six months resulted in clinical improvement. CONCLUSION: Assessment of FR auto-antibodies in serum is recommended for schizophrenic patients. Clinical negative or positive symptoms are speculated to be influenced by the level and evolution of FRalpha antibody titers which determine folate flux to the brain with up- or down-regulation of brain folate intermediates linked to metabolic processes affecting homocysteine levels, synthesis of tetrahydrobiopterin and neurotransmitters. Folinic acid intervention appears to stabilize the disease process. [less ▲]Detailed reference viewed: 68 (3 ULg)
Folipidine, a new type quinoline alkaloid from plants of the Haplophyllum genus
; ; et al
in Chemistry of Natural Compounds (2005), 41(1, JAN-FEB), 60-64
The new quinoline alkaloid folipidine, the structure of which was established by chemical transformations and spectral data (UV, IR, mass, NMR) using APT 2D H-1-H-1 COSY, NOESY, and H-1-(13)CHSQC, HMBC ... [more ▼]
The new quinoline alkaloid folipidine, the structure of which was established by chemical transformations and spectral data (UV, IR, mass, NMR) using APT 2D H-1-H-1 COSY, NOESY, and H-1-(13)CHSQC, HMBC, was isolated from two plants of the Haplophyllum mints. Folipidine is the first representative of a new type of quinoline alkaloids that contain a heteroaromatic skeleton of [3,4-b]conjugated pyrrole and quinoline fragments. The total alkaloids of these plants exhibit antitumor activity. Folipidine does not possess such activity. [less ▲]Detailed reference viewed: 48 (1 ULg)
Follicle Stimulating Hormone -Secreting Pituitary adenomas
Beckers, Albert ; Stevenaert, Achille ; et al
in Journal of Clinical Endocrinology and Metabolism (1985), 61(3), 525-528
This retrospective study concerns 40 patients with an apparently nonsecretory pituitary adenoma who were operated on during an 11-yr period from 1971 to 1981. Among them, 6 men had elevated serum FSH ... [more ▼]
This retrospective study concerns 40 patients with an apparently nonsecretory pituitary adenoma who were operated on during an 11-yr period from 1971 to 1981. Among them, 6 men had elevated serum FSH levels. LH levels were normal in 5 and slightly elevated in 1. Testosterone levels were low in 2 patients and within normal limits in 2 others. Sexual impotency had developed from 6 months to 1 yr before surgery in all patients. Primary hypogonadism could be eliminated on clinical grounds (recent onset of hypogonadism, previous fertility of 5 of the 6, and postoperative improvement). After transsphenoidal adenomectomy, FSH levels returned to normal values in all, and clinical recovery occurred in most patients. Tumor tissue obtained at operation stained positively for the gonadotropins, but was negative for other pituitary hormones in all patients. The most probable explanation for these findings was that the tumors were responsible for the elevated FSH secretion. This explanation is supported by the immunocytochemical identification of gonadotropin-containing cells in the tumors. We conclude that these 6 men frm a series of 40 patients who presented with pituitary tumor but no GH, PRL, or ACTH hypersecretion had primary gonadotropinomas. [less ▲]Detailed reference viewed: 19 (0 ULg)
A follicle-stimulating-hormone secreting pituitary adenoma treated with long acting repeatable bromocriptine.
; Beckers, Albert ;
in Journal of Endocrinological Investigation (1990), 13Detailed reference viewed: 10 (0 ULg)
Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8.
; ; Heinen, Ernst et al
in Journal of Experimental Medicine (2008), 205(6), 1293-302
The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) mediates engulfment of apoptotic germinal center B cells by tingible-body macrophages (TBMphis ... [more ▼]
The secreted phosphatidylserine-binding protein milk fat globule epidermal growth factor 8 (Mfge8) mediates engulfment of apoptotic germinal center B cells by tingible-body macrophages (TBMphis). Impairment of this process can contribute to autoimmunity. We show that Mfge8 is identical to the mouse follicular dendritic cell (FDC) marker FDC-M1. In bone-marrow chimeras between wild-type and Mfge8(-/-) mice, all splenic Mfge8 was derived from FDCs rather than TBMphis. However, Mfge8(-/-) TBMphis acquired and displayed Mfge8 only when embedded in Mfge8(+/+) stroma, or when situated in lymph nodes draining exogenous recombinant Mfge8. These findings indicate a licensing role for FDCs in TBMphi-mediated removal of excess B cells. Lymphotoxin-deficient mice lacked FDCs and splenic Mfge8, and suffer from autoimmunity similar to Mfge8(-/-) mice. Hence, FDCs facilitate TBMphi-mediated corpse removal, and their malfunction may be involved in autoimmunity. [less ▲]Detailed reference viewed: 93 (6 ULg)
Follicular Dendritic Cells Do Not Produce Tnf-Alpha nor its Receptor
; ; et al
in Advances in Experimental Medicine and Biology (1993), 329Detailed reference viewed: 19 (0 ULg)
Follicular dendritic cells in lymph nodes after x-irradiation.
; Heinen, Ernst ; Radoux, Dominique et al
in International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine (1982), 42(2), 121-30
Follicular dendritic cells (FDC), non lymphoid cells present in lymph follicles, are characterized by numerous cytoplasmic processes retaining antigen-antibody complexes. Their origin, nature and function ... [more ▼]
Follicular dendritic cells (FDC), non lymphoid cells present in lymph follicles, are characterized by numerous cytoplasmic processes retaining antigen-antibody complexes. Their origin, nature and function are unknown. Mice inguinal lymph nodes after 4.5 or 7.5 Gy X-irradiation were depleted of lymphoid cells. Ultrastructural observations during the first few days post-irradiation show that FDC are unaltered and possess dendritic processes enveloping dense material. Furthermore, they show intense metabolic activity. A lamina densa, never observed so well-developed in other lymph node cells, was detected around the nuclear envelope. The localization of junctions between FDC was analysed. FDC preserve their typical cytoplasmic processes even if lymphoid cells are rare. The latter thus seem not to be responsible for the maintenance of FDC integrity or their development. The possible role of this for antibody production is discussed. Irradiated lymph nodes of lymphoid cells are highly convenient for studying FDC. Isolation of FDC from irradiated lymph organs would seem to be possible. [less ▲]Detailed reference viewed: 26 (0 ULg)
The follicular dendritic cells in normal and pathological conditions
Book published by Springer (1995)Detailed reference viewed: 15 (0 ULg)
Follicular dendritic cells in vitro modulate the expression of Fas and Bcl-2 on germinal center B cells.
; Heinen, Ernst ;
in Cell & Tissue Research (2000), 299(3), 395-402
Germinal center (GC) B cells are highly susceptible to apoptosis. The cellular mechanism regulating this sensitivity, however, has not yet been fully delineated. To investigate whether follicular ... [more ▼]
Germinal center (GC) B cells are highly susceptible to apoptosis. The cellular mechanism regulating this sensitivity, however, has not yet been fully delineated. To investigate whether follicular dendritic cells (FDC) are capable of regulating the susceptibility to apoptosis of GC B cells, we constructed a GC model in vitro: emperipolesis of tonsillar B cells by FDC. We then analyzed the expressions of apoptosis-related proteins (Bcl-2 and Fas) on the cells by three-color flow cytometry. B cells nonentrapped by FDC decreased rapidly in number owing to early apoptosis in vitro, whereas entrapped B cells were rescued for at least 18 h and showed peculiar regulation of Fas and Bcl-2. GC founder cells (CD38+, IgD+; GCFC) and GC B cells (CD38+, IgD-) showed approximately a twofold increased expression of Fas; in contrast, mantle zone B cells (CD38-, IgD+) and memory B cells (CD38-, IgD-) showed no changes. Bcl-2 expression in mantle zone and memory B cells was reduced by approximately one-half; however, GCFC and GC B cells continued to express little Bcl-2 and this did not change. Our findings strongly suggest that FDC play a part in the modulation of the susceptibility to apoptosis on B cells within GC. [less ▲]Detailed reference viewed: 16 (0 ULg)
Follicular dendritic cells innervation within spleen of five mouse strains with different incubation periods after intraperitoneal BSE inoculation.
; ; et al
Poster (2005, February)Detailed reference viewed: 16 (1 ULg)
Follicular dendritic cells isolated from human tonsils.
; Heinen, Ernst ; et al
in Advances in Experimental Medicine and Biology (1985), 186Detailed reference viewed: 12 (0 ULg)
Follicular dendritic cells related to nerve fibres and cellular prion protein expression in ileal and jejunal Peyer’s patches of cows and calves
Defaweux, Valérie ; Antoine, Nadine ; et al
Poster (2005, February)
Prion pathogenesis following oral exposure is thought to involve gut-associated lymphoid tissue, which includes Peyer’s patches (PP). Before neuroinvasion, early accumulation of infectious prion protein ... [more ▼]
Prion pathogenesis following oral exposure is thought to involve gut-associated lymphoid tissue, which includes Peyer’s patches (PP). Before neuroinvasion, early accumulation of infectious prion protein (PrPsc) takes place on follicular dendritic cells (FDC) which are resident cells in germinal centres. The strain, the infection pathway and the lesions in the central nervous system are similar between bovine spongiform encephalopathy (BSE) and variant Creutzfeldt Jakob diseases. But in BSE, the agent tropism differs from lymphoid organs. Only bovine ileal PP are infectious. In order to study the replication and the possible ways of neuroinvasion of PrPsc in bovine PP, we studies the expression of cellular prion protein (PrPc), necessary for PrPsc accumulation, and compared the innervation of germinal centres related to FDC on ileal and jejunal PP of cows and calves. We performed classical immunoperoxydase staining and double immunofluorescence staining analyzed with a confocal microscopy. Differences in the innervation of germinal centres and expression of PrPc were evident. More contacts between FDC and nerve fibres are observed in calves PP. PrPc expression, carried out with different anti-PrPc antibodies, highlighted a heterogeneous labelling between calves and cows PP. Such results permit us to show that the innervation of PP is a dynamic process which could influence the first way of neuroinvasion in prion diseases. Moreover differences in the affinity of some antibody for PrPc allow us to postulate that PrPc glycoforms differ with age of bovines and thus could interfere with PrPsc tropism. [less ▲]Detailed reference viewed: 17 (6 ULg)
Follicular dendritic cells: isolation procedures, short and long term cultures.
Heinen, Ernst ; ; et al
in Advances in Experimental Medicine and Biology (1993), 329Detailed reference viewed: 28 (1 ULg)
Follicular dendritic cells: whose children?
Heinen, Ernst ;
in Immunology Today (1994), 15(5), 201-4
At the recent Germinal Centre Conference in Spa*, over 200 immunologists gathered to study the fate of lymph follicles, B- and T-cell selection, cell migration, accessory cells, and pathological ... [more ▼]
At the recent Germinal Centre Conference in Spa*, over 200 immunologists gathered to study the fate of lymph follicles, B- and T-cell selection, cell migration, accessory cells, and pathological conditions such as lymphoproliferative diseases and AIDS. Here, Ernst Heinen and Alain Bosseloir report on this fascinating field. [less ▲]Detailed reference viewed: 26 (2 ULg)
Follicular fluids, immunological fingerprint and infertility
; Munaut, Carine ; PERRIER d'HAUTERIVE, Sophie et al
Conference (2010)Detailed reference viewed: 9 (0 ULg)