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See detailGedroomde figuren. Reflecties bij de hervorming van de opleiding (Nederlandse) taal- en letterkunde
Spinoy, Erik ULg

in Janssens, Guy (Ed.) Welk nieuw profiel voor de studie Nederlands? (2001)

This article reflects on the future of Dutch studies in academic education.

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See detailGeen smart city zonder integraal 3D-model
Billen, Roland ULg

in GeoPlatform (2013), 2(8), 14-16

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See detail"Den Gefallenen der beiden Weltkriege". Eupen und das Gedenken an seine toten Weltkriegssoldaten
Brüll, Christoph ULg; Mießen, Werner

in Velle, Karel (Ed.) Liber Amicorum Alfred Minke (2011)

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See detailGefitinib monotherapy in advanced non-small cell lung cancer (NSCLC): Experience from a large, Western community implementation study
van Puijenbroek, R.; Bosquee, Léon ULg; Meert, A. P. et al

in European Respiratory Journal (2007, June), 29(1), 128-133

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See detailGefitinib monotherapy in advanced nonsmall cell lung cancer: a large Western community implementation study
van Puijenbroek, R.; Bosquee, Léon ULg; Meert, A. P. et al

in European Respiratory Journal (2007), 29(1), 128-133

Epidermal growth factor receptor tyrosine kinase inhibitors represent a new treatment option for patients with advanced nonsmall cell lung cancer (NSCLC). This retrospective study examined to what extent ... [more ▼]

Epidermal growth factor receptor tyrosine kinase inhibitors represent a new treatment option for patients with advanced nonsmall cell lung cancer (NSCLC). This retrospective study examined to what extent previous clinical trial experience matches large-scale Western community implementation of this treatment. In the Belgian expanded access programme, the data from 513 patients with advanced or metastatic NSCLC, not suitable for further chemotherapy and receiving oral gefitinib 250 mg center dot day(-1) until disease progression, death or unacceptable toxicity, were analysed. The median (range) duration of gefitinib treatment was 2.3 months (0.0-32.7). Its use was predominantly in second- or third-line treatment. The overall response and disease control rates were 8.9 and 41.2%, respectively. In univariate analysis, response was more common in females and never-smokers. In multivariate analysis, female sex was the only significant predictive factor (odds ratio (OR) (95% confidence interval (Cl)) 0.329 (0.129-0.839)). Symptom improvement was reported in 108 patients of whom 32 (29.6%) had an objective response, 66 (61.1%) experienced disease stabilisation and 10 (9.3%) progressed. Gefitinib was well tolerated; only 7.8% of the patients reported grade 3 or 4 toxicity. The overall median survival was 4.7 months, with a 1-yr survival rate of 21%. Survival was strongly influenced by a better performance status (PS) (good PS: hazard ratio (HR) (95%Cl) 0.110 (0.077-0.157)) and adenocarcinoma with bronchioloalveolar carcinoma features histology (HR (95%Cl) 0.483 (0.279-0.834)). In conclusion, the activity of gefitinib was confirmed in the present large Western community implementation study. Response, present in a small subgroup, led to a rewarding survival and could be predicted by sex only. Baseline performance status and adenocarcinoma with bronchioloalveolar carcinoma features histology were significant factors for survival. [less ▲]

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See detailGefühlskulturen: Überlegungen zu einer kontrastiven Poetik der Affekte am Beispiel des ridicule.
Pontzen, Alexandra ULg

in Sieburg, Heinz; Dieter Heimböckel, Dieter (Eds.) Zwischen Provokation und Usurpation. Interkulturalität als (un)vollendetes Projekt der Literatur- und Sprachwissenschaften (2010)

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See detail"Gefühltes Komma - richtiges Komma?"
Münzberg, Franziska ULg

Scientific conference (2014, April 11)

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See detail"Gegenwart und Vergangenheit in eins" : Hugo von Hofmannsthals Gedächtnis-Konzept und seine mediale Realisierung während und nach dem Ersten Weltkrieg.
Viehöver, Vera ULg

in Krumeich, Gerd; Witte, Bernd; Borsò, Vittoria (Eds.) Medialität und Gedächtnis : Interdisziplinäre Beiträge zur kulturellen Verarbeitung europäischer Krisen (2001)

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See detailEin ‘geheimer Faden.’ E.T.A. Hoffmanns Roman "Die Elixiere des Teufels" und Goethes "Wahlverwandtschaften"
Küpper, Achim ULg

in Germanistische Mitteilungen (2005), (62), 79-97

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See detailDie Geheimnisse der Schrift: Heinrich von Kleists Poetik der Verschlossenheit und das Prinzip der Verschiebung in seinen Texten
Küpper, Achim ULg

in Brittnacher, Hans Richard; von der Lühe, Irmela (Eds.) Risiko – Experiment – Selbstentwurf. Kleists radikale Poetik (2013)

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See detailGehlenite from three occurrences of high-temperature skarns, Romania: new mineralogical data
Marincea, Stefan ULg; Dumitras, Delia; Ghinet, C. et al

in Canadian Mineralogist (2011), 49

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See detailGeht es noch kleiner?
Pfennig, Andreas ULg

in Miniplant-Technik: in der Prozessindustrie (2006)

See detailHet geïntegreerde contrastieve onderzoeksdesign onder de loep
Hiligsmann, Philippe; Rasier, Laurent ULg

in Rasier, Laurent; Van Heuven, Vincent; Defrancq, Bart (Eds.) et al Nederlands in het perspectief van uitspraakverwerving en contrastieve taalkunde (2011)

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See detailGel Beads to Investigate Sedimentation
Leleu, David ULg; Pfennig, Andreas ULg

Conference (2016, March 14)

Separation of liquid-liquid dispersions with multiple phases involves different interactions between the different dispersed species present in the system, which makes it difficult to predict e.g. the ... [more ▼]

Separation of liquid-liquid dispersions with multiple phases involves different interactions between the different dispersed species present in the system, which makes it difficult to predict e.g. the separation behaviour. Nevertheless such systems are relevant in chemical engineering e.g. for systems involving gas bubbles and simultaneously solid particles like in a fermentation broth. Models for describing the sedimentation behaviour as a basis for settler design are available in principle but have not been systematically validated for variation in size-distribution and e.g. density differences between the various species in the system. Thus, to design technical separation equipment, the separation process has to be better understood, which requires the study of the sedimentation as a first step. This project is focused on the interactions which may occur between each species during the sedimentation e.g. the effect on sedimentation of descending particles when they meet ascending drops. However, a proper study of the sedimentation with fluid phases is difficult due to other phenomena occurring simultaneously, e.g. coalescence. To overcome this issue, the use of gel beads is proposed, which due to their solid interface cannot coalesce. In addition, it is easy to define their parameters which are the density, the hardness and the size distribution. Besides, they can also be preserved during an extended period of time, experiments can thus be reproduced many times with identical beads. During the project, gel beads are designed with different particle size distributions and with different densities. Different batches of the produced gel beads will be mixed to simulate systems with different dispersed phases discriminated via density and different size distributions. With these multiple dispersed phases Experiments will be performed in a settling cell in order to evaluate the overall sedimentation velocity at certain hold up. Simultaneously a new method for measurement of local hold-up profile in the dispersion is tested, which allows hold-up measurement even in opaque systems. Finally sedimentation models found in the literature are compared and adapted to experimental results for predict the sedimentation of systems which involve different dispersed phases. In the presentation the new hold-up measurement will be presented together with an error analysis, experiments on the sedimentation of multiple dispersed phases and the model evaluation will be presented. [less ▲]

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See detailA gel retardation assay system for studying protein binding to simple repetitive DNA sequences.
Maueler, W.; Muller, Marc ULg; Kohne, A. C. et al

in Electrophoresis (1992), 13(1-2), 7-10

Simple repetitive DNA sequences have been regarded as mere "junk" present in all eukaryotic genomes. In fact, mixed simple repeat (gt)n(ga)m sequences are present in major histocompatibility complex MHC ... [more ▼]

Simple repetitive DNA sequences have been regarded as mere "junk" present in all eukaryotic genomes. In fact, mixed simple repeat (gt)n(ga)m sequences are present in major histocompatibility complex MHC-DRB genes for long evolutionary times, including such distant animals as artiodactyla and man. We describe herein an unsophisticated method which reveals that at least certain simple repetitive (gt)n(ga)m sequences bind nuclear proteins and show characteristics of a specific DNA-protein interaction via gel retardation. [less ▲]

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See detailGel-casted porous Al2O3 ceramics by use of natural fibres as pore developers
Gaydardzhiev, Stoyan ULg; Gusovius, Hans; Wilker, Viola et al

in Journal of Porous Materials (2007)

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See detailGelatinase A expression and localization in human breast cancers. An in situ hybridization study and immunohistochemical detection using confocal microscopy.
Polette, M.; Gilbert, N.; Stas, I. et al

in Virchows Archiv : An International Journal of Pathology (1994), 424

The gelatinase A (72 kDa type IV collagenase) is a matrix metallo-proteinase which degrades basement membrane collagens. Various studies emphasize its role in stromal invasion of cancers, but there is ... [more ▼]

The gelatinase A (72 kDa type IV collagenase) is a matrix metallo-proteinase which degrades basement membrane collagens. Various studies emphasize its role in stromal invasion of cancers, but there is some controversy about its origin. Gelatinase A was localized by immunohistochemistry using confocal microscopy in 15 human mammary carcinomas. In addition, the cells responsible for the synthesis of this enzyme were detected by in situ hybridization. Most invasive and non-invasive tumour cells were labelled by immunohistochemistry. Of particular interest was the pattern observed in some pre-invasive areas. Gelatinase A was found in fibroblasts in close contact with pre-invasive tumour clusters. Confocal observation allowed a more precise localization of gelatinase A to the periphery of tumour clusters along the basement membranes and in peritumour fibroblasts. The malignant epithelial cells were negative by immunohistochemistry in these areas. By in situ hybridization, mRNAs encoding gelatinase A were detected only in fibroblasts in close contact with pre-invasive and well differentiated tumour clusters. These findings support the hypothesis that peritumour fibroblasts produce gelatinase A and that breast cancer cells may bind this enzyme to their cell surface and/or internalize it. [less ▲]

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See detailIl gelato. Il dolce freddo che ha conquistato tutti i palati
Aresti, Alessandro ULg

in Arcangeli, Massimo (Ed.) Peccati di lingua. Le 100 parole italiane del Gusto (2015)

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See detailGeldanamycin inhibits tyrosine phosphorylation-dependent NF-kB activation
Crèvecoeur, Julie ULg; Piette, Jacques ULg; Gloire, Geoffrey ULg

in Biochemical Pharmacology (2008), 75(11), 2183-2191

Hsp90 is a protein chaperone regulating the stability and activity of many signalling molecules. The requirement of Hsp90 activity in the NF-κB pathway has been recently reported by several authors using ... [more ▼]

Hsp90 is a protein chaperone regulating the stability and activity of many signalling molecules. The requirement of Hsp90 activity in the NF-κB pathway has been recently reported by several authors using the Hsp90 ATPase inhibitor Geldanamycin (GA), an anti-tumour drug. Hsp90 inhibition blocks the synthesis and activation of the IKK complex, the major kinases complex responsible for IκBα phosphorylation on serine 32 and 36, a key step for its degradation and the nuclear translocation of NF-κB. However, the effect of GA on other IκBα kinases, including tyrosine kinases, is unknown. In the present study, we investigated the effect of GA on NF-κB activation induced by sodium pervanadate (PV), a tyrosine phosphatase inhibitor triggering c-Src-mediated tyrosine phosphorylation of IκBα. We reporte for the first time that GA inhibits PV-induced IκBα tyrosine phosphorylation and degradation. Using an in vitro kinase assay, we demonstrated that GA inhibits the activity of c-Src as an IκBα tyrosine kinase, but not its cellular expression. As a result, GA blocked PV-induced NF-κB DNA binding activity on an exogenous κB element and on the endogenous iκbα promoter, thereby inhibiting IκBα transcription. Finally, we demonstrated that, despite NF-κB inhibition, pre-treatment with GA does not potentiate PV-induced apoptosis. We conclude that c-Src requires Hsp90 for its tyrosine kinase activity, and its inhibition by GA blocks c-Src-dependent signalling pathways, such as NF-κB activation induced by sodium pervanadate. The effect of GA on PV-induced apoptosis is discussed in the light of recent publications in the literature. [less ▲]

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