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See detailINPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse
Jacoby, Monique; Cox, James J.; Gayral, Stéphanie et al

in Nature Genetics (2009), 41

The primary cilium is an antenna-like structure that protrudes from the cell surface of quiescent/differentiated cells and participates in extracellular signal processing1–3. Here, we report that mice ... [more ▼]

The primary cilium is an antenna-like structure that protrudes from the cell surface of quiescent/differentiated cells and participates in extracellular signal processing1–3. Here, we report that mice deficient for the lipid 5-phosphatase Inpp5e develop a multiorgan disorder associated with structural defects of the primary cilium. In ciliated mouse embryonic fibroblasts, Inpp5e is concentrated in the axoneme of the primary cilium. Inpp5e inactivation did not impair ciliary assembly but altered the stability of pre-established cilia after serum addition. Blocking phosphoinositide 3-kinase (PI3K) activity or ciliary platelet-derived growth factor receptor a (PDGFRa) restored ciliary stability. In human INPP5E, we identified a mutation affecting INPP5E ciliary localization and cilium stability in a family with MORM syndrome, a condition related to Bardet-Biedl syndrome. Together, our results show that INPP5E plays an essential role in the primary cilium by controlling ciliary growth factor and PI3K signaling and stability, and highlight the consequences of INPP5E dysfunction. [less ▲]

Detailed reference viewed: 90 (19 ULg)
See detailInput of 12CO2 and 13CO2 soil concentration measurements to understand trends in soil carbon production and emission.
Longdoz, Bernard; Plain, Caroline; Parent, Florian et al

Poster (2011, April 05)

Detailed reference viewed: 24 (4 ULg)
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See detailInput of supercritical carbon dioxide to polymer synthesis: an overview
Boyère, Cédric; Jérôme, Christine ULg; Debuigne, Antoine ULg

in European Polymer Journal (2014), 61

The ongoing search for environmentally friendlier alternative to the organic solvents used in chemical processes has led to the development of technologies based on supercritical carbon dioxide (scCO2 ... [more ▼]

The ongoing search for environmentally friendlier alternative to the organic solvents used in chemical processes has led to the development of technologies based on supercritical carbon dioxide (scCO2), which is non-flammable, non-toxic and relatively inert fluid. Polymer chemistry does not escape this trend and last achievements in the field of polymer synthesis in scCO2 are reviewed here. Without claiming to be exhaustive, we go through and discuss the benefits of the main polymerization processes in scCO2 including homogeneous, precipitation, dispersion, suspension and emulsion systems. A particular attention is drawn to water/carbon dioxide emulsion polymerization and to the suited surface active agents. This review also underlines that heterogeneous polymerization based on CO2 is more than a strategy for reducing the ecological footprint of the polymer production but it allows structuring the polymer materials into particles or highly interconnected macroporous networks. [less ▲]

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See detailInput-to-output stabilization of nonlinear systems via backstepping
Efimov, Denis ULg; Fradkov, Alexander

in International Journal of Robust and Nonlinear Control (2009), 19

An extension of a backstepping method for the stabilization of nonlinear systems with respect to a set is presented. Robust control laws providing the system with input-to-output stability are proposed ... [more ▼]

An extension of a backstepping method for the stabilization of nonlinear systems with respect to a set is presented. Robust control laws providing the system with input-to-output stability are proposed. Possibilities of non-strict Lyapunov functions’ application are discussed. The differences between a conventional backstepping method and an approach proposed in Kolesnikov (Synergetic Control Theory. Energoatomizdat: Moscow, 1994; 344) are analyzed. Performance of the obtained solutions is demonstrated by computer simulation for pendulum with an actuator example. [less ▲]

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See detailIns(1,3,4,5)P4 negatively regulates PtdIns(3,4,5)P3 signaling in neutrophils
Jia, Y.; Subramanian, K. K.; Erneux, C. et al

in Immunity (2007), 27

Many neutrophil functions are regulated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) that mediates protein membrane translocation via binding to pleckstrin homolog (PH) domains within ... [more ▼]

Many neutrophil functions are regulated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) that mediates protein membrane translocation via binding to pleckstrin homolog (PH) domains within target proteins. Here we show that inositol 1,3,4,5-tetrakisphosphate(Ins(1,3,4,5)P4), a cytosolic small molecule, bound the same PH domain of target proteins and competed for binding to PtdIns(3,4,5)P3. In neutrophils, chemoattractant stimulation triggered rapid elevation in Ins(1,3,4,5)P4 concentration. Depletion of Ins(1,3,4,5)P4 by deleting the gene encoding InsP3KB, which converts Ins(1,4,5)P3 to Ins(1,3,4,5)P4, enhanced membrane translocation of the PtdIns(3,4,5)P3-specific PH domain. This led to enhanced sensitivity to chemoattractant stimulation, elevated superoxide production, and enhanced neutrophil recruitment to inflamed peritoneal cavity. On the contrary, augmentation of intracellular Ins(1,3,4,5)P4 concentrationblockedPHdomainmediated membrane translocation of target proteins and dramatically decreased the sensitivity of neutrophils to chemoattractant stimulation. These findings establish a role for Ins(1,3,4,5)P4 in cellular signal transduction pathways and provide another mechanism for modulating PtdIns(3,4,5)P3 signaling in neutrophils. [less ▲]

Detailed reference viewed: 38 (7 ULg)
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See detailL'insaisissabilité de la résidence principale de l'indépendant
Georges, Frédéric ULg

in Revue du Notariat Belge (2008)

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See detailL'insanité d'esprit en matière de libéralité
Desir, Sarah ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2011), 27

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See detailLes insaponifiables d'avocats/soja s'opposent aux effets délétères d'H2O2 sur le métabolisme du cartilage
Mathy-Hartet, Marianne; Devel, P; Piccardi, N et al

in Revue du Rhumatisme (2003), 70

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See detailInSAR Applied to the Study of Active Volcanic and Seismic Areas in Africa
Wauthier, Christelle ULg

Doctoral thesis (2011)

Two active volcanic areas situated in immature portions of the East African Rift System (EARS): the Lake Kivu (Dem. Rep. of Congo) and Lake Natron (Tanzania) regions, which are located in the western and ... [more ▼]

Two active volcanic areas situated in immature portions of the East African Rift System (EARS): the Lake Kivu (Dem. Rep. of Congo) and Lake Natron (Tanzania) regions, which are located in the western and eastern branch, respectively, are still poorly known. Both areas indeed lack of ground-based networks, due to security problems or difficult field accessibility. The Lake Kivu area includes two volcanoes erupting frequently: the Nyamulagira and Nyiragongo volcanoes. The SAR database covering these volcanoes in- cludes data from JERS, ERS-1&2, ENVISAT, ALOS, RADARSAT-1&2 satellites back from year 1996. SAR Interferometry (InSAR) is thus applied to study the ground de- formations. MT-InSAR approaches, such as the ”‘StaMPS”’ method, are used to give us new complementary information to better constrain the previous established eruption models, or gain new insights on eruptions missed by the conventional InSAR, as well as on magmatic and tectonic activity. When enough constrains are available, the ground displacements are modeled using a 3D-Mixed Boundary Elements Method combined with a neighborhood algorithm. Hence, the 1996, 2002, 2004 and 2010 eruptions of Nyamu- lagira are modeled. The modeling results, coupled with the StaMPS MT-InSAR results, bring new insights concerning the magma plumbing system of this poorly known volcano and its eruptive mechanisms. The collapse of the eastern flank of Nyamulagira, along the NNW-trend fractures network linking Nyamulagira and Nyiragongo volcanoes, can also be identified. InSAR also captures the ground displacements associated with the January 2002 Nyiragongo eruption. The modeling of this major event evidences a deep magma intrusion beneath the Lake Kivu. Such intrusions should be taken into account for hazard assessment. The magma could indeed finds its way to the Lake Kivu floor, as evidenced by the presence of several old phreato-magmatic cones, and causes a lake overturn. The low dikes overpressures found in the North Kivu and Lake Natron areas indicate that, although the rift is considered as immature, the rift extension is driven by the supply of magma from depth, rather than by the tectonics. A new criterion to identify the rifting stage is found to be the stress state. In the southern part of the rift, tectonic activity dominates, indicating that the tectonics is probably driving the rift opening there. [less ▲]

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See detailInSAR Coherence for Crop Parameter Monitoring
Blaes, Xavier; Defourny, Pierre; De Rauw, Dominique ULg et al

in ESA (Ed.) Proc. FRINGE'99 Symposium (1999)

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See detailL'inscription dédicatoire de l'église de Waha
Kurth, Godefroid ULg

in Bulletin de la Commission Royale d'Histoire (1900), X, 3(5e série), 29

Detailed reference viewed: 41 (1 ULg)
See detailL'inscription des protections environnementales dans les procédures d'urbanisme, Rapport de synthèse
Pâques, Michel ULg

in L'environnement dans le droit de l'urbanisme en Europe (2008)

Detailed reference viewed: 46 (12 ULg)
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See detailL'inscription du patrimoine culturel immatériel dans la politique patrimoniale
Lempereur, Françoise ULg

in Cahiers de l'Urbanisme (Les) (2008), 69

Detailed reference viewed: 18 (10 ULg)
See detailL'inscription du patrimoine culturel immatériel dans la société contemporaine
Lempereur, Françoise ULg

Scientific conference (2010, March 02)

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See detailInscriptiones Lesbi, Nesi, Tenedi
Famerie, Etienne ULg

Report (2015)

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See detailInscriptiones Lesbi, Tenedi, Nesi. Concordance des éditions
Famerie, Etienne ULg

in Horos (2015), 26-29

Concordance of the whole corpus of inscriptions of Lesbus, in relation with the inventory of the collection stored in the Archaeological Museum (Lesbus)

Detailed reference viewed: 12 (1 ULg)