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See detailInterest of biochemical markers of bone turnover for long-term prediction of new vertebral fracture in postmenopausal osteoporotic women
Bruyère, Olivier ULg; Collette, Julien ULg; Delmas, Pierre et al

in Maturitas (2003), 44(4), 259-265

Objective: To analyse the interest of baseline levels and short-term (3-months) changes in serum osteocalcin (BGP), serum bone-specific alkaline phosphatase (BALP) and urinary C-telopeptide of type I ... [more ▼]

Objective: To analyse the interest of baseline levels and short-term (3-months) changes in serum osteocalcin (BGP), serum bone-specific alkaline phosphatase (BALP) and urinary C-telopeptide of type I collagen/creatinine ratio (U-TX) to predict 3-years changes in bone mineral density (BMD) and spinal deformity index (SDI) in postmenopausal osteoporotic women. Methods: Data were derived from a cohort of 603 osteoporotic women corresponding to the placebo arm of a 3-years prospective, double-blind study. Results: Baseline values of BALP, BGP and U-CTX were negatively and significantly correlated with baseline spinal BMD. Significant correlations were also observed between the changes in BMD observed after 36 months at the spine and baseline BALP (r = 0.20, P = 0.0001), BGP (r = 0.09, P = 0.05) and U-CTX (r = -0.11, P = 0.02). At 3 years, 71 women (15.9%) showed an increase in their SDI, corresponding to the occurrence of at least one new vertebral deformity. Baseline values of the four bone turnover markers (BTM) were not significantly related to the occurrence of new vertebral deformities. However, when considering the changes in the BTM observed after 3-months of follow-up, BGP (P = 0.003) and U-CTX (P = 0.047) were identified as significant predictors of an increase of SDI. The associated odds ratios (95% confidence interval (CI)) were 10.922 (2.218-53.78) for unit changes of log BGP and 1.369 (1.003-1.867) for unit changes of log U-CTX. The relative risk (RR) (IC 95%) of having a new vertebral fracture over 36 months was 0.31 (0.15-0.65) when being in the lowest quartile of 3-months changes in BGP as compared with the highest. Conclusion: We conclude that two sequential measurements of BGP and U-CTX performed at 3-months intervals could be of interest to identify postmenopausal osteoporotic women with the highest risk to present new vertebral deformities. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailInterest of cerebral Doppler in neonates
Battisti, Oreste ULg

Conference given outside the academic context (1993)

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See detailInterest of DOC in the study of consciousness
Vanhaudenhuyse, Audrey ULg

Conference (2007)

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See detailInterest of Face Mask--Cpap in One Case of Severe Accidental Hypothermia
Canivet, Jean-Luc ULg; Larbuisson, Robert ULg; Lamy, Maurice ULg

in Acta Anaesthesiologica Belgica (1989), 40(4), 281-3

one case of severe accidental hypothermia; rectal temperature was 25 degrees C. Hypoxemia unmodified by 100 O2 inhalation in an ordinary face-mask was easily corrected using a face-mask CPAP; a ... [more ▼]

one case of severe accidental hypothermia; rectal temperature was 25 degrees C. Hypoxemia unmodified by 100 O2 inhalation in an ordinary face-mask was easily corrected using a face-mask CPAP; a ventilation-perfusion mismatching could be implicated in the cold induced hypoxemia. Active rewarming (1.5 degrees C/h) was pursued from 25 to 37 degrees C, using non aggressive methods: warming blankets and a Bennett heated humidifier inserted in the CPAP system. Even in severe hypothermia successful results may be obtained without resort to sophisticated methods. [less ▲]

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See detailInterest of Health Economic Analyses
Hiligsmann, Mickaël ULg

Conference given outside the academic context (2011)

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See detailInterest of lasofoxifene in the treatment of osteoporosis. Evaluation of "Lasofoxifene in postmenopausal women with osteoporosis". N Engl J Med 2010;362:686-96.
Reginster, Jean-Yves ULg

in Expert Opinion on Pharmacotherapy (2010), 11(10), 1773-5

Lasofoxifene, a new selective estrogen receptor modulator (SERM), was investigated to assess its efficacy and safety in the management of postmenopausal osteoporosis. A dose of 0.5 mg/day of lasofoxifene ... [more ▼]

Lasofoxifene, a new selective estrogen receptor modulator (SERM), was investigated to assess its efficacy and safety in the management of postmenopausal osteoporosis. A dose of 0.5 mg/day of lasofoxifene, given to postmenopausal women with osteoporosis, induced a reduction in vertebral fracture rates after 3 years and a reduction, after 5 years, of nonvertebral fractures, estrogen receptor-positive and invasive breast cancers, major coronary heart diseases and strokes. However, this dose was associated with significant side effects including venous thromboembolisms, pulmonary embolisms, leg cramps, hot flushes, uterine polyps, endometrial hypertrophy, arthralgia and vaginal candidiasis. Since no effect was evidenced on hip fractures, the risk-benefit ratio of this new medication, compared with previously marketed SERMs is, at best, uncertain. [less ▲]

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See detailInterest of Locometrix compared with others clinical tests to assess gait’s profile in some specific old populations
Gillain, Sophie ULg; Warzee, Emmanuelle ULg; Maquet, Didier ULg et al

in Journal of Nutrition, Health & Aging (The) (2009), 13(Supp 1),

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See detailInterest of Locometrix to assess gait’s profile in specific old populations
Gillain, Sophie ULg; Warzee, Emmanuelle ULg; Lekeu, Françoise ULg et al

in Journal of Nutrition, Health & Aging (The) (2009, June), 13(Supp 1),

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See detailInterest of routine dosage of meropenem in difficult to treat infections
Frippiat, Frédéric ULg; Bensahi, Ilham; Denooz, Raphael ULg et al

Poster (2010, October 23)

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See detailInterest of screening cardiovascular risk factors in general population
Saint-Remy, Annie ULg; Krzesinski, Jean-Marie ULg

in Journal of Hypertension (Supplement) (2006), 24(S4), 233

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See detailInterest of the androgen deficiency in aging males (ADAM) questionnaire for the identification of hypogonadism in elderly community-dwelling male volunteers
Tancredi, Annalisa ULg; Reginster, Jean-Yves ULg; Schleich, FLorence ULg et al

in European Journal of Endocrinology (2004), 151(3), 355-360

Objective: To date, serum free testosterone measurement is considered to be the gold standard for the diagnosis of hypogonadism in elderly males but it is not available to all subjects suspected of a ... [more ▼]

Objective: To date, serum free testosterone measurement is considered to be the gold standard for the diagnosis of hypogonadism in elderly males but it is not available to all subjects suspected of a decrease in testicular function. Therefore, we evaluated whether the Androgen Deficiency in Aging Males (ADAM) questionnaire, in its original or in a modified 'quantitative' version (qADAM), could be used as a surrogate to biochemical determinations for the identification of hypogonadism in elderly males. Methods: 5028 men, aged 50-70 years, spontaneously consulting for the assessment of their gonadal function were studied. ADAM and qADAM, allocating a value of 1 point for any positive answer to each of the 10 questions of the ADAM test, were assessed for their ability to discriminate between males with free testosterone levels below or above 70 ng/l. Results: The sensitivity and specificity of the ADAM score were 81% and 21.6% respectively. The use of ADAM resulted in an appropriate classification of our population in normal or hypogonadal subjects in 44.5% of the cases. The area under the receiver operating characteristics (ROC) curve for the qADAM (0.529) revealed a highly marginal interest of this quantitative approach compared with the original scoring system. Conclusions: The ADAM test has a high sensitivity to identify aging males with low free testosterone levels. However, due to its lack of specificity, this test cannot be used as a surrogate to serum free testosterone testing for the identification of androgen deficiency in elderly, community-dwelling males. [less ▲]

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See detailInterest of the simple calculated osteoporosis risk estimation (SCORE) tool for a more rational use of bone densitometry
Ben Sedrine, Wafa ULg; Devogelaer, JP; Kaufman, JM et al

in Value in Health (2000, March), 3

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See detailInterest of the simple calculated osteoporosis risk estimation (SCORE) tool for a more rational use of bone densitometry
Ben Sedrine, Wafa ULg; Devogelaer, JP; Kaufman, JM et al

in Osteoporosis International (2000), SS(S5), 13

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See detailInterest of the simple calculated osteoporosis risk estimation (SCORE) tool for a more rational use of bone densitometry
Ben Sedrine, Wafa ULg; Devogelaer, Jean-Pierre; Kaufman, Jean-Marc et al

in Annals of the Rheumatic Diseases (2000), 59(Suppl.1), 80-81

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See detailInterest of the use of electronic nose for field monitoring of odours in the environment
Nicolas, Jacques ULg

in Lehr Jay H.; Keeley Jack (Eds.) Water encyclopedia. Volume 2 : Water quality control. (2005)

Electronic nose is a promising technique for field monitoring of malodours in the environment. It is based on an array of non-specific gas sensors coupled with some form of mathematical data processing ... [more ▼]

Electronic nose is a promising technique for field monitoring of malodours in the environment. It is based on an array of non-specific gas sensors coupled with some form of mathematical data processing method to analyse the global response patterns. Some applications concerning the control of water quality are reported in the literature. They often impliy the generation of a headspace gas above liquid samples, but they also concern the odour emitted in the air from wastewater. The typical needs of the final user require both qualitative and quantitative approaches, i.e. both discriminating between slight variations in complex gas mixtures and monitoring a global odour signal which can be correlated with classical characterisation variables of water or air quality. Although potential applications in odour assessment by electronic noses are numerous, a number of challenges still need to be overcome: understanding and controlling the impact of environmental parameters (such as temperature and humidity), improving sensor sensitivity and noise reduction or developing calibration procedures to account for sensor drift. The present limitations of electronic nose technology restrict its use in the environment to the odour monitoring in the surroundings of the emission with instruments specifically designed for the application. [less ▲]

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