Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailInnovations technologiques en radiothérapie-oncologie
Coucke, Philippe ULg; Louis, Céline ULg; Bolle, Stéphanie

in Revue Médicale de Liège (2007), 62 (5-6)

InnovatIve technologIes In radIatIon oncology SUMMARY : At present, radiation oncology is again flourishing thanks to the development of highly accurate techniques as intensity modulated radiation therapy ... [more ▼]

InnovatIve technologIes In radIatIon oncology SUMMARY : At present, radiation oncology is again flourishing thanks to the development of highly accurate techniques as intensity modulated radiation therapy, stereotactic radiation therapy and hadrontherapy. These therapeutic modalities are made possible by the advent of image guided radiation therapy and respiratory gating that allows a better patient repositioning during the irradiation and between fractions. Nowadays, thanks to these recent technological advances, one can more easily conceive dose escalation, hypofractionation and combined treatment of radiation with sensitizing drugs and this together with a better protection of normal tissue aiming at, simultaneously, improved tumour control and better quality of life. This article describes these innovative technologies that, when integrated to other anti-tumoral therapeutic modalities, seem to be very promising. Keywords : - [less ▲]

Detailed reference viewed: 73 (6 ULg)
Full Text
See detailInnovative algorithms to combine phenotypic, genealogical and genomic information originating from diverse sources
Vandenplas, Jérémie ULg

Doctoral thesis (2014)

Along with technical developments, international exchanges of genetic material (e.g., frozen semen, embryos) have increased since the 1970s. However, genetic evaluations are traditionally based on ... [more ▼]

Along with technical developments, international exchanges of genetic material (e.g., frozen semen, embryos) have increased since the 1970s. However, genetic evaluations are traditionally based on phenotypic and genealogical data which are internally recorded, i.e., within well defined borders. Because imported (i.e., external) genetic material is usually strongly selected in their respective populations, internal genetic evaluations for external animals could be biased and less accurate if external data used for their selection is ignored. Moreover, comparison of internal and external animals based on their internal and external estimates of genetic merit is needed to select and potentially import the most suitable ones according to the internal breeding goal. However, such comparison is usually not possible among internal and external genetic evaluations due, e.g., to differences among units of measurement. Thereby, several approaches and algorithms have been developed to render internal and external genetic evaluations comparable, and to combine or blend phenotypic and genealogical data and external information, i.e., estimates of genetic merit and associated reliabilities. Furthermore, the recent development of genomic selection also increased needs for combining phenotypic, genealogical and genomic data and information. Therefore, the aim of this thesis was first to develop innovative algorithms to combine diverse sources of phenotypic, genealogical and genomic data and information, and second to test them on simulated and real data in order to check their correctness. Based on a Bayesian view of the linear mixed models and addressing several issues highlighted by previous studies, systems of equations combining simultaneously diverse sources of data and external information were developed for (multivariate) genetic and single-step genomic evaluations. Double counting of contributions due to relationships and due to records were considered as well as computational burden. The performances of the developed systems of equations were evaluated using simulated datasets and real datasets originating from genetic (genomic) evaluations for Holstein cattle and for show jumping horses. The different results showed that the developed equations integrated and blended several sources of information in a proper way into a genetic or a single-step genomic evaluation.It was also observed that double counting of contributions due to relationships and due to records was (almost) avoided. Furthermore, more reliable estimates of genetic merit were also obtained for external animals and for their relatives after integration of external information. Also, the developed equations can be easily adapted to complex models, such as multivariate mixed models. Indeed, it was shown that external information correlated to the internal phenotypic traits was properly integrated using the developed equations. Finally, research of this thesis led to the development of a genomic evaluation system for Holstein cattle in the Walloon Region of Belgium for production traits, as well as for other traits, like somatic cell score. Based on the research of this thesis, future research topics, e.g., concerning integration of correlated external information and of genomic information, were finally presented. [less ▲]

Detailed reference viewed: 48 (15 ULg)
See detailInnovative analytical strategies for small molecules analysis by ion-mobility mass spectrometry
Eppe, Gauthier ULg; Goscinny, Séverine; Far, Johann ULg et al

Conference (2014, January)

Detailed reference viewed: 39 (13 ULg)
Peer Reviewed
See detailInnovative analytical strategy using ion-mobility for structural or functional selenium isomers identification by ion mobility spectrometry
Far, Johann ULg; Kune, Christopher ULg; Lobinski, Ryszard et al

Poster (2013, July)

Selenium (Se) is a trace element which is both essential and toxic depending on its concentration and its chemical form. Se-rich yeast is one of the most popular Se source for supplementation. The ... [more ▼]

Selenium (Se) is a trace element which is both essential and toxic depending on its concentration and its chemical form. Se-rich yeast is one of the most popular Se source for supplementation. The classical method of speciation is related to multidimensional liquid chromatography (LC) hyphenated to mass spectrometry (MS) Recent advances in Se speciation led to greatly improve the Se speciation in these samples but isomers identification and quantification remain challenging. This work focuses on the elaboration of an innovative analytical strategy for the detection and the structural elucidation of isobaric selenium compounds present in Se-rich yeast. A specific complex formation agent acts as a chemical probe for the detection of chemical function. The addition of a complexing agent can improve the discrimination between structural or functional Se isomers using ion mobility techniques as Ion Mobility Spectrometry (IMS) by increasing the molecular weight (i.e. the m/z ratio in MS) and the collision cross section of a target ion after selective complexation. This Ion Mobility orthogonal separation improves the structural elucidation. Crown ethers used as shifting agents can specifically form complexes with primary amines. The addition of crown ether to different low molecular weight fractions obtained by multidimensional LC of a water extract from Se-rich yeast permitted to detect Se isomers and confirmed their structure using IMS. [less ▲]

Detailed reference viewed: 19 (5 ULg)
Peer Reviewed
See detailInnovative analytical strategy using ion-mobility shifting additive for isobaric selenium compound identification in selenomethionine standards by IMS
Kune, Christopher ULg; Far, Johann ULg; Eppe, Gauthier ULg et al

Conference (2013, July 09)

Selenium (Se) is a trace element which is both essential and toxic depending on its concentration and its chemical form. Selenomethionine (SeMet) is one of the widely used selenium standard during ... [more ▼]

Selenium (Se) is a trace element which is both essential and toxic depending on its concentration and its chemical form. Selenomethionine (SeMet) is one of the widely used selenium standard during Selenium speciation studies. This work was focused on the elaboration of an analytical strategy for the detection and the structural elucidation of an isobaric Se interference, which is found in standard solutions of SeMet by high resolution mass spectrometry (Rm/Δm > 20.000). The structural elucidation of these compounds requires the isolation of the respective parent ion. Nevertheless, the mass difference between SeMet and its interference is less than 0.02Da which is well below the window selection of conventional techniques in mass spectrometry (Quadripole, ion trap). The empirical formula and double bound equivalent (DBE) of these ions suggest different tridimensional structures which lead to a discrimination depending on the ion mobility. This separation is observed, both in gaseous and liquid phase, by Ion Mobility Spectrometry (IMS), Capillary Electrophoresis (CE) and Liquid Chromatography (LC) which are hyphenated to mass spectrometry as detector. The separation efficiency of these ions by IMS and CE is improved by using specific shifting agents (18-Crown-6 Ether) selective to only one of these ions. This strategy has successfully separated the two isobaric ions present and leads to the structural elucidation of the isobar contaminant of SeMet. [less ▲]

Detailed reference viewed: 40 (23 ULg)
Full Text
Peer Reviewed
See detailAN INNOVATIVE APPROACH TO SELECT THE PREDICTION MODEL IN THE DEVELOPMENT OF NIR SPECTROSCOPIC METHODS
Ziemons, Eric ULg; Mantanus, Jérôme ULg; Rozet, Eric ULg et al

Poster (2012, March)

Taking into account its non-invasive, non-destructive character and fast data acquisition, near infrared spectroscopy is more and more integrated in production processes to acquire analytical results ... [more ▼]

Taking into account its non-invasive, non-destructive character and fast data acquisition, near infrared spectroscopy is more and more integrated in production processes to acquire analytical results. Implementation of a NIR quantitative method is performed using an iterative heuristic approach that will ultimately build a model allowing the prediction of the concentration of the analyte of interest. In this context, the aim of the present study was to develop an innovative approach based on statistical tolerance intervals and the desirability index FMI (Fitting Model Index) to select the most appropriate prediction model from a list of candidate models instead of using conventional criteria such as R², RMSEC, RMSECV and RMSEP [1-2] without objective decision rules. This new approach is illustrated on different steps of a real pharmaceutical manufacturing process: water and Active Pharmaceutical Ingredient (API) determinations in pharmaceutical pellets. Variability sources such as production campaigns, batches, days and operators were introduced in the calibration and validation sets. Partial Least Square (PLS) regression on the calibration sets was performed to build prediction models of which the ability to quantify accurately was tested with the validation sets. Regarding the product specifications, the acceptance limits were set at 20% and 5%, for the moisture and API determination, respectively.As can be seen from Figure 1 and 2, this innovative approach based on the desirability index FMI of the accuracy profile enabled to build and select the most appropriate prediction model in full accordance with its very final goal, to quantify as accurately as possible the analytes of interest. [1] Hubert Ph. et al., J. Pharm. Biomed. Anal., 36, 2007, 579-586. [2] Rozet E. et al., Ana. Chim. Acta, 591, 2007, 239-247. [less ▲]

Detailed reference viewed: 62 (14 ULg)
Full Text
Peer Reviewed
See detailInnovative artificial fog production device - A technical facility for research activities.
Colomb, M.; Dufour, J.; Hirech, M. et al

Conference (2004)

A new innovative fog production device has been developed in close cooperation with partners of a European project called “FOG” funded by the EU. It is set up in the fog chamber of the road and bridges ... [more ▼]

A new innovative fog production device has been developed in close cooperation with partners of a European project called “FOG” funded by the EU. It is set up in the fog chamber of the road and bridges laboratory at Clermont-Ferrand. Most of the activities of this laboratory are dedicated to road safety but the facility is open to any other activity, such as environmental research. The recent developments consist in setting up a controllable device able to produce stable visibility levels and homogeneous fog, representative of various types of natural water droplet distribution. The fog characteristics were determined and compared to natural fog. Results are presented for a selection of conditions including stabilized visibility levels for dense fog, less than 50 metres meteorological visibility and two kinds of droplet distribution. [less ▲]

Detailed reference viewed: 39 (3 ULg)
Full Text
Peer Reviewed
See detailInnovative bolted beam-to-column joints for seismic resistant building frames
Coméliau, Ludivine ULg; Demonceau, Jean-François ULg; Jaspart, Jean-Pierre ULg

in Dubina, Dan; Grecea, Daniel (Eds.) CONNECTIONS VII proceedings (2012)

In the present paper, innovative joint configurations leading to more economical solutions for full-strength beam-to-column joints for seismic building frames are detailed. The specificities of these ... [more ▼]

In the present paper, innovative joint configurations leading to more economical solutions for full-strength beam-to-column joints for seismic building frames are detailed. The specificities of these joints are due to the fact that (i) the column is made of high strength steel while the beam are made of mild carbon steel and (ii) the design of some components allows partially neglecting the overstrength factor. Also, methods for the characterisation of specific joint components not directly covered by the Eurocode recommendations are proposed. [less ▲]

Detailed reference viewed: 84 (14 ULg)
Full Text
See detailINNOVATIVE BOLTED BEAM-TO-COLUMN JOINTS IN MOMENT RESISTANT BUILDING FRAME: FROM EXPERIMENTAL TESTS TO DESIGN GUIDELINES
Hoang, Van Long ULg; Demonceau, Jean-François ULg; Jaspart, Jean-Pierre ULg

in Dubina, Dan; Landolfo, Raffaele; Stratan, Aurel (Eds.) et al Application of High Strength Steels in Seismic Resistant Structures (2013)

Detailed reference viewed: 31 (4 ULg)
Full Text
Peer Reviewed
See detailInnovative Concepts in Navigation Lock Design
Rigo, Philippe ULg; Daniel, Ryszard

in The Port Infrastructure Seminar , 2010, TUDelft, NL (2010, June)

This paper presents the new report n°106 of PIANC InCom WG29 on Innovations in Navigation Lock Design, published by PIANC in August 2009, as well as some additional contributions on lock gates (gate ... [more ▼]

This paper presents the new report n°106 of PIANC InCom WG29 on Innovations in Navigation Lock Design, published by PIANC in August 2009, as well as some additional contributions on lock gates (gate contact technology). The paper highlights the main objectives and issues of his PIANC report with a specific emphasis on gates and specifically on the contact aspects. Locks are key structures for the development of the navigation in canals and in natural rivers where weirs regulate water levels to enable navigation. They may also be strategic infrastructure for port development. The core of this report has three major parts. The first part presents an exhaustive list of design goals associated with locks. This section is particularly important for decision makers who have to launch a new project. The second part reviews the design principles that must be considered by designers. This section is methodologically oriented. The third part is technically oriented. All main technical aspects (hydraulics, structures, foundations, including computational aspects, etc.) are reviewed, focussing on changes and innovations occurring since 1986. Perspectives and trends for the future are also listed. When appropriate, recommendations are listed. It is impossible to give the details of all lock innovation areas in this paper. As an example, the lock gates and, in particular, the modern views on their contact issues have been chosen. These new solutions are welcome to limit the maintenance and to extend the service life of lock gates. [less ▲]

Detailed reference viewed: 94 (2 ULg)
Full Text
See detailInnovative designs for the imaging suite on Solar Orbiter
Auchere, Frederic; Song, Xueyen; Rouesnel, Frederic et al

in Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series (2005, August 01)

Orbiting around the Sun on an inclined orbit with a 0.2 UA perihelion, the Solar Orbiter probe will provide high resolution views of the Sun from various angles unattainable from Earth. Together with a ... [more ▼]

Orbiting around the Sun on an inclined orbit with a 0.2 UA perihelion, the Solar Orbiter probe will provide high resolution views of the Sun from various angles unattainable from Earth. Together with a set of high resolution imagers, the Full Sun Imager is part of the EUV Imaging suite of the Solar Orbiter mission. The mission's ambitious characteristics draw severe constraints on the design of these instruments. We present a photometrically efficient, compact, and lightweight design for the Full Sun Imager. With a 5 degrees field of view, this telescope will be able to see the global solar coronal structure from high viewing angles. Thermal solutions reducing the maximum power trapped in the High Resolution Imagers are also proposed. [less ▲]

Detailed reference viewed: 41 (3 ULg)
Full Text
Peer Reviewed
See detailInnovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoïds in cannabis plant material
De Backer, Benjamin ULg; Debrus, Benjamin ULg; Lebrun, Pierre ULg et al

Poster (2009, August)

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their ... [more ▼]

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their neutral counterparts. Converely, HPLC permits the determination of the original composition of plant cannabinoids by direct analysis. Several HPLC methods have been described in the literature, but most of them failed to separate efficiently all the cannabinoids or were not validated according to general guidelines. By use of an innovative methodology for modelling chromatographic responses, a simple and accurate HPLC/DAD method was develop [less ▲]

Detailed reference viewed: 169 (64 ULg)
Full Text
Peer Reviewed
See detailInnovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material
De Backer, Benjamin ULg; Debrus, Benjamin ULg; Lebrun, Pierre ULg et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2009), 877(32), 4115-4124

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their ... [more ▼]

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their neutral counterparts. Conversely, HPLC permits the determination of the original composition of plant cannabinoids by direct analysis. Several HPLC methods have been described in the literature, but most of them failed to separate efficiently all the cannabinoids or were not validated according to general guidelines. By use of an innovative methodology for modelling chromatographic responses, a simple and accurate HPLC/DAD method was developed for the quantification of major neutral and acidic cannabinoids present in cannabis plant material: Δ9-tetrahydrocannabinol (THC), THC-acid (THCA), cannabidiol (CBD), CBD-acid (CBDA), cannabigerol (CBG), CBG-acid (CBGA) and cannabinol (CBN). Δ8-tetrahydrocannabinol (∆8-THC) was determined qualitatively. Following the practice of design of experiments, predictive multilinear models were developed and used in order to find optimal chromatographic analytical conditions. The method was validated following an approach using accuracy profiles based on β-expectation tolerance intervals for the total error measurement, and assessing the measurements uncertainty. This analytical method can be used for diverse applications, e.g. plant phenotype determination, evaluation of psychoactive potency and control of material quality. [less ▲]

Detailed reference viewed: 305 (84 ULg)
Peer Reviewed
See detailInnovative Electrodes for Dye Sensitized Solar Cells
Langley, Daniel ULg; Giusti, Gael; Zhang, Shanting et al

Conference (2014)

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailInnovative green supercritical fluid chromatography development for the determination of polar compounds
Dispas, Amandine ULg; Lebrun, Pierre ULg; Sassiat, Patrick et al

in Journal of Chromatography. A (2012), 1256

In the context of green analytical chemistry, a supercritical fluid chromatography method was developed. In order to prove the potential of this technology, a worst case was selected, i.e. the separation ... [more ▼]

In the context of green analytical chemistry, a supercritical fluid chromatography method was developed. In order to prove the potential of this technology, a worst case was selected, i.e. the separation of very polar compounds. For that purpose, an innovative methodology based on design of experiments (DoE) and design space (DS) was previously developed and successfully tested on liquid chromatography. For the first time, this methodology was applied to a supercritical fluid chromatography (SFC) separation. First, a screening design was used to select the stationary phase and the nature of the mobile phase based on a maximization of the number of peaks eluted and a minimization of the number of co-eluted peaks. Then, a central composite design with orthogonal blocks defined a set of experiments used to model the retention times of each peak at the beginning, the apex, and the end. The gradient slope, the isocratic plateau before the gradient, the temperature, and the concentration of trifluoroacetic acid (TFA) in the mobile phase were the potentially influential factors. The critical quality attributes (CQAs), i.e. the separation (S) between peaks of the most critical pair, and the analysis time were the responses considered to assess the quality of the separation. The DS was computed as the multidimensional subspace where the probability for the separation and analysis time criteria to be within acceptance limits was higher than a defined quality level. The DS was computed propagating the prediction error from the modeled responses to the quality criterion using Monte Carlo simulations. The optimal condition was predicted at a gradient slope of 3.8% min−1 to linearly modify the modifier proportion between 5 and 40%, an isocratic time of 3 minutes, a concentration of TFA of 25 mM, and a temperature of 60.5 °C. This optimal condition was experimentally tested to confirm the prediction. Furthermore, chromatographic conditions included in the DS and on the limits of the DS were experimentally tested to assess the robustness of the developed SFC method. [less ▲]

Detailed reference viewed: 63 (21 ULg)