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See detailImaging-guided percutaneous spinal biopsy
Stulko, J.; Miezentseva, V. A.; Gerard, L. et al

in Revue Médicale de Liège (2013), 68(3), 128-33

The aim of this article is to present the value and limitations of image-guided percutaneous biopsy in spinal disorders. The indications and contraindications of percutaneous spinal biopsy and the ... [more ▼]

The aim of this article is to present the value and limitations of image-guided percutaneous biopsy in spinal disorders. The indications and contraindications of percutaneous spinal biopsy and the different techniques and materials used are discussed. The decision for this type of biopsy and the choice of technique should be made by a multidisciplinary team. Percutaneous spinal biopsy is a safe, inexpensive and possible as an outpatient. The effectiveness of percutaneous spinal biopsy is around 70%. [less ▲]

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See detailImatinib and Nilotinib Inhibit Hematopoietic Progenitor Cell Growth, but Do Not Prevent Adhesion, Migration and Engraftment of Human Cord Blood CD34+ Cells
Belle, Ludovic ULg; Bruck, France; FOGUENNE, Jacques ULg et al

in PLoS ONE (2012), 7(12), 52564

Background: The availability of tyrosine kinase inhibitors (TKIs) has considerably changed the management of Philadelphia chromosome positive leukemia. The BCR-ABL inhibitor imatinib is also known to ... [more ▼]

Background: The availability of tyrosine kinase inhibitors (TKIs) has considerably changed the management of Philadelphia chromosome positive leukemia. The BCR-ABL inhibitor imatinib is also known to inhibit the tyrosine kinase of the stem cell factor receptor, c-Kit. Nilotinib is 30 times more potent than imatinib towards BCR-ABL in vitro. Studies in healthy volunteers and patients with chronic myelogenous leukemia or gastrointestinal stromal tumors have shown that therapeutic doses of nilotinib deliver drug levels similar to those of imatinib. The aim of this study was to compare the inhibitory effects of imatinib and nilotinib on proliferation, differentiation, adhesion, migration and engraftment capacities of human cord blood CD34+ cells. Design and Methods: After a 48-hour cell culture with or without TKIs, CFC, LTC-IC, migration, adhesion and cell cycle analysis were performed. In a second time, the impact of these TKIs on engraftment was assessed in a xenotransplantation model using NOD/SCID/IL-2Rc (null) mice. <br />Results: TKIs did not affect LTC-IC frequencies despite in vitro inhibition of CFC formation due to inhibition of CD34+ cell cycle entry. Adhesion of CD34+ cells to retronectin was reduced in the presence of either imatinib or nilotinib but only at high concentrations. Migration through a SDF-1a gradient was not changed by cell culture in the presence of TKIs. Finally, bone marrow cellularity and human chimerism were not affected by daily doses of imatinib and nilotinib in a xenogenic transplantation model. No significant difference was seen between TKIs given the equivalent affinity of imatinib and nilotinib for KIT. <br />Conclusions: These data suggest that combining non-myeloablative conditioning regimen with TKIs starting the day of the transplantation could be safe. [less ▲]

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See detailImatinib improves survival of chronic Graft-versus-host disease by inhibiting TGF-β and PDGF-R in mice
Fransolet, Gilles ULg; Belle, Ludovic ULg; SOMJA, Joan ULg et al

Poster (2014, January)

Introduction: Graft-versus-host disease (GVHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). Approximately 15% of the patients develop the sclerodermatous ... [more ▼]

Introduction: Graft-versus-host disease (GVHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). Approximately 15% of the patients develop the sclerodermatous cGvHD (scl-cGvHD) form of the disease characterized by multiple organ fibrosis and loss of skin elasticity. A few studies have suggested potential benefits of imatinib, a tyrosine kinase inhibitor, as a treatment of fibrosis in scl-cGVHD due to its ability to inhibit simultaneously the PDGF receptor and TGF-β pathways (via ABL inhibition), which are both involved in fibrosis . Aim: This work investigates the impact of imatinib on fibrosis in the B10.D2 to BALB/cJ scl-cGvHD murine model. Lethally irradiated BALB/cJ recipient mice were injected with 107 bone marrow cells + 7.107 splenocytes from B10.D2 donor mice. Recipients were treated with imatinib 150 mg/kg/day (50 mg/kg in the morning followed by 100 mg/kg in the evening) by oral gavage or the same volume of sterile water. Mice health status was evaluated with a scoring system encompassing five criteria (weight loss, activity, fibrosis, hair loss and mice posture; 0-1-2 points/criteria). Mice were sacrificed at a score of 8/10 according to our local ethical committee. Results: Mice given daily 150 mg/kg imatinib had a better survival than control mice (42 versus 33 days, p = 0,0357). cGvhD scores were suggestively lower in imatinib-treated than in control mice (p ≤ 0,15). Further, histological analyses evidenced reduction in the levels of both PDGF receptor (p = 0,033) and c-Abl (p = 0,185) phosphorylation in imatinib as compared to control mice. Finally, no significant differences were observed in the number or frequency of lymphocyte subsets in the 2 groups of mice. Conclusion: Imatinib slightly decreased fibrosis and significantly improved survival in a severe scl-cGvHD murine model. [less ▲]

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See detailImazalil modulates CYPs 1A1 and 3A4 activities in the human Caco-2 cells as an intestinal model to assess food safety
Sergent, Thérèse; Ribonnet, Laurence; Jassogne, C. et al

in Toxicology Letters (2007), 172

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See detailImbalance between lipoxin A(4) and leukotriene B-4 in chronic mastitis-affected cows
Boutet, Philippe ULg; Bureau, Fabrice ULg; Degand, Guy ULg et al

in Journal of Dairy Science (2003), 86(11), 3430-3439

Persistent accumulation of inflammatory cells in the udder, with neutrophils being the predominant cell type, is a characteristic feature of chronic mastitis in dairy cows. Leukotriene (LT) B-4 is a ... [more ▼]

Persistent accumulation of inflammatory cells in the udder, with neutrophils being the predominant cell type, is a characteristic feature of chronic mastitis in dairy cows. Leukotriene (LT) B-4 is a potent chemotactic agent, known to induce recruitment and accumulation of neutrophils in the bovine mammary gland. The LTB4-stimulated neutrophil functional responses are closely opposed by lipoxin (LX) A(4), which promotes the resolution of inflammation. We thus hypothesized that the chronic inflammation of the udder could be associated with an unfavorable ratio between these two eicosanoids and that the persistence of neutrophil accumulation could be due to an increase in LTB4 synthesis and/or an impaired LXA(4) production. In an attempt to verify this hypothesis, we first measured LXA(4), LTB4, and their ratio in the milk of healthy and acute and chronic mastitis-affected quarters. Next, we studied the relationships between these variables and the degree of udder inflammation as assessed by somatic cell count measurement. The LTB4 concentration was low in healthy quarters, drastically increased in acute mastitis, and reached intermediate levels in chronic mastitis-affected quarters. However, whereas LXA(4) concentration was highly increased in acute mastitis, healthy and chronic quarters had similarly low values. The LXA(4):LTB4 ratio was thus significantly lower in chronic mastitis-affected cows. The LTB4 concentrations measured in chronic quarters were highly correlated to somatic cell count and to milk neutrophil and macrophage numbers. A weaker correlation was observed between LXA(4) and these variables. For both eicosanoids, the highest correlation was observed with the number of neutrophils. These results show the existence of an LXA(4):LTB4 imbalance in chronic mastitis-affected cows because of low LXA(4) concentrations. Further studies are needed to determine whether administration of LX or stable analogs could have therapeutic potential in the control of chronic bovine mastitis. [less ▲]

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See detailImbalance between oxygen photoreduction and antioxidant capacities in Symbiodinium cells exposed to combined heat and high light stress
Roberty, Stéphane ULg; Fransolet, David; Cardol, Pierre ULg et al

in Coral Reefs (in press)

During last decades coral reefs have been affected by several large-scale bleaching events and such phenomenon is expected to increase in frequency and severity in the future thus compromising their ... [more ▼]

During last decades coral reefs have been affected by several large-scale bleaching events and such phenomenon is expected to increase in frequency and severity in the future thus compromising their survival. High sea surface temperature accompanied by high levels of solar irradiance has been found to be responsible for the induction of an oxidative stress ultimately ending with the disruption of the symbiosis between cnidarians and Symbiodinium. Since two decades many studies have pointed out the water-water cycle as being one of the primary mediators of this phenomenon, but the impacts of environmental stress on the O2 reduction by PSI and the associated ROS-detoxifying enzymes remain to be determined. In this study, we analyzed the impacts of an acute thermal and light stress on the WWC in the model Symbiodinium strain A1. We observed that high light treatment at 26°C resulted in the up-regulation of superoxide dismutase (SOD), ascorbate peroxidase (APX) and glutathione reductase (GR) activities and an increased production of Reactive Oxygen Species (ROS) with no significant change in O2-dependent electron transport. Under high light and at 33°C, O2-dependent electron transport was significantly increased relative to total electron transport. This increase was concomitant with a two-fold increase in ROS generation compared to the treatment at 26°C, while enzymes involved in the WWC were largely inactivated. These data show for the first time that combined heat and light stress inactivate antioxidant capacities of the WWC, and suggests that its photoprotective functions are overwhelmed under these conditions. This study also indicates that cnidarians may be more prone to bleach if they harbor Symbiodinium cells having a highly active Mehler-type electron transport, unless they are able to quickly up-regulate their antioxidant capacities. [less ▲]

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See detailImidazol(in)ium carboxylates as N-heterocyclic carbene ligand precursors for Suzuki-Miyaura reactions
Tudose, Adriana; Delaude, Lionel ULg; André, Benoît et al

in Tetrahedron Letters (2006), 47(48), 8529-8533

Simple catalysts formed in situ from palladium acetate and a variety of imidazolium and imidazolinium carboxylates and dithiocarboxylates have been screened in the coupling of aryl halides with trans-2 ... [more ▼]

Simple catalysts formed in situ from palladium acetate and a variety of imidazolium and imidazolinium carboxylates and dithiocarboxylates have been screened in the coupling of aryl halides with trans-2-phenylvinylboronic acid. Imidazol(in)ium carboxylates show an excellent activity, which compares to that displayed by the parent imidazol(in)ium chlorides, whereas imidazol(in)ium dithiocarboxylates are poorly efficient. Interestingly, the base employed exerts a profound influence on the trans/cis stereochemistry of the coupling product. (c) 2006 Elsevier Ltd. All rights reserved. [less ▲]

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See detailImidazol(in)ium-2-carboxylates as N-heterocyclic carbene precursors for the synthesis of second generation ruthenium metathesis catalysts
Sauvage, Xavier ULg; Demonceau, Albert ULg; Delaude, Lionel ULg

in Advanced Synthesis & Catalysis (2009), 351(11-12), 2031-2038

Five well-known ruthenium-N-heterocyclic carbene (NHC) catalysts for olefin metathesis and related reactions, including the second generation Grubbs and Hoveyda-Grubbs catalysts, were prepared by ... [more ▼]

Five well-known ruthenium-N-heterocyclic carbene (NHC) catalysts for olefin metathesis and related reactions, including the second generation Grubbs and Hoveyda-Grubbs catalysts, were prepared by phosphane exchange between first generation ruthenium-benzylidene or indenylidene complexes and NHCs generated in situ upon thermolysis of imidazol(in)ium-2-carboxylates. Because N-heterocyclic carbene -carbon dioxide adducts (NHC · CO2) are stable zwitterionic compounds that can be stored and handled with no particular precautions, this procedure is particularly attractive from a practical point of view. Reaction courses were conveniently monitored by 31P NMR spectroscopy and the experimental conditions were carefully adjusted to obtain high yields of pure products within short periods of time. [less ▲]

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See detailImidazol(in)ium-2-carboxylates as N-heterocyclic carbene precursors in ruthenium-arene catalysts for olefin metathesis and cyclopropanation
Tudose, Adriana; Demonceau, Albert ULg; Delaude, Lionel ULg

in Journal of Organometallic Chemistry (2006), 691(24-25), 5356-5365

Five imidazol(in)ium-2-carboxylates bearing cyclohexyl, mesityl, or 2,.6-diisopropylphenyl substituents on their nitrogen atoms were prepared from the corresponding N-heterocyclic carbenes (NHCs) by ... [more ▼]

Five imidazol(in)ium-2-carboxylates bearing cyclohexyl, mesityl, or 2,.6-diisopropylphenyl substituents on their nitrogen atoms were prepared from the corresponding N-heterocyclic carbenes (NHCs) by reaction with carbon dioxide. They were characterized by IR and NMR spectroscopies, and by TGA. Their ability to act as NHC precursors for in situ catalytic applications was probed in ruthenium-promoted olefin metathesis and cyclopropanation reactions. When visible light induced ring-opening metathesis polymerization of cyclooctene or cyclopropanation of styrene with ethyl diazoacetate were carried out at 60 degrees C in the presence of [RuCl2(p-cymene)](2), the NHC (.) CO2 adducts and their NHC (.) HX counterparts (X = Cl, BF4) displayed similar activities. When metathesis polymerizations were performed at room temperature, the carboxylates proved far superior to the corresponding imidazol(in)ium acid salts. They displayed the same level of activity as the preformed RuCl2(p-cymene)(IMes) complex, whereas the combination of NHC (.) HX and KO-t-Bu were almost totally inactive. Results obtained for cyclopropanation reactions at room temperature did not show such a large discrepancy of behavior between the two types of adducts. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailImidazolidinones structurally-related to penicillins: synthesis, molecular modeling and biological evalutation
Marchand-Brynaert, Jacqueline; Lamotte-Brasseur, Josette; Dive, Georges ULg

in Drug Metabolism and Drug Interactions (1994), 11(2), 85-109

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See detailImidazolopyrazinones as potential antioxydants
Devillers, Ingrid; Dive, Georges ULg; De Tollenaere, Catherine et al

in Bioorganic & Medicinal Chemistry Letters (2001), 11(17), 2305-2309

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See detailImiquimod et PDT dans le traitement des carcinomes basocellulaires, des kératoses actiniques et de la maladie de Bowen
Wauters, Odile ULg; Nikkels, Arjen ULg

in Dermatologie Actualité (2009), 117

Le traitement des carcinomes basocellulaires (CBC) superficiels, des petits CBC nodulaires, des kératoses actiniques (KA) et de la maladie de Bowen soit par imiquimod soit par photothérapie dynamique (PDT ... [more ▼]

Le traitement des carcinomes basocellulaires (CBC) superficiels, des petits CBC nodulaires, des kératoses actiniques (KA) et de la maladie de Bowen soit par imiquimod soit par photothérapie dynamique (PDT) est actuellement bien ancré dans l'arsenal thérapeutique du dermatologue. Les réussites thérapeutiques de ces deux modalités sont incontestables et avoisinent les 80 % dans les deux cas. Chaque méthode est liée à des effets indésirables propres et inhérents aux différents mécanismes d'action. Cette revue compare les données de la littérature évaluant l'efficacité, le taux de récidive, la tolérance, et les résultats cosmétiques pour les différentes indications reconnues en Belgique. Afin de mieux pouvoir cerner le niveau de preuve scientifique des études, le niveau d'évidence des publications est également mentionné. Ensuite seront discutés les avantages et les limites de ces techniques en pratique quotidienne. [less ▲]

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See detailImiquimod-responsive basal cell carcinomas and factor XIIIa-enriched dendrocytes.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Clinical & Experimental Dermatology (2003), 28 Suppl 1

Dermal dendrocytes (DDs) are dendritic cells that exhibit immunoreactivity for factor XIIIa, and are frequently found in conjunction with basal cell carcinomas (BCCs). Imiquimod was applied to 12 ... [more ▼]

Dermal dendrocytes (DDs) are dendritic cells that exhibit immunoreactivity for factor XIIIa, and are frequently found in conjunction with basal cell carcinomas (BCCs). Imiquimod was applied to 12 superficial BCCs every 3 days for 8 weeks. One week after completion of treatment, seven lesions appeared to have resolved, while five displayed evidence of residual BCC. Prior to initiation of treatment, the seven imiquimod-responsive BCCs were surrounded by numerous DDs, whereas the five imiquimod-resistant BCCs had fewer DDs next to them at the time of entry into the study. It appears that the pretreatment density in DDs may affect the efficacy of imiquimod in eradicating skin tumours. [less ▲]

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See detailIMISCOE Research Network, Training and Research Inventory
Gsir, Sonia ULg

Report (2011)

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See detailIMISCOE Research Network, Training and Research Inventory
Gsir, Sonia ULg

Report (2012)

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See detailIMISCOE Research Network, Training and Research Inventory 2015
Mescoli, Elsa ULg

Report (2015)

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See detailL'Imitation de Jésus-Christ
Henneau, Marie-Elisabeth ULg

in Corbin, Alain; Lemaître, Nicole; Thélamon, Françoise (Eds.) et al Histoire du Christianisme. Pour mieux comprendre notre temps (2007)

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See detailL’imitation du cirque
Dubouclez, Olivier ULg

in LEXI/textes (2007)

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