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See detailFluorodeoxyglucose F Positron Emission Tomography Coupled With Computed Tomography in Suspected Acute Renal Allograft Rejection.
LOVINFOSSE, Pierre ULg; Weekers, L.; Bonvoisin, C. et al

in American Journal of Transplantation (2016)

Management of kidney transplant recipients (KTRs) with suspected acute rejection (AR) ultimately relies on kidney biopsy; however, noninvasive tests predicting nonrejection would help avoid unnecessary ... [more ▼]

Management of kidney transplant recipients (KTRs) with suspected acute rejection (AR) ultimately relies on kidney biopsy; however, noninvasive tests predicting nonrejection would help avoid unnecessary biopsy. AR involves recruitment of leukocytes avid for fluorodeoxyglucose F18 (18 F-FDG), thus 18 F-FDG positron emission tomography (PET) coupled with computed tomography (CT) may noninvasively distinguish nonrejection from AR. From January 2013 to February 2015, we prospectively performed 32 18 F-FDG PET/CT scans in 31 adult KTRs with suspected AR who underwent transplant biopsy. Biopsies were categorized into four groups: normal (n = 8), borderline (n = 10), AR (n = 8), or other (n = 6, including 3 with polyoma BK nephropathy). Estimated GFR was comparable in all groups. PET/CT was performed 201 +/- 18 minutes after administration of 3.2 +/- 0.2 MBq/kg of 18 F-FDG, before any immunosuppression change. Mean standard uptake values (SUVs) of both upper and lower renal poles were measured. Mean SUVs reached 1.5 +/- 0.2, 1.6 +/- 0.3, 2.9 +/- 0.8, and 2.2 +/- 1.2 for the normal, borderline, AR, and other groups, respectively. One-way analysis of variance demonstrated a significant difference of mean SUVs among groups. A positive correlation between mean SUV and acute composite Banff score was found, with r2 = 0.49. The area under the receiver operating characteristic curve was 0.93, with 100% sensitivity and 50% specificity using a mean SUV threshold of 1.6. In conclusion, 18 F-FDG PET/CT may help noninvasively prevent avoidable transplant biopsies in KTRs with suspected AR. [less ▲]

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See detailFluorodeoxyglucose positron emission tomography and somatostatin receptor scintigraphy for diagnosing and staging carcinoid tumours: correlations with the pathological indexes p53 and Ki-67
Belhocine, Tarik; Willems, Jacqueline ULg; Rigo, Pierre ULg et al

in Nuclear Medicine Communications (2002), 23(8), 727-734

We performed this study in order to evaluate the diagnostic accuracy of whole-body fluorodeoxyglucose positron emission tomography (FDG PET) imaging and somatostatin receptor scintigraphy (SRS) for ... [more ▼]

We performed this study in order to evaluate the diagnostic accuracy of whole-body fluorodeoxyglucose positron emission tomography (FDG PET) imaging and somatostatin receptor scintigraphy (SRS) for localizing primary carcinoid tumours and evaluating the extent of the disease. A secondary aim was to correlate those findings with the histological characteristics of the lesions. FDG PET was performed in 17 patients and SRS in 16. All patients had pathologically proven carcinoids. All lesions were verified by histopathological analysis or by follow-up. Ki-67 and p53 expression were assessed as an indicator of the tumours' aggressiveness. FDG PET correctly identified 4/7 primary tumours and 8/11 metastatic spreads, as compared to six and 10 respectively, for SRS. Most tumours were typical carcinoids with low Ki-67 expression. No correlation was found between the histological features and the tracer's uptake. We conclude that SRS remains the modality of choice for evaluating patients with carcinoid tumours, regardless of their proliferative activity. FDG PET should be reserved to patients with negative results on SRS. ((C) 2002 Lippincott Williams Wilkins). [less ▲]

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See detailFluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration.
Laureys, Steven ULg; Salmon, Eric ULg; Garraux, Gaëtan ULg et al

in Journal of Neurology (1999), 246(12), 1151-8

Fluorodopa (FDOPA) and fluorodeoxyglucose (FDG) PET was performed in six patients in early stages of corticobasal degeneration (CBD) and compared to Parkinson's disease (PD) patients with a similar degree ... [more ▼]

Fluorodopa (FDOPA) and fluorodeoxyglucose (FDG) PET was performed in six patients in early stages of corticobasal degeneration (CBD) and compared to Parkinson's disease (PD) patients with a similar degree of bradykinesia and rigidity and to healthy controls. Statistical parametric mapping analysis comparing CBD to controls showed metabolic decrease in premotor, primary motor, supplementary motor, primary sensory, prefrontal, and parietal associative cortices, and in caudate and thalamus contralateral to the side of clinical signs. Except for the prefrontal regions a similar metabolic pattern was observed when CBD was compared to PD. Putamen FDOPA uptake was decreased in both CBD and PD. Caudate FDOPA uptake in CBD patients was decreased contralateral to clinical signs when compared to controls, but was higher than in PD. In early stages of CBD, FDOPA and FDG PET patterns differed from those observed in PD. In CBD the asymmetry in FDOPA uptake was less pronounced than that of clinical signs or metabolic impairment. [less ▲]

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See detailLes fluoroquinolones
Damas, Pierre ULg

in Revue Médicale de Liège (1996), 51(1), 50-52

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See detailFluoxetine and norfluoxetine quantitation in rat serum by LC-chip-MS/MS
Houbart, Virginie ULg; Charlier, Thierry; Pawluski, Jodi et al

Poster (2014, June)

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See detailFluoxetine therapy in obese diabetic and glucose intolerant patients.
Kutnowski, M.; Daubresse, J. C.; Friedman, H. et al

in International Journal of Obesity & Related Metabolic Disorders (1992), 16 Suppl 4

A double-blind placebo-controlled trial was conducted, involving 97 obese diabetic and glucose intolerant patients receiving either 60 mg fluoxetine daily (47 patients) or a placebo (50 patients); a ... [more ▼]

A double-blind placebo-controlled trial was conducted, involving 97 obese diabetic and glucose intolerant patients receiving either 60 mg fluoxetine daily (47 patients) or a placebo (50 patients); a similar calorie-restricted diet was prescribed to all patients. Weight loss was significantly higher in the fluoxetine-treated patients, whose diabetic status improved. Drop-out rate was not significantly different for both groups of patients. [less ▲]

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See detailFlurbiprofen in the symptomatic management of rheumatoid arthritis: a valuable alternative
Richy, F.; Rabenda, Véronique ULg; Mawet, Audrey ULg et al

in International Journal of Clinical Practice (2007), 61(8), 1396-1406

Background: The withdrawal of certain cyclooxygenase-2 selective drugs and the availability of over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) have increased the pressure for researching ... [more ▼]

Background: The withdrawal of certain cyclooxygenase-2 selective drugs and the availability of over-the-counter non-steroidal anti-inflammatory drugs (NSAIDs) have increased the pressure for researching and prescribing conventional NSAIDs with a favourable efficacy/tolerance ratio in inflammatory diseases, particularly rheumatoid arthritis. The aim of this comprehensive meta-analysis was to evaluate the absolute and relative efficacy and safety of flurbiprofen in the management of rheumatoid arthritis. Methods: A systematic and exhaustive bibliographic research of published literature has been performed. The inclusion criteria are summarised as follows: randomised trial and rheumatoid arthritis and flurbiprofen and oral administration and anti-inflammatory doses from 100 to 300 mg and (placebo or aspirin or indomethacin or naproxen or ibuprofen or ketoprofen) and (articular pain or stiffness or swelling or mobility or patient/physician reported efficacy or tolerance or gastrointestinal (GI) tolerance). Studies were conducted from January 1975 to January 2006. Analyses have been stratified by comparisons and outcomes. Publication bias and robustness have been extensively investigated. Results: Fourteen studies, accounting for 1103 patient-years, have been included in the quantitative review. The mean daily doses administrated were 200 mg flurbiprofen, 4000 mg aspirin, 150 indomethacin, 750 mg naproxen and 1800 mg ibuprofen. Flurbiprofen was superior to placebo for all outcomes, and superior to three of four other NSAIDs in terms of formal symptomatic measures (pain, stiffness and swelling). Several patients or physicians reported the efficacy of flurbiprofen as superior to indomethacin and naproxen, while its safety, and particularly its GI tolerance were better compared with aspirin and indomethacin. Sensitivity analyses have reported a sufficient robustness against systematic publication bias assumptions. Conclusions: This meta-analysis has shown that flurbiprofen is an interesting alternative to commonly prescribed NSAIDs in the symptomatic management of rheumatoid arthritis, especially given its favourable efficacy/tolerance ratio. [less ▲]

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See detailFlushing operations with limited sediment availability
Dewals, Benjamin ULg; Brasseur, Nicolas; Erpicum, Sébastien ULg et al

in Proc. 33rd IAHR Congress: Water Engineering for a Sustainable Environment (2009)

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See detailFLUSHING PORCINE DCD LIVERS WITH CYCLO-DEXTRIN COMPLEXED CURCUMIN DOES NOT REDUCE ISCHEMIA REPERFUSION INJURY
MEURISSE, Nicolas ULg; PARKINNEN, J; CEULEMANS, L et al

Poster (2014, April)

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See detailFlussi Migratori
Mazzola, Alessandro ULg

Speech/Talk (2016)

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See detailFlüssig-Flüssig-Extraktion
Pfennig, Andreas ULg; Pilhofer, T; Schröter, J

in Fluid-Verfahrenstechnik, Band 2, Wiley-VCH (2006)

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See detailFlüssig-Flüssig-Extraktion
Kalem, Murat; Kröckel,, Jan; Bertakis, Evangelos et al

in RWTH Themenheft (2009)

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See detailFlüssig-Flüssig-Extraktion: Vom Laborexperiment zur Technikumsanlage
Henschke, M; Pfennig, Andreas ULg

Conference (1998, September 21)

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See detailFlüssiger Kationenaustauscher
Erhardt, F; Pfennig, Andreas ULg; Przybylski, M -D et al

Patent (2012)

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See detailFlutter and limit cycle oscillation suppression using linear and nonlinear tuned vibration absorbers
Verstraelen, Edouard ULg; Kerschen, Gaëtan ULg; Dimitriadis, Grigorios ULg

in Proceedings of the SEM IMAC XXXV (2017, February)

Aircraft are more than ever pushed to their limits for performance reasons. Consequently, they become increasingly nonlinear and they are more prone to undergo aeroelastic limit cycle oscillations ... [more ▼]

Aircraft are more than ever pushed to their limits for performance reasons. Consequently, they become increasingly nonlinear and they are more prone to undergo aeroelastic limit cycle oscillations. Structural nonlinearities affect aircraft such as the F-16, which can undergo store-induced limit cycle oscillations (LCOs). Furthermore, transonic buzz can lead to LCOs because of moving shock waves in transonic flight conditions on many aircraft. This study presents a numerical investigation of passive LCO suppression on a typical aeroelastic system with pitch and plunge degrees of freedom and a hardening stiffness nonlinearity. The absorber used is made of a piezoelectric patch glued to the plunge springs and connected to a resistor and an inductance forming a RLC circuit. A mechanical tuned mass damper absorber of similar configuration is also considered. The piezoelectric absorber features significant advantages in terms of size, weight and tuning convenience. The results show that both types of absorber increase the linear flutter speed of the system in a similar fashion but, when optimal, they lead to a sub-critical bifurcation while a super-critical bifurcation was observed without absorber. Finally, it is shown that the addition of a properly tuned nonlinear spring (mechanical absorber) or capacitor (piezo- electric absorber) can restore the super-criticality of the bifurcation. The tuning of the nonlinearity is carried out using numerical continuation. [less ▲]

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See detailFlutter and stall flutter of a rectangular wing in a wind tunnel
Norizham, Abdul Razak ULg; Andrianne, Thomas ULg; Dimitriadis, Grigorios ULg

in AIAA Journal (2011), 49(10), 2258-2271

The aeroelastic behavior of a rectangular wing with pitch and plunge degrees of freedom was observed experimentally using pressure, acceleration and PIV measurements. The wing was set at different static ... [more ▼]

The aeroelastic behavior of a rectangular wing with pitch and plunge degrees of freedom was observed experimentally using pressure, acceleration and PIV measurements. The wing was set at different static angles of attack and wind tunnel airspeeds. The wing's dynamic behavior was governed by a two-parameter bifurcation from steady to Limit Cycle Oscillations (LCO), the two parameters being the airspeed and the static angle of attack. At the lowest static angle, the wing underwent a classical flutter phenomenon that was transformed into a supercritical Hopf bifurcation at higher angles. The latter was combined with a fold bifurcation at intermediate angles of attack. All LCOs observed were either low amplitude oscillations with time-varying amplitude or high amplitude oscillations with nearly steady amplitude. They were caused by two different types of dynamic stall phenomena. During low amplitude LCOs the periodically stalled flow covered only the rear part of the wing. During high amplitude LCOs, trailing edge and leading edge separation occured. Trailing edge separation was characterized by a significant amount of unsteadiness, varying visibly from cycle to cycle. The occurrence of leading edge separation was much more regular and had the tendency to stabilize the amplitude of the LCO motion. [less ▲]

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See detailFlutter Clearance of a Non-linear aircraft
Benini, Guilherme; Vio, Gareth Arthur; Dimitriadis, Grigorios ULg et al

in Proceedings of the 2005 International Forum on Aeroelasticity and Structural Dynamics (2005, June)

Flight flutter testing is always carried out under the assumption that aircraft are linear. Recently, this assumption has started to come under question, especially as far as military aircraft are ... [more ▼]

Flight flutter testing is always carried out under the assumption that aircraft are linear. Recently, this assumption has started to come under question, especially as far as military aircraft are concerned. This paper deals with possible methodologies for flight flutter testing of aircraft that are no longer assumed linear. Simulated flight testing is performed for a simple non-linear aeroelastic system with cubic stiffness. The flutter speeds predicted using some of the classical linear flutter prediction methods as well as a non-linear method are compared. It is shown that, for non-linear system undergoing Hopf Bifurcations, classical linear flutter prediction can predict the flutter envelope with reasonable accuracy. However, fully non-linear system identification and stability analysis can not only predict the flutter point but also determine whether it is a linear or non-linear flutter point (i.e. whether divergent or Limit Cycle Oscillations will ensue). Additionally, the non-linear method can predict the amplitudes of LCOs that will occur post-critically. The application of the nonlinear method was successful for noise free data, but the problem of noise corruption still needs further investigation. [less ▲]

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See detailFlutter Prediction from Flight Flutter Test Data
Dimitriadis, Grigorios ULg; Cooper, Jonathan E

in Journal of Aircraft (2001), 38(2), 355-367

The most common approach to flight flutter testing is to track estimated modal damping ratios of an aircraft over a number of flight conditions. These damping trends are then extrapolated to predict ... [more ▼]

The most common approach to flight flutter testing is to track estimated modal damping ratios of an aircraft over a number of flight conditions. These damping trends are then extrapolated to predict whether it is safe to move to the next test point and also to determine the utter speed. In the quest for more reliable and efficient flight flutter testing procedures, a number of alternative data analysis methods have been proposed. Five of these approaches are compared on two simulated aeroelastic models. The comparison is based on both the accuracy of prediction and the efficiency of each method. It is found that, for simple aeroelastic systems, the Nissim and Gilyard method (Nissim, E., and Gilyard, G. B., “Method for Experimental Determination of Flutter Speed by Parameter Identification,” AIAA Paper 89-1324, 1989) yields the best flutter predictions and is also the least computationally expensive approach.However, for larger systems, simpler approaches such as the damping fit and envelope function methods are found to be most reliable. [less ▲]

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See detailFluvial architecture of Belgian river systems in contrasting environments:implications for reconstructing the sedimentation history
Notebaert, Bastiaan; Houbrechts, Geoffrey ULg; Verstraeten, G. et al

in Netherlands Journal of Geosciences - Geologie en Mijnbouw (2011), 90(1), 31-50

Accurate dating is necessary to get insight in the temporal variations in sediment deposition in floodplains. The interpretation of such dates is however dependent on the fluvial architecture of the ... [more ▼]

Accurate dating is necessary to get insight in the temporal variations in sediment deposition in floodplains. The interpretation of such dates is however dependent on the fluvial architecture of the floodplain. In this study we discuss the fluvial architecture of three contrasting Belgian catchments (Dijle, Geul and Amblève catchment) and how this influences the dating possibilities of net floodplain sediment storage. Although vertical aggradation occurred in all three floodplains during the last part of the Holocene, they differ in the importance of lateral accretion and vertical aggradation during the entire Holocene. Holocene floodplain aggradation is the dominant process in the Dijle catchment. Lateral reworking of the floodplain sediments by river meandering was limited to a part of the floodplain, resulting in stacked point bar deposits. The fluvial architecture allows identifying vertical aggradation without erosional hiatuses. Results show that trends in vertical floodplain aggradation in the Dijle catchment are mainly related to land use changes. In the other two catchments, lateral reworking was the dominant process, and channel lag and point bar deposits occur over the entire floodplain width. Here, tracers were used to date the sediment dynamics: lead from metal mining in the Geul and iron slag from ironworks in the Amblève catchment. These methods allow the identification of two or three discrete periods, but their spatial extent and variations is identified in a continuous way. The fluvial architecture and the limitation in dating with tracers hampered the identification of dominant environmental changes for sediment dynamics in both catchments. Dating methods which provide only discrete point information, like radiocarbon or OSL dating, are best suited for fluvial systems which contain continuous aggradation profiles. Spatially more continuous dating methods, e.g. through the use of tracers, allow to reconstruct past surfaces and allow to reconstruct reworked parts of the floodplain. As such they allow a better reconstruction of past sedimentation rates in systems with important lateral reworking. [less ▲]

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See detailFluvial archives, a valuable record of vertical crustal deformation
Demoulin, Alain ULg; Mather, Anne; Whittaker, Alexander

in Quaternary Science Reviews (2017)

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature ... [more ▼]

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature of crustal deformation and its history. In recent decades, geomorphic analysis of rivers has proved powerful in elucidating the tectonic evolution of actively uplifting and eroding orogens. Here, we review the main recent developments that have improved and expanded qualitative and quantitative information about vertical tectonic motions (the effects of horizontal deformation are not addressed). Channel long profiles have received considerable attention in the literature, and we briefly introduce basic aspects of the behaviour of bedrock rivers from field and numerical modelling perspectives, before describing the various metrics that have been proposed to identify the information on crustal deformation contained within their steady-state characteristics. Then, we review the literature dealing with the transient response of rivers to tectonic perturbation, through the production of knickpoints propagating through the drainage network. Inverse modelling of river profiles for uplift in time and space is also shown to be very effective in reconstructing regional tectonic histories. Finally, we present a synthetic morphometric approach for deducing the tectonic record of fluvial landscapes. As well as the erosional imprint of tectonic forcing, sedimentary deposits, such as fluvial terrace staircases, are also considered as a classical component of tectonic geomorphology. We show that these studies have recently benefited from rapid advances in dating techniques, allowing more reliable reconstruction of incision histories and estimation of incision rates. The combination of progress in the understanding of transient river profiles and larger, more rigorous data sets of terrace ages has led to improved understanding of river erosion and the implications for terrace profile correlation, i.e., extrapolation of local data to entire profiles. Finally, planform changes in fluvial systems are considered at the channel scale in alluvial rivers and regional level in terms of drainage reorganisation. Examples are given of how numerical modelling can efficiently combine with topographic data to shed new light on the (dis)equilibrium state of drainage systems across regional drainage divides. [less ▲]

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