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See detailImplementing quantum algorithms in hyperfine levels of ultracold polar molecules
Vranckx, Stéphane; Pellegrini, Philippe; Desouter-Lecomte, Michèle ULg

in Journal of Physics: Conference Series (2012), 388(11), 112010

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See detailImplementing quantum algorithms in hyperfine levels of ultracold polar molecules by optimal control
Pellegrini, Philippe; Vranckx, Stéphane; Desouter, Michèle ULg

in Physical Chemistry Chemical Physics [=PCCP] (2011), 13

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See detailImplementing river restoration taking into account constraints of water supply protection: the case study of the Bocq River at Spontin
Peeters, Alexandre ULg; De le Court, Bernard; Verniers, Gisèle

Poster (2013, September)

In the Bocq basin, eastern tributary of the Meuse, restoration works consist of making 20 obstacles passable to improve the free movement of fish and sediment. This presentation focuses on a particular ... [more ▼]

In the Bocq basin, eastern tributary of the Meuse, restoration works consist of making 20 obstacles passable to improve the free movement of fish and sediment. This presentation focuses on a particular case study involving river restoration in a groundwater abstraction zone. In the sixties, a reach of more than 600 meters of the Bocq was completely channelized in order to avoid any risk of contamination of the nearby important drinking water well field area. Ecological quality was consequently impoverished due to the loss of natural habitats (streambed and banks made of concrete and masonry). In addition, the hydraulic conditions (high flow, low depth) make it totally insurmountable for fish. The restoration project started with a 3-year period of consultation with the water abstraction owner to finally reach an agreement on a restoration project taking into account the need of protection of the water abstraction. The project consisted on building rock weirs at regular interval in order to create a succession of 23 steps and pools. Furthermore, various habitats schemes were implemented such as fish shelter, rock berms for aquatic vegetation, and spawning gravel introduction. In addition a small dike and an expansion area for flooding have been completed to protect the water abstraction. This project is being monitored on the basis of geomorphological and ecological analysis. Geomorphological monitoring focuses on the bedload transport with an analysis of flood and the clogging of the gravel layer. Ecological monitoring is based on two indicators (macroinvertebrates and fishes) as well as the analysis of microhabitats. The first results show an improvement after 1 year. [less ▲]

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See detailImplementing river restoration taking into account constraints of water supply protection: the case study of the Bocq River at Spontin
Peeters, Alexandre ULg; De le Court, Bernard; Verniers, Gisèle et al

Poster (2013, October)

In the Bocq basin, eastern tributary of the Meuse, restoration works consist of making 20 obstacles passable to improve the free movement of fish and sediment. This presentation focuses on a particular ... [more ▼]

In the Bocq basin, eastern tributary of the Meuse, restoration works consist of making 20 obstacles passable to improve the free movement of fish and sediment. This presentation focuses on a particular case study involving river restoration in a groundwater abstraction zone. In the sixties, a reach of more than 600 meters of the Bocq was completely channelized in order to avoid any risk of contamination of the nearby important drinking water well field area. Ecological quality was consequently impoverished due to the loss of natural habitats (streambed and banks made of concrete and masonry). In addition, the hydraulic conditions (high flow, low depth) make it totally insurmountable for fish. The restoration project started with a 3-year period of consultation with the water abstraction owner to finally reach an agreement on a restoration project taking into account the need of protection of the water abstraction. The project consisted on building rock weirs at regular interval in order to create a succession of 23 steps and pools. Furthermore, various habitats schemes were implemented such as fish shelter, rock berms for aquatic vegetation, and spawning gravel introduction. In addition a small dike and an expansion area for flooding have been completed to protect the water abstraction. This project is being monitored on the basis of geomorphological and ecological analysis. Geomorphological monitoring focuses on the bedload transport with an analysis of flood and the clogging of the gravel layer. Ecological monitoring is based on two indicators (macroinvertebrates and fishes) as well as the analysis of microhabitats. The first results show an improvement after 1 year. [less ▲]

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See detailImplementing sustainability strategies through accounting controls: An exploration of practices in seven multinational corporations
Crutzen, Nathalie ULg; Schaltegger, Stefan

in Proceedings of the 36th Annual Congress of the European Accounting Association (EAA) (2013, May)

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See detailImplementing the Bianco and Yohai estimator for logistic regression
Croux, C.; Haesbroeck, Gentiane ULg

in Computational Statistics & Data Analysis (2003), 44(1-2), 273-295

A fast and stable algorithm to compute a highly robust estimator for the logistic regression model is proposed. A criterium. for the existence of this estimator at finite samples is derived and the ... [more ▼]

A fast and stable algorithm to compute a highly robust estimator for the logistic regression model is proposed. A criterium. for the existence of this estimator at finite samples is derived and the problem of the selection of an appropriate loss function is discussed. It is shown that the loss function can be chosen such that the robust estimator exists if and only if the maximum likelihood estimator exists. The advantages of using a weighted version of this estimator are also considered. Simulations and an example give further support for the good performance of the implemented estimators. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailL'implication dans la recherche clinique : un chemin vers la psychanalyse
Naziri, Despina ULg

in Revue Belge de Psychanalyse (2002), 40

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See detailL’implication dans la recherche clinique : un chemin vers la psychanalyse
Naziri, Despina ULg

in Revue Belge de Psychanalyse (2003), 40(printemps), 3-24

L'article débute par un bref rappel des liens entre psychologie clinique et modèle psychanalytique et de la spécificité de la recherche clinique. Puis j’illustrerai ce type de recherche à travers mon ... [more ▼]

L'article débute par un bref rappel des liens entre psychologie clinique et modèle psychanalytique et de la spécificité de la recherche clinique. Puis j’illustrerai ce type de recherche à travers mon travail sur le recours répétitif à l’avortement en explicitant mon cheminement, tant au niveau de la pensée que de l’expérience, et en reprenant quelques repères de mon itinéraire personnel. [less ▲]

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See detailImplication de la clusterine dans la survie des cellules prostatiques lors de l'apoptose
Ammar, Hayet ULg

Doctoral thesis (2014)

Prostate cancer is the second leading cause of cancer death in men. Although androgen ablation remains the most effective management option, most patients with advanced disease progress to castration ... [more ▼]

Prostate cancer is the second leading cause of cancer death in men. Although androgen ablation remains the most effective management option, most patients with advanced disease progress to castration resistant prostate cancer (CRPC), within two years of treatment. This results, in part, from the increase in the anti-apoptotic molecules expression following androgen withdrawal. Among the proteins involved in this phenomenon, clusterin, also known as testosterone repressed message-2 (TRPM- 2), which exists in two forms: a pro-apoptotic nuclear form (nClU) and a secreted survival factor (sClU). In our study we investigated the role of the secreted form of clusterin in preventing cells from TNFα-induced apoptosis. For this, we first generated a sCLU inducible stable prostatic cancer MLL rat cell line by using the Tet-On gene expression system. With this model we revealed a new mechanism by which sCLU promotes survival in androgenindependent prostate cancer cells, implicating its receptor megalin and the Akt survival pathway. By applying a comparative proteomic analysis in the androgen-independent epithelial cell line MLLTet-sClu induced to overexpress sClu or non induced control-cells, we identified five proteins known to play a role in cancer. These proteins candidates are heat shock proteins Hsp90 and Hsp70, osteopontin (bone sialoprotein, OPN), proliferating cell nuclear antigen (PCNA) and ADP-ribosylation factor 1 (Arf1). Altogether, our data provide new mechanistic insight in sCLU dependent activation of the major survival pathway upregulated in refractory prostate cancer. The identification of the new sCLU protein targets open new avenues for more research to elucidate the significance of clusterin in prostate cancer progression and resistance to therapy. [less ▲]

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See detailImplication de la compétition pour les acides aminés dans le contrôle biologique de la pourriture bleue des pommes en post-récolte
Krimi Bencheqroun, S.; Bajji, M.; Labhilili, M. et al

Conference (2008, April)

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See detailImplication de la dipeptidyl peptidase IV dans l’insuffisance cardiaque expérimentale et clinique
Gomez Malaver, Nelson ULg

Doctoral thesis (2012)

BNP1-32 is a cardiac hormone showing cardiac and renal protection. Paradoxically, in overt congestive heart failure, high levels of plasma BNP seem devoid of biological effectiveness. Moreover, treatments ... [more ▼]

BNP1-32 is a cardiac hormone showing cardiac and renal protection. Paradoxically, in overt congestive heart failure, high levels of plasma BNP seem devoid of biological effectiveness. Moreover, treatments targeting the BNP system are less effective in dogs with severe heart failure than in healthy dogs or dogs in mild heart failure. The origin of this paradox is not yet clear. Dipeptidyl peptidase IV (DPP4) is an ubiquitary exopeptidase that cleaves small peptides having a proline or an alanine in the N-terminal second position. Human BNP1-32 is a known substrate for DPP4, its second amino acid is a proline and this structure is conserved among several species including the pig and the dog. In dogs, BNP3-32, coming from the cleavage of BNP1-32 by DPP4, shows reduced biological activity. We made 2 hypotheses: (1) in canine congestive heart failure, increased DPP4 activity participates in the “resistance to BNP” and (2) in a pig model of tachycardiomyopathy, inhibition of DPP4 reduces cardiorenal dysfunction increases the effectiveness of exogenous BNP1-32 and decreases myocardial molecular alterations. In the first study, we identified physiologic determinants of plasma DPP4 activity and evaluated DPP4 activity in dogs in heart failure. Population included 81 healthy dogs and 47 dogs at different stages of heart failure. Plasma DPP4 activity was higher in healthy growing dogs than in healthy adults. In healthy adults, DPP4 activity was positively correlated with body weight with no effect of age, sex and of circadian rhythm. DPP4 activity was higher in dogs in asymptomatic cardiac insufficiency than in healthy dogs and in dogs in congestive heart failure without any effect of the disease. In the second study, a tachycardiomyopathy was induced in 12 pigs by rapid right ventricular pacing. Sitagliptin, an oral inhibitor of DPP4, was administered in half of the pigs. In this model, inhibition of plasma DPP4 activity improved global cardiac function, maintained glomerular filtration rate and, increased cardiac contractility during BNP perfusion. Functional improvement was associated with a reduction of myocardial gene expression of calmoduline, sodium-calcium exchanger, BNP and interleukin-6 as well as an increase in myocardial SDF-1 protein concentration. In conclusion, the “BNP resistance” observed in congestive heart failure is not due to increased plasma DPP4 activity but DPP4 inhibition reduces cardiorenal alterations in experimental myocardial failure. DPP4 inhibitors have been developed for treatment of type 2 diabetes. It remains to be studied (1) if this treatment, initially targeted to control glycemia, may protect the heart and the kidney in patients with type 2 diabetes with or without metabolic syndrome (2) if this treatment may be used to treat heart failure and the cardiorenal syndrome. [less ▲]

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See detailImplication de la neurohypophyse dans le stress psychique
Scantamburlo, Gabrielle ULg; Ansseau, Marc ULg; Legros, Jean-Jacques ULg

in Encéphale (L') (2001), 27(3, May-Jun), 245-59

Effects of different psychological stimuli on oxytocin (OT) and vasopressin (AVP) secretion are reviewed in animals and in humans. The secretion of neuropituitary hormones is also discussed in various ... [more ▼]

Effects of different psychological stimuli on oxytocin (OT) and vasopressin (AVP) secretion are reviewed in animals and in humans. The secretion of neuropituitary hormones is also discussed in various psychiatric diseases such an anorexia nervosa, bipolar disorder, schizophrenia and obsessive-compulsive disorder. AVP and OT are secreted into the hypophyseal portal circulation by neurons which project from the paraventricular nucleus to the external zone of the median eminence. AVP and OT-containing neurons in the suprachiasmatic and paraventricular nuclei project to limbic areas, including the hippocampus, the subiculum, the ventral nucleus of the amygdala and the nucleus of the diagonal band. Specific AVP receptors which are pharmacologically different from the pressor and antidiuretic AVP receptors have been found in the anterior pituitary. OT receptors have been identified in a variety of forebrain sites. The neurohypophyseal secretion is regulated by the cholinergic muscarinic, histaminergic and beta-adrenergic systems. Stress alters the secretion of one or more of the hypothalamic factors which interact at the pituitary to increase the secretion of ACTH. AVP and OT have been shown to modulate the effect of Corticotropin-Releasing Factor (CRF) on ACTH secretion and appear to play a key role in mediating the ACTH response to stress. Although AVP is a relatively weak secretagogue for ACTH, it markedly potentiates the activity of CRF both in vitro and in vivo. The role of OT is more complex. In vitro, OT stimulates ACTH release at high doses whereas in human it inhibits ACTH secretion at low doses. The type of stressor appear to determine the relative importance of these secretatogues in ACTH response. Several recent studies indicate that psychological stressors display a similar degree of variety of secretagogue release patterns as was found earlier for physical stressors. A bewildering array of technique produces a bewildering array of conclusions. In rats, OT may be an important secretagogue during a novel stimulus, whereas the role for AVP is less clear. Indeed two studies out of ten suggest a stimulating role for AVP. In response to frustration and submission, OT and AVP are secreted. Regarding social isolation, results are difficult to interpret and the role of AVP could be species-dependent. In contrast plasma OT levels do not change. After restraint, ACTH release is primarily mediated by the active increase of OT and AVP does not appear to play a role. When restraint is associated with moderate levels of physical components and during immobilisation, all two secretagogs are involved in the ACTH response. With fear, ACTH response appears to be driven by OT. In humans, one study indicates that high emotionality women increase plasma OT in response to uncontrollable noise. Various neuroendocrine dysregulations have been observed in psychiatric disease. Either an increase or a decrease of the hypothalamic-pituitary-adrenal (HPA) function have been described in several illnesses. Effects of OT appear to be reciprocal to the effects of AVP. OT has been called the "amnestic" neuropeptide due to its capacity to attenuate memory consolidation and retrieval. AVP exhibits a central activating action on mood, memory and selective attention. Underweight patients with anorexia nervosa have abnormally high levels of centrally directed AVP and reduced OT levels. These modifications could enhance the retention of cognitive distortions of aversive consequences of eating. Patients with bipolar disorder show a biphasic secretion of AVP. Depressive episodes are associated with decreased vasopressinergic activity whereas manic episodes involve an increased release. AVP might be responsible for an increased catecholamine activity. In addition, lithium could act as an antagonist to AVP. In schizophrenic patients, studies using the apomorphine stimulation suggest increased oxytoninergic and decreased vasopressinergic functions. These findings are consistent with the beneficial role of AVP on schizophrenic symptoms noted in several trials. The increased OT could be responsible for "positive" symptomatology such as delusions and hallucinations. Obsessive compulsive disorder (OCD) includes a range of cognitive and behavioral disturbances that could be influenced by OT. In animals, several studies have emphasized the role of AVP in promoting repetitive grooming behaviors and maintaining conditioned response to aversive stimuli. In OCD patients, one study have reported that AVP/OT ratio was negatively correlated with symptom severity. However, an independent report found similar AVP concentrations in OC patients without a personal or family history of tic disorder and in normal subjects. Whether these modifications are only a consequence of the central disturbances or whether those peptides could participate in the pathogenesis of these affections remains to be elucidated. [less ▲]

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See detailImplication de la protéine transmembranaire d’enveloppe du virus de la leucémie bovine dans la fusion cellulaire et l’infectivité virale.
GATOT, Jean-Stéphane ULg; Callebaut, Isabelle; Mornon, Jean-Paul et al

in Séminaire de la Recherche Télévie (1999, March 16)

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See detailImplication de la sous-famille Erg des facteurs de transcription Ets dans la régulation de l'épissage chez l'Homme
Vincent, Côme ULg

Master's dissertation (2013)

The human family of Ets proteins and the Erg subfamily composed of 3 members (ERG, FLI1 and FEV) are known as transcription factors, involved in many cellular processes. On the other hand, most protein ... [more ▼]

The human family of Ets proteins and the Erg subfamily composed of 3 members (ERG, FLI1 and FEV) are known as transcription factors, involved in many cellular processes. On the other hand, most protein-coding genes contain intervening sequences (introns) that must be precisely removed from pre-mRNA through the process of pre-mRNA splicing. The first aim of this project was to molecularly characterise the link between these two actors. To achieve this goal, three different approaches were used. Firth, the link between the Erg subfamily and nuclear speckles, subnuclear structures that are enriched in pre-mRNA splicing factors, was studied using immunofluorescence and confocal microscopy, then an MS2-tethering assay was performed and finally, endogenous targets whose splicing would be dependent on this subfamily were identified. The results of these approaches highlighted interconnectivity between gene expression machineries. Moreover, such understanding of molecular basis of cancer-involved proteins provide new possibilities for earlier detection as well as better diagnosis, prevention and novel treatment strategies. [less ▲]

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