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See detailMode Of Membrane Interaction And Fusogenic Properties Of A De Novo Transmembrane Model Peptide Depend On The Length Of The Hydrophobic Core
Lorin, A.; Charloteaux, Benoît ULg; Fridmann-Sirkis, Y. et al

in Journal of Biological Chemistry (2007), 282(25), 18388-96

Model peptides composed of alanine and leucine residues are often used to mimic single helical transmembrane domains. Many studies have been carried out to determine how they interact with membranes ... [more ▼]

Model peptides composed of alanine and leucine residues are often used to mimic single helical transmembrane domains. Many studies have been carried out to determine how they interact with membranes. However, few studies have investigated their lipid-destabilizing effect. We designed three peptides designated KALRs containing a hydrophobic stretch of 14, 18, or 22 alanines/leucines surrounded by charged amino acids. Molecular modeling simulations in an implicit membrane model as well as attenuated total reflection-Fourier transform infrared analyses show that KALR is a good model of a transmembrane helix. However, tryptophan fluorescence and attenuated total reflection-Fourier transform infrared spectroscopy indicate that the extent of binding and insertion into lipids increases with the length of the peptide hydrophobic core. Although binding can be directly correlated to peptide hydrophobicity, we show that insertion of peptides into a membrane is determined by the length of the peptide hydrophobic core. Functional studies were performed by measuring the ability of peptides to induce lipid mixing and leakage of liposomes. The data reveal that whereas KALR14 does not destabilize liposomal membranes, KALR18 and KALR22 induce 40 and 50% of lipid-mixing, and 65 and 80% of leakage, respectively. These results indicate that a transmembrane model peptide can induce liposome fusion in vitro if it is long enough. The reasons for the link between length and fusogenicity are discussed in relation to studies of transmembrane domains of viral fusion proteins. We propose that fusogenicity depends not only on peptide insertion but also on the ability of peptides to destabilize the two leaflets of the liposome membrane. [less ▲]

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See detailMode visibilities in rapidly rotating stars
Reese, Daniel ULg; Prat, V.; Barban, C. et al

in Astronomy and Astrophysics (2013), 550

Context: Mode identification is a crucial step to comparing observed frequencies with theoretical ones, but has proven to be difficult in rapidly rotating stars. Aims: To further constrain mode ... [more ▼]

Context: Mode identification is a crucial step to comparing observed frequencies with theoretical ones, but has proven to be difficult in rapidly rotating stars. Aims: To further constrain mode identification, we aim to accurately calculate mode visibilities and amplitude ratios in rapid rotators. Methods: We derive the relevant equations for calculating mode visibilities in different photometric bands while fully taking into account the geometric distortion from both the centrifugal deformation and the pulsation modes, the variations in effective gravity, and an approximate treatment of the temperature variations. These equations are then applied to 2D oscillation modes, calculated using the TOP code, in fully distorted 2D models based on the SCF method. The specific intensities come from a grid of Kurucz atmospheres, thereby taking into account limb and gravity darkening. Results: We obtain mode visibilities and amplitude ratios for 2 M_{\odot} models rotating at 0 to 80 % of the critical rotation rate. These calculations confirm previous results, such as the increased visibility of chaotic modes, the simpler frequency spectra of pole-on stars, or the dependence of amplitude ratios on inclination and azimuthal order. In addition, the geometric shape of the star reduces the contrast between pole-on and equator-on visibilities of island modes. We also show that modes with similar (ell, |m|) values frequently have similar amplitude ratios, even in the most rapidly rotating models. [less ▲]

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See detailModel Analysis: A Systems Theory Contribution to Systems Biology
Bullinger, Eric ULg

Scientific conference (2002, April 05)

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See detailA Model Based Study of Carbon Fluxes at Ten European Forest Sites
Falge, E.; Tenhunen, J.; Aubinet, Marc ULg et al

in Valentini, Riccardo (Ed.) Fluxes of Carbon, Water and Energy of European Forests (2003)

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See detailModel based, gain-scheduled anti-windup control for LPV systems
Forni, Fulvio ULg; Galeani, Sergio

in 46th IEEE Conference on Decision and Control (cdc 2007) (2007)

In this paper we show that a recently proposed technique for anti-windup control of exponentially unstable plants can be easily extended to solve the corresponding robust anti-windup problem for linear ... [more ▼]

In this paper we show that a recently proposed technique for anti-windup control of exponentially unstable plants can be easily extended to solve the corresponding robust anti-windup problem for linear parameter varying systems, for which the time varying parameters are measured online. For this class of plants, it is shown that the proposed technique is minimally conservative with respect to the size of the resulting operating region: in particular, such a region is (up to an arbitrarily small quantity) exactly the largest set on which asymptotic stability can be guaranteed for the considered plant, for the given saturation level and uncertainty characteristics. [less ▲]

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See detailModel calculations of the Sivers function satisfying the Burkardt sum rule
Courtoy, Aurore ULg; Scopetta, S.; Vento, V.

in Physical Review D - Particles, Fields, Gravitation and Cosmology (2009), 79(7),

It is shown that, at variance with previous analyses, the MIT bag model can explain the available data of the Sivers function and satisfies the Burkardt sum rule to a few percent accuracy. The agreement ... [more ▼]

It is shown that, at variance with previous analyses, the MIT bag model can explain the available data of the Sivers function and satisfies the Burkardt sum rule to a few percent accuracy. The agreement is similar to the one recently found in the constituent quark model. Therefore, these two model calculations of the Sivers function are in agreement with the present experimental and theoretical wisdom. © 2009 The American Physical Society. [less ▲]

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See detailModel Checking in Practice: An Analysis of the ACCESS.bus Protocol using SPIN
Boigelot, Bernard ULg; Godefroid, Patrice

in Lecture Notes in Computer Science (1996), 1051

This paper presents a case study of the use of model checking for analyzing an industrial protocol, the ACCESS.bus protocol. Our analysis of this protocol was carried out using SPIN, an automated ... [more ▼]

This paper presents a case study of the use of model checking for analyzing an industrial protocol, the ACCESS.bus protocol. Our analysis of this protocol was carried out using SPIN, an automated verification system which includes an implementation of model-checking algorithms. A model of the protocol was developed, and properties expressed by linear-time temporal-logic formulas were checked on this model. This analysis revealed subtle flaws in the design of the protocol. Developers who worked on implementations of ACCESS.bus were unaware of these flaws at a very late stage of their development process. We also present suggestions for solving the detected problems. [less ▲]

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See detailModel complexity and performance: How far can we simplify?
Raick, Caroline ULg; Soetaert, Karline; Grégoire, Marilaure ULg

in Progress in Oceanography (2006), 70(1), 27-57

Handling model complexity and reliability is a key area of research today. While complex models containing sufficient detail have become possible due to increased computing power, they often lead to too ... [more ▼]

Handling model complexity and reliability is a key area of research today. While complex models containing sufficient detail have become possible due to increased computing power, they often lead to too much uncertainty. On the other hand, very simple models often crudely oversimplify the real ecosystem and can not be used for management purposes. Starting from a complex and validated 1D pelagic ecosystem model of the Ligurian Sea (NW Mediterranean Sea), we derived simplified aggregated models in which either the unbalanced algal growth, the functional group diversity or the explicit description of the microbial loop was sacrificed. To overcome the problem of data availability with adequate spatial and temporal resolution, the outputs of the complex model are used as the baseline of perfect knowledge to calibrate the simplified models. Objective criteria of model performance were used to compare the simplified models' results to the complex model output and to the available data at the DYFAMED station in the central Ligurian Sea. We show that even the simplest (NPZD) model is able to represent the global ecosystem features described by the complex model (e.g. primary and secondary productions, particulate organic matter export flux, etc.). However, a certain degree of sophistication in the formulation of some biogeochemical processes is required to produce realistic behaviors (e.g. the phytoplankton competition, the potential carbon or nitrogen limitation of the zooplankton ingestion, the model trophic closure, etc.). In general, a 9 state-variable model that has the functional group diversity removed, but which retains the bacterial loop and the unbalanced algal growth, performs best. (C) 2006 Elsevier Ltd. All rights reserved. [less ▲]

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See detailModel Discrimination Tools in Apoptosis
Cimatoribus, C.; Eißing, T.; N., Elvassore et al

in Foundations of Systems Biology in Engineering, FOSBE 2005 (2005, August)

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See detailModel emulsion systems
Blecker, Christophe ULg; Paquot, Michel ULg

Conference (1995, April)

Detailed reference viewed: 47 (30 ULg)
See detailModel Extension Facilitates Parameter Estimation for Kinetic Reaction Networks
Fey, Dirk; Bullinger, Eric ULg

Poster (2007, September)

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See detailModel Extension Facilitates Parameter Estimation for Kinetic Reaction Networks
Fey, Dirk; Bullinger, Eric ULg

Poster (2007, September)

Detailed reference viewed: 2 (0 ULg)
See detailA model for assessing water chemistry by using aquatic bryophyte assemblages in north-eastern France
Vanderpoorten, Alain ULg; Thiébaut, G.; Trémolières, M. et al

in Verhandlungen der Internationalen Vereinigung für Theoretische und Angewandte Limnologie = Proceedings of the International Association of Theoretical and Applied Limnology (2001), 27

Detailed reference viewed: 7 (1 ULg)
See detailA model for optimal sea-river shipping management
Marchal, Jean ULg; Zhang, Z. M.

in Proceedings of the Third Research Roundtable Conference on Shortsea Shipping (1996, June)

Detailed reference viewed: 15 (0 ULg)
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See detailA model for ternary projective relations between regions
Billen, Roland ULg; Clementini, Eliseo

in Lecture Notes in Computer Science (2004)

Detailed reference viewed: 19 (3 ULg)
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See detailA model for the bright rim in RCW 62.
Manfroid, Jean ULg

in Astronomy and Astrophysics (1976), 51

Abstract image available at: http://cdsads.u-strasbg.fr/abs/1976A&A....51..235M

Detailed reference viewed: 5 (0 ULg)
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See detailA model for the generalized parton distribution of the pion
Stassart, Pierre ULg; Bissey, F.; Cudell, Jean-René ULg et al

in AIP Conference Proceedings (2005), 756

Detailed reference viewed: 6 (3 ULg)